Dimitroff, Charles
Overview
overview
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Charles Dimitroff, Ph.D., is a global leader in the study of sugars, known as glycobiology, and is highly motivated to translate glycobiological findings to help cure diseases and improve the overall health of humans. His research focuses on understanding how complex sugars or ‘glycans’ regulate immune and cancer cell functions with the goal of developing new approaches to boost the immune system to fight diseases and to treat cancer progression. As a principal investigator for over 26 years, his efforts have helped identify the nature and impact of glycans on inflammation and cancer, while operating one of the most reputable translational glycobiology programs in the US.
Dr. Dimitroff has studied the nature of lectin – carbohydrate interactions and their impact in inflammation and cancer for the last 26 years. He has an expertise in glycobiology studies relating to tumor biology and adaptive immunity and is qualified to perform pre-clinical research investigating how glycome-related molecules contribute to the pathogenesis of inflammation and cancer. He conducts both in vitro and in vivo experiments designed to characterize the identity and function of lectins and their carbohydrate-binding ligands on leukocytes and cancer cells.
Scholarly & Creative Works
selected publications
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Article
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2021Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways. JOURNAL OF AUTOIMMUNITY. 117.Full Text via DOI: 10.1016/j.jaut.2020.102575 Web of Science: 000614250900007
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2020Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand. GLYCOBIOLOGY. 30:895-909.Full Text via DOI: 10.1093/glycob/cwaa034 Web of Science: 000593026300005
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2019I-branched carbohydrates as emerging effectors of malignant progression. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116:13729-13737.Full Text via DOI: 10.1073/pnas.1900268116 Web of Science: 000474535700008
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2018Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked GlycansFull Text via DOI: 10.3389/fimmu.2018.02857 Web of Science: 000453354300001
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2018Loss of GCNT2/I-branched glycans enhances melanoma growth and survivalFull Text via DOI: 10.1038/s41467-018-05795-0 Web of Science: 000442376200014
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2018Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycansFull Text via DOI: 10.1038/s41467-018-05770-9 Web of Science: 000441865400001
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2015Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant PotentialFull Text via DOI: 10.1038/jid.2015.95 Web of Science: 000356180100024
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2014Isolation and Characterization Of Chimeric Human Fc-expressing Proteins Using Protein A Membrane Adsorbers And A Streamlined WorkflowFull Text via DOI: 10.3791/51023 Web of Science: 000348513500034
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2013Human fucosyltransferase 6 enables prostate cancer metastasis to boneFull Text via DOI: 10.1038/bjc.2013.690 Web of Science: 000328646300010
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2013Definition of Molecular Determinants of Prostate Cancer Cell Bone ExtravasationFull Text via DOI: 10.1158/0008-5472.CAN-12-3264 Web of Science: 000313739500052
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2012Galectins and their ligands: negative regulators of anti-tumor immunityFull Text via DOI: 10.1007/s10719-012-9379-0 Web of Science: 000309868800007
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2012Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 ExpressionFull Text via DOI: 10.4049/jimmunol.1103433 Web of Science: 000302150300027
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2012Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor ImmunityFull Text via DOI: 10.1038/jid.2011.335 Web of Science: 000299215500022
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2011Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct IncorporationFull Text via DOI: 10.1074/jbc.M110.194597 Web of Science: 000291464700068
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2009Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell traffickingFull Text via DOI: 10.1073/pnas.0906074106 Web of Science: 000271907400049
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2008Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expressionFull Text via DOI: 10.1016/j.jaci.2007.08.014 Web of Science: 000252372000022
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2003Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigenFull Text via DOI: 10.1172/JCI200319220 Web of Science: 000185763100010
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2001CD44 is a major E-selectin ligand on human hematopoietic progenitor cellsFull Text via DOI: 10.1083/jcb.153.6.1277 Web of Science: 000169318100014
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2000A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cellsFull Text via DOI: 10.1073/pnas.250484797 Web of Science: 000165728800070
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Book Chapter
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Conference
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2020
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2020Deep Learning to Discover Cancer Glycome Genes Signifying the Origins of Cancer. 2425-2431.Full Text via DOI: 10.1109/BIBM49941.2020.9313450 Web of Science: 000659487102075
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2016
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2016ST3Gal1 truncates O-glycans and augments galectin-3 binding to CD45 in human B cells. 1486-1486.Web of Science: 000392935600276
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2016Structural characterization of the N-glycome from malignant melanoma cells reveals galectin ligands. 1442-1443.Web of Science: 000392935600170
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2015
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2012Galectin-1 can bind human melanoma-specific CD8+T cells and trigger immunosuppression. S101-S101.Web of Science: 000302866900596
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2011Blocking galectin-1 ligand biosynthesis enhances immunity against melanoma. S96-S96.Web of Science: 000289035600575
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2010Abstract 5178: Homing of circulating prostate cancer cells to bone is regulated by alpha 1,3 fucosyltransferase 7. 5178-5178.Full Text via DOI: 10.1158/1538-7445.am10-5178
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2010Galectin-1 is a potent inducer of a regulatory phenotype on skin-resident memory T cells. S113-S113.Web of Science: 000276455100672
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2009
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2007
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2004
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2002Expression of selectin ligands on blasts from human acute leukemias. 81-81.Web of Science: 000176187000177
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2001
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1999
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Meeting Abstract
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2020Galectin-9 helps govern human B cell adhesion to and migration through human vascular endothelium.. GLYCOBIOLOGY. 1071-1071.Web of Science: 000606577100109
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Publication
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2007A novel adhesion molecule plays a critical role in T cell migration to inflamed skin. S161-S161.Full Text via DOI: 10.1016/j.jaci.2006.11.570 Web of Science: 000251460401019
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Review
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2018Galectin-Glycan Interactions as Regulators of B Cell ImmunityFull Text via DOI: 10.3389/fimmu.2018.02839 Web of Science: 000452075100001
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2015Galectin-Binding O-Glycosylations as Regulators of Malignancy. 3195-3202.Full Text via DOI: 10.1158/0008-5472.CAN-15-0834 Web of Science: 000359562100001
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2013Leveraging fluorinated glucosamine action to boost antitumor immunity. 206-213.Full Text via DOI: 10.1016/j.coi.2012.11.003 Web of Science: 000319369100013
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2012Galectin-1 research in T cell immunity: Past, present and future. 107-116.Full Text via DOI: 10.1016/j.clim.2011.09.011 Web of Science: 000300388200005
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2007Targeting selectins and selectin ligands in inflammation and cancer. 1473-1491.Full Text via DOI: 10.1517/14728222.11.11.1473 Web of Science: 000251116800008
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1998Cancer metastasis: A search for therapeutic inhibition. 279-290.Full Text via DOI: 10.3109/07357909809039778
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Research
research interests
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Cancer glycobiology - melanoma glycobiology; Lymphocyte glyco-immunology; Use of carbohydrate inhibitors, MALDI-TOF-TOF MS/MS of glycans and “homegrown” selectin/ galectin-human Fc chimeras and glycosyltransferase mutant cell lines/mice as glycobiological tools to identity and characterize selectin/galectin ligands functioning in inflammation, tumorigenesis, metastasis, tumor immune evasion and lymphomagenesis
Native human tissues/cells as sources to isolate the relevant immune/cancer cells.
Contact
full name
- Charles Dimitroff
Identifiers
ORCID iD
- https://orcid.org/0000-0002-4224-7621 (confirmed)
