El-Hage, Nazira

Nazira El-Hage
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Positions

Associate Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine

Contact Info

nelhage@fiu.edu

selected publications

Article
- 2019
  
  Selective Disruption of the Blood-Brain Barrier by Zika Virus. FRONTIERS IN MICROBIOLOGY. 10.
  Full Text via DOI: 10.3389/fmicb.2019.02158 Web of Science: 000486385000003
- 2019
  
  Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes. JOURNAL OF NEUROVIROLOGY. 25:263-274.
  Full Text via DOI: 10.1007/s13365-018-0715-4 Web of Science: 000467445200013
- 2019
  
  Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLOS ONE. 14.
  Full Text via DOI: 10.1371/journal.pone.0208543 Web of Science: 000458181200007
- 2018
  
  Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13.
  Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
- 2018
  
  Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13.
  Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
- 2018
  
  Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells. SCIENTIFIC REPORTS. 8.
  Full Text via DOI: 10.1038/s41598-018-25943-2 Web of Science: 000432273000001
- 2017
  
  Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 12:120-132.
  Full Text via DOI: 10.1007/s11481-016-9688-3 PMID: 27287620 Web of Science: 000394969800009
- 2017
  
  Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes. VIRUSES-BASEL. 9.
  Full Text via DOI: 10.3390/v9080201 PMID: 28788100 Web of Science: 000408742900006
- 2017
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. SCIENTIFIC REPORTS. 7.
  Full Text via DOI: 10.1038/s41598-017-01819-9 PMID: 28500326 Web of Science: 000401262400055
- 2016
  
  Coupling of transient near infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in brain. SCIENTIFIC REPORTS. 6.
  Full Text via DOI: 10.1038/srep29792 PMID: 27465276 Web of Science: 000380649400001
- 2016
  
  beta-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. JOURNAL OF NEUROVIROLOGY. 22:866-870.
  Full Text via DOI: 10.1007/s13365-016-0464-1 PMID: 27400929 Web of Science: 000389342900016
- 2015
  
  Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. FRONTIERS IN MICROBIOLOGY. 6.
  Full Text via DOI: 10.3389/fmicb.2015.00653 PMID: 26217309 Web of Science: 000358382000001
- 2015
  
  Fluorescently-labeled RNA packaging into HIV-1 particles: Direct examination of infectivity across central nervous system cell types. JOURNAL OF VIROLOGICAL METHODS. 224:20-29.
  Full Text via DOI: 10.1016/j.jviromet.2015.07.023 PMID: 26272129 Web of Science: 000361864000004
- 2015
  
  HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. FRONTIERS IN MICROBIOLOGY. 6.
  Full Text via DOI: 10.3389/fmicb.2015.00614 PMID: 26157430 Web of Science: 000357132300002
Correction
- 2018
  
  Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells (vol 8, 7653, 2018). SCIENTIFIC REPORTS.
  Full Text via DOI: 10.1038/s41598-018-32120-y Web of Science: 000445032700001
- 2018
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation (vol 7, year 2017). SCIENTIFIC REPORTS.
  Full Text via DOI: 10.1038/s41598-018-23078-y PMID: 29540788 Web of Science: 000427370700001
Meeting Abstract
- 2018
  
  Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROVIROLOGY.
  Web of Science: 000434755400207
- 2018
  
  Pathogenic strains of ZIKV induce gene expression promoting inflammation and apoptosis in primary human placental trophoblasts. JOURNAL OF NEUROVIROLOGY.
  Web of Science: 000434755400041
- 2018
  
  Presence of HIV-1 RNA in Extracellular Vesicles from HIV-1 cART-treated Cells. JOURNAL OF NEUROVIROLOGY.
  Web of Science: 000434755400076
- 2018
  
  The role of the blood-brain barrier in Zika virus infection. JOURNAL OF NEUROVIROLOGY.
  Web of Science: 000434755400155
- 2018
  
  Virosomes: An interplay between Virus and Exosomes from infected cells. JOURNAL OF NEUROVIROLOGY.
  Web of Science: 000434755400013
- 2018
  
  Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S60-S60.
  Web of Science: 000429149100207
- 2018
  
  Pathogenic strains of ZIKV induce gene expression promoting inflammation and apoptosis in primary human placental trophoblasts. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S12-S12.
  Web of Science: 000429149100041
- 2018
  
  Presence of HIV-1 RNA in Extracellular Vesicles from HIV-1 cART-treated Cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S22-S22.
  Web of Science: 000429149100076
- 2018
  
  The role of the blood-brain barrier in Zika virus infection. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S45-S45.
  Web of Science: 000429149100155
- 2018
  
  Virosomes: An interplay betweenVirus and Exosomes from infected cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S4-S4.
  Web of Science: 000429149100013
- 2017
  
  Autophagy is cytoprotective in neurons and necessary against Tat and morphine-induced toxicity in autophagy-deficient mice. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S31-S32.
  Web of Science: 000414227700067
- 2017
  
  Development of a polydrug exosome-based mimetic to treat HIV-associated neuroinflammation/neurotoxicity and opiate abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S69.
  Web of Science: 000414227700166
- 2017
  
  Drug-drug interaction of cART and Morphine mediated by autophagy exacerbates the overall effect of cART in brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S38-S38.
  Web of Science: 000414227700084
- 2017
  
  Intranasal administration of small interfering (si) RNA Beclin1 encapsulated with linear polyethylenimine (PEI) nano-plexes to attenuate HIV-1 infection in the brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S70.
  Web of Science: 000414227700167
- 2017
  
  MRI-assisted magnetically guided CNS delivery of magneto-electro nanoparticles in non-human primate. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S48-S48.
  Web of Science: 000414227700110
- 2017
  
  NIR-stimuli sensitive 'smart' magnetic nanoagent for on demand drug delivery. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S70-S70.
  Web of Science: 000414227700168
- 2016
  
  Exosomes from donor and recipient cells: Role of exosomes in HIV latency in cART treated cells. JOURNAL OF NEUROVIROLOGY. S6-S6.
  Web of Science: 000394093700013
- 2016
  
  ROLE OFAUTOPHAGYON HIV-INFECTED HUMAN ASTROCYTES FUNCTIONALITY.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S41-S41.
  Web of Science: 000377566000105
- 2016
  
  THE ROLE OF AUTOPHAGY IN HIV-1 TAT INDUCED NEURODEGENERATION USING BECLIN-1 HETEROZYGOUS MOUSE BEHAVIOR MODEL.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S25-S25.
  Web of Science: 000377566000063
- 2015
  
  Differing roles of autophagy in HIV-associated Neurocognitive Impairment and Encephalitis with Implications for Morphine Co-exposure. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S96-S97.
  Web of Science: 000367554100105
- 2015
  
  Effect of Magneto-electric nanoparticle on deep brain motor coordination activity. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S99-S100.
  Web of Science: 000367554100113
- 2015
  
  Methanandamide bound to Magnetic Electric Nanoparticle did not compromise resistance and permeability of the Blood Brain Barrier. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S111-S111.
  Web of Science: 000367554100144
- 2015
  
  Role of autophagy pathways in the neuropathogenesis of HIV-1 clade B/C and the exacerbating effects of drug of abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S105-S105.
  Web of Science: 000367554100127
Review
- 2018
  
  Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis. JOURNAL OF NEUROSCIENCE RESEARCH.
  Full Text via DOI: 10.1002/jnr.24322 Web of Science: 000447203700002
- 2018
  
  Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.
  Full Text via DOI: 10.3389/fcimb.2018.00362 Web of Science: 000447588800001
- 2018
  
  Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus. FRONTIERS IN IMMUNOLOGY.
  Full Text via DOI: 10.3389/fimmu.2018.02340 Web of Science: 000447256100001
- 2017
  
  Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 31-50.
  Full Text via DOI: 10.1007/s11481-016-9692-7 PMID: 27372507 Web of Science: 000394969800004
- 2017
  
  HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency. CURRENT PHARMACEUTICAL DESIGN. 4133-4144.
  Full Text via DOI: 10.2174/1381612823666170622101319 PMID: 28641535 Web of Science: 000414366900008
- 2017
  
  Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications. VIRUSES-BASEL.
  Full Text via DOI: 10.3390/v9070176 PMID: 28684681 Web of Science: 000406684400018
- 2017
  
  Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 371-388.
  Full Text via DOI: 10.1007/s11481-017-9743-8 PMID: 28444557 Web of Science: 000406359000001
- 2016
  
  Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections. JOURNAL OF BIOMEDICAL SCIENCE.
  Full Text via DOI: 10.1186/s12929-016-0292-x PMID: 27784307 Web of Science: 000386719500001

principal investigator on

Impact of ¿-opioid receptor (MOR) splice variant interactions with the chemokine receptor CCR awarded by National Institute on Drug Abuse 2016 - 2019
Role of Autophagy in Microglia-induced NeuroAIDS in Substance Abuse awarded by National Institute on Drug Abuse 2014 - 2019
Cell-based Platform for Gene Delivery to the Brain awarded by National Institutes of Health 2018
Development of nanoscale approaches for Zika virus pathogenesis and therapeutics awarded by Florida Department of Health 2017 - 2018

investigator on

Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug Abusers awarded by National Institute on Drug Abuse 2016 - 2021
Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2017 - 2020
Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2015 - 2020
Role of exosome extracellular vesicles in opiate abuse and HIV neuropathogenesis awarded by National Institute on Drug Abuse 2017 - 2020
Intranasal Nanodelivery of Oxytocin to Treat Morphine Addiction in HIV Patients by Gene Editing awarded by National Institute on Drug Abuse 2017 - 2019

teaching activities

GMS6939-01: Graduate Seminar Spring Term 2019
GMS6939-01: Graduate Seminar Spring Term 2019
GMS6939-01: Graduate Seminar Spring Term 2019
GMS6939-01: Graduate Seminar Spring Term 2019
GMS6979-02: Research Credits Spring Term 2019
GMS6979-02: Research Credits Spring Term 2019
GMS6979-02: Research Credits Spring Term 2019
GMS6979-02: Research Credits Spring Term 2019
GMS6979-02: Research Credits Spring Term 2019
GMS6979-05: Research Credits Fall Term 2019
GMS6979-05: Research Credits Fall Term 2019
GMS6979-05: Research Credits Fall Term 2019
GMS6979-05: Research Credits Fall Term 2019
GMS6979-05: Research Credits Fall Term 2019

full name

Nazira El-Hage

visualizations

Recent publications and grants in Scholars@FIU

Co-author Network

Co-investigator Network

publication subject areas

Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Cell Biology
Immunology
Microbiology
Neurosciences & Neurology
Pharmacology & Pharmacy
Research & Experimental Medicine
Science & Technology - Other Topics
Virology

Citation index-derived subject areas the researcher has published in