Hand-held Optical Imager for Breast Cancer Imaging Grant

abstract

  • Early-stage diagnosis of breast cancer is essential for improving the survival rate of women affected (1 in 8) in the United States. Near-infrared (NIR) optical imaging is a non-invasive and non-ionizing modality that is emerging as a diagnostic tool for breast cancer. In recent years, hand-held based optical imagers developed towards clinical translation of the technology are not capable of contouring along tissue curvatures, nor perform three-dimensional (3D) tomographic imaging to diagnose deep and/or early stage tumors. The overall objective of the proposed work is to implement the recently developed portable cart-based hand-held optical imager for tissue phantom and in-vivo breast imaging studies (in normal and breast cancer subjects), in order to demonstrate near-real time 2D tumor detection and 3D tomographic analysis, towards breast cancer diagnosis. The specific aims include: (i) Demonstrate real-time simultaneous bilateral breast imaging in tissue phantoms and in-vivo, using a novel hand-held optical imager, in order to detect tumor-mimicking targets in near real-time. (ii) Demonstrate the feasibility of 3D target localization in tissue phantoms and in-vivo, via 3D tomographic imaging studies using the hand-held optical imager; and (iii) Determine the effectiveness of tumor detection in breast cancer subjects using the hand-held optical imager, in comparison to the gold-standard x- ray mammography. The hypothesis of the application relies on a three-fold innovative implementation: (i) the 'forked' probe design aids in performing simultaneous bilateral imaging of both the breast tissues, in order to improve the signal-to-noise (SNR) ratio between the normal and diseased tissue; (ii) co-registered measurements using a hand-held probe on any tissue volume and curvature aids in near real-time target detections as well as 3D tomographic imaging; and (iii) simultaneous illumination and detection at multiple locations on the tissue will allow rapid imaging time, appropriate for a clinical environment. The study design involves the following: (i) Perform simultaneous bilateral imaging on breast phantoms, in-vivo on healthy and breast cancer subjects to determine the effectiveness of 2D target (tumor) detectability with maximum SNR. (ii) Implement a coregistered imaging approach to obtain positional information of the probe(s) towards 3D tomographic analysis in phantom and in-vivo. (iii) Determine the 3D target (tumor) location(s) via tomographic analysis in phantoms and in-vivo; and (iv) Compare the optical images to the gold standard x-ray mammography images in breast cancer subject studies, in order to assess the feasibility of the hand-held optical imager in a clinical environment. The proposed research significantly impacts by accelerating the clinical translation of the emerging optical imaging technology towards early-stage breast cancer diagnosis, due to the unique and innovative method of 3D target localization using a portable and inexpensive hand-held optical imager. The technology also has potential towards prognostic breast imaging, image-guided breast cancer therapy, and volumetric analysis of tumors in response to chemotherapeutic trials. PUBLIC HEALTH RELEVANCE: The portable hand-held optical imager with its capabilities of 2D near real-time surface imaging and 3D tomographic analysis has potential for early-stage diagnostic/prognostic breast imaging in younger women and/or women with dense breasts.

date/time interval

  • September 26, 2011 - August 31, 2014

sponsor award ID

  • 2R15CA119253-02

local award ID

  • AWD000000001811

contributor

keywords

  • Affect
  • Algorithms
  • Bilateral
  • Biomedical Engineering
  • Biopsy
  • Breast
  • Clinical
  • Computer software
  • Contrast Media
  • Detection
  • Development
  • Devices
  • Diagnosis
  • Diagnostic
  • Diagnostic Neoplasm Staging
  • Early Diagnosis
  • Effectiveness
  • Environment
  • Florida
  • Future
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  • Gold
  • Grant
  • Hand
  • Hand functions
  • Housing
  • Image
  • Imaging technology
  • International
  • Laboratories
  • Light
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  • Location
  • Magnetic Resonance Imaging
  • Mammary Gland Parenchyma
  • Mammography
  • Measurement
  • Methods
  • Modality
  • Noise
  • Nuclear
  • Operative Surgical Procedures
  • Optics
  • Patients
  • Performance
  • Positron-Emission Tomography
  • Research
  • Research Design
  • Signal Transduction
  • Staging
  • Study Subject
  • Surface
  • Surgeon
  • Survival Rate
  • Technology
  • Time
  • Tissues
  • Translations
  • Tumor stage
  • Ultrasonography
  • United States
  • Universities
  • Woman
  • Work
  • base
  • breast cancer diagnosis
  • cancer imaging
  • cancer therapy
  • design
  • flexibility
  • high risk
  • imaging modality
  • improved
  • in vivo
  • innovation
  • malignant breast neoplasm
  • novel
  • optical imaging
  • prognostic
  • reconstruction
  • response
  • tissue phantom
  • tool
  • tumor