Felty, Quentin
- Associate Professor, Environmental Health Sciences , Robert Stempel College of Public Health and Social Work
Overview
overview
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Dr. Quentin Felty received a doctorate in environmental health sciences from the University of Alabama at Birmingham School of Public Health where he was a National Cancer Institute Cancer Prevention and Control Training Program fellow. His ongoing research is focused on understanding the molecular mechanism of susceptibility to estrogenic chemical associated vascular cell dysfunction resulting in obliterative intimal lesions in the pulmonary arteries of pulmonary arterial hypertension (PAH) patients.
In addition, he also studies the role of deviant endothelial stem cells in the spread of breast cancer. Dr. Felty’s laboratory uses state-of-the-art approaches to understand the impact of estrogenic chemicals on the Inhibitor of Differentiation protein 3 (ID3). His areas of research consist of identifying a biological based mechanism by which elevated exposure to complex mixtures of endocrine disrupting chemicals promote vascular cell dysfunction and its implications to brain vascular health, pulmonary vascular health, and the metastatic spread of cancer stem cells, as well as developing novel 3D human blood-brain barrier tissue culture to study gene-environment effects on aging and identifying novel redox signaling molecules involved in the maintenance of vascular stem cells and its application to aging.
Scholarly & Creative Works
selected publications
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Article
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2020Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 146:2777-2815.Full Text via DOI: 10.1007/s00432-020-03320-9 Web of Science: 000551783900003
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2020Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma. MOLECULAR NEUROBIOLOGY.Full Text via DOI: 10.1007/s12035-020-01979-2 Web of Science: 000544199400001
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2018Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast Carcinogenesis. CELLS. 7.Full Text via DOI: 10.3390/cells7120234 Web of Science: 000455320700012
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2018NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2+ve breast cancer signaling pathways. BREAST CANCER RESEARCH AND TREATMENT. 172.Full Text via DOI: 10.1007/s10549-018-4905-9 Web of Science: 000447497300021
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2017Environmental estrogen-like endocrine disrupting chemicals and breast cancer. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 457:89-102.
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2015ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: Its implication for understanding microvascular diseases. MICROVASCULAR RESEARCH. 98:126-138.
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2015Microvascular Lesions by Estrogen-Induced ID3: Its Implications in Cerebral and Cardiorenal Vascular Disease. JOURNAL OF MOLECULAR NEUROSCIENCE. 55:618-631.
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2015Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. MOLECULAR NEUROBIOLOGY. 52:1341-1363.
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2015Pulmonary Arterial Hypertension: A Stem Cell Hypothesis. LUNG STEM CELLS IN THE EPITHELIUM AND VASCULATURE. 289-306.Full Text via DOI: 10.1007/978-3-319-16232-4_16 Web of Science: 000378209000017
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2015Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells. BRITISH JOURNAL OF CANCER. 112:1687-1702.
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2015Vascular endothelial growth factor receptor 3 signaling contributes to angioobliterative pulmonary hypertension. PULMONARY CIRCULATION. 5:101-116.
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2014Bayesian Network and Mechanistic Hierarchical Structure Modeling of Increased likelihood of Developing Intractable Childhood Epilepsy from the Combined Effect of mtDNA Variants, Oxidative Damage, and Copy Number. JOURNAL OF MOLECULAR NEUROSCIENCE. 54:752-766.
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2011Redox sensitive Pyk2 as a target for therapeutics in breast cancer. FRONTIERS IN BIOSCIENCE. 16:568-577.
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2010Gene Environment Interactions and Vascular Lesions. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 139-152.Full Text via DOI: 10.1007/978-1-4419-6752-7_6 Web of Science: 000282535900006
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2010Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 223-252.Full Text via DOI: 10.1007/978-1-4419-6752-7_9 Web of Science: 000282535900009
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2008Estrogen-induced redox sensitive Id3 signaling controls the growth of vascular cells. ATHEROSCLEROSIS. 198:12-21.Full Text via DOI: 10.1016/j.atherosclerosis.2007.12.048 PMID: 18281048 Web of Science: 000255491800002
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2006Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. FRONTIERS IN BIOSCIENCE. 11:889-898.
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Book Chapter
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2019Estrogenic chemicals and cardiovascular disease. 746-749.Full Text via DOI: 10.1016/B978-0-12-409548-9.11674-4
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2019Malformations of cortical development and epilepsy in children. 211-218.Full Text via DOI: 10.1016/B978-0-12-409548-9.11744-0
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2011Environment, Genetic and Epigenetic Alterations and Pediatric Central Nervous System Tumors. 559-568.Full Text via DOI: 10.1016/B978-0-444-52272-6.00071-4
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2011Estrogenic Chemicals and Cardiovascular Disease. 605-608.Full Text via DOI: 10.1016/B978-0-444-52272-6.00148-3
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2011Malformations of Cortical Development and Epilepsy in Children. 595-602.Full Text via DOI: 10.1016/B978-0-444-52272-6.00073-8
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Conference
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Letter
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2018Letter to the Editor: Is Id3 proliferative or antiproliferative?. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY.Full Text via DOI: 10.1152/ajplung.00205.2018 Web of Science: 000442116600008
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Meeting Abstract
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2018Exosomal ID3 is pro-metastatic through guiding NRF1-induced breast cancer stem cells across the blood-brain-barrier. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-1128 Web of Science: 000468818903101
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2015Id3 generated cancer stem-like cells: A microvascular niche for the development of glioma. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-4179 Web of Science: 000371597103266
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2014ID3 expression and oxidative DNA damage are associated with growth of benign and malignant vascular lesions. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-3002 Web of Science: 000349910200009
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2014Redox signaling to nuclear respiratory factor-1 proteins by reactive oxygen species contributes to the estrogen-induced breast tumor development. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-3179 Web of Science: 000349910200183
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2013PCB153-induced angiogenesis depends on redoxsensitive Pyk2 signaling.. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2013-3899 Web of Science: 000331220603133
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2011Estrogen-induced redox signaling via NRF-1 is involved in the development of breast cancer. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2011-LB-12 Web of Science: 000209701305418
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2010Alteration in signature of mRNA and protein expression by environmental estrogen PCB153: implications for vascular lesions. NEW BIOTECHNOLOGY.Full Text via DOI: 10.1016/j.nbt.2010.01.088 Web of Science: 000209825000128
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2009Estrogenic PCBs increase blood vessel formation by redox signaling. CANCER RESEARCH.Web of Science: 000209702803334
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2009NRF-1 signaling participates in the estrogen-mediated growth of breast cancer cells.. CANCER RESEARCH.Web of Science: 000209701803459
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20074-OH-E2-induced oxidants through NRF-1 controls transcription of G1-S and G2-M phase cell cycle genes. FEBS JOURNAL. 179-179.Web of Science: 000253283800541
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2007Estrogen-induced vascular lesions formation is mediated by redox sensitive Id3 signaling. FEBS JOURNAL. 145-145.Web of Science: 000253283800405
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Proceedings Paper
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2011Identifying gene alterations required for the development of astrocytoma. 19TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2011). 1037-1041.Web of Science: 000314989301008
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2011Identifying gene-protein interactions in response to environmental estrogenic chemicals using Bayesian networks: its implication in the etiology of pulmonary vascular lesions. 19TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2011). 1056-1062.Web of Science: 000314989301011
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2009Hierarchical clustering method identifies adaptation of mitochondrial signaling to the treatment of mitochondrial blockers that regulates the expression of cell cycle genes.. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 708-714.Web of Science: 000290045000109
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2009Meta-analysis of brain tumor microarray data using Oncomine identifies NRF1, Tfam and Myc co-expressed genes: its implications in the development of childhood brain tumors. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 720-726.Web of Science: 000290045000111
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2009Oncomine meta-analysis of breast cancer microarray data identifies upregulation of NRF-1 expression in human breast carcinoma. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 715-719.Web of Science: 000290045000110
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Review
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2018Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders. BIOMED RESEARCH INTERNATIONAL.
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2017Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease. BIOMED RESEARCH INTERNATIONAL.
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2017Gender, Estrogen, and Obliterative Lesions in the Lung. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.Full Text via DOI: 10.1155/2017/8475701 Web of Science: 000398314200001
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2007Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. 235-257.
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2007Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: Potential molecular targets for cancer therapy. FRONTIERS IN BIOSCIENCE. 154-173.
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chaired theses and dissertations
- Doke, Mayur Arvind, The Role of ID3 and PCB153 in the Hyperproliferation and Dysregulation of Lung Endothelial Cells 2018
- Avecilla, Vincent E, ID3, Estrogenic Chemicals, and the Pathogenesis of Tumor-Like Proliferative Vascular Lesions 2017
- Assaggaf, Hamza M, Molecular Risk Factors of Pulmonary Arterial Hypertension 2017
Research
research interests
- Pulmonary and Brain Vascular Health and Cancer Metastasis
principal investigator on
co-principal investigator on
- Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU - UM Braman Family Breast Cancer Institute. awarded by U.S. Department of Defense 2007 - 2012
- Advanced Research Cooperation in Environmental Health Research awarded by National Institutes of Health 2009 - 2010
Teaching
teaching activities
- PHC6312-UHA: Health Impacts of Air, Water, and Land Pollution Spring Term 2019
- PHC6315-U01: Introduction to Environmental Health Sciences Fall Term 2019
- PHC6914-U01: Current Topics in Environmental Health Sciences Research Lab Fall Term 2019
- PHC6914-U01: Current Topics in Environmental Health Sciences Research Lab Spring Term 2019
- PHC6917-U01: Environmental and Occupational Health Sciences Pre Doctoral Research Fall Term 2019
- PHC7327-RVC: Emerging Issues in Environmental Health Sciences Fall Term 2019
Videos
videos
Contact
full name
- Quentin Felty
Identifiers
ORCID iD
- https://orcid.org/0000-0002-7151-0441 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cardiovascular System & Cardiology
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Environmental Sciences & Ecology
- Neurosciences & Neurology
- Oncology
- Pharmacology & Pharmacy
- Physiology
- Public, Environmental & Occupational Health
- Research & Experimental Medicine
- Respiratory System
- Science & Technology - Other Topics
- Toxicology