El-Hage, Nazira
- Associate Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine
Overview
overview
- Dr. Nazira El-Hage earned her Ph.D. from the Department of Microbiology and Immunology at the University Of Kentucky in 2002. She moved to Virginia Commonwealth University in 2007 as an Assistant Professor in the Department of Pharmacology and Toxicology and in 2014, she was promoted to an Associate Professor in the Department of Immunology and Nano-medicine at Florida International University in Miami, Florida. Her research focuses on the underlying mechanisms of HIV-induced pathology in the central nervous system in the context of opioid drug abuse. Furthermore, she have a keen interest in the autophagy pathway and in understanding how this pathway contributes to the neurological disorder associated with HIV and how opioid exacerbates the disorder in HIV-infected glial cells. Her research has been funded by the National Institutes of Health (NIH)/National Institute on Drug Abuse (NIDA) since 2009 and she also received funding from the Florida Department Health to study the neurological effects of the Zika virus in brain cells and embryonic development, focusing on the autophagy pathway.
Scholarly & Creative Works
selected publications
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Article
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2021Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread. RETROVIROLOGY. 18.Full Text via DOI: 10.1186/s12977-021-00550-8 Web of Science: 000620940200001
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2021Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles. PHARMACEUTICS. 13.Full Text via DOI: 10.3390/pharmaceutics13020223 Web of Science: 000623002300001
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2020Stem Cell Extracellular Vesicles and their Potential to Contribute to the Repair of Damaged CNS Cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 15:520-537.Full Text via DOI: 10.1007/s11481-019-09865-y Web of Science: 000567805400018
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2020Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(A) mice: importance of administration routes. SCIENTIFIC REPORTS. 10.Full Text via DOI: 10.1038/s41598-020-68874-7 Web of Science: 000550057200131
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2020Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy. VIRUSES-BASEL. 12.Full Text via DOI: 10.3390/v12060608 Web of Science: 000551247500001
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2020Comparative Cytotoxicity of Inorganic Arsenite and Methylarsenite in Human Brain Cells. ACS CHEMICAL NEUROSCIENCE. 11:743-751.Full Text via DOI: 10.1021/acschemneuro.9b00653 Web of Science: 000518702400007
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2019GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice. JOURNAL OF CONTROLLED RELEASE. 315:139-149.Full Text via DOI: 10.1016/j.jconrel.2019.10.027 Web of Science: 000500710700012
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2019Selective Disruption of the Blood-Brain Barrier by Zika Virus. FRONTIERS IN MICROBIOLOGY. 10.Full Text via DOI: 10.3389/fmicb.2019.02158 Web of Science: 000486385000003
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2019Purification of High Yield Extracellular Vesicle Preparations Away from Virus. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/59876 Web of Science: 000493374200043
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2019Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes. JOURNAL OF NEUROVIROLOGY. 25:263-274.Full Text via DOI: 10.1007/s13365-018-0715-4 Web of Science: 000467445200013
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2019Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLOS ONE. 14.Full Text via DOI: 10.1371/journal.pone.0208543 Web of Science: 000458181200007
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2018Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13.Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
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2018Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-25943-2 Web of Science: 000432273000001
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2017Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 12:120-132.
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2016Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNAFull Text via DOI: 10.1074/jbc.M115.662171 Web of Science: 000368068300021
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2016Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers. SCIENTIFIC REPORTS. 6.
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2016beta-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. JOURNAL OF NEUROVIROLOGY. 22:866-870.
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2015Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. FRONTIERS IN MICROBIOLOGY. 6.
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2015Fluorescently-labeled RNA packaging into HIV-1 particles: Direct examination of infectivity across central nervous system cell types. JOURNAL OF VIROLOGICAL METHODS. 224:20-29.
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2015HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. FRONTIERS IN MICROBIOLOGY. 6.
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2014Effects of HIV-1 tat on enteric neuropathogenesisFull Text via DOI: 10.1523/JNEUROSCI.2283-14.2014
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Book Chapter
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2010Opioids, astroglial chemokines, microglial reactivity, and neuronal injury in HIV-1 encephalitis. 353-377.Full Text via DOI: 10.1007/978-1-4419-0793-6_16
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Conference
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2011Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia. 3613-3628.Full Text via DOI: 10.1093/brain/awr281
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Correction
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2018Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells (vol 8, 7653, 2018). SCIENTIFIC REPORTS.Full Text via DOI: 10.1038/s41598-018-32120-y Web of Science: 000445032700001
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Editorial Material
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2020Extracellular Vesicles in HIV, Drug Abuse, and Drug Delivery. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 387-389.Full Text via DOI: 10.1007/s11481-020-09946-3 Web of Science: 000551013600001
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Meeting Abstract
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2018Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400207
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2018Pathogenic strains of ZIKV induce gene expression promoting inflammation and apoptosis in primary human placental trophoblasts. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400041
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2018Presence of HIV-1 RNA in Extracellular Vesicles from HIV-1 cART-treated Cells. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400076
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2018The role of the blood-brain barrier in Zika virus infection. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400155
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2018Virosomes: An interplay between Virus and Exosomes from infected cells. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400013
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2018Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S60-S60.Web of Science: 000429149100207
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2018Pathogenic strains of ZIKV induce gene expression promoting inflammation and apoptosis in primary human placental trophoblasts. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S12-S12.Web of Science: 000429149100041
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2018Presence of HIV-1 RNA in Extracellular Vesicles from HIV-1 cART-treated Cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S22-S22.Web of Science: 000429149100076
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2018The role of the blood-brain barrier in Zika virus infection. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S45-S45.Web of Science: 000429149100155
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2018Virosomes: An interplay betweenVirus and Exosomes from infected cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S4-S4.Web of Science: 000429149100013
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2017Autophagy is cytoprotective in neurons and necessary against Tat and morphine-induced toxicity in autophagy-deficient mice. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S31-S32.Web of Science: 000414227700067
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2017Development of a polydrug exosome-based mimetic to treat HIV-associated neuroinflammation/neurotoxicity and opiate abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S69.Web of Science: 000414227700166
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2017Drug-drug interaction of cART and Morphine mediated by autophagy exacerbates the overall effect of cART in brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S38-S38.Web of Science: 000414227700084
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2017Intranasal administration of small interfering (si) RNA Beclin1 encapsulated with linear polyethylenimine (PEI) nano-plexes to attenuate HIV-1 infection in the brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S70.Web of Science: 000414227700167
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2017MRI-assisted magnetically guided CNS delivery of magneto-electro nanoparticles in non-human primate. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S48-S48.Web of Science: 000414227700110
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2017NIR-stimuli sensitive 'smart' magnetic nanoagent for on demand drug delivery. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S70-S70.Web of Science: 000414227700168
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2016Exosomes from donor and recipient cells: Role of exosomes in HIV latency in cART treated cells. JOURNAL OF NEUROVIROLOGY. S6-S6.Web of Science: 000394093700013
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2016ROLE OFAUTOPHAGYON HIV-INFECTED HUMAN ASTROCYTES FUNCTIONALITY.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S41-S41.Web of Science: 000377566000105
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2016THE ROLE OF AUTOPHAGY IN HIV-1 TAT INDUCED NEURODEGENERATION USING BECLIN-1 HETEROZYGOUS MOUSE BEHAVIOR MODEL.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S25-S25.Web of Science: 000377566000063
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2015Differing roles of autophagy in HIV-associated Neurocognitive Impairment and Encephalitis with Implications for Morphine Co-exposure. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S96-S97.Web of Science: 000367554100105
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2015Effect of Magneto-electric nanoparticle on deep brain motor coordination activity. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S99-S100.Web of Science: 000367554100113
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2015Methanandamide bound to Magnetic Electric Nanoparticle did not compromise resistance and permeability of the Blood Brain Barrier. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S111-S111.Web of Science: 000367554100144
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2015Role of autophagy pathways in the neuropathogenesis of HIV-1 clade B/C and the exacerbating effects of drug of abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S105-S105.Web of Science: 000367554100127
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Review
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2021Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). 1-382.Full Text via DOI: 10.1080/15548627.2020.1797280 Web of Science: 000636121800001
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2020Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration. FRONTIERS IN NEUROLOGY.Full Text via DOI: 10.3389/fneur.2020.583459 Web of Science: 000593917400001
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2020The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy. AGING AND DISEASE. 895-915.Full Text via DOI: 10.14336/AD.2019.0927 Web of Science: 000556664900017
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2020Use of Stem Cell Extracellular Vesicles as a "Holistic" Approach to CNS Repair. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2020.00455 Web of Science: 000553754600001
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2018Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis. JOURNAL OF NEUROSCIENCE RESEARCH.Full Text via DOI: 10.1002/jnr.24322 Web of Science: 000447203700002
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2018Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.Full Text via DOI: 10.3389/fcimb.2018.00362 Web of Science: 000447588800001
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2018Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus. FRONTIERS IN IMMUNOLOGY.Full Text via DOI: 10.3389/fimmu.2018.02340 Web of Science: 000447256100001
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2017Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 31-50.
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2017HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency. CURRENT PHARMACEUTICAL DESIGN. 4133-4144.
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2017Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 371-388.
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2016Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections. JOURNAL OF BIOMEDICAL SCIENCE.
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2007HIV-1 neuropathogenesis: Glial mechanisms revealed through substance abuse. 567-586.Full Text via DOI: 10.1111/j.1471-4159.2006.04227.x
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2006Impact of opiate-HIV-1 interactions on neurotoxic signaling. 98-105.Full Text via DOI: 10.1007/s11481-005-9000-4
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Research
research interests
- Neurocognitive Disorders; Neuroaid; HIV-1; Exosomes; Extracellular Vesicles; PKH67; Zika Virus Infection; Microcephaly; Flaviviridae
principal investigator on
- Impact of ¿-opioid receptor (MOR) splice variant interactions with the chemokine receptor CCR awarded by National Institute on Drug Abuse 2016 - 2019
- Role of Autophagy in Microglia-induced NeuroAIDS in Substance Abuse awarded by National Institute on Drug Abuse 2014 - 2019
- Cell-based Platform for Gene Delivery to the Brain awarded by National Institutes of Health 2018
- Development of nanoscale approaches for Zika virus pathogenesis and therapeutics awarded by Florida Department of Health 2017 - 2018
investigator on
- Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug Abusers awarded by National Institute on Drug Abuse 2016 - 2021
- Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2017 - 2020
- Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2015 - 2020
- Role of exosome extracellular vesicles in opiate abuse and HIV neuropathogenesis awarded by National Institute on Drug Abuse 2017 - 2020
- Intranasal Nanodelivery of Oxytocin to Treat Morphine Addiction in HIV Patients by Gene Editing awarded by National Institute on Drug Abuse 2017 - 2019
Teaching
teaching activities
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
Contact
full name
- Nazira El-Hage
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cell Biology
- Immunology
- Microbiology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Virology