Environmental Health Sciences Academic Department
The Department of Environmental Health Sciences (EHS) identifies and explores common biological and environmental pathways that contribute to a broad range of diseases in an effort to develop applicable prevention and intervention strategies. Our graduate level EHS programs prepare students for professional roles in which they will apply the highest quality performance of mechanism-based and evidence-based research to help detect, prevent and control adverse influences of the environment on human health, while communicating the complex interactions between genetic variation and environmental stressors.
The EHS department advocates for research-led teaching, so students are able to get the most up-to-date information as we share our passion for the field. Our interdisciplinary faculty of physicians, chemists, toxicologists, cancer scientists, molecular biologists, environmental/water resource scientists and other public health scientists give great breadth to our teaching and research, which also provides students with an excellent opportunity to help reduce risk and improve public health at the local and global level upon graduation.
Affiliation
people
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Position
- Albores Garcia, Damaris, Postdoctoral Associate
- Azzam, Diana, Research Assistant Professor
- Chambers, Jeremy, Assistant Professor
- Cooke, Marcus, Professor
- Deoraj, Alok, Senior Instructor
- Dziedzic, Jennifer, Research Associate
- Fan, Zhangqiuzi, Postdoctoral Associate
- Felty, Quentin, Associate Professor
- Hossain, Muhammad, Research Assistant Professor
- Nadolny, Christina, Postdoctoral Associate
- Rodriguez Jozic, Monica, Postdoctoral Associate
- Roy, Deodutta, Professor
- Setegn, Shimelis, Temporary Research Assistant Professional
- Tieu, Kim, Professor
organization within
Publications
select organization publications
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Article
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2020Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma. MOLECULAR NEUROBIOLOGY.Full Text via DOI: 10.1007/s12035-020-01979-2 Web of Science: 000544199400001
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2020Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal Neurons. TOXICOLOGICAL SCIENCES. 174:147-158.Full Text via DOI: 10.1093/toxsci/kfz239 Web of Science: 000535691100014
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2019Exosome release and neuropathology induced by alpha-synuclein: new insights into protective mechanisms of Drp1 inhibition. ACTA NEUROPATHOLOGICA COMMUNICATIONS. 7.Full Text via DOI: 10.1186/s40478-019-0821-4 Web of Science: 000509586300001
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2019Land Use Evaluation over the Jema Watershed, in the Upper Blue Nile River Basin, Northwestern Highlands of Ethiopia. LAND. 8.Full Text via DOI: 10.3390/land8030050 Web of Science: 000464342900001
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2019Analysis of the Spatial Patterns of Rainfall across the Agro-Climatic Zones of Jema Watershed in the Northwestern Highlands of Ethiopia. GEOSCIENCES. 9.Full Text via DOI: 10.3390/geosciences9010022 Web of Science: 000459746300022
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2019Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin. TOXICOLOGICAL SCIENCES. 167:249-257.Full Text via DOI: 10.1093/toxsci/kfy238 Web of Science: 000462862400022
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2018Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast Carcinogenesis. CELLS. 7.Full Text via DOI: 10.3390/cells7120234 Web of Science: 000455320700012
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2018NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2+ve breast cancer signaling pathways. BREAST CANCER RESEARCH AND TREATMENT. 172.Full Text via DOI: 10.1007/s10549-018-4905-9 Web of Science: 000447497300021
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2018The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Na-v 1.6. EXPERIMENTAL NEUROLOGY. 308.Full Text via DOI: 10.1016/j.expneurol.2018.07.005 Web of Science: 000442714900011
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2018Analysis of the Spatial Variability of Soil Texture in a Tropical Highland: The Case of the Jema Watershed, Northwestern Highlands of Ethiopia. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 15.Full Text via DOI: 10.3390/ijerph15091903 Web of Science: 000445765600112
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2018Direct-acting DNA ethylating agents associated with tobacco use primarily originate from the tobacco itself, not combustion. JOURNAL OF HAZARDOUS MATERIALS. 358.Full Text via DOI: 10.1016/j.jhazmat.2018.07.011 Web of Science: 000442334400043
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2018Novel approach to integrated DNA adductomics for the assessment of in vitro and in vivo environmental exposures. ARCHIVES OF TOXICOLOGY. 92.Full Text via DOI: 10.1007/s00204-018-2252-6 Web of Science: 000440099900017
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2017A New Role for ER alpha: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes. MOLECULAR CANCER RESEARCH. 15:152-164.
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2017Environmental estrogen-like endocrine disrupting chemicals and breast cancer. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 457:89-102.
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2017Mitochondrial Dynamics in Neurodegenerative Diseases. ENVIRONMENTAL FACTORS IN NEURODEGENERATIVE DISEASES. 211-246.Full Text via DOI: 10.1016/bs.ant.2017.07.006 Web of Science: 000424949900009
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2017Mitochondrial division inhibitor-1 is neuroprotective in the A53T-alpha-synuclein rat model of Parkinson's disease. SCIENTIFIC REPORTS. 7.
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2017PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease. BRAIN. 140:3233-3251.
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2017Sab is differentially expressed in the brain and affects neuronal activity. BRAIN RESEARCH. 1670:76-85.
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2017Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity. TOXICOLOGY. 382:24-35.
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2016Concurrent beneficial (vitamin D production) and hazardous (cutaneous DNA damage) impact of repeated low-level summer sunlight exposuresFull Text via DOI: 10.1111/bjd.14863 Web of Science: 000391821300073
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2016Analysis of Chemotherapeutic Drug Delivery at the Single Cell Level Using 3D-MSI-TOF-SIMS. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 27:2033-2040.
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2016Assessing plant growth, water quality and economic effects from application of a plant-based aquafeed in a recirculating aquaponic system. AQUACULTURE INTERNATIONAL. 24:415-427.Full Text via DOI: 10.1007/s10499-015-9934-3 Web of Science: 000372553000030
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2016Estimation of Climate Change Impacts on Water Resources in the Great River Watershed, Jamaica. LANDSCAPE DYNAMICS, SOILS AND HYDROLOGICAL PROCESSES IN VARIED CLIMATES. 703-723.Full Text via DOI: 10.1007/978-3-319-18787-7_31 Web of Science: 000376132100032
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2016Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases. SCIENTIFIC REPORTS. 6.
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2016Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2 '-deoxyguanosine. FREE RADICAL BIOLOGY AND MEDICINE. 99:385-391.Full Text via DOI: 10.1016/j.freeradbiomed.2016.08.018 PMID: 27585947 Web of Science: 000387995400036
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2016Urinary 8-oxo-7,8-dihydro-2 '-deoxyguanosine analysis by an improved ELISA: An inter-laboratory comparison study. FREE RADICAL BIOLOGY AND MEDICINE. 95:169-179.Full Text via DOI: 10.1016/j.freeradbiomed.2016.03.016 PMID: 27016072 Web of Science: 000376169800014
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20158-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine concentrations in various human body fluids: implications for their measurement and interpretation. ARCHIVES OF TOXICOLOGY. 89:201-210.
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2015A rapid and sensitive high-throughput screening method to identify compounds targeting protein-nucleic acids interactions. NUCLEIC ACIDS RESEARCH. 43.
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2015A trivalent approach for determining in vitro toxicology: Examination of oxime K027. JOURNAL OF APPLIED TOXICOLOGY. 35:219-227.
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2015ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: Its implication for understanding microvascular diseases. MICROVASCULAR RESEARCH. 98:126-138.
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2015Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 16:25285-25322.
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2015Microvascular Lesions by Estrogen-Induced ID3: Its Implications in Cerebral and Cardiorenal Vascular Disease. JOURNAL OF MOLECULAR NEUROSCIENCE. 55:618-631.
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2015Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. MOLECULAR NEUROBIOLOGY. 52:1341-1363.
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2015Pulmonary Arterial Hypertension: A Stem Cell Hypothesis. LUNG STEM CELLS IN THE EPITHELIUM AND VASCULATURE. 289-306.Full Text via DOI: 10.1007/978-3-319-16232-4_16 Web of Science: 000378209000017
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2015Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells. BRITISH JOURNAL OF CANCER. 112:1687-1702.
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2015Rescue of cells from apoptosis increases DNA repair in UVB exposed cells: implications for the DNA damage response. TOXICOLOGY RESEARCH. 4:725-738.Full Text via DOI: 10.1039/c4tx00197d Web of Science: 000353587200018
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2015Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 463:538-544.
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2015Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertension. PULMONARY CIRCULATION. 5:101-116.
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2014Novel method for the high-throughput processing of slides for the comet assay. SCIENTIFIC REPORTS. 4.Full Text via DOI: 10.1038/srep07200 Web of Science: 000346195800007
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2014Bayesian Network and Mechanistic Hierarchical Structure Modeling of Increased likelihood of Developing Intractable Childhood Epilepsy from the Combined Effect of mtDNA Variants, Oxidative Damage, and Copy Number. JOURNAL OF MOLECULAR NEUROSCIENCE. 54:752-766.
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2013Discovering gene-environment interactions in Glioblastoma through a comprehensive data integration bioinformatics method. NEUROTOXICOLOGY. 35:1-14.
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2011Redox sensitive Pyk2 as a target for therapeutics in breast cancer. FRONTIERS IN BIOSCIENCE. 16:568-577.
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2010Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 197-219.Full Text via DOI: 10.1007/978-1-4419-6752-7_8 Web of Science: 000282535900008
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2010Environmental Factors, Genes, and the Development of Human Cancers Introduction. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 3-9.Full Text via DOI: 10.1007/978-1-4419-6752-7_1 Web of Science: 000282535900001
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2010Gene Environment Interactions and Vascular Lesions. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 139-152.Full Text via DOI: 10.1007/978-1-4419-6752-7_6 Web of Science: 000282535900006
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2010Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 223-252.Full Text via DOI: 10.1007/978-1-4419-6752-7_9 Web of Science: 000282535900009
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2008Estrogen-induced redox sensitive Id3 signaling controls the growth of vascular cells. ATHEROSCLEROSIS. 198:12-21.Full Text via DOI: 10.1016/j.atherosclerosis.2007.12.048 PMID: 18281048 Web of Science: 000255491800002
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2006Development of a self-proliferating Leydig cell line: A hyper-sensitive E-screening model. ONCOLOGY REPORTS. 16:73-77.PMID: 16786125 Web of Science: 000238520400010
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2006Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. FRONTIERS IN BIOSCIENCE. 11:889-898.
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2006SKCG-1: a new candidate growth regulatory gene at chromosome 11q23.2 in human sporadic Wilms tumours. BRITISH JOURNAL OF CANCER. 94:1524-1532.
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Editorial Material
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2018Mycosporine-like amino acids: does Nature make a better sunscreen?Full Text via DOI: 10.1111/bjd.16598 Web of Science: 000435078600101
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2016Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 741-745.
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Letter
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2018Letter to the Editor: Is Id3 proliferative or antiproliferative?. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY.Full Text via DOI: 10.1152/ajplung.00205.2018 Web of Science: 000442116600008
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Meeting Abstract
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2018Exosomal ID3 is pro-metastatic through guiding NRF1-induced breast cancer stem cells across the blood-brain-barrier. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-1128 Web of Science: 000468818903101
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2018Role of NRF1 regulatory gene-networks in glioblastoma. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-1127 Web of Science: 000468818903100
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2017A novel splice variant of Sab (SH3BP5) alters mitochondrial physiology.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000426664300567
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2017Alterations in outer mitochondrial signaling promote organelle and neuronal dysfunction.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000426664300568
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2017Has the duration and temperature of lysis buffer been minimized for the comet assay?. FASEB JOURNAL.Web of Science: 000405461402320
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2017Measurement of 8-oxo-7,8-dihydro-2 '-deoxyguanosine in urine by an improved ELISA. TOXICOLOGY LETTERS. S52-S52.Full Text via DOI: 10.1016/j.toxlet.2017.07.128 Web of Science: 000425486700105
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2017Oxidative stress and feto-maternal well-being in pregnancy. TOXICOLOGY LETTERS. S52-S52.Full Text via DOI: 10.1016/j.toxlet.2017.07.129 Web of Science: 000425486700106
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2017TDP1/TOP1 RATIO AS A PREDICTIVE INDICATOR FOR THE RESPONSE OF GLIOBLASTOMA CANCER CELLS TO IRINOTECAN TREATMENT. NEURO-ONCOLOGY. 74-75.Web of Science: 000415152501122
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2016
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2016
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2016Sab-mediated signaling regulates mitochondrial fission. FASEB JOURNAL.Web of Science: 000406444002472
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2016Sab-mediated signaling regulates mitochondrial fission. FASEB JOURNAL.Web of Science: 000406444006138
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2015COMPAC-50, High-Throughput Comet Assay Tank. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000360226400139
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2015Id3 generated cancer stem-like cells: A microvascular niche for the development of glioma. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-4179 Web of Science: 000371597103266
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2015Identification of novel chemotherapies targeting mitochondrial-cell communication. FASEB JOURNAL.Web of Science: 000361722705237
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2015Overexpression of NRF1 leads to the generation of cancer stem-like cells and resistance to anoikis _ pathways to anchorage-independent growth during estrogen-induced malignant transformation. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-803 Web of Science: 000371578501256
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2015Phosphodeficient NRF1 mutant suppresses the susceptibility of the breast epithelial cells to develop tumors when exposed to estrogen - a major breast cancer risk factor. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-4559 Web of Science: 000371597104187
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2014ID3 expression and oxidative DNA damage are associated with growth of benign and malignant vascular lesions. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-3002 Web of Science: 000349910200009
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2014Redox signaling to nuclear respiratory factor-1 proteins by reactive oxygen species contributes to the estrogen-induced breast tumor development. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-3179 Web of Science: 000349910200183
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2013PCB153-induced angiogenesis depends on redoxsensitive Pyk2 signaling.. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2013-3899 Web of Science: 000331220603133
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2012Novel 4-N-modified gemcitabine analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503201668
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2011Estrogen-induced redox signaling via NRF-1 is involved in the development of breast cancer. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2011-LB-12 Web of Science: 000209701305418
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2010Alteration in signature of mRNA and protein expression by environmental estrogen PCB153: implications for vascular lesions. NEW BIOTECHNOLOGY.Full Text via DOI: 10.1016/j.nbt.2010.01.088 Web of Science: 000209825000128
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2009Estrogenic PCBs increase blood vessel formation by redox signaling. CANCER RESEARCH.Web of Science: 000209702803334
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2009NRF-1 signaling participates in the estrogen-mediated growth of breast cancer cells.. CANCER RESEARCH.Web of Science: 000209701803459
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2009Redox Status Contributes to Tamoxifen-Resistant Growth of Breast Cancer.. CANCER RESEARCH. 810S-810S.Web of Science: 000272920702093
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20074-OH-E2-induced oxidants through NRF-1 controls transcription of G1-S and G2-M phase cell cycle genes. FEBS JOURNAL. 179-179.Web of Science: 000253283800541
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2007Estrogen-induced vascular lesions formation is mediated by redox sensitive Id3 signaling. FEBS JOURNAL. 145-145.Web of Science: 000253283800405
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2007Is in utero imprinting of the brain by pesticides involved in childhood brain cancer development?. EPIDEMIOLOGY. S169-S170.Web of Science: 000249018300556
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Patent
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Proceedings Paper
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2011Identifying gene alterations required for the development of astrocytoma. 19TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2011). 1037-1041.Web of Science: 000314989301008
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2009Hierarchical clustering method identifies adaptation of mitochondrial signaling to the treatment of mitochondrial blockers that regulates the expression of cell cycle genes.. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 708-714.Web of Science: 000290045000109
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2009Meta-analysis of brain tumor microarray data using Oncomine identifies NRF1, Tfam and Myc co-expressed genes: its implications in the development of childhood brain tumors. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 720-726.Web of Science: 000290045000111
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2009Oncomine meta-analysis of breast cancer microarray data identifies upregulation of NRF-1 expression in human breast carcinoma. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 715-719.Web of Science: 000290045000110
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Review
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2018Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression. CELLULAR ONCOLOGY.Full Text via DOI: 10.1007/s13402-018-0395-3 Web of Science: 000444812800001
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2018Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 29-41.
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2018Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders. BIOMED RESEARCH INTERNATIONAL.
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2017Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease. BIOMED RESEARCH INTERNATIONAL.
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2017Gender, Estrogen, and Obliterative Lesions in the Lung. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.Full Text via DOI: 10.1155/2017/8475701 Web of Science: 000398314200001
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2017Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease. FRONTIERS IN GENETICS.Full Text via DOI: 10.3389/fgene.2017.00177 Web of Science: 000415602000001
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2017Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP. TRENDS IN PHARMACOLOGICAL SCIENCES. 541-555.
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2016Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms17122086 Web of Science: 000392280500130
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2013Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 60-79.
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2011Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 115-133.
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2007Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. 235-257.
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2007Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: Potential molecular targets for cancer therapy. FRONTIERS IN BIOSCIENCE. 154-173.
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