Manuel Barbieri
- Professor, Biological Sciences , College of Arts, Sciences & Education
Publications
selected publications
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Article
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2020Role of RIN1 on telomerase activity driven by EGF-Ras mediated signaling in breast cancer. EXPERIMENTAL CELL RESEARCH. 396.Full Text via DOI: 10.1016/j.yexcr.2020.112318 Web of Science: 000589411600014
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2019Clitoria ternatea Flower Petal Extract Inhibits Adipogenesis and Lipid Accumulation in 3T3-L1 Preadipocytes by Downregulating Adipogenic Gene Expression. MOLECULES. 24.Full Text via DOI: 10.3390/molecules24101894 Web of Science: 000470996600052
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2018Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest. PHYTOTHERAPY RESEARCH. 32.Full Text via DOI: 10.1002/ptr.6089 Web of Science: 000440930900015
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2018Leucodine blocks mitotic clonal expansion during preadipoctye differentiation through cell cycle arrest. PHYTOCHEMISTRY LETTERS. 24.Full Text via DOI: 10.1016/j.phytol.2017.12.011 Web of Science: 000432718900016
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2018The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: Application to F-18-Radiolabeling. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 148:314-324.
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2017Biomedical Properties and Origins of Sesquiterpene Lactones, with a Focus on Dehydroleucodine. NATURAL PRODUCT COMMUNICATIONS. 12:995-1005.Web of Science: 000404832100039
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2016Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. CANCER LETTERS. 372:10-23.
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2016Rin1 restores host phagocytic activity during invasion by Pseudomonas aeruginosa. JOURNAL OF MEDICAL MICROBIOLOGY. 65:351-361.Full Text via DOI: 10.1099/jmm.0.000235 Web of Science: 000377846700002
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2015A Novel Insight into Dehydroleucodine Mediated Attenuation of Pseudomonas aeruginosa Virulence Mechanism. BIOMED RESEARCH INTERNATIONAL.Full Text via DOI: 10.1155/2015/216097 Web of Science: 000365209800001
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2015Inhibitory effect of Clitoria ternatea flower petal extract on fructose-induced protein glycation and oxidation-dependent damages to albumin in vitro. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE. 15.
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2014Volatile constituents of five species of Portlandia (Rubiaceae). JOURNAL OF ESSENTIAL OIL RESEARCH. 26:125-129.Full Text via DOI: 10.1080/10412905.2013.851039 Web of Science: 000331360700009
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2013Conversion of Aristolochic Acid I into Aristolic Acid by Reaction with Cysteine and Glutathione: Biological Implications. JOURNAL OF NATURAL PRODUCTS. 76:965-968.
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2013Phospholipase A(1): A novel virulence factor in Trypanosoma cruzi. MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 187:77-86.
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2013Regulation of Rab5 Function during Phagocytosis of Live Pseudomonas aeruginosa in Macrophages. INFECTION AND IMMUNITY. 81:2426-2436.
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2013Saw palmetto ethanol extract inhibits adipocyte differentiation. JOURNAL OF NATURAL MEDICINES. 67:619-625.
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2012Aristolochic Acid I Metabolism in the Isolated Perfused Rat Kidney. CHEMICAL RESEARCH IN TOXICOLOGY. 25:130-139.
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2012Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells. PHYTOCHEMISTRY LETTERS. 5:581-585.Full Text via DOI: 10.1016/j.phytol.2012.05.018 Web of Science: 000307596700038
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2012Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 525:16-24.
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2012Secondary metabolite uptake by the Aristolochia-feeding papilionoid butterfly Battus polydamas. BIOCHEMICAL SYSTEMATICS AND ECOLOGY. 40:126-137.Full Text via DOI: 10.1016/j.bse.2011.10.006 Web of Science: 000299712700024
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2011Dehydroleucodin: a guaiane-type sesquiterpene lactone. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE. 67:O3470-U211.
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2011The effect of dehydroleucodine in adipocyte differentiation. EUROPEAN JOURNAL OF PHARMACOLOGY. 671:18-25.
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2009Functional determinants of ras interference 1 mutants required for their inhbitory activity on endocytosis. EXPERIMENTAL CELL RESEARCH. 315:820-835.
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2009Inhibition of early endosome fusion by Rab5-binding defective Ras interference 1 mutants. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 482:83-95.
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2009Intracellular Trafficking and Signaling: The Role of Endocytic Rab GTPase. TRAFFICKING INSIDE CELLS: PATHWAYS, MECHANISMS AND REGULATION. 405-418.Full Text via DOI: 10.1007/978-0-387-93877-6_19 Web of Science: 000270966400019
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2006Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 103.Full Text via DOI: 10.1073/pnas.0510197103 Web of Science: 000238660400039
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2006Rab22a regulates the sorting of transferrin to recycling endosomesFull Text via DOI: 10.1128/MCB.26.7.2595-2614.2006
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2006Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 340:967-975.
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2006Rin1 is a negative regulator of the IL3 receptor signal transduction pathways. ANTICANCER RESEARCH. 26:905-916.PMID: 16619486 Web of Science: 000236674800013
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2006Rin1 regulates insulin receptor signal transduction pathways. EXPERIMENTAL CELL RESEARCH. 312:1106-1118.
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2006Role of Rab5 in insulin receptor-mediated endocytosis and signaling. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 449:130-142.
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2004Role of Rab5 in EGF receptor-mediated signal transductionFull Text via DOI: 10.1078/0171-9335-00381
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1999A Salmonella virulence protein that inhibits cellular traffickingFull Text via DOI: 10.1093/emboj/18.14.3924
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1998Protein kinase B/akt and Rab5 mediate Ras activation of endocytosisFull Text via DOI: 10.1074/jbc.273.31.19367
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1996Characterization of Rab5:Q79L-stimulated endosome fusionFull Text via DOI: 10.1006/abbi.1996.0047
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1995Myristoylation cannot functionally replace the isoprenylation of Rab5Full Text via DOI: 10.1006/abbi.1995.1070
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1992Trypanosoma cruzi: Inhibition of metacyclogenesis by mannoseFull Text via DOI: 10.1016/S0006-291X(05)81465-2
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Book
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2004Receptor tyrosine kinase signaling and trafficking - Paradigms revisited. Ed. 286.Full Text via DOI: 10.1007/978-3-540-69494-6_1
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Book Chapter
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2001Measurement of Rab5 protein kinase B/akt and regulation of Ras-activated endocytosis. 145-156.Full Text via DOI: 10.1016/S0076-6879(01)29075-2
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Conference
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1996
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Meeting Abstract
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2018EXPLORATION OF VERY LONG-RANGE LINKAGE DISEQUILIBRIUM WITHIN THE EXTENDED HLA REGION. HLA. 433-434.Web of Science: 000430290800236
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2017Antiproliferative Activity of Natural Compounds Isolated from Artemisia species.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000426664303402
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2017
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2017Role of Small GTPases on differentiation of pre-adipocyte. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000426664302001
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2017SNPS CORRELATING WITH FUNCTIONAL HLA REGION EPITOPES AND SUPERTYPES OFFER INSIGHT INTO GWAS. HLA. 360-360.Web of Science: 000400973300048
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2016Dihydro derivatives of dehydroleucodine inhibit early adipogenesis. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000396047100059
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2016FUNCTIONAL ANNOTATIONS OF COMMON DISEASE MARKERS IN IMMUNE REGULATORY GENES. HLA. 215-215.Web of Science: 000383951500035
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2016Infection of Pseudomonas aeruginosa selectively affects human leukocyte antigen (HLA) gene expression.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000396047100629
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2016Methylglyoxal levels increased in hypercholesterolemic rabbits. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000396046900551
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2016Rab5-Activating Protein 6 (RAP6) Activity in Adipogenesis. FASEB JOURNAL.Web of Science: 000406444003284
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2016Selective effect of Rin1 mutants on insulin signaling during pre-adipocyte differentiation.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000396046900785
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2015A single amino acid change in Ras Interference 1 alters its function. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000209928500412
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2015RIN1 Mediated Rescue of Rab5 Activity: A Novel Insight on Pseudomonas-Phagosome Interaction. FASEB JOURNAL.Web of Science: 000361722705152
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2015Rab5-Activating Protein 6 (RAP6) is required for Rab5 activation upon insulin stimulation. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000209928500390
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2014Requirements of Rab5-activity, growth factor-dependent in highly invasive breast cancer cell lines.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000352094103090
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2013Antimicrobial activity of dehydroleucodine on Pseudomonas aeruginosa growth and virulence. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000209348704383
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2013Rab5 function in breast cancer cells. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000209348700190
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2012Selective activation of Rab5 by distinct endocytic pathways.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000209348607117
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2011Activation of Rab5 via Diverse Routes of Epidermal Growth Factor Receptor Endocytosis.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000305505503192
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2011Inhibition of Rab5 activation by Exotoxin S of Pseudomonas aeruginosa.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000305505504234
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Review
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2020A hypothesis for a novel role of RIN1-the modulation of telomerase function by the MAPK signaling pathway. BIOCELL. 525-534.Full Text via DOI: 10.32604/biocell.2020.011407 Web of Science: 000604967300007
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2017Biomedical properties and origins of sesquiterpene lactones, with a focus on dehydroleucodine. 995-1005.Full Text via DOI: 10.1177/1934578x1701200638
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chaired theses and dissertations
advised honors theses
- Godieva, Victoria, Phyloextracts from Genus Artemisia: Controlling Survival and Melanogenesis of Murine Metastatic Cells 2017
- Florit, Daniela, An overview on Human Leukocyte Antigen (HLA) region gene expression during Pseudomonas aeruginosa infection 2015
- Gonzalez, Victor M., The Role of Ras Oncogene in Differentiation of 3T3-L1 Preadipocytes 2013
- Stefancin, Chad V., Antimicrobial effect of Artemisia species on Pseudomonas aeruginosa 2013
- Rivero, Nathalie, The Effect of Natural Products and Small Gtpases in Adipogenesis 2012
- Noriega, Manuela, The Expression of Rap6 in the Adult Mouse Brain and Early Mouse Embryonic Development 2010
- Murphy, Travis, Studying Key Amino Acids in the Function of Ras Interference 1 (Rinl) SH2 and Vps9 Domains 2009
Research
principal investigator on
- Functional Genomics of Disease-associated HLA Region Polymorphisms awarded by U.S. Department of Defense 2013 - 2016
- Effect of Clitoria ternatea flower petal extract on in vitro fat formation awarded by National Institutes of Health 2014 - 2016
- Intracellular Receptor Trafficking awarded by National Institute of General Medical Sciences 2008 - 2014
- ASCB MAC - Linkage Fellow: Manuel Barbieri, PhD awarded by National Institutes of Health 2011 - 2012
- ASCB MAC - 2009 Summer Research Experience awarded by National Institutes of Health 2009 - 2010
investigator on
- 2007-2008 MBRS Support of Continuous Research Excellence at FIU. awarded by National Institutes of Health 2007 - 2009
Teaching
teaching activities
- BSC3941-U09: Biological Sciences Research Internship Fall Term 2019
- BSC6913-U03: Student Research Lab Fall Term 2019
- BSC6926-U02: Workshop in Biology Spring Term 2019
- PCB4023-UHA: Cell Biology Spring Term 2019
- PCB6025-U01: Molecular and Cellular Biology I Fall Term 2019
Contact
full name
- Manuel Barbieri
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Biotechnology & Applied Microbiology
- Cell Biology
- Chemistry
- Environmental Sciences & Ecology
- Evolutionary Biology
- Food Science & Technology
- General & Internal Medicine
- Hematology
- Immunology
- Infectious Diseases
- Integrative & Complementary Medicine
- Life Sciences & Biomedicine - Other Topics
- Microbiology
- Oncology
- Parasitology
- Pathology
- Pharmacology & Pharmacy
- Plant Sciences
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Toxicology