Chen, Ji'An
Contact Info
Overview
overview
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Jian Chen is a research associate in Dr. Barry P. Rosen’s lab. His main focus is to investigate the molecular mechanism of cross-resistance of heavy metals (eg, arsenic, antimony) and antibiotic, biotransformation and transport of environmental organicoarsenicals (eg, roxarsone).
Chen is interested in global biogeochemical cycles of trace elements, mainly arsenic, in the environment and their bioremediation. Arsenic contamination in soils and food increases human risks of diseases. He identified several genes involved in arsenic detoxification, such arsM gene from alga Chlamydomonas, which can convert toxic A(III) to non-toxic methylated arsenicals, and further genetic engineered soil bacteria P. putida with arsM for arsenic bioremediation. He is also trying to elucidate the molecular details of the pathways of biotransformations and transport of environmental organicoarsenicals, including the herbicide MSMA (monosodium methylarsenate) and the antimicrobial growth promoter for poultry and swine Roxarsone (3-nitro-4-hydroxybenzenearsonic acid). Function of genes arsH, arsP, arsJ et al., involved in organoarsenicals detoxification are disclosed.
research interests
- Arsenous Acid Derivative; Arsenite Oxidase; Arsenic; Microcystins; Cyanoginosin LR; Cyanobacterial Toxins; Ghrelin Receptors; Acyltransferases; Growth Hormone Releasing Hexapeptide
Scholarly & Creative Works
selected publications
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Article
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2020The Pseudomonas putida NfnB nitroreductase confers resistance to roxarsone. SCIENCE OF THE TOTAL ENVIRONMENT. 748.Full Text via DOI: 10.1016/j.scitotenv.2020.141339 Web of Science: 000581049800047
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2019Reduction of Organoarsenical Herbicides and Antimicrobial Growth Promoters by the Legume Symbiont Sinorhizobium meliloti. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 53:13648-13656.Full Text via DOI: 10.1021/acs.est.9b04026 Web of Science: 000500838900011
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2019Role of ArsEFG in Roxarsone and Nitarsone Detoxification and Resistance. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 53:6182-6191.Full Text via DOI: 10.1021/acs.est.9b01187 Web of Science: 000470793900008
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2019Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic. COMMUNICATIONS BIOLOGY. 2.Full Text via DOI: 10.1038/s42003-019-0365-y Web of Science: 000465423400001
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2019The antibiotic action of methylarsenite is an emergent property of microbial communities. MOLECULAR MICROBIOLOGY. 111.Full Text via DOI: 10.1111/mmi.14169 Web of Science: 000458286600012
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2017A novel MAs(III)-selective ArsR transcriptional repressor. MOLECULAR MICROBIOLOGY. 106:469-478.
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2017Arsenic methylation by a genetically engineered Rhizobium-legume symbiont. PLANT AND SOIL. 416:259-269.
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2017Conserved cysteine residues determine substrate specificity in a novel As(III) S-adenosylmethionine methyltransferase from Aspergillus fumigatus. MOLECULAR MICROBIOLOGY. 104:250-259.
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2016Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds. NATURE PLANTS. 2.
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2016Organoarsenical Biotransformations by Shewanella putrefaciens. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 50:7956-7963.
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2016Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance. MOLECULAR MICROBIOLOGY. 100:945-953.
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2015ArsH is an organoarsenical oxidase that confers resistance to trivalent forms of the herbicide monosodium methylarsenate and the poultry growth promoter roxarsone. MOLECULAR MICROBIOLOGY. 96:1042-1052.
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2014Biosensor for Organoarsenical Herbicides and Growth Promoters. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 48:1141-1147.
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2014Volatilization of Arsenic from Polluted Soil by Pseudomonas putida Engineered for Expression of the arsM Arsenic(III) S-Adenosine Methyltransferase Gene. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 48:10337-10344.
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2013Engineering the Soil Bacterium Pseudomonas putida for Arsenic Methylation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 79:4493-4495.
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2012A Novel Biosensor Selective for Organoarsenicals. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 78:7145-7147.
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2011Biotransformation and Volatilization of Arsenic by Three Photosynthetic Cyanobacteria. PLANT PHYSIOLOGY. 156:1631-1638.
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Meeting Abstract
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2018Novel biosensor for organoarsenical herbicides and antimicrobial growth promoters. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000447609100050
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Review
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2020The Arsenic Methylation Cycle: How Microbial Communities Adapted Methylarsenicals for Use as Weapons in the Continuing War for Dominance. FRONTIERS IN ENVIRONMENTAL SCIENCE.Full Text via DOI: 10.3389/fenvs.2020.00043 Web of Science: 000531624300001
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2019Organoarsenical compounds: Occurrence, toxicology and biotransformation. CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY.Full Text via DOI: 10.1080/10643389.2019.1619375 Web of Science: 000473043900001
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2019Pathways of arsenic uptake and efflux. ENVIRONMENT INTERNATIONAL. 585-597.Full Text via DOI: 10.1016/j.envint.2019.02.058 Web of Science: 000462597500067
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Contact
full name
- Jian Chen
Identifiers
ORCID iD
- https://orcid.org/0000-0002-8508-675X (confirmed)
- https://orcid.org/0000-0002-0875-0004 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in