Center for Translational Science Organization
FIU Center for Translational Science is an important part of FIU’s focus on training the next generation of scientists and doctors through a robust focus on training doctoral students and postdoctoral fellows.
FIU-CTS faculty, staff, fellows and students are representative of the global research community as well as the South Florida Community. FIU has a deep commitment to diversity, equity, and inclusion. We have found that research, at its best, thrives utilizing a global collaborative approach, which includes new ideas and thought processes by a diverse group of individuals, working toward a common goal to understand and develop potential therapeutics for human diseases.
Overview
abbreviation
- CTS
webpage
Affiliation
people
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Position
- Cui, Shiquan, Postdoctoral Associate
- Houghten, Richard, Research Professor
- Nefzi, Adel, Research Professor
- Rayala, Ramanjaneyulu, Postdoctoral Associate
- Tantak, Mukund, Postdoctoral Associate
- Xiong, Xinrui, Research Associate
- Zhang, Tingting, Postdoctoral Associate
organization within
Scholarly & Creative Works
select organization publications
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Article
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2021Encoding mu-opioid receptor biased agonism with interaction fingerprintsFull Text via DOI: 10.1007/s10822-021-00422-5 Web of Science: 000712176800001
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2021Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) AntagonistFull Text via DOI: 10.1021/acs.jmedchem.1c01417 Web of Science: 000709633100049
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2021Integrated Analysis of Weighted Gene Coexpression Network Analysis Identifying Six Genes as Novel Biomarkers for Alzheimer's DiseaseFull Text via DOI: 10.1155/2021/9918498 Web of Science: 000684846500004
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2021Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound InfectionsFull Text via DOI: 10.3389/fmicb.2021.708904
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2021Discovery of a Lead Compound for Specific Inhibition of Type I Collagen Production in FibrosisFull Text via DOI: 10.1021/acsmedchemlett.1c00006 Web of Science: 000629174700018
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2021Identification of Four Genes as Prognosis Signatures in Lung Adenocarcinoma MicroenvironmentFull Text via DOI: 10.2147/PGPM.S283414 Web of Science: 000605607400001
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2020Detergent-insoluble inclusion constitutes the first pathology in PFN1 transgenic ratsFull Text via DOI: 10.1111/jnc.15139 Web of Science: 000558663100001
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2020Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinaseFull Text via DOI: 10.1016/j.bmcl.2020.127108 Web of Science: 000522861200012
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2019Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogsFull Text via DOI: 10.1039/c9ob00882a Web of Science: 000471015200015
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2019Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based LibrariesFull Text via DOI: 10.3390/molecules24061100 Web of Science: 000465503800076
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2018Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar PotencyFull Text via DOI: 10.1021/acsmedchemlett.8b00425 Web of Science: 000447471800021
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2018Synthesis of Novel Oxazolyl Amino Acids and Their Use in the Parallel Synthesis of Disubstituted Oxazole LibrariesFull Text via DOI: 10.1055/s-0036-1589148 Web of Science: 000427997500016
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2017Antibacterial and Antibiofilm Activities of a Novel Synthetic Cyclic Lipopeptide against Cariogenic Streptococcus mutans UA159Full Text via DOI: 10.1128/AAC.00776-17 Web of Science: 000406259400076
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2016Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by antimicrobial peptides (AMPs) and plant essential oilsFull Text via DOI: 10.1080/13880209.2016.1190763 Web of Science: 000389443300045
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2016Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis AgentsFull Text via DOI: 10.1128/AAC.00288-16 Web of Science: 000378094400020
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2016Synthesis and anticancer activity study of indolyl hydrazide-hydrazonesFull Text via DOI: 10.1007/s00044-016-1522-1
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2016Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazinesFull Text via DOI: 10.1016/j.bmcl.2016.03.063 Web of Science: 000373739700021
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2016Studies toward the oxidative and reductive activation of C-S bonds in 2 '-S-aryl-2 '-thiouridine derivativesFull Text via DOI: 10.1016/j.tet.2016.02.063 Web of Science: 000374198700010
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2016One-pot synthesis and in-vitro anticancer evaluation of 5-(2′-indolyl)thiazolesFull Text via DOI: 10.1038/srep23401
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2015Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT)Full Text via DOI: 10.1021/acs.chemrestox.5b00432 Web of Science: 000367118000019
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2015Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE PathogensFull Text via DOI: 10.1021/jm501628s Web of Science: 000353602200006
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2015A convenient synthesis of 3,4-cis-disubstituted pyrrolidin-2-onesFull Text via DOI: 10.1016/j.tetlet.2014.11.023 Web of Science: 000348259800015
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2015Easy Conversion of Dimethyl -(Bromomethyl)fumarate into Functionalized Allyl Ethers Mediated by DABCOFull Text via DOI: 10.1080/00397911.2015.1093144 Web of Science: 000365095000011
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2014One-Electron Oxidation of Gemcitabine and Analogs: Mechanism of Formation of C3 ' and C2 ' Sugar RadicalsFull Text via DOI: 10.1021/ja5083156 Web of Science: 000344516600035
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2014Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agentsFull Text via DOI: 10.1016/j.bmcl.2014.08.022 Web of Science: 000341435000006
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2014AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein alphaFull Text via DOI: 10.1016/j.ab.2014.05.007 Web of Science: 000338406500004
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2014Combinatorial Synthesis of Oxazol-Thiazole Bis-Heterocyclic CompoundsFull Text via DOI: 10.1021/co400133a Web of Science: 000329879700006
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2013Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization StudiesFull Text via DOI: 10.1021/jm401543h Web of Science: 000329331600020
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2013Parallel synthesis of bis-oxazole peptidomimeticsFull Text via DOI: 10.1016/j.tetlet.2013.10.078 Web of Science: 000327577200021
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2013Antimalarial and cytotoxic activities of chiral triaminesFull Text via DOI: 10.1016/j.bmcl.2013.06.035 Web of Science: 000322611900017
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2013Parallel synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones on solid-phaseFull Text via DOI: 10.1021/co400064d
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2013Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustineFull Text via DOI: 10.1186/1741-7015-11-81 Web of Science: 000318938000001
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2013Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing CyclopeptidesFull Text via DOI: 10.1007/978-1-62703-652-8_1 Web of Science: 000335641200002
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2012Parallel synthesis of structurally diverse aminobenzimidazole tethered sultams and benzothiazepinonesFull Text via DOI: 10.1016/j.tetlet.2012.09.135 Web of Science: 000312231400006
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2012Fluorescent Mu selective opioid ligands from a mixture based cyclic peptide libraryFull Text via DOI: 10.1021/co300110t
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2012Prediction of the experimental regioselectivity of C-60 fullerene bis-adductsFull Text via DOI: 10.1002/poc.2943 Web of Science: 000310486900004
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2012Bromination at C-5 of pyrimidine and C-8 of purine nucleosides with 1,3-dibromo-5,5-dimethylhydantoinFull Text via DOI: 10.1016/j.tetlet.2012.04.081 Web of Science: 000304851500033
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2012Ugi four-center three-component reaction for the parallel solid-phase synthesis of N-substituted thiomopholinonesFull Text via DOI: 10.1016/j.tetlet.2011.12.074 Web of Science: 000301833600002
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2012Parallel Synthesis of Aminobenzimidazole-Tethered ThiazolesFull Text via DOI: 10.1055/s-0031-1289644 Web of Science: 000300198400007
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2011Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymesFull Text via DOI: 10.1007/s11030-011-9333-2 Web of Science: 000300364700017
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2011Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug DiscoveryFull Text via DOI: 10.2174/138620711795767866 Web of Science: 000292772100004
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2011Integrating computational and mixture-based screening of combinatorial librariesFull Text via DOI: 10.1007/s00894-010-0850-1 Web of Science: 000291041800025
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2011Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis-Diazacyclic LibrariesFull Text via DOI: 10.1111/j.1747-0285.2011.01100.x Web of Science: 000289474100004
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2010Two-Step Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole-Containing CyclopeptidesFull Text via DOI: 10.1021/jo1016822 Web of Science: 000284080300055
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2010Diversity-oriented synthesis of N-aryl-N-thiazolyl compoundsFull Text via DOI: 10.1016/j.tetlet.2010.06.117 Web of Science: 000281356700002
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2010ChemInform Abstract: Utility of Soluble Peptide Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199543292
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2010Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctionsFull Text via DOI: 10.1016/j.bmcl.2010.06.029 Web of Science: 000279866300053
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2010Parallel synthesis of 19-membered ring macro-heterocycles via intramolecular thioether formationFull Text via DOI: 10.1016/j.tetlet.2010.05.029 Web of Science: 000279340000001
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2010Solid-Phase Synthesis of N-Substituted Pyrrolidinone-Tethered N-Substituted Piperidines via Ugi ReactionFull Text via DOI: 10.1021/cc100054u Web of Science: 000279618200025
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2010ChemInform Abstract: Mixture‐Based Synthetic Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199949239
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2010Synthesis of Chiral PolyaminothiazolesFull Text via DOI: 10.1021/cc9001907 Web of Science: 000277355600003
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2010Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studiesFull Text via DOI: 10.1007/s10822-010-9328-6 Web of Science: 000276965100005
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2009Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: A double diversity for the identification of new antitubercular compoundsFull Text via DOI: 10.1016/j.bmcl.2009.07.010 Web of Science: 000268863800063
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2009Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligandsFull Text via DOI: 10.1016/j.bmc.2009.06.026 Web of Science: 000268099700026
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2009Modeling of peptides containing D-amino acids: Implications on cyclizationFull Text via DOI: 10.1007/s10822-009-9295-y
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2009Synthetic Small-Molecule Prohormone Convertase 2 InhibitorsFull Text via DOI: 10.1124/mol.108.051334 Web of Science: 000263559500019
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2009Saoussanabiloide, a novel antifungal alkaloid from Echiochilon fruticosum Desf. growing in TunisiaFull Text via DOI: 10.1080/14786410802267619 Web of Science: 000273303000002
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2006491 POSTER Trageting XIAP in paediatric cancersFull Text via DOI: 10.1016/s1359-6349(06)70496-7
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2006Synthesis of platinum(II) chiral tetraamine coordination complexesFull Text via DOI: 10.1021/cc060045h Web of Science: 000240403200020
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2006A versatile access to new macrocyclic oligoheterocycles (MOH)Full Text via DOI: 10.1016/j.bmcl.2006.04.039 Web of Science: 000238182700001
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2006Efficient approach for the parallel solid-phase synthesis of 1,1,3,4-tetrasubstituted-5-oxopiperazin-1-ium compoundsFull Text via DOI: 10.1016/j.tetlet.2006.03.196 Web of Science: 000237820800003
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2005Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosisFull Text via DOI: 10.1182/blood-2005-02-0695 Web of Science: 000231495000040
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2005"Volatilizable" supports for high-throughput organic synthesisFull Text via DOI: 10.1021/ja0402396
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2005Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cellsFull Text via DOI: 10.1182/blood-2004-08-3168 Web of Science: 000229009000050
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2004Peptidic complex mixtures as therapeutic agents in CNS autoimmunityFull Text via DOI: 10.1016/j.molimm.2003.11.006
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2004Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activityFull Text via DOI: 10.1016/S1535-6108(03)00332-5 Web of Science: 000188400300007
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2003Solid-phase synthesis of 3-amino-1,2,4-triazolesFull Text via DOI: 10.1016/j.tetlet.2003.08.074
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2003Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-supportFull Text via DOI: 10.1016/S0040-4039(03)01219-X Web of Science: 000183780300037
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2003Solid-phase synthesis of indolines via palladium-catalyzed cyclizationFull Text via DOI: 10.1016/S0040-4039(03)00317-4
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2003Solid-phase synthesis of new fused tetra, penta and hexacyclic beta-carboline derivativesFull Text via DOI: 10.1016/S0040-4039(03)00181-3 Web of Science: 000181242600052
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2002Opioid activity of 4-imidazolidinone positional analogues of Leu-enkephalinFull Text via DOI: 10.1016/S0960-894X(02)00678-9 Web of Science: 000178693100034
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2002Parallel solid-phase synthesis of disubstituted 1,6-piperazine-2-onesFull Text via DOI: 10.1021/cc0200235 Web of Science: 000179254700002
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2002Parallel solid-phase synthesis of trisubstituted triazinobenzimidazoledionesFull Text via DOI: 10.1021/cc010089k
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2002An expedient method for the solid-phase synthesis of alpha-aminoalkyl phosphonopeptidesFull Text via DOI: 10.1016/S0040-4039(02)00695-0 Web of Science: 000175894400034
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2002Solid-phase synthesis of 1,5-disubstituted 2-aryliminoimidazolidinesFull Text via DOI: 10.1021/jo0109366
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2002Solid-phase synthesis of 1,2,5-trisubstituted 4-imidazolidinonesFull Text via DOI: 10.1021/cc0100565 Web of Science: 000175658100006
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2002Solid-phase parallel synthesis of 2-aminoimidazolidin-4-onesFull Text via DOI: 10.1016/S0040-4020(02)00299-5
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2002An efficient approach for solid-phase synthesis of peptidomimetics based on 4-imidazolidinonesFull Text via DOI: 10.1016/S0040-4039(02)00263-0 Web of Science: 000174765600006
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2002Solid-phase synthesis of linear ureas tethered to hydantoins and thiohydantoinsFull Text via DOI: 10.1021/cc010064l Web of Science: 000174633500013
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2001Solid-phase synthesis of bis-cyclic guanidines from tripeptidesFull Text via DOI: 10.1016/S0040-4020(01)01010-9
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2001Solid-phase synthesis of alpha,alpha-difluoro-beta-amino acids via the Reformatsky reactionFull Text via DOI: 10.1021/jo010872z Web of Science: 000172489500053
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2001Solid-phase synthesis of 2,3,5-trisubstituted 4H-imidazolonesFull Text via DOI: 10.1021/cc010022x
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2001Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-dionesFull Text via DOI: 10.1021/ol010102+
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2001Parallel synthesis of 4,5-dihydro-1H-1,4-benzodiazepine-2,3-dionesFull Text via DOI: 10.1016/S0040-4039(01)00939-X Web of Science: 000170062400003
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2001An N-methyl-D-aspartate receptor channel blocker with neuroprotective activityFull Text via DOI: 10.1073/pnas.061449498
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2001Tethered libraries: Solid-phase synthesis of substituted urea-linked bicyclic guanidinesFull Text via DOI: 10.1021/cc0000803 Web of Science: 000169606600009
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2001Solid phase synthesis of [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-onesFull Text via DOI: 10.1016/S0040-4039(00)02022-0
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2001Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysineFull Text via DOI: 10.1021/cc000061t Web of Science: 000167935000010
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2000ChemInform Abstract: Manual Multiple Synthesis MethodsFull Text via DOI: 10.1002/chin.200045266
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2000Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptidesFull Text via DOI: 10.1021/ol000225e Web of Science: 000089831900026
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2000An efficient two-step synthesis of mono-, di- and triureas from resin-bound amidesFull Text via DOI: 10.1016/S0040-4039(00)00845-5 Web of Science: 000088200200003
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2000Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamidesFull Text via DOI: 10.1016/S0040-4020(00)00253-2 Web of Science: 000087032100006
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2000Solid phase synthesis of 1-substituted pyroglutamatesFull Text via DOI: 10.1016/S0040-4039(99)02208-X Web of Science: 000085305600017
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2000Solid phase synthesis of 1,3-disubstituted succinimidesFull Text via DOI: 10.1016/S0040-4039(99)02166-8 Web of Science: 000085038700008
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2000Orphanin FQ/Nociceptin receptor binding studiesFull Text via DOI: 10.1016/S0196-9781(00)00231-X
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1999Solid phase synthesis of 1,4-benzothiazepin-5-one derivativesFull Text via DOI: 10.1016/S0040-4039(99)00964-8 Web of Science: 000081122400006
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1999Solid-Phase Synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethionesFull Text via DOI: 10.1021/cc980019m Web of Science: 000081948200005
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1998Efficient solid phase synthesis of 3,5-disubstituted hydantoinsFull Text via DOI: 10.1016/S0040-4039(98)01874-7 Web of Science: 000076524100004
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1998Combinatorial chemistry: From peptides and peptidomimetics to small organic and heterocyclic compoundsFull Text via DOI: 10.1016/S0960-894X(98)00412-0 Web of Science: 000075976300002
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1998Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-onesFull Text via DOI: 10.1016/S0040-4039(98)00645-5 Web of Science: 000073724300014
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1998Mapping the prion protein using recombinant antibodiesFull Text via DOI: 10.1128/jvi.72.11.9413-9418.1998
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1997Solid phase synthesis of 1,3,4,7-tetrasubstituted perhydro-1,4-diazepine-2,5-dionesFull Text via DOI: 10.1016/S0040-4039(97)01086-1 Web of Science: A1997XK06100007
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1997Polyalanine-based peptides as models for self-associated β-pleated- sheet complexesFull Text via DOI: 10.1021/bi963015b
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1997First Japanese Conference on Combinatorial Chemistry and High Throughput ScreeningFull Text via DOI: 10.1007/bf01715632
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1997Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureasFull Text via DOI: 10.1016/S0040-4039(96)02516-6 Web of Science: A1997WG34800010
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1996Induction of neonatal tolerance by plasmid DNA vaccination of miceFull Text via DOI: 10.1172/JCI119094
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1996Pseudo-prolines as a solubilizing, structure-disrupting protection technique in peptide synthesisFull Text via DOI: 10.1021/ja961509q Web of Science: A1996VK78000002
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1996Exploring antibody polyspecificity using synthetic combinatorial librariesFull Text via DOI: 10.1007/BF01718697
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1995Inhibition of a plant virus infection by analogs of melittinFull Text via DOI: 10.1073/pnas.92.26.12466
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1995
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1995A comparison of combinatorial library approaches for the study of opioid compoundsFull Text via DOI: 10.1007/BF02172068
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1995CHEMOSELECTIVE LIGATION OF MULTIFUNCTIONAL PEPTIDES TO TOPOLOGICAL TEMPLATES VIA THIOETHER FORMATION FOR TASP SYNTHESISFull Text via DOI: 10.1016/0040-4039(94)02230-9 Web of Science: A1995QA28200011
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1995A review of the utility of soluble peptide combinatorial librariesFull Text via DOI: 10.1002/bip.360370306
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1995Formation of an extremely stable polyalanine β-sheet macromoleculeFull Text via DOI: 10.1006/bbrc.1995.1770
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1993The broad utility of soluble peptide libraries for drug discoveryFull Text via DOI: 10.1016/0378-1119(93)90244-W
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1993Influence of tryptophan residues on melittin's hemolytic activityFull Text via DOI: 10.1016/0167-4838(93)90024-L
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1992Design of Model Amphipathic Peptides Having Potent Antimicrobial ActivitiesFull Text via DOI: 10.1021/bi00165a020
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1992High frequency of malaria‐specific T cells in non‐exposed humansFull Text via DOI: 10.1002/eji.1830220311
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1992Perturbation of peptide conformations induced in anisotropic environmentsFull Text via DOI: 10.1002/bip.360320602
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1989The Chemistry of Site-Directed Serology for HIV InfectionsFull Text via DOI: 10.1089/aid.1989.5.487
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1988Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparumFull Text via DOI: 10.1038/334258a0
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1988Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues Threonine351-Serine365 of the factor VIII heavy chainFull Text via DOI: 10.1172/JCI113559
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1987A chemically synthesized peptide with mycobacterial characteristicsFull Text via DOI: 10.1002/jcla.1860010308
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1987The degradation of dynorphin A in brain tissue in vivo and in vitroFull Text via DOI: 10.1016/0196-9781(87)90046-5
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1986Antipeptide Antibodies: Do They Distinguish HLA-Alloantigens?Full Text via DOI: 10.1515/znc-1986-5-627
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1986Specificity of Rabbit Antibodies Elicited by Related Synthetic PeptidesFull Text via DOI: 10.1515/znc-1986-5-620
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1985Anti-peptide antibodies detect oncogene-related proteins in urineFull Text via DOI: 10.1073/pnas.82.23.7924
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1985Mobility and evolutionary variability factors in protein antigenicityFull Text via DOI: 10.1038/317090b0
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1985Prodynorphin peptide immunocytochemistry in rhesus monkey brainFull Text via DOI: 10.1016/0196-9781(85)90149-4
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1984The structure of an antigenic determinant in a proteinFull Text via DOI: 10.1016/0092-8674(84)90412-4
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1983Autoradiography of [3H]β-endorphin binding in brainFull Text via DOI: 10.1016/0006-8993(83)90113-0
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1983Chemical basis of antigenic variation in foot-and-mouth disease virusFull Text via DOI: 10.1038/306694a0
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1983α-Neo-endorphin: Receptor binding properties of the tritiated ligandFull Text via DOI: 10.1016/0024-3205(83)90689-6
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1983[3H]Dynorphin a binds selectively to guinea pig brainFull Text via DOI: 10.1016/0014-2999(83)90489-2
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1983Reduction of Sulfoxides in Peptides and ProteinsFull Text via DOI: 10.1016/S0076-6879(83)91050-9
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1983[3H] dynorphin binding to guinea pig and rat brainFull Text via DOI: 10.1016/0024-3205(83)90499-X
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1982Identification of a β-endorphin-like peptide in cultured human placental cellsFull Text via DOI: 10.1038/295593a0
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1982Tritiated porcine dynorphin (1-17): Synthesis and characterizationFull Text via DOI: 10.1016/0024-3205(82)90215-6
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1979Reduction of sulfoxides in peptides and proteinsFull Text via DOI: 10.1016/0003-2697(79)90702-4
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1979β-Endorphin: Characteristics of binding sites in the rat brainFull Text via DOI: 10.1016/0006-291X(79)91847-3
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1978Cyclopeptide Alkaloids. Synthesis of the Ring System and Its Ion AffinityFull Text via DOI: 10.1021/ja00494a030
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1977Human somatotropin. Reaction with hydrogen peroxideFull Text via DOI: 10.1016/0003-9861(77)90203-X
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1977Reaction of Human Choriomammotropin with Hydrogen PeroxideFull Text via DOI: 10.1111/j.1432-1033.1977.tb11649.x
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1974Synthesis of Pure p-Chlorophenyl-L-alanine form L-PhenylalanineFull Text via DOI: 10.1021/jm00251a025
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Book
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1985
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Book Chapter
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2017Reversed-phase chromatography: The effect of induced conformations on peptide retention. 633-642.Full Text via DOI: 10.1201/9780203751947
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2013Soluble synthetic combinatorial libraries: The use of molecular diversities for drug discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
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2011Solid-phase synthesis of heterocycles from peptides and amino acids. 269-318.Full Text via DOI: 10.1002/9781118141649.ch9
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2007The versatility of nonsupport-bound combinatorial libraries. 139-171.Full Text via DOI: 10.1002/9783527614912.ch05
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2006Mixture-Based Combinatorial Libraries. 1487-1494.Full Text via DOI: 10.1016/B978-012369442-3/50211-7
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2006CHAPTER 208 Mixture-Based Combinatorial Libraries. 1487-1494.Full Text via DOI: 10.1016/b978-012369442-3/50211-7
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2002Combinatorial libraries: Equimolar incorporation of benzaldehyde mixtures in reductive alkylation reactions. 57-58.Full Text via DOI: 10.1007/0-306-46862-x_18
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2002Novel D-amino acid hexapeptide calmodulin antagonists identified from synthetic combinatorial libraries. 605-606.Full Text via DOI: 10.1007/0-306-46862-x_263
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2002Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides. 264-266.Full Text via DOI: 10.1007/0-306-46862-x_109
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2001Identification of Novel Ligands for Vasopressin V2 Receptor from Positional Scanning Libraries. 921-922.Full Text via DOI: 10.1007/978-94-010-0464-0_430
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2001New Antiproliferative Agents from a Peptidomimetic Library. 640-641.Full Text via DOI: 10.1007/978-94-010-0464-0_298
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2001Solid Phase Synthesis of 1,2,4-Triazinan-3-ones. 259-260.Full Text via DOI: 10.1007/978-94-010-0464-0_117
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2001Solid Phase Synthesis of 1,2,5-Substituted Derivatives of 4-Imidazolidinone. 257-258.Full Text via DOI: 10.1007/978-94-010-0464-0_116
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2001Solid-Phase Synthesis of Substituted Dihydroimidazoles and Their Bis Analogs. 255-256.Full Text via DOI: 10.1007/978-94-010-0464-0_115
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2001Solid-Phase Synthesis of α-Difluoro-β-amino Acids by a Reformatsky Reaction. 261-262.Full Text via DOI: 10.1007/978-94-010-0464-0_118
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2000
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2000Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides. 192-197.Web of Science: 000166933900049
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2000Synthetic Combinatorial Libraries: A New Tool for Antimicrobial Agent Discovery. 311-319.Full Text via DOI: 10.1007/978-3-642-60250-4_17
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1999
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1999Preparation of heterocyclic positional scanning combinatorial libraries from peptides. 123-127.Web of Science: 000081131800040
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1998Tetrakis(Pyridine)Silver(2+)Peroxydisulfate. 177-181.Full Text via DOI: 10.1002/9780470132630.ch30
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1997Synthesis and Screening of Positional Scanning Combinatorial Libraries. 13-24.Full Text via DOI: 10.1385/0-89603-392-9:13
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1997Peptidomimetic synthetic combinatorial libraries. 109-125.Full Text via DOI: 10.1016/s1874-5113(97)80006-8
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19961 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
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1996The design of self-assembling peptide complexes using conformationally defined libraries. 65-71.Full Text via DOI: 10.1016/S1080-8914(96)80010-X
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1996Generation and use of nonsupport-bound peptide and peptidomimetic combinatorial libraries. 220-226.Full Text via DOI: 10.1016/s0076-6879(96)67015-3
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1996The generation of peptide combinatorial libraries using tea-bag synthesis. 835-845.Full Text via DOI: 10.1016/b978-012442710-5.50085-x
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199510 Soluble Chemical Combinatorial Libraries Current Capabilities and Future Possibilities. 395-417.Full Text via DOI: 10.1016/b978-012310920-0/50011-5
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1995Cyclic peptide template synthetic combinatorial libraries. 461-462.Full Text via DOI: 10.1007/978-94-011-1468-4_207
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1995Design of conformationally defined combinatorial libraries. 85-86.Full Text via DOI: 10.1007/978-94-011-1468-4_30
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1995Detailed studies of antibody specificity using synthetic peptide combinatorial libraries. 113-114.Full Text via DOI: 10.1007/978-94-011-1468-4_42
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1995Direct determination of the extent of racemization during post peptide synthesis reactions. 416-417.Full Text via DOI: 10.1007/978-94-011-1468-4_187
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1995Extending the range of molecular diversity through amide alkylation of peptide libraries. 463-464.Full Text via DOI: 10.1007/978-94-011-1468-4_208
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1995Libraries from libraries: The generation of peptidomimetic combinatorial diversities. 459-460.Full Text via DOI: 10.1007/978-94-011-1468-4_206
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1995Polyalkylamine chemical combinatorial libraries. 465-466.Full Text via DOI: 10.1007/978-94-011-1468-4_209
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1995Study of peptide-antibody interactions using a decapeptide positional scanning library. 815-816.Full Text via DOI: 10.1007/978-94-011-1468-4_374
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1994Identification of an antigenic determinant for the surface antigen of hepatitis B virus using peptide libraries. 1016-1017.Full Text via DOI: 10.1007/978-94-011-0683-2_343
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1994New, potent N-acetylated all D-amino acid opioid peptides. 984-985.Full Text via DOI: 10.1007/978-94-011-0683-2_331
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1994Optimal peptide length determination using synthetic peptide combinatorial libraries. 971-974.Full Text via DOI: 10.1007/978-94-011-0683-2_327
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1993A priori determination of peptide ligands for opiate receptors using synthetic peptide combinatorial libraries. 649-650.Full Text via DOI: 10.1007/978-94-011-1470-7_294
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1993Inhibition of melittin’s hemolytic activity using synthetic peptide combinatorial libraries. 761-762.Full Text via DOI: 10.1007/978-94-011-1470-7_349
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1993Positional scanning synthetic peptide combinatorial libraries. 65-66.Full Text via DOI: 10.1007/978-94-011-1470-7_19
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1992Chapter 17. Progress in Antimicrobial Peptides. 159-168.Full Text via DOI: 10.1016/S0065-7743(08)60415-7
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1992Comparison of structural and functional approaches for the study of peptide-mAb interactions. 867-868.Full Text via DOI: 10.1007/978-94-011-2264-1_351
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1992The relationship between potential induced conformation of melittin and its hemolytic activity. 433-434.Full Text via DOI: 10.1007/978-94-011-2264-1_162
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1992The use of a peptide library composed of 34 012 224 hexamers for basic research and drug discovery. 560-561.Full Text via DOI: 10.1007/978-94-011-2264-1_218
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1991Induced conformations of peptides during RPHPLC: Positional dependence of methionine oxidation. 478-480.Full Text via DOI: 10.1007/978-94-011-3034-9_200
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1991The effect of induced conformation on antimicrobial and hemolytic activity of amphipathic peptides. 738-739.Full Text via DOI: 10.1007/978-94-011-3034-9_306
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1987IDENTIFICATION OF FOLDED STRUCTURES IN IMMUNOGENIC PEPTIDES BY 2D NMR SPECTROSCOPY. 477-480.Full Text via DOI: 10.1016/b978-0-08-035588-7.50109-6
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1987Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Peptides. 463-470.Full Text via DOI: 10.1007/978-1-4613-1787-6_46
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1985The Antigenic Structure of the Rabies Virus Glycoprotein. 3-12.Full Text via DOI: 10.1007/978-3-642-70060-6_1
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1980CHARACTERIZATION OF A HIGH AFFINITY 3H-βh-ENDORPHIN RECEPTOR IN RAT BRAIN CRUDE SYNAPTOSOMAL FRACTION. 225-228.Full Text via DOI: 10.1016/b978-0-08-025488-3.50061-1
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Conference
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2016ase-modified 7-deazapurine nucleosidesWeb of Science: 000431905704664
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2013TNFα-Based Peptides as Bioprobes for Exosites of ADAM ProteasesFull Text via DOI: 10.17952/23aps.2013.136
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2010
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2005Solid-phase synthesis of triazinobenzimidazole libraries. U3443-U3444.Web of Science: 000236797306695
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2004Efficient synthesis of fused tetracyclic benzimidazole systems. 39-40.Web of Science: 000238911100013
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2004Parallel solid-phase synthesis of difluorinated dipeptide analogs. 63-64.Web of Science: 000238911100025
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2003Solid-phase synthesis of alpha,alpha-difluorinated beta-amino acids by Reformatsky reaction. 353-353.Web of Science: 000183878800350
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2003
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2002Solid phase synthesis of alpha,alpha-difluoro-beta-amino acid derivatives by Reformatsky reaction.. U556-U556.Web of Science: 000176296703054
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2002Solid phase synthesis of alpha,alpha-difluoro-beta-amino acid derivatives by reformatsky reaction.. B209-B209.Web of Science: 000176296801157
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1999Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides. 265-266.Web of Science: 000085202200109
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1987SYNTHETIC PEPTIDE PROBES OF FACTOR VIII IMMUNOLOGY AND FUNCTION. 536-536.Full Text via DOI: 10.1055/s-0038-1644768
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Editorial Material
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Letter
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1998Solid-phase synthesis of trisubstituted bicyclic guanidines via cyclization of reduced N-acylated dipeptides. 8622-8623.Full Text via DOI: 10.1021/jo9810617 Web of Science: 000077376200001
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Note
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1985Isolation of populations of antipeptide antibodies directed against different epitopes of the same fragment. 148-150.Full Text via DOI: 10.1515/znc-1985-1-230
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Other Scholarly Work
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2004Combinatorial chemistry: Libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds. (vol 69,3603, 2004). 5516-5516.Full Text via DOI: 10.1021/jo040002s Web of Science: 000223008100057
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1999Mixture-based synthetic combinatorial libraries. 3743-3778.Full Text via DOI: 10.1021/jm990174v Web of Science: 000082783200001
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Preprint
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Proceedings Paper
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1996The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations. 709-715.Full Text via DOI: 10.1016/0968-0896(96)00067-3
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Review
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2020The value of antimicrobial peptides in the age of resistance. e216-e230.Full Text via DOI: 10.1016/S1473-3099(20)30327-3
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2017Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?. 1719-1729.Full Text via DOI: 10.1016/j.drudis.2017.07.002
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2013Shifting from the single to the multitarget paradigm in drug discovery. 495-501.Full Text via DOI: 10.1016/j.drudis.2013.01.008
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2012Expanding the medicinally relevant chemical space with compound libraries. 718-726.Full Text via DOI: 10.1016/j.drudis.2012.04.001
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2011Synthesis of functionalized tetrasubstituted pyrazolyl heterocycles - A review. 5258-5275.Full Text via DOI: 10.1016/j.ejmech.2011.09.016 Web of Science: 000298120500003
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2010Recent methodologies toward the synthesis of valdecoxib: A potential 3,4-diarylisoxazolyl COX-II inhibitor. 4697-4707.Full Text via DOI: 10.1016/j.ejmech.2010.07.045 Web of Science: 000283911300001
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2008Visualization of the chemical space in drug discovery. 322-333.Full Text via DOI: 10.2174/157340908786786010
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2004Improved, high yield synthesis of 3H-quinazolin-4-ones, the key intermediates of recently developed drugs. 2549-2553.Full Text via DOI: 10.2174/0929867043364423
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2003Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries. 118-122.Full Text via DOI: 10.1038/nm0103-118
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2000Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. 276-285.Full Text via DOI: 10.1016/S1359-6446(00)01513-0
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2000Parallel array and mixture-based synthetic combinatorial chemistry: Tools for the next millennium. 273-282.Full Text via DOI: 10.1146/annurev.pharmtox.40.1.273
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1997The current status of heterocyclic combinatorial libraries. 449-472.Full Text via DOI: 10.1021/cr960010b Web of Science: A1997WR43100006
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1996Libraries from libraries: Generation and comparison of screening profiles. 41-45.Full Text via DOI: 10.1007/BF01718699
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1996Novel antimicrobial compounds identified using synthetic combinatorial library technology. 60-65.Full Text via DOI: 10.1016/0167-7799(96)80922-X
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1995Peptide, peptidomimetic, and organic synthetic combinatorial libraries. 481-496.Full Text via DOI: 10.1002/med.2610150603
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1995Generation and utilization of synthetic combinatorial libraries. 174-180.Full Text via DOI: 10.1016/S1357-4310(95)91867-1
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Research
administers grant
- A High-Throughput Chemical Screen to Identify Inhibitors of the Fungal Azole Transporter Cdr1p
- A Human iPSC-Based Chimeric Mouse Brain Model of Neurodegeneration in Alzheimer's Disease in Down Syndrome
- Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome Organization
- Developmental PBDE Exposure, Gut Microbiome, and Diabetes
- Discovery of small molecule glucagon receptor agonists and ketogenic compounds
- FIU Drug Discovery Project
- Gene Deregulation in Cortical Dementia
- Genetics, Epigenetics, and Post-translational Modifications and the Development of Ventilator Induced Lung Injury (VILI)
- High throughput screening for anti-adhesion drugs against placental and cerebral malaria
- Immunoregulatory effect of microparticle delivered STING agonist in the control of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS)
- Melanocortin Receptor Selective Ligands
- Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease
- NPQ/SPEXIN THE ENDOGENOUS LIGAND FOR THE GALANIN RECEPTOR 3
- Novel ROR gamma antagonists for inflammation and autoimmune disease
- Novel and potent compounds that promote axon growth
- PKG Signaling and Sepsis Induced ALI
- Perinatal NO signaling in congenital heart disease
- Reconnecting the injured cervical spinal cord by transplanted human iPSC-derived neural progenitors
- Redesign Rat Model for ALS Research
- Study on HNRNPA1 Pathobiology in ALS
- Synthesis and in vitro and in vivo screening of fused and tethered heterocyclic peptidomimetics for the discovery of new analgesics with decreased side effects
- Synthesis and screening of small molecule compounds for the discovery of new analgesics
- Synthesis of Compounds 2155-14 and 2155-18
- Synthesis of Select Compounds
- Synthesis of Select Compounds
- T cell in sarcodiosis
- TMEM20 and Neurodegeneration in Parkinson's Disease
- Understanding Down Syndrome Brain Development Using Human IPSC-based Mouse Chimeras