Marisela Agudelo
- Assistant Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine
Publications
selected publications
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Article
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2018Ethanol-induced modulation of GPR55 expression in human monocyte-derived dendritic cells is accompanied by H4K12 acetylation. ALCOHOL. 71.Full Text via DOI: 10.1016/j.alcohol.2018.05.008 Web of Science: 000445443800004
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2018Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-26095-z Web of Science: 000432655800009
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2018Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters. ANTIOXIDANTS & REDOX SIGNALING. 28:324-337.
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2018Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. ALCOHOL. 66:35-43.
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2016Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.
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2016Microglia-derived HIV Nef plus exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides. JOURNAL OF NEUROVIROLOGY. 22:129-139.
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2015Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). FRONTIERS IN MICROBIOLOGY. 6.
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2015DJ1 expression downregulates in neuroblastoma cells (SK-N-MC) chronically exposed to HIV-1 and cocaine. FRONTIERS IN MICROBIOLOGY. 6.
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2015Investigation of Neuropathogenesis in HIV-1 Clade B and C Infection Associated with IL-33 and ST2 Regulation. ACS CHEMICAL NEUROSCIENCE. 6:1600-1612.
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2015Preparation and characterization of anti-HIV nanodrug targeted to microfold cell of gut-associated lymphoid tissue. INTERNATIONAL JOURNAL OF NANOMEDICINE. 10:5819-5835.
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2015Sustained-release nanoART formulation for the treatment of neuroAIDS. INTERNATIONAL JOURNAL OF NANOMEDICINE. 10:1077-1093.
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2014Commentary on the Interactions of HIV and Alcohol in the Central Nervous System. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 38:624-625.
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2014Immunoneuropathogenesis of HIV-1 clades B and C: Role of redox expression and thiol modification. FREE RADICAL BIOLOGY AND MEDICINE. 69:136-144.Full Text via DOI: 10.1016/j.freeradbiomed.2013.12.025 PMID: 24480751 Web of Science: 000333490500014
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2013Differential expression and functional role of cannabinoid genes in alcohol users. DRUG AND ALCOHOL DEPENDENCE. 133:789-793.
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2012Alcohol-induced serotonergic modulation: The role of histone deacetylases. ALCOHOL. 46:635-642.
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2012HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: Role in HIV associated neurocognitive disorder. NEUROCHEMISTRY INTERNATIONAL. 61:807-814.
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2012Inhibition of Nuclear Factor Erythroid 2-Related Factor 2 Exacerbates HIV-1 gp120-Induced Oxidative and Inflammatory Response: Role in HIV Associated Neurocognitive Disorder. NEUROCHEMICAL RESEARCH. 37:1697-1706.
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2011Effects of Alcohol on Histone Deacetylase 2 (HDAC2) and the Neuroprotective Role of Trichostatin A (TSA). ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 35:1550-1556.
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2011HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND). NEUROCHEMISTRY INTERNATIONAL. 58:656-664.
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2011Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS. JOURNAL OF NEUROVIROLOGY. 17:230-238.
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2010Role of Dendritic Cells in HIV Infection: DC-SIGN and Novel Therapeutic Approaches. DENDRITIC CELLS: TYPES, LIFE CYCLES AND BIOLOGICAL FUNCTIONS. 167-177.Web of Science: 000284081600010
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Correction
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Meeting Abstract
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2018DIFFERENTIAL EPIGENETIC EFFECTS OF ALCOHOL EXPOSURE AND THE TRANSIENT ANTI-OXIDANT PROTECTIVE EFFECT OF TRICHOSTATIN A, IN HUMAN DENDRITIC CELLS. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH.Web of Science: 000443221503261
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2018DIFFERENTIAL EPIGENETIC EFFECTS OF ALCOHOL EXPOSURE AND TRANSIENT ANTI-OXIDANT PROTECTIVE EFFECT OF TRICHOSTATIN A, IN HUMAN DENDRITIC CELLS. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH.Web of Science: 000443221501346
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2018CHRONIC ALCOHOL TREATMENT MODULATES GPR55 EXPRESSION THROUGH EPIGENETIC PATHWAYS IN HUMAN MONOCYTE-DERIVED DENDRITIC CELLS (MDDC).. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400223
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2018Imaging flow cytometry as a novel epigenetic tool to detect post-translational modifications and extracellular histone release induced by alcohol abuse. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400097
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2018CHRONIC ALCOHOL TREATMENT MODULATES GPR55 EXPRESSION THROUGH EPIGENETIC PATHWAYS IN HUMAN MONOCYTE-DERIVED DENDRITIC CELLS (MDDC).. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S65-S65.Web of Science: 000429149100223
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2018Imaging flow cytometry as a novel epigenetic tool to detect post-translational modifications and extracellular histone release induced by alcohol abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S28-S28.Web of Science: 000429149100097
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2017Alcohol induces epigenetic immunomodulation of human monocyte-derived dendritic cells. ALCOHOL.Web of Science: 000397359400010
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2017Exploring benefits of Methanandamide: towards developing a nanoformulation to combat against cannabinoids induced effects in HIV patients. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S76-S76.Web of Science: 000414227700184
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2017Functional effects of chronic alcohol stress in human monocyte-derived dendritic cells and the immunoprotective role of trichostatin A as demonstrated by single cell imaging flow cytometry. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S39-S39.Web of Science: 000414227700086
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2017Mass Spectrometry and Single Cell Imaging Flow Cytometry as screening tools to detect H3 and H4 post-translational modifications after acute and chronic alcohol exposure of human monocyte-derived dendritic cells (MDDC). JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S55-S55.Web of Science: 000414227700129
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2016EFFECT OF TOBACCO SMOKE AND HIV INFECTION ON MUCOCILIARY CLEARANCE. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S48-S48.Web of Science: 000377566000123
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2016EPIGENETIC MODULATIONS DUE TO CHRONIC ALCOHOL TREATMENT AND ITS ASSOCIATION WITH THE CANNABINERGIC PATHWAY.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S35-S36.Web of Science: 000377566000090
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2016PERIPHERAL EFFECTS OF THE INTERACTION BETWEEN ALCOHOL AND THE HDAC INHIBITOR MOCETINOSTAT.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S3-S3.Web of Science: 000377566000003
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2015Ex-vivo and in-vitro evidence of epigenetic mechanisms of alcohol abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S58-S58.Web of Science: 000367554100004
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2015HIV and Morphine: Oxidative Stress Impact Cell Cycle Regulation and Neurodegeneration. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S104-S104.Web of Science: 000367554100125
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2015Marijuana promotes HIV replication in glia cells but inhibits HIV-exNef associated neuropathology. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S68-S68.Web of Science: 000367554100030
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2015Marijuana up-regulates HIV replication in microglia-like cells and restricts exNef-modulation of glia immune function. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S65-S65.Web of Science: 000367554100022
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2015Polydrug nanocarriers to treat opiate addiction and reduce HIV exNef-associated neuropathogenesis. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S95-S95.Web of Science: 000367554100102
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2015Sustained Release NanoART Formulation for the Treatment of NeuroAIDS. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S77-S77.Web of Science: 000367554100055
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2014Association of Mental Disorders with Cocaine Use in HIV-1 Infected Females in South Florida. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 39-40.Web of Science: 000333121600098
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2014Bath salts alter synaptic plasticity gene expression in neurons. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 62-62.Web of Science: 000333121600158
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2014Cannabinoid Agonists Regulate Alcohol-induced Inflammation in Human Dendritic Cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 3-4.Web of Science: 000333121600004
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2014Immunopathogenesis of HIV-1 Infection in Cocaine users: Role of Arachidonic Acid. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 55-55.Web of Science: 000333121600139
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2014Polydrug mediated effects on HIV Nef plus exosome release and neuropathogenesis is modulated by Nef peptide magnetic nanocarriers. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 46-47.Web of Science: 000333121600116
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2014Role of HDAC2 and miR-485 in regulation of synaptic plasticity genes in HIV infection: Implication in HAND. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 6-6.Web of Science: 000333121600011
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2013DUAL MECHANISM ENHANCED BBB CROSSING BY TRANSFERRIN CONJUGATED FLUORESCENT MAGNETIC LIPOSOME.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 414-414.Web of Science: 000320312000098
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2013DYSREGULATION OF IL-33 AND ST2 IN HIV1 B AND C CLADES.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 435-436.Web of Science: 000320312000159
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2013HIV NEUROPATHOGENESIS: ROLE OF NEF plus EXOSOMES (EXNEF), METHAMPHETAMINE AND OPIATES. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 430-431.Web of Science: 000320312000144
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2012Differential Regulation of IL-33 By HIV-1 B and C Clade Infection in Human Astrocytes (HA): Role in Neuropathogenesis.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S81-S81.Web of Science: 000302288800200
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2012The Interactive Role of Histone Deacetylases and Cannabinoid Genes in Alcohol Abusers. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S27-S28.Web of Science: 000302288800047
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2011Activation of the Antioxidant Defensive Enzymes Against HIV-1 gp120 are Mediated by Oxidative Stress and Elevated Intracellular Calcium Levels. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S55-S56.Web of Science: 000302402500134
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2011Association of Dopamine Receptor D2 C957T Gene SNP in Learning and Memory Among HIV-Positive Alcohol Abusers. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S51-S51.Web of Science: 000302402500122
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2011Differential Expression of Cannabinoid Genes in Alcoholics. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S23-S23.Web of Science: 000302402500039
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2011Differential Regulation of Neuroplasticity Associated Genes by HIV-1B and C Clades. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S57-S57.Web of Science: 000302402500139
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2011Differential Regulation of Thiol Modification by HIV-1 Clade B and C Protein. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S57-S58.Web of Science: 000302402500140
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2011Molecular Mechanism of Immunosuppression by Cocaine in HIV-1 Infected Subjects: Role of TLR3. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S31-S31.Web of Science: 000302402500062
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2010Effects of Alcohol on Cannabinoid (CB2) and Serotonin (5-HT3) Receptors in the Human Neuroblastoma Cell Line, SK-N-MC, and the Role of Histone Deacetylase 2 (HDAC2).. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S39-S39.Web of Science: 000276567600089
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2010HIV-1 Tat upregulates expression of histone deacetylase-2 in human neurons: Implication for HAND. JOURNAL OF NEUROVIROLOGY. 75-76.Web of Science: 000283409800163
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2010Histone Deacetylase Activity in Development of HIV-Associated Neurocognitive Disorder.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S46-S46.Web of Science: 000276567600109
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2010Human Immunodeficiency Virus type-1 Glade B and C gp120 Inhibit NMDA-receptor mediated induction of Arachidonic Acid: Implications on Neuro-AIDS. JOURNAL OF NEUROVIROLOGY. 76-76.Web of Science: 000283409800164
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2010Neuropathogenic Mechanisms of HIV-1 Clade B and C: Role of Methamphetamine (METH).. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S53-S53.Web of Science: 000276567600130
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Research
principal investigator on
- Synthetic cannabinoids and their effects on extracellular histone release and inflammation: using single cell imaging flow cytometry as a novel epigenetic tool awarded by FIU Foundation 2018 - 2019
- EtOH-induced Immunomodulation: Role of Histone Deacetylases and Cannabinoid Genes awarded by National Institute on Alcohol Abuse and Alcoholism 2015 - 2019
- EtOH-induced Immunomodulation: Role of Histone Deacetylases and Cannabinoid Genes awarded by National Institutes of Health 2013 - 2015
co-principal investigator on
- Florida Science Training and Research (STAR) Fellowship awarded by U.S. Department of Health & Human Servic 2015 - 2020
investigator on
- Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug Abusers awarded by National Institute on Drug Abuse 2016 - 2021
- Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2017 - 2020
- Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2015 - 2020
- Role of exosome extracellular vesicles in opiate abuse and HIV neuropathogenesis awarded by National Institute on Drug Abuse 2017 - 2020
Contact
full name
- Marisela Agudelo
visualizations
Recent publications and grants in Scholars@FIU
research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Immunology
- Infectious Diseases
- Materials Science
- Microbiology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Physics
- Psychiatry
- Science & Technology - Other Topics
- Substance Abuse
- Toxicology
- Virology