Becker, David
- Associate Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education
Contact Info
Overview
overview
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David A. Becker is an Associate Professor in Chemistry and Biochemistry.
B.A. University of Rochester
Ph.D. Massachusetts Institute of Technology
Postdoctoral Research Associate, Columbia University
research interests
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Organic Chemistry
Azulenyl nitrones
Spin Trapping
Neuroprotection
Neurodegeneration
Free radicals
Aging
Scholarly & Creative Works
selected publications
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Article
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2012A Peculiarly Cerebroid Convex Zygo-Dodecahedron is an Axiomatically Balanced "House of Blues": The Circle of Fifths to the Circle of Willis to Cadherin Cadenzas. SYMMETRY-BASEL. 4:644-666.Full Text via DOI: 10.3390/sym4040644 Web of Science: 000208832800005
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2008Neuroprotective antioxidant STAZN protects against myocardial ischemia/reperfusion injury. BIOCHEMICAL PHARMACOLOGY. 75:448-456.
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2007Stilbazulenyl nitrone decreases oxidative stress and reduces lung injury after hemorrhagic Shock/Resuscitation and LPS. ANTIOXIDANTS & REDOX SIGNALING. 9.Full Text via DOI: 10.1089/ars.2007.1765 Web of Science: 000250226500016
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2007Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose-response and therapeutic window. BRAIN RESEARCH. 1180:101-110.
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2005Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: Neurobehavior, histopathology, and pharmacokinetics. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 313.Full Text via DOI: 10.1124/jpet.105.083386 Web of Science: 000229203200017
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2005A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. EXPERIMENTAL NEUROLOGY. 191.Full Text via DOI: 10.1016/j.expneurol.2004.07.012 Web of Science: 000226225900009
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2004Kinetic studies on stilbazulenyl-bis-nitrone (STAZN), a nonphenolic chain-breaking antioxidant in solution, micelles, and lipid membranes. JOURNAL OF ORGANIC CHEMISTRY. 69.Full Text via DOI: 10.1021/jo030390i Web of Science: 000221268200003
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2003Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia. ANNALS OF NEUROLOGY. 54.Full Text via DOI: 10.1002/ana.10659 Web of Science: 000185158100007
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2003Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemiaFull Text via DOI: 10.1002/ana.10659 Web of Science: 000185158100007
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2002Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats. JOURNAL OF NEUROSURGERY. 96.Full Text via DOI: 10.3171/jns.2002.96.6.1077 Web of Science: 000176026900024
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2002Stilbazulenyl nitrone (STAZN): A nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 124.Full Text via DOI: 10.1021/ja011507s Web of Science: 000175227600036
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2002Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics.. JOURNAL OF BIOLOGICAL CHEMISTRY. 277.Full Text via DOI: 10.1074/jbc.M108585200 Web of Science: 000173166800020
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1999An optimal redox status for the survival of axotomized ganglion cells in the developing retina. NEUROSCIENCE. 93.Full Text via DOI: 10.1016/S0306-4522(99)00138-4 Web of Science: 000081196200030
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1998Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. ANNALS OF NEUROLOGY. 44:763-770.
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1998Mutant CuZn superoxide dismutase in motor neuron disease. JOURNAL OF INHERITED METABOLIC DISEASE. 21.Full Text via DOI: 10.1023/A:1005475206997 Web of Science: 000075453600013
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1998Azulenyl nitrone spin traps protect against MPTP neurotoxicity. EXPERIMENTAL NEUROLOGY. 152.Full Text via DOI: 10.1006/exnr.1998.6824 Web of Science: 000075127600017
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1998Redox behaviour of azulenyl nitrones: fully reversible one electron oxidation by cyclic voltammetry at potentials in the range of biological antioxidants. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2.Full Text via DOI: 10.1039/a708702k Web of Science: 000074273000003
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1998Mutant Cu,Zn superoxide dismutase in motor neuron disease. AGE. 21.Full Text via DOI: 10.1007/s11357-998-0012-x Web of Science: 000078262100007
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1998Mutant Cu,Zn superoxide dismutase in motor neuron diseaseFull Text via DOI: 10.1007/s11357-998-0012-x Web of Science: 000078262100007
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1998Azulenyl nitrones: Colorimetric detection of oxyradical end products and neuroprotection in the gerbil transient forebrain ischemia/reperfusion model. FREE RADICAL BIOLOGY AND MEDICINE. 24.Full Text via DOI: 10.1016/S0891-5849(97)00338-9 Web of Science: 000073018000008
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1996Highly sensitive colorimetric detection and facile isolation of diamagnetic free radical adducts of novel chromotropic nitrone spin trapping agents readily derived from guaiazulene. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 118.Full Text via DOI: 10.1021/ja952895z Web of Science: A1996TT38100028
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Conference
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2003
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1994STABILIZED ISOXAZOLIUM ANHYDROBASES - SYNTHESIS AND REACTIVITY STUDIES. 151-ORGN.Web of Science: A1994MY95500228
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Meeting Abstract
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2013Photographic evidence for the mechanism and regiochemistry of Markovnikov and anti-Markovnikov additions of hydrogen bromide to alkenes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000323851301953
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2007Design, synthesis and neuroprotective effects of azulenyl nitrone spin traps in animal models of cerebral ischemia. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207593906783
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2003
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1997Azulenyl nitrones: Evidence for enhanced free radical scavenging as a ramification of structure and oxidation potential.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: A1997WP18702088
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1996Highly sensitive colorimetric detection and facile isolation of diamagnetic free radical adducts of novel chromotropic nitrone spin trapping agents readily derived from guaiazulene. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: A1996UA48500781
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1994STABILIZED ISOXAZOLIUM ANHYDROBASES - SYNTHESIS AND REACTIVITY STUDIES. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: A1994MY95500228
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Review
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1999Diagnostic and therapeutic applications of azulenyl nitrone spin traps. CELLULAR AND MOLECULAR LIFE SCIENCES.Full Text via DOI: 10.1007/s000180050457 Web of Science: 000083951400006
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Works By Students
chaired theses and dissertations
- Birudukota, Nagaraju, Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones 2016
- Perez, Gloria Patricia, Synthetic Studies Toward a Novel Hydroxylamine of Potential Utility in the Preparation of Mitochondriotropic Nitrones 2016
- Tamrakar, Relina, Synthesis of Azulenylsilane Nitrones as Diagnostic Tools for Superoxide Detection 2011
- Kolhe, Amolkumar, Synthetic Studies of Azulenyl and Pseudoazulenyl Nitrones 2009
Research
principal investigator on
Contact
full name
- David Becker
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
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