Felty, Quentin
- Associate Professor, Environmental Health Sciences , Robert Stempel College of Public Health and Social Work

Overview
overview
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Dr. Quentin Felty received a doctorate in environmental health sciences from the University of Alabama at Birmingham School of Public Health where he was a National Cancer Institute Cancer Prevention and Control Training Program fellow. His ongoing research is focused on understanding the molecular mechanism of susceptibility to estrogenic chemical associated vascular cell dysfunction resulting in obliterative intimal lesions in the pulmonary arteries of pulmonary arterial hypertension (PAH) patients.
In addition, he also studies the role of deviant endothelial stem cells in the spread of breast cancer. Dr. Felty’s laboratory uses state-of-the-art approaches to understand the impact of estrogenic chemicals on the Inhibitor of Differentiation protein 3 (ID3). His areas of research consist of identifying a biological based mechanism by which elevated exposure to complex mixtures of endocrine disrupting chemicals promote vascular cell dysfunction and its implications to brain vascular health, pulmonary vascular health, and the metastatic spread of cancer stem cells, as well as developing novel 3D human blood-brain barrier tissue culture to study gene-environment effects on aging and identifying novel redox signaling molecules involved in the maintenance of vascular stem cells and its application to aging.
research interests
- Pulmonary and Brain Vascular Health and Cancer Metastasis
Scholarly & Creative Works
selected publications
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Article
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2022Polychlorinated Biphenyls and Pulmonary HypertensionFull Text via DOI: 10.3390/ijerph19084705 Web of Science: 000786342400001
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2020Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparitiesFull Text via DOI: 10.1007/s00432-020-03320-9 Web of Science: 000551783900003
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2018Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast CarcinogenesisFull Text via DOI: 10.3390/cells7120234 Web of Science: 000455320700012
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2018NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2+ve breast cancer signaling pathwaysFull Text via DOI: 10.1007/s10549-018-4905-9 Web of Science: 000447497300021
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2017Environmental estrogen-like endocrine disrupting chemicals and breast cancerFull Text via DOI: 10.1016/j.mce.2016.10.003 Web of Science: 000413128000011
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2015Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain TumorsFull Text via DOI: 10.1007/s12035-014-8930-3 Web of Science: 000361903400023
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2015Microvascular Lesions by Estrogen-Induced ID3: Its Implications in Cerebral and Cardiorenal Vascular DiseaseFull Text via DOI: 10.1007/s12031-014-0401-9 Web of Science: 000349289600007
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2015Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertensionFull Text via DOI: 10.1086/679704 Web of Science: 000374052800010
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2014PCB153-Induced Overexpression of ID3 Contributes to the Development of Microvascular LesionsFull Text via DOI: 10.1371/journal.pone.0104159 Web of Science: 000339812700104
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2011Redox sensitive Pyk2 as a target for therapeutics in breast cancerFull Text via DOI: 10.2741/3706 Web of Science: 000290092700013
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2008Estrogen-induced redox sensitive Id3 signaling controls the growth of vascular cellsFull Text via DOI: 10.1016/j.atherosclerosis.2007.12.048 Web of Science: 000255491800002
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2006Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cellsFull Text via DOI: 10.2741/1845 Web of Science: 000232528000071
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2005Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengersFull Text via DOI: 10.1021/bi047629p Web of Science: 000228962500019
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2005Mitochondrial signals to nucleus regulate estrogen-induced cell growthFull Text via DOI: 10.1016/j.mehy.2003.12.056 Web of Science: 000225481400031
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Book Chapter
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2019Estrogenic chemicals and cardiovascular disease. 746-749.Full Text via DOI: 10.1016/B978-0-12-409548-9.11674-4
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2019Malformations of cortical development and epilepsy in children. 211-218.Full Text via DOI: 10.1016/B978-0-12-409548-9.11744-0
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2015Pulmonary Arterial Hypertension: A Stem Cell Hypothesis. 289-306.Full Text via DOI: 10.1007/978-3-319-16232-4_16 Web of Science: 000378209000017
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2011Environment, Genetic and Epigenetic Alterations and Pediatric Central Nervous System Tumors. 559-568.Full Text via DOI: 10.1016/B978-0-444-52272-6.00071-4
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2011Estrogenic Chemicals and Cardiovascular Disease. 605-608.Full Text via DOI: 10.1016/B978-0-444-52272-6.00148-3
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2011Malformations of Cortical Development and Epilepsy in Children. 595-602.Full Text via DOI: 10.1016/B978-0-444-52272-6.00073-8
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2010Gene Environment Interactions and Vascular Lesions. 139-152.Full Text via DOI: 10.1007/978-1-4419-6752-7_6 Web of Science: 000282535900006
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2010Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors. 223-252.Full Text via DOI: 10.1007/978-1-4419-6752-7_9 Web of Science: 000282535900009
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Conference
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2020Aberrant transcription factor activity of NRF1, NFE2L2, E2F1, RFX1, and MEF2 associated with severity of astrocytomaFull Text via DOI: 10.1158/1538-7445.AM2020-4391 Web of Science: 000590059301273
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2019Abstract 2441: Association between NRF1 regulatory gene networks and cancer and aging. 2441-2441.Full Text via DOI: 10.1158/1538-7445.sabcs18-2441
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2019Association between NRF1 regulatory gene networks and cancer and agingFull Text via DOI: 10.1158/1538-7445.AM2019-2441 Web of Science: 000488279400400
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2018Exosomal ID3 is pro-metastatic through guiding NRF1-induced breast cancer stem cells across the blood-brain-barrierFull Text via DOI: 10.1158/1538-7445.AM2018-1128 Web of Science: 000468818903101
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2015Id3 generated cancer stem-like cells: A microvascular niche for the development of gliomaFull Text via DOI: 10.1158/1538-7445.AM2015-4179 Web of Science: 000371597103266
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2014ID3 expression and oxidative DNA damage are associated with growth of benign and malignant vascular lesionsFull Text via DOI: 10.1158/1538-7445.AM2014-3002 Web of Science: 000349910200009
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2013PCB153-induced angiogenesis depends on redoxsensitive Pyk2 signaling.Full Text via DOI: 10.1158/1538-7445.AM2013-3899 Web of Science: 000331220603133
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2011Identifying gene alterations required for the development of astrocytoma. 1037-1041.Web of Science: 000314989301008
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2011Estrogen-induced redox signaling via NRF-1 is involved in the development of breast cancerFull Text via DOI: 10.1158/1538-7445.AM2011-LB-12 Web of Science: 000209701305418
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2010Alteration in signature of mRNA and protein expression by environmental estrogen PCB153: implications for vascular lesions. S54-S54.Full Text via DOI: 10.1016/j.nbt.2010.01.088 Web of Science: 000209825000128
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2009
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2007
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2007Estrogen-induced vascular lesions formation is mediated by redox sensitive Id3 signaling. 145-145.Web of Science: 000253283800405
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2006
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Letter
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2018Letter to the Editor: Is Id3 proliferative or antiproliferative?. L334-L335.Full Text via DOI: 10.1152/ajplung.00205.2018 Web of Science: 000442116600008
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Other Scholarly Work
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2010Differential role of estrogen receptor positive NRF1(High) and NRF1(Low) cells in breast cancer development and progression. S25-S25.Full Text via DOI: 10.1016/j.nbt.2010.01.021 Web of Science: 000209825000061
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Preprint
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Review
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2017Gender, Estrogen, and Obliterative Lesions in the LungFull Text via DOI: 10.1155/2017/8475701 Web of Science: 000398314200001
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2007Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. 235-257.Full Text via DOI: 10.1080/15287390600974924 Web of Science: 000247875600001
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2007Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: Potential molecular targets for cancer therapy. 154-173.Full Text via DOI: 10.2741/2056 Web of Science: 000243745000013
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2005Estrogen, mitochondria, and growth of cancer and non-cancer cellsFull Text via DOI: 10.1186/1477-3163-4-1
Works By Students
chaired theses and dissertations
- Doke, Mayur Arvind, The Role of ID3 and PCB153 in the Hyperproliferation and Dysregulation of Lung Endothelial Cells 2018
- Avecilla, Vincent E, ID3, Estrogenic Chemicals, and the Pathogenesis of Tumor-Like Proliferative Vascular Lesions 2017
- Assaggaf, Hamza M, Molecular Risk Factors of Pulmonary Arterial Hypertension 2017
Research
principal investigator on
- ID3, epigenetic reprogramming, and hyper-proilferative vascular remodeling awarded by National Heart, Lung, & Blood Institute 2019 - 2023
- Estrogen-induced Pyk2 signaling in the abnormal growth of vascular cells awarded by General Medical Sciences 2010 - 2015
- Metastases and Promotion of Aggressive Neovascular Phenotype in Breast Cancer. awarded by Florida Department of Health 2009 - 2012
co-principal investigator on
- Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU - UM Braman Family Breast Cancer Institute. awarded by U.S. Department of Defense 2007 - 2012
- Advanced Research Cooperation in Environmental Health Research awarded by Environmental Health Sciences 2009 - 2010
Videos
videos
Contact
full name
- Quentin Felty
Identifiers
ORCID iD
- https://orcid.org/0000-0002-7151-0441 (confirmed)
visualizations
publication subject areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cardiovascular System & Cardiology
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Environmental Sciences & Ecology
- Neurosciences & Neurology
- Oncology
- Pharmacology & Pharmacy
- Physiology
- Public, Environmental & Occupational Health
- Research & Experimental Medicine
- Respiratory System
- Science & Technology - Other Topics
- Toxicology