A Novel Hand-Held Based Optical Imager for Fluorescence Imaging of Breast Cancer. Grant

abstract

  • Diagnostic imaging of early stage breast cancer is essential for decreasing the death rate caused by cancer in the United States. Near-infrared (NIR) optical imaging using external fluorescence contrast agents is an emerging non-invasive modality that can become an important tool in the diagnosis of early-stage breast cancer and prognosis of the disease. To date, most of the work in fluorescence-enhanced optical tomographic imaging is carried out using: (i) small volume phantom or in-vivo animal models that lack clinically relevant depth information; (ii) non-flexible optical probes that are restricted to image only specific tissue volumes or shapes; or (iii) measurement geometries that interrogate limited tissue volumes. In the current application, we propose to develop a hand-held optical fiber probe (~ 2' diameter) to perform fluorescence imaging of breast cancer using large tissue phantoms and in-vitro tissue models. The hand- held optical probe will be unique in terms of its: (i) flexibility to image any tissue shape and volume; (ii) non- compressibility, portability, and patient comfort due to its hand-held based design; and (iii) novel measurement geometry that can interrogate greater tissue volumes with reduced imaging time. The developmental aims are to: (i) design and construction of a hand-held optical with optimal fiber configuration for simultaneous NIR light illumination and collection measurement geometry; (ii) develop and optimize a rapid data acquiring frequency-domain intensified charge coupled device (ICCD) detection system; (iii) perform fluorescence-enhanced absorption imaging studies using tissue-mimicking phantoms and in-vitro tissue samples and assess the precision and accuracy of the fluorescence measurements; and (iv) integrate an undergraduate student with current research at various stages of the proposed work. The milestone of the proposed work is to develop a hand-held optical-based imagerthat is robust, rapid, flexible, non- compressible, comfortable, portable, and applicable for any given breast volume and shape, that is expected to render high-resolution diagnostic and prognostic breast cancer imaging in the clinic.

date/time interval

  • September 1, 2007 - August 31, 2011

sponsor award ID

  • 1R15CA119253-01A1

local award ID

  • AWD000000000653

contributor

keywords

  • 3-Dimensional
  • Algorithms
  • Animal Model
  • Biomedical Engineering
  • Brain
  • Brain Mapping
  • Brain imaging
  • Breast
  • Caliber
  • Cancer Diagnostics
  • Cancer Etiology
  • Cancer Prognosis
  • Charge
  • Clinic
  • Clinical
  • Collection
  • Contrast Media
  • Coupled
  • Data
  • Death Rate
  • Depth
  • Detection
  • Development
  • Device or Instrument Development
  • Devices
  • Diagnostic
  • Diagnostic Imaging
  • Disease
  • Early Diagnosis
  • Elements
  • Epilepsy
  • Fiber
  • Florida
  • Fluorescence
  • Frequencies
  • Future
  • Hand
  • Image
  • Imaging Techniques
  • In Vitro
  • Institutes
  • Intensive Care Units
  • International
  • Invasive
  • Lead
  • Light
  • Lighting
  • Mammary Gland Parenchyma
  • Measurement
  • Modality
  • Monitor
  • Nature
  • Noise
  • Numbers
  • Optics
  • Patients
  • Pediatric Hospitals
  • Pliability
  • Population
  • Rate
  • Research
  • Research Personnel
  • Resolution
  • Scheme
  • Sensitivity and Specificity
  • Shapes
  • Signal Transduction
  • Staging
  • Students
  • System
  • Technology
  • Time
  • Tissue Model
  • Tissue Sample
  • Tissues
  • Translations
  • United States
  • Universities
  • Work
  • absorption
  • base
  • cancer diagnosis
  • cancer imaging
  • clinically relevant
  • data acquisition
  • design
  • design and construction
  • fluorescence imaging
  • improved
  • in vivo
  • innovation
  • instrument
  • malignant breast neoplasm
  • novel
  • optical fiber
  • optical imaging
  • outcome forecast
  • portability
  • prognostic
  • programs
  • tissue phantom
  • tomography
  • tool