Nazira El-Hage
- Associate Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine
Contact Info
Publications
selected publications
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Article
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2019Selective Disruption of the Blood-Brain Barrier by Zika Virus. FRONTIERS IN MICROBIOLOGY. 10.Full Text via DOI: 10.3389/fmicb.2019.02158 Web of Science: 000486385000003
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2019Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes. JOURNAL OF NEUROVIROLOGY. 25:263-274.Full Text via DOI: 10.1007/s13365-018-0715-4 Web of Science: 000467445200013
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2019Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLOS ONE. 14.Full Text via DOI: 10.1371/journal.pone.0208543 Web of Science: 000458181200007
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2018Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13.Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
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2018Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13.Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
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2018Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-25943-2 Web of Science: 000432273000001
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2017Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 12:120-132.
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2016beta-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. JOURNAL OF NEUROVIROLOGY. 22:866-870.
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2015Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. FRONTIERS IN MICROBIOLOGY. 6.
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2015Fluorescently-labeled RNA packaging into HIV-1 particles: Direct examination of infectivity across central nervous system cell types. JOURNAL OF VIROLOGICAL METHODS. 224:20-29.
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2015HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. FRONTIERS IN MICROBIOLOGY. 6.
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Correction
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2018Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells (vol 8, 7653, 2018). SCIENTIFIC REPORTS.Full Text via DOI: 10.1038/s41598-018-32120-y Web of Science: 000445032700001
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Meeting Abstract
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2018Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400207
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2018Pathogenic strains of ZIKV induce gene expression promoting inflammation and apoptosis in primary human placental trophoblasts. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400041
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2018Presence of HIV-1 RNA in Extracellular Vesicles from HIV-1 cART-treated Cells. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400076
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2018The role of the blood-brain barrier in Zika virus infection. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400155
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2018Virosomes: An interplay between Virus and Exosomes from infected cells. JOURNAL OF NEUROVIROLOGY.Web of Science: 000434755400013
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2018Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S60-S60.Web of Science: 000429149100207
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2018Pathogenic strains of ZIKV induce gene expression promoting inflammation and apoptosis in primary human placental trophoblasts. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S12-S12.Web of Science: 000429149100041
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2018Presence of HIV-1 RNA in Extracellular Vesicles from HIV-1 cART-treated Cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S22-S22.Web of Science: 000429149100076
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2018The role of the blood-brain barrier in Zika virus infection. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S45-S45.Web of Science: 000429149100155
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2018Virosomes: An interplay betweenVirus and Exosomes from infected cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S4-S4.Web of Science: 000429149100013
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2017Autophagy is cytoprotective in neurons and necessary against Tat and morphine-induced toxicity in autophagy-deficient mice. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S31-S32.Web of Science: 000414227700067
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2017Development of a polydrug exosome-based mimetic to treat HIV-associated neuroinflammation/neurotoxicity and opiate abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S69.Web of Science: 000414227700166
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2017Drug-drug interaction of cART and Morphine mediated by autophagy exacerbates the overall effect of cART in brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S38-S38.Web of Science: 000414227700084
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2017Intranasal administration of small interfering (si) RNA Beclin1 encapsulated with linear polyethylenimine (PEI) nano-plexes to attenuate HIV-1 infection in the brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S70.Web of Science: 000414227700167
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2017MRI-assisted magnetically guided CNS delivery of magneto-electro nanoparticles in non-human primate. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S48-S48.Web of Science: 000414227700110
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2017NIR-stimuli sensitive 'smart' magnetic nanoagent for on demand drug delivery. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S70-S70.Web of Science: 000414227700168
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2016Exosomes from donor and recipient cells: Role of exosomes in HIV latency in cART treated cells. JOURNAL OF NEUROVIROLOGY. S6-S6.Web of Science: 000394093700013
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2016ROLE OFAUTOPHAGYON HIV-INFECTED HUMAN ASTROCYTES FUNCTIONALITY.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S41-S41.Web of Science: 000377566000105
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2016THE ROLE OF AUTOPHAGY IN HIV-1 TAT INDUCED NEURODEGENERATION USING BECLIN-1 HETEROZYGOUS MOUSE BEHAVIOR MODEL.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S25-S25.Web of Science: 000377566000063
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2015Differing roles of autophagy in HIV-associated Neurocognitive Impairment and Encephalitis with Implications for Morphine Co-exposure. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S96-S97.Web of Science: 000367554100105
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2015Effect of Magneto-electric nanoparticle on deep brain motor coordination activity. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S99-S100.Web of Science: 000367554100113
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2015Methanandamide bound to Magnetic Electric Nanoparticle did not compromise resistance and permeability of the Blood Brain Barrier. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S111-S111.Web of Science: 000367554100144
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2015Role of autophagy pathways in the neuropathogenesis of HIV-1 clade B/C and the exacerbating effects of drug of abuse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S105-S105.Web of Science: 000367554100127
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Review
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2018Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis. JOURNAL OF NEUROSCIENCE RESEARCH.Full Text via DOI: 10.1002/jnr.24322 Web of Science: 000447203700002
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2018Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.Full Text via DOI: 10.3389/fcimb.2018.00362 Web of Science: 000447588800001
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2018Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus. FRONTIERS IN IMMUNOLOGY.Full Text via DOI: 10.3389/fimmu.2018.02340 Web of Science: 000447256100001
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2017Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 31-50.
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2017HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency. CURRENT PHARMACEUTICAL DESIGN. 4133-4144.
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2017Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 371-388.
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2016Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections. JOURNAL OF BIOMEDICAL SCIENCE.
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Research
principal investigator on
- Impact of ¿-opioid receptor (MOR) splice variant interactions with the chemokine receptor CCR awarded by National Institute on Drug Abuse 2016 - 2019
- Role of Autophagy in Microglia-induced NeuroAIDS in Substance Abuse awarded by National Institute on Drug Abuse 2014 - 2019
- Cell-based Platform for Gene Delivery to the Brain awarded by National Institutes of Health 2018
- Development of nanoscale approaches for Zika virus pathogenesis and therapeutics awarded by Florida Department of Health 2017 - 2018
investigator on
- Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug Abusers awarded by National Institute on Drug Abuse 2016 - 2021
- Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2017 - 2020
- Nano-delivery of methanandamide across BBB to block cannabinoid induced effects in HIV-1 infection awarded by National Institute on Drug Abuse 2015 - 2020
- Role of exosome extracellular vesicles in opiate abuse and HIV neuropathogenesis awarded by National Institute on Drug Abuse 2017 - 2020
- Intranasal Nanodelivery of Oxytocin to Treat Morphine Addiction in HIV Patients by Gene Editing awarded by National Institute on Drug Abuse 2017 - 2019
Teaching
teaching activities
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6939-01: Graduate Seminar Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-02: Research Credits Spring Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
- GMS6979-05: Research Credits Fall Term 2019
Contact
full name
- Nazira El-Hage
visualizations
Recent publications and grants in Scholars@FIU
research areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cell Biology
- Immunology
- Microbiology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Virology