Chand, Hitendra
- Associate Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine
Scholarly & Creative Works
selected publications
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Article
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2021Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodiesFull Text via DOI: 10.1016/j.jaut.2021.102779 Web of Science: 000736583900001
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2021Distinct Exosomal miRNA Profiles from BALF and Lung Tissue of COPD and IPF PatientsFull Text via DOI: 10.3390/ijms222111830 Web of Science: 000718516800001
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2021Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 virusesFull Text via DOI: 10.1016/j.jaut.2021.102715 Web of Science: 000701894700004
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2021SARS-CoV-2, Inflammatory Apoptosis, and Cytokine Storm SyndromeFull Text via DOI: 10.2174/2666958702101010022
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2021HIV-1 Productively Infects and Integrates in Bronchial Epithelial CellsFull Text via DOI: 10.3389/fcimb.2020.612360 Web of Science: 000619020700001
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2021SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential MechanismFull Text via DOI: 10.1007/s12035-020-02245-1 Web of Science: 000607527000002
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2020Development of Multifunctional Biopolymeric Auto-Fluorescent Micro- and Nanogels as a Platform for Biomedical ApplicationsFull Text via DOI: 10.3389/fbioe.2020.00315 Web of Science: 000535564500001
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2020Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung InjuryFull Text via DOI: 10.3389/fphar.2019.01619 Web of Science: 000510030100001
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2019Nontoxic amphiphilic carbon dots as promising drug nanocarriers across the blood-brain barrier and inhibitors of beta-amyloidFull Text via DOI: 10.1039/c9nr08194a Web of Science: 000507989900026
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2019MRI-Guided, Noninvasive Delivery of Magneto-Electric Drug Nanocarriers to the Brain in a Nonhuman PrimateFull Text via DOI: 10.1021/acsabm.9b00592 Web of Science: 000616372000019
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2019TGF-beta 1 increases viral burden and promotes HIV-1 latency in primary differentiated human bronchial epithelial cellsFull Text via DOI: 10.1038/s41598-019-49056-6 Web of Science: 000483017100031
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2019Nanoparticle based treatment for cardiovascular diseasesFull Text via DOI: 10.2174/1871529X18666180508113253
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2018Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaquesFull Text via DOI: 10.1172/JCI121935 Web of Science: 000452071300027
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2018A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial CellsFull Text via DOI: 10.1038/s41598-018-32114-w Web of Science: 000444571200004
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2018Noxa/HSP27 complex delays degradation of ubiquitylated IkB alpha in airway epithelial cells to reduce pulmonary inflammationFull Text via DOI: 10.1038/mi.2017.117 Web of Science: 000433899600014
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2018IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cellsFull Text via DOI: 10.1038/s41598-017-18884-9 Web of Science: 000419940000029
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2017Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondriaFull Text via DOI: 10.1038/s41467-017-00975-w Web of Science: 000412493800009
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2017Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and Is Associated with COPD SeverityFull Text via DOI: 10.1080/15412555.2016.1262340 Web of Science: 000398033800013
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2017Extent of allergic inflammation depends on intermittent versus continuous sensitization to house dust miteFull Text via DOI: 10.1080/08958378.2017.1311389 Web of Science: 000400856000003
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2016T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airwaysFull Text via DOI: 10.1186/s12931-016-0446-0 Web of Science: 000385976200001
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2016Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus InfectionFull Text via DOI: 10.1165/rcmb.2015-0133OC Web of Science: 000377592300008
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2015HIF-1 alpha Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in MiceFull Text via DOI: 10.1371/journal.pone.0137757 Web of Science: 000361043100083
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2014A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expressionFull Text via DOI: 10.1038/ncomms6567 Web of Science: 000345914100002
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2013Deacetylation of p53 induces autophagy by suppressing Bmf expressionFull Text via DOI: 10.1083/jcb.201205064 Web of Science: 000318215100008
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2012Acute Inflammation Induces Insulin-like Growth Factor-1 to Mediate Bcl-2 and Muc5ac Expression in Airway Epithelial CellsFull Text via DOI: 10.1165/rcmb.2012-0079OC Web of Science: 000314406800008
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2012Intracellular Insulin-like Growth Factor-1 Induces Bcl-2 Expression in Airway Epithelial CellsFull Text via DOI: 10.4049/jimmunol.1102673 Web of Science: 000303299900051
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2011Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infectionFull Text via DOI: 10.1016/j.virol.2011.01.024 Web of Science: 000288773100019
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2009Human tissue factor pathway inhibitor-2 is internalized by cells and translocated to the nucleus by the importin systemFull Text via DOI: 10.1016/j.abb.2008.11.028 Web of Science: 000263388100008
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2009Discriminating Virulence Mechanisms among Bacillus anthracis Strains by Using a Murine Subcutaneous Infection ModelFull Text via DOI: 10.1128/IAI.00647-08 Web of Science: 000262776100044
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2007Identification of a human TFPI-2 splice variant that is upregulated in human tumor tissuesFull Text via DOI: 10.1186/1476-4598-6-20 Web of Science: 000245097300001
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2006Identification of a novel human tissue factor splice variant that is upregulated in tumor cellsFull Text via DOI: 10.1002/ijc.21550 Web of Science: 000236214700015
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2005A reference preparation of buffalo pituitary follicle stimulating hormone using lectin affinity chromatographyFull Text via DOI: 10.1080/10826060500218198 Web of Science: 000233088700006
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2004Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2Full Text via DOI: 10.1074/jbc.M400802200 Web of Science: 000220870400077
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2004The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic miceFull Text via DOI: 10.1182/blood-2003-06-1930 Web of Science: 000188393800054
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2003Molecular cloning, expression, and characterization of bovine tissue factor pathway inhibitor-2Full Text via DOI: 10.1016/S0003-9861(03)00332-1 Web of Science: 000184939300014
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2003Human tissue factor pathway inhibitor-2 does not bind or inhibit activated matrix metalloproteinase-1Full Text via DOI: 10.1016/S0304-4165(03)00074-6 Web of Science: 000183462800002
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Book Chapter
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2019Cell-Line-Based Studies of Nanotechnology Drug-Delivery Systems: A Brief Review. 375-393.Full Text via DOI: 10.1016/B978-0-12-814033-8.00012-6 Web of Science: 000472668000013
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2019Chapter 12 Cell-Line-Based Studies of Nanotechnology Drug-Delivery Systems A Brief Review. 375-393.Full Text via DOI: 10.1016/b978-0-12-814033-8.00012-6
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Conference
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2018
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2018
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2018
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2018
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2017
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2017
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2012NOXA Interacts With HSP27 To Inhibit NF-ºB-Mediated Inflammation In Cigarette Smokers. a1318-a1318.Full Text via DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1318
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Letter
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2020Metabolomics to Predict Antiviral Drug Efficacy in COVID-19. 396-398.Full Text via DOI: 10.1165/rcmb.2020-0206LE Web of Science: 000567767500015
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2017Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner. 1456-+.Full Text via DOI: 10.1016/j.jaci.2017.05.038 Web of Science: 000414304300032
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2010Anti-IgE therapy results in decreased myeloid dendritic cells in asthmatic airways. 1157-1158.Full Text via DOI: 10.1016/j.jaci.2010.01.020 Web of Science: 000277686700028
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2007Quantitative real-time reverse transcription polymerase chain reaction analysis of a novel tissue factor splice variant in select human solid tumors. 640-641.Full Text via DOI: 10.1111/j.1538-7836.2007.02359.x Web of Science: 000244277800041
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Other Scholarly Work
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Preprint
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Review
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2021Human Immunodeficiency Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Coinfection: A Systematic Review of the Literature and Challenges. 266-282.Full Text via DOI: 10.1089/aid.2020.0284 Web of Science: 000634648400001
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2020Role of Non-Coding RNAs in Lung Circadian Clock Related DiseasesFull Text via DOI: 10.3390/ijms21083013 Web of Science: 000535565300355
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2019Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease. 678-688.Full Text via DOI: 10.1165/rcmb.2019-0184TR Web of Science: 000499728500007
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2019Nanoparticle-mediated approaches for Alzheimer's disease pathogenesis, diagnosis, and therapeutics. 125-140.Full Text via DOI: 10.1016/j.jconrel.2019.10.034 Web of Science: 000499615300012
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2015Intimacy and a deadly feud: the interplay of autophagy and apoptosis mediated by amino acids. 2089-2099.Full Text via DOI: 10.1007/s00726-015-2084-0 Web of Science: 000361792600004
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2014Molecular Processes that Drive Cigarette Smoke-Induced Epithelial Cell Fate of the Lung. 471-482.Full Text via DOI: 10.1165/rcmb.2013-0348TR Web of Science: 000332513500001
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2005Structure, function and biology of tissue factor pathway inhibitor-2. 1122-1130.Full Text via DOI: 10.1160/TH05-07-0509 Web of Science: 000234214900004
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Research
principal investigator on
- A LncRNA in Pulmonary Mucosal Immunity and HIV-Associated Comorbidities awarded by Allergy and Infectious Diseases 2020 - 2022
- Novel long noncoding RNAs in the airway mucous response awarded by Allergy and Infectious Diseases 2020 - 2022
- Novel long noncoding RNAs in the airway mucous response awarded by Allergy and Infectious Diseases 2019 - 2022
- Preclinical model efficacy testing of a Photoelectrochemical Oxidative Filter-Based Air Purification Unit in Mitigating the Hyperreactive Respiratory Responses to Inhaled Allergens awarded by Molekule Inc. 2021 - 2022
- Targeting Hyperplastic Airway Cells Using a Small Molecule Inhibitor awarded by Allergy and Infectious Diseases 2017 - 2019
- Targeting Chronic Mucous Hypersecretion Using a Small Molecule Inhibitor awarded by American Lung Association 2016 - 2018
investigator on
Identifiers
ORCID iD
- https://orcid.org/0000-0002-0574-9307 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in