Cabrerizo, Mercedes
- Associate Professor, Electrical and Computer Engineering , College of Engineering and Computing

Overview
overview
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Mercedes Cabrerizo received her Ph.D. degree in Electrical Engineering and her Master of Science degree in Computer Engineering both from Florida International University. She is a Ware Foundation Associate Professor in Neuroscience and Learning with the department of Electrical and Computer Engineering at Florida International University. Her research interests are in image and signal processing with applications to Neuroscience. She has been affiliated with the Brain Institute at Nicklaus Children’s Hospital doing signal and image processing of medical data, focusing on 3D source localization in patients with Epilepsy. She also works in collaboration with the Neurology department at Baptist Hospital on multimodal imaging to localize and validate the 3D source with the highest precision for surgical planning.
More recently, she is involved in the design of IRB approved protocols for (1) repetitive transcranial magnetic stimulation (rTMS) to provide therapeutic sessions to patients with Epilepsy at, (2) FDA approved rTMS for patients with depression in collaboration with the Department of Psychiatry and Behavioral Health at the Herbert Wertheim College of Medicine at FIU as well as with Baptist Hospital, (3) EEG-triggered fMRI (combining electroencephalography and
magnetic resonance imaging) in collaboration with a joint Neuroengineering program between FIU, Nicklaus Children’s Hospital and Baptist Hospital. She became a National Academy of Inventors’ Charter Fellow in 2014, and is accredited for the use of transcranial magnetic stimulation by Harvard Medical School; in 2015, and is certified by the Danish Research Center for Magnetic Resonance in 2015 and by the Experimental Psychology at University College London (UCL) in 2016.
research interests
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Dr. Mercedes Cabrerizo research interests are:
• Signal and image processing with applications to Neuroscience focusing on 3D source localization in patients with Epilepsy.
• Multimodal imaging to localize and validate the 3D source with the highest precision for surgical planning in collaboration with the Neurology department at Baptist Hospital.
• Analyzing EEG data (scalp and subdural) in order to conduct experiments with human subjects with the purpose of exploring patterns that will lead us into seizure prediction.
• Integrated neuroimaging platform that includes TMS, MRI, fMRI, CT, PET, FLAIR, DTI, EEG, and ECG recordings towards detection of electrodes leading to seizures.
• Assessment of EEG time and frequency based features in a unified decisional space using nonlinear decision functions to classify types of Epilepsy and epileptic and control EEG records in pediatric/adult population.
• Involved in the design of IRB approved protocols for (1) repetitive transcranial magnetic stimulation (rTMS) to provide therapeutic sessions to patients with Epilepsy at, (2) FDA approved rTMS for patients with depression in collaboration with the Department of Psychiatry and Behavioral Health at the Herbert Wertheim College of Medicine at FIU as well as with Baptist Hospital, (3) EEG-triggered fMRI (combining electroencephalography and magnetic resonance imaging) in collaboration with a joint Neuro-engineering program between FIU, Nicklaus Children’s Hospital and Baptist Hospital, and (4) FDA approved Neuro-navigated Transcranial Magnetic Stimulation (TMS) for the non-invasive mapping of the motor and language areas of the brain.
Scholarly & Creative Works
selected publications
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Article
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2021Penalized Functional Connectivity Maps for Patients With Focal Epilepsy. IEEE ACCESS. 9:204-217.Full Text via DOI: 10.1109/ACCESS.2020.3046851 Web of Science: 000606555500001
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2020Deep convolutional neural network for mixed random impulse and Gaussian noise reduction in digital images. IET IMAGE PROCESSING. 14:3791-3801.Full Text via DOI: 10.1049/iet-ipr.2019.0931 Web of Science: 000626224500020
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2020Gaussian discriminative component analysis for early detection of Alzheimer's disease: A supervised dimensionality reduction algorithm. JOURNAL OF NEUROSCIENCE METHODS. 344.Full Text via DOI: 10.1016/j.jneumeth.2020.108856 Web of Science: 000557763400007
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2020A Gaussian-based model for early detection of mild cognitive impairment using multimodal neuroimaging. JOURNAL OF NEUROSCIENCE METHODS. 333.Full Text via DOI: 10.1016/j.jneumeth.2019.108544 Web of Science: 000515428500008
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2020A distributed multitask multimodal approach for the prediction of Alzheimer's disease in a longitudinal study. NEUROIMAGE. 206.Full Text via DOI: 10.1016/j.neuroimage.2019.116317 Web of Science: 000507987000002
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2020Dynamics and Distant Effects of Frontal/Temporal Epileptogenic Focus Using Functional Connectivity Maps. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 67:632-643.Full Text via DOI: 10.1109/TBME.2019.2919263 Web of Science: 000510903800030
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2019A survey on applications and analysis methods of functional magnetic resonance imaging for Alzheimer's disease. JOURNAL OF NEUROSCIENCE METHODS. 317:121-140.Full Text via DOI: 10.1016/j.jneumeth.2018.12.012 Web of Science: 000461264000014
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2019Greater Regional Cortical Thickness is Associated with Selective Vulnerability to Atrophy in Alzheimer's Disease, Independent of Amyloid Load and APOE Genotype. JOURNAL OF ALZHEIMERS DISEASE. 69:145-156.Full Text via DOI: 10.3233/JAD-180231 Web of Science: 000467519100013
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2018Denoising of ultrasound images affected by combined speckle and Gaussian noise. IET IMAGE PROCESSING. 12.Full Text via DOI: 10.1049/iet-ipr.2018.5292 Web of Science: 000451759800025
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2018A Robust Edge Detection Approach in the Presence of High Impulse Noise Intensity Through Switching Adaptive Median and Fixed Weighted Mean Filtering. IEEE TRANSACTIONS ON IMAGE PROCESSING. 27.Full Text via DOI: 10.1109/TIP.2018.2857448 Web of Science: 000442340100009
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2018Gaussian Discriminant Analysis for Optimal Delineation of Mild Cognitive Impairment in Alzheimer's Disease. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 28.Full Text via DOI: 10.1142/S012906571850017X Web of Science: 000442776900005
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2018A Neuroimaging Web Services Interface as a Cyber Physical System for Medical Imaging and Data Management in Brain Research: Design Study. JMIR MEDICAL INFORMATICS. 6.Full Text via DOI: 10.2196/medinform.9063 Web of Science: 000438272800019
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2017A Cross-Correlated Delay Shift Supervised Learning Method for Spiking Neurons with Application to Interictal Spike Detection in Epilepsy. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 27.
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2017EEG processing: a many-core approach utilising the Intel single-chip cloud computer platform. INTERNATIONAL JOURNAL OF EMBEDDED SYSTEMS. 9.Full Text via DOI: 10.1504/IJES.2017.10007719 Web of Science: 000415236600007
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2017The Relationship of Brain Amyloid Load and APOE Status to Regional Cortical Thinning and Cognition in the ADNI Cohort. JOURNAL OF ALZHEIMERS DISEASE. 59:1269-1282.
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2015A practical guideline for intracranial volume estimation in patients with Alzheimer's disease. BMC BIOINFORMATICS. 16.
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2015A probabilistic approach for pediatric epilepsy diagnosis using brain functional connectivity networks. BMC BIOINFORMATICS. 16.
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2015Estimating Intracranial Volume in Brain Research: An Evaluation of Methods. NEUROINFORMATICS. 13:427-441.
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2015Scalp EEG brain functional connectivity networks in pediatric epilepsy. COMPUTERS IN BIOLOGY AND MEDICINE. 56:158-166.
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2014An Optimal Decisional Space for the Classification of Alzheimer's Disease and Mild Cognitive Impairment. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 61:2245-2253.
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2014Classification of FMRI Patterns-A Study of the Language Network Segregation in Pediatric Localization Related Epilepsy. HUMAN BRAIN MAPPING. 35:1446-1460.
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2014Induced Effects of Transcranial Magnetic Stimulation on the Autonomic Nervous System and the Cardiac Rhythm. SCIENTIFIC WORLD JOURNAL.Full Text via DOI: 10.1155/2014/349718 Web of Science: 000343482700001
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2014Quasi-Stationarity of EEG for Intraoperative Monitoring during Spinal Surgeries. SCIENTIFIC WORLD JOURNAL.Full Text via DOI: 10.1155/2014/468269 Web of Science: 000332257900001
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2014Significance of Normalization on Anatomical MRI Measures in Predicting Alzheimer's Disease. SCIENTIFIC WORLD JOURNAL.Full Text via DOI: 10.1155/2014/541802 Web of Science: 000330650300001
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2012A 3-D Liver Segmentation Method with Parallel Computing for Selective Internal Radiation Therapy. IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE. 16:62-69.
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2012A NEW PARAMETRIC FEATURE DESCRIPTOR FOR THE CLASSIFICATION OF EPILEPTIC AND CONTROL EEG RECORDS IN PEDIATRIC POPULATION. INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 22.
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2012An effective intra-operative neurophysiological monitoring scheme for aneurysm clipping and spinal fusion surgeries. JOURNAL OF NEURAL ENGINEERING. 9.
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2012Peak Detection of Somatosensory Evoked Potentials Using an Integrated Principal Component Analysis-Walsh Method. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 29:165-173.
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2011CLASSIFICATION AND MEDICAL DIAGNOSIS OF SCALP EEG USING ARTIFICIAL NEURAL NETWORKS. INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL. 7:6905-6918.Web of Science: 000297957500021
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2011Subdural EEG Classification Into Seizure and Nonseizure Files Using Neural Networks in the Gamma Frequency Band. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 28:20-29.
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2010A Comparative Study of Intracranial EEG Files Using Nonlinear Classification Methods. ANNALS OF BIOMEDICAL ENGINEERING. 38:187-199.
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2010A Windows-Based Interface for Teaching Image Processing. COMPUTER APPLICATIONS IN ENGINEERING EDUCATION. 18:213-224.Full Text via DOI: 10.1002/cae.20171 Web of Science: 000277374000002
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2010Classification of Leukemia Blood Samples Using Neural Networks. ANNALS OF BIOMEDICAL ENGINEERING. 38:1473-1482.
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2010SUBDURAL INTERICTAL EEG ANALYSIS FOR EXTRACTING DISCRIMINATING FEATURES TOWARDS ELECTRODE CLASSIFICATION USING ARTIFICIAL NEURAL NETWORKS. NEURAL COMPUTATION AND PARTICLE ACCELERATORS: RESEARCH, TECHNOLOGY AND APPLICATIONS. 233-255.Web of Science: 000284290100007
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2009A spreadsheet application for processing long-term EEG recordings. COMPUTERS IN BIOLOGY AND MEDICINE. 39:844-851.
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2009Classification of electroencephalographic seizure recordings into ictal and interictal files using correlation sum. COMPUTERS IN BIOLOGY AND MEDICINE. 39:604-614.
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2009Seizure Detection: An Assessment of Time- and Frequency-Based Features in a Unified Two-Dimensional Decisional Space Using Nonlinear Decision Functions. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 26:381-391.
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2008Adaptive eye-gaze tracking using neural-network-based user profiles to assist people with motor disability. JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT. 45:801-817.
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2006An inverse solution to functional brain mapping in. language processing using an eigensystem study. INVERSE PROBLEMS IN SCIENCE AND ENGINEERING. 14:437-452.Full Text via DOI: 10.1080/17415970600574138 Web of Science: 000239428900009
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2005Detection of interictal spikes and artifactual data through orthogonal transformations. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 22:53-64.Full Text via DOI: 10.1097/01.WNP.0000150880.19561.6F PMID: 15689714 Web of Science: 000226883600007
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2005Integrated study of topographical functional maps based on an auditory comprehension paradigm using an eigensystem study and spectrum analysis. BRAIN TOPOGRAPHY. 17:151-163.
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2004Interictal spike detection using the Walsh transform. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 51.Full Text via DOI: 10.1109/TBME.2004.826642 Web of Science: 000220967700023
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2004Remote eye gaze tracking system as a computer interface for persons with severe motor disability. COMPUTERS HELPING PEOPLE WITH SPECIAL NEEDS: PROCEEDINGS. 3118.Web of Science: 000222635100113
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Book Chapter
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2016Autonomous bicycle with gyroscope sensor. 555-565.
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Conference
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Meeting Abstract
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2018Inter-Ictal EEG Spike Inflow-Outflow Connectivity Pattern Analysis using Partial Directed Coherence (PDC), and Its Relation to Connectivity Mapping in Time and Frequency Domains. Validation of Inter-Hemispheric Connectivity Analysis using EEG Wada Data in Temporal Lobe Epilepsy Cases. EPILEPSIA.Web of Science: 000451817900568
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Proceedings Paper
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2019Longitudinal Prediction Modeling of Alzheimer Disease using Recurrent Neural Networks. 2019 IEEE EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL & HEALTH INFORMATICS (BHI).Web of Science: 000508002200064
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2018A Deep Neural Network Approach for Early Diagnosis of Mild Cognitive Impairment Using Multiple Features. 2018 17TH IEEE INTERNATIONAL CONFERENCE ON MACHINE LEARNING AND APPLICATIONS (ICMLA). 1341-1346.Full Text via DOI: 10.1109/ICMLA.2018.00218 Web of Science: 000463034400210
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2018Early Diagnosis of Mild Cognitive Impairment Using Random Forest Feature Selection. 2015 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS). 133-136.Web of Science: 000458897900034
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2017A Gaussian Discriminant Analysis-based Generative Learning Algorithm for the Early Diagnosis of Mild Cognitive Impairment in Alzheimer's Disease. 2017 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM). 538-542.Web of Science: 000426504100097
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2017A Neuroimaging Feature Extraction Model for Imaging Genetics with Application to Alzheimer's Disease. 2017 IEEE 17TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE). 15-20.Full Text via DOI: 10.1109/BIBE.2017.00010 Web of Science: 000427878000003
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2017A Novel Gaussian Discriminant Analysis-based Computer Aided Diagnosis System for Screening Different Stages of Alzheimer's Disease. 2017 IEEE 17TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE). 279-284.Full Text via DOI: 10.1109/BIBE.2017.00054 Web of Science: 000427878000047
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2017Classification of Interictal Epileptiform Discharges using Partial Directed Coherence. 2017 IEEE 17TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE). 473-478.Full Text via DOI: 10.1109/BIBE.2017.00086 Web of Science: 000427878000079
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2017Computerized Neuropsychological Assessment in Mild Cognitive Impairment Based on Natural Language Processing-oriented Feature Extraction. 2017 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM). 543-546.Web of Science: 000426504100098
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2017Connectivity Dynamics of Interictal Epileptiform Activity. 2017 IEEE 17TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE). 425-430.Full Text via DOI: 10.1109/BIBE.2017.00078 Web of Science: 000427878000071
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2017Pattern analysis of the interaction of regional amyloid load, cortical thickness and APOE genotype in the progression of Alzheimer's disease. 2017 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM). 2171-2176.Web of Science: 000426504100382
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2017REAL-TIME R-SPIKE DETECTION IN THE CARDIAC WAVEFORM THROUGH INDEPENDENT COMPONENT ANALYSIS. 2017 IEEE SIGNAL PROCESSING IN MEDICINE AND BIOLOGY SYMPOSIUM (SPMB).Web of Science: 000426447400012
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2017ROBUST PREDICTION OF COGNITIVE TEST SCORES IN ALZHEIMER'S PATIENTS. 2017 IEEE SIGNAL PROCESSING IN MEDICINE AND BIOLOGY SYMPOSIUM (SPMB).Web of Science: 000426447400047
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2016A Web Platform for Data Acquisition and Analysis for Alzheimer's Disease. 2012 PROCEEDINGS OF IEEE SOUTHEASTCON.Web of Science: 000387067900024
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2016Application of Cross-Correlated Delay Shift Rule in Spiking Neural Networks for Interictal Spike Detection. 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC). 796-799.PMID: 28268446 Web of Science: 000399823501044
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2016Connectivity Maps of Different Types of Epileptogenic Patterns. 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC). 1018-1021.PMID: 28268497 Web of Science: 000399823501098
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2016Connectivity Patterns of Interictal Epileptiform Discharges Using Coherence Analysis. 2013 IEEE SIGNAL PROCESSING IN MEDICINE AND BIOLOGY SYMPOSIUM (SPMB).Web of Science: 000400683800003
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2016Epilepsy, A Cyberattack on Brains' Networked Control System. 2016 15TH IEEE INTERNATIONAL CONFERENCE ON MACHINE LEARNING AND APPLICATIONS (ICMLA 2016). 622-625.Full Text via DOI: 10.1109/ICMLA.2016.89 Web of Science: 000399100100100
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2015A Novel Semi-Automatic Method for Accurate Registration of FDG_CT and FLT_CT Image Modalities. 2013 IEEE SIGNAL PROCESSING IN MEDICINE AND BIOLOGY SYMPOSIUM (SPMB).Web of Science: 000380570400037
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2015Pediatric Epilepsy: Clustering by Functional Connectivity using Phase Synchronization. 2015 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE (BIOCAS). 330-333.Web of Science: 000398907900094
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2014Altered Small-World Anatomical Networks in Apolipoprotein-E4 (ApoE4) Carriers using MRI. 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC). 2468-2471.Web of Science: 000350044702113
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2014Comparative Reliability Analysis of Publicly Available Software Packages for Automatic Intracranial Volume Estimation. 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC). 2342-2345.Web of Science: 000350044702081
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2014Integrating MRI Multivariate Markers with Cognitive Neuropsychological Scores for an Optimal Decisional Space in Predicting Alzheimer's Disease. PROCEEDINGS OF THE 2ND INTERNATIONAL CONGRESS ON PERSONALIZED MEDICINE (UPCP 2013).Web of Science: 000342205300004
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2014Multivariate Analysis of Structural MRI and PET (FDG and 18F-AV-45) for Alzheimer's Disease and Its Prodromal Stages. 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC). 1051-1054.Web of Science: 000350044701013
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2013A Somatosensory Evoked Potential Monitoring Algorithm Using Time Frequency Filtering. 2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER). 351-354.Web of Science: 000331259200089
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2013Functional Connectivity Network based on Graph Analysis of Scalp EEG for Epileptic Classification. 2013 IEEE SIGNAL PROCESSING IN MEDICINE AND BIOLOGY SYMPOSIUM (SPMB).Web of Science: 000350799000014
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2013Novel Time-Frequency-Eigen Filter for Intraoperative Neurophysiologic Monitoring in Spinal Surgeries. 2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER). 1578-1581.Web of Science: 000331259200391
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2013Regional MRI Measures and Neuropsychological Test for Multi-dimensional Analysis in Alzheimer's Disease. 2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER). 533-536.Web of Science: 000331259200134
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2013Resting State Functional Connectivity Based on Principal Component Transformation of Cortical fMRI Measurements. 2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER). 1501-1504.Web of Science: 000331259200372
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2012Spatial and Temporal Analysis of Interictal Activity in the Epileptic Brain. 2012 IEEE SIGNAL PROCESSING IN MEDICINE AND BIOLOGY SYMPOSIUM (SPMB).Web of Science: 000319418400010
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2008An eye gaze tracking system using customized user profiles to help persons with motor challenges access computers. COMPUTERS HELPING PEOPLE WITH SPECIAL NEEDS, PROCEEDINGS. 1161-1168.Web of Science: 000258398900175
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2007Can EEG processing reveal seizure prediction patterns?. PROCEEDINGS OF THE IASTED INTERNATIONAL CONFERENCE ON GRAPHICS AND VISUALIZATION IN ENGINEERING. 47-+.Web of Science: 000246337600009
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2006Pattern extraction in interictal EEG recordings towards detection of electrodes leading to seizures. BIOMEDICAL SCIENCES INSTRUMENTATION, VOL 39. 243-248.PMID: 16817615 Web of Science: 000239353700040
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2004A new mathematical approach based on orthogonal operators for the detection of interictal spikes in epileptogenic data. BIOMEDICAL SCIENCES INSTRUMENTATION, VOL 40.Web of Science: 000221906600029
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2004An integrated auditory-comprehension process augmented through topographical maps and a new eigensystem study. BIOMEDICAL SCIENCES INSTRUMENTATION, VOL 40.Web of Science: 000221906600031
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2003A new algorithm for the EEG functional brain mapping based on an Auditory-Comprehension process. 7TH WORLD MULTICONFERENCE ON SYSTEMICS, CYBERNETICS AND INFORMATICS, VOL IV, PROCEEDINGS.Web of Science: 000189329700006
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Review
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2019A comprehensive survey on impulse and Gaussian denoising filters for digital images. SIGNAL PROCESSING.Full Text via DOI: 10.1016/j.sigpro.2018.12.006 Web of Science: 000457667000023
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Research
co-principal investigator on
- MRI: Development of an Instrument for a Comprehensive Study of Alzheimer's Disease: Multimodal Imaging, Visualization, Machine Learning and Therapeutic Brain Stimulation awarded by National Science Foundation 2019 - 2024
- BPC-AE: An Extended CAHSI Alliance to Broaden Participation in Graduate Studies awarded by National Science Foundation 2021 - 2023
- MRI: Development of an Integrated Neuroimaging Instrument with Temporal and Spatial Alignments for Brain Research awarded by National Science Foundation 2015 - 2021
- Functional Brain Mapping in Pediatric Epilepsy awarded by Ware Foundation 2009 - 2011
subproject principal investigator on
- NSF Graduate Research Fellowships awarded by National Science Foundation 2020 - 2025
Contact
full name
- Mercedes Cabrerizo
Identifiers
ORCID iD
- https://orcid.org/0000-0002-0302-7300 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Computer Science
- Education & Educational Research
- Engineering
- Imaging Science & Photographic Technology
- Life Sciences & Biomedicine - Other Topics
- Mathematical & Computational Biology
- Mathematics
- Medical Informatics
- Neurosciences & Neurology
- Radiology, Nuclear Medicine & Medical Imaging