Anuradha Godavarty
- Associate Professor, Biomedical Engineering , College of Engineering and Computing
Overview
overview
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Dr. Godavarty’s research work focuses in the area of optical-based molecular imaging (diffuse optical and fluorescence-enhanced optical imaging) and tomography. Optical imaging is based on the principles of near-infrared light propagation in scattering media (such as biological tissues) and the use of external fluorescent contrast agents to better differentiate normal and diseased tissues based on the differences in their optical properties. The research work requires an understanding of transport phenomena in biological systems, application of experimental skills towards instrument development, incorporation of optimization and mathematical tools towards image reconstructions, and development of biomedical aspects of engineering towards practical applications, such as cancer diagnostics, wound imaging, functional brain mapping.
Near-infrared (NIR) light propagation in a dense scattering media is modeled based on the physics of light transport. The bioinstrumentation involved in the development of optical-based imaging systems is complimented by the 2D/3D tomographic (i.e. image reconstruction) analysis carried out using computational tools. Bioinstrumentation includes the development of optical-based imaging systems using near-infrared (NIR) light sources (i.e. laser diodes) and detectors (i.e. PMTs, CCD, CMOS cameras). Three-dimensional tomographic analysis of the optical images is carried out using appropriate light propagation models and computationally intense mathematical tools in order to locate regions of interest.
Our Optical Imaging Laboratory focuses on various clinical applications of near-infrared optical imaging technology. Some of the key projects performing (-ed) include:
Non-contact hand-held optical imaging scanner for real-time assessment of oxygenation changes and perfusion changes in wound healing of diabetic foot ulcers, venous leg ulcers and arterial ulcers (clinical partners include dermatologist, podiatric surgeons, diabetologist, nursing faculty, statistics faculty)
Diffuse optical imaging of breast cancer in-vivo using a hand-held 3D tomographic imaging device (clinical partners include breast surgeon, radiologist).
Development of a novel 3D tomographic hand-held optical imager for imaging of large tissue volumes.
Functional brain mapping of cognition of motor functions in response to physical therapy in pediatrics/adults with cerebral palsy and correlation to muscle kinematics (partners include physical therapy faculty).
Functional brain mapping of cognition of joint attention in pediatrics with autism (clinical partners include neuropsychologist, psychology faculty).
Publications
selected publications
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Article
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2021Development of a Smartphone-Based Optical Device to Measure Hemoglobin Concentration Changes for Remote Monitoring of WoundsFull Text via DOI: 10.3390/bios11060165 Web of Science: 000665291300001
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2020Physiological wound assessment from coregistered and segmented tissue hemoglobin maps. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION. 37:1249-1256.Full Text via DOI: 10.1364/JOSAA.394985 Web of Science: 000555713900002
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2019Tissue Oxygenation Changes to Assess Healing in Venous Leg Ulcers Using Near-Infrared Optical Imaging. ADVANCES IN WOUND CARE.Full Text via DOI: 10.1089/wound.2018.0880 Web of Science: 000469484100001
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2019Breath-Hold Paradigm to Assess Variations in Oxygen Flow in Diabetic Foot Ulcers Using a Noncontact Near-Infrared Optical Scanner. ADVANCES IN WOUND CARE. 1-17.Full Text via DOI: 10.1089/wound.2018.0922 Web of Science: 000464272300001
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2019Development and Validation of a Smartphone-Based Near-Infrared Optical Imaging Device to Measure Physiological Changes In-Vivo. MICROMACHINES. 10.Full Text via DOI: 10.3390/mi10030180 Web of Science: 000464418400002
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2018Assessing the Healing of Venous Leg Ulcers Using a Noncontact Near-Infrared Optical Imaging Approach. ADVANCES IN WOUND CARE. 7:134-143.
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2015Noninvasive surface imaging of breast cancer in humans using a hand-held optical imager. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS. 1.Full Text via DOI: 10.1088/2057-1976/1/4/045001 Web of Science: 000422560200001
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2015Functional near-infrared imaging reconstruction based on spatiotemporal features: venous occlusion studies. APPLIED OPTICS. 54:D82-D90.Full Text via DOI: 10.1364/AO.54.000D82 Web of Science: 000353980900014
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2014Motor response investigation in individuals with cerebral palsy using near infrared spectroscopy: pilot study. APPLIED OPTICS. 53:503-510.
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2013Effect of Porosity on Photocatalytic Activity of Plasma-Sprayed TiO2 Coating. JOURNAL OF THERMAL SPRAY TECHNOLOGY. 22:1193-1200.Full Text via DOI: 10.1007/s11666-013-9964-1 Web of Science: 000324241500012
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2013Fronto-temporal mapping and connectivity using NIRS for language-related paradigms. JOURNAL OF NEUROLINGUISTICS. 26:178-194.Full Text via DOI: 10.1016/j.jneuroling.2012.06.002 Web of Science: 000310413400011
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2013Functional connectivity in the brain in joint attention skills using near infrared spectroscopy and imaging. BEHAVIOURAL BRAIN RESEARCH. 250:28-31.
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2013Photocatalytic activity of spark plasma sintered TiO2-graphene nanoplatelet composite. SCRIPTA MATERIALIA. 68:719-722.Full Text via DOI: 10.1016/j.scriptamat.2013.01.012 Web of Science: 000317163800016
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2013Resolution of a Gen-2 handheld optical imager: diffuse and fluorescence imaging studies. APPLIED OPTICS. 52:8060-8066.
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2013Three-dimensional fluorescence tomography of human breast tissues in vivo using a hand-held optical imager. PHYSICS IN MEDICINE AND BIOLOGY. 58:1563-1579.
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2012Gen-2 Hand-Held Optical Imager towards Cancer Imaging: Reflectance and Transillumination Phantom Studies. SENSORS. 12:1885-1897.
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2012Hand-Held Optical Devices for Breast Cancer: Spectroscopy and 3-D Tomographic Imaging. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS. 18:1298-1312.Full Text via DOI: 10.1109/JSTQE.2011.2170664 Web of Science: 000308113800006
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2012Hand-held optical imager (Gen-2): improved instrumentation and target detectability. JOURNAL OF BIOMEDICAL OPTICS. 17.
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2011Frontal activation and connectivity using near-infrared spectroscopy: Verbal fluency language study. BRAIN RESEARCH BULLETIN. 84:197-205.Full Text via DOI: 10.1016/j.brainresbull.2011.01.002 PMID: 21255633 Web of Science: 000288885800001
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2011Frontal cortical connectivity and lateralisation of joint attention experience using near infrared spectroscopy. JOURNAL OF NEAR INFRARED SPECTROSCOPY. 19:105-116.Full Text via DOI: 10.1255/jnirs.921 Web of Science: 000292228600002
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2010Automated coregistered imaging using a hand-held probe-based optical imager. REVIEW OF SCIENTIFIC INSTRUMENTS. 81.
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2010Improved detection limits using a hand-held optical imager with coregistration capabilities. BIOMEDICAL OPTICS EXPRESS. 1:126-134.
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2010Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies. APPLIED OPTICS. 49:4343-4354.
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2010Two-dimensional Fast surface imaging using a hand-held optical device: In-vitro and in-vivo fluorescence studies. TRANSLATIONAL ONCOLOGY. 3:16-22.
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2009Diffuse optical imaging of brain activation to joint attention experience. BEHAVIOURAL BRAIN RESEARCH. 202:32-39.
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2009Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies. APPLIED OPTICS. 48:6408-6416.
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2009Noise filtration in fluorescence-enhanced optical tomography: breast phantom studies. INVERSE PROBLEMS IN SCIENCE AND ENGINEERING. 17:97-104.Full Text via DOI: 10.1080/17415970802083482 Web of Science: 000261195000008
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2008Three-dimensional fluorescence-enhanced optical tomography using a hand-held probe based imaging system. MEDICAL PHYSICS. 35:3354-3363.
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2007Design and development of a hand-held optical probe toward fluorescence diagnostic imaging. JOURNAL OF BIOMEDICAL OPTICS. 12.
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2007Fluorescence-enhanced three-dimensional lifetime imaging: a phantom study. PHYSICS IN MEDICINE AND BIOLOGY. 52:4155-4170.
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2007Noise pre-filtering techniques in fluorescence-enhanced optical tomography. OPTICS EXPRESS. 15:11285-11300.
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2006Fluorescence-enhanced optical tomography of a large tissue phantom using point illumination geometries. JOURNAL OF BIOMEDICAL OPTICS. 11.
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2005Fluorescence photon migration by the boundary element methodFull Text via DOI: 10.1016/j.jcp.2005.04.003
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2000Distribution and catalytic activity of eutectic salts in steam gasification of coalFull Text via DOI: 10.1021/ef990156o
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Book Chapter
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2014Near-infrared fluorescence imaging and spectroscopy in random media and tissues. 587-652.Full Text via DOI: 10.1201/b17289
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Conference
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2018Tissue oxygenation changes in venous leg ulcersFull Text via DOI: 10.1364/TRANSLATIONAL.2018.JTu3A.7
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2012Non-invasive optical imaging technology: Breast cancer imaging and functional brain mapping. 125.Full Text via DOI: 10.1109/PAHCE.2012.6233458
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2012Flexible gen-2 hand-held optical imager: Flat and curved phantom studiesFull Text via DOI: 10.1364/biomed.2012.bsu3a.74
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2012In vivo breast imaging using a gen-2 hand-held optical imagerFull Text via DOI: 10.1364/biomed.2012.btu3a.66
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2012Temporal mapping and connectivity using NIRS for language-related tasksFull Text via DOI: 10.1364/biomed.2012.btu3a.58
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2009Brain Connectivity Studies of Joint Attention Using Frequency-Domain Diffuse Optical Imaging. 7-8.Full Text via DOI: 10.1007/978-3-642-01697-4_4
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2009Clinical translation of a novel hand-held based optical imager: In vitro and in vivo studies. 3-4.Full Text via DOI: 10.1007/978-3-642-01697-4_2
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2009Fluorescence tomographic imaging using a hand-held optical imager: Extensive phantom studies. 1-2.Full Text via DOI: 10.1007/978-3-642-01697-4_1
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2008A hand-held probe-based optical imager with self co-registration facilitiesFull Text via DOI: 10.1364/biomed.2008.bmd49
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2008Joint attention studies using diffuse optical imagingFull Text via DOI: 10.1364/biomed.2008.bmd19
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2005Image reconstruction for diagnosis and prognosis of breast cancer using fluorescence measurements: Phantom studies. 203-209.Full Text via DOI: 10.1117/12.589209
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2003Advances in 3-D frequency domain fluorescence tomography. 211-218.Full Text via DOI: 10.1117/12.478183
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2003Hybrid approach to Bayesian image reconstruction. 591-599.Full Text via DOI: 10.1117/12.478184
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2003Fluorescence-enhanced tomographic imaging in large phantoms using gain-modulated ICCD camera. 433-443.Full Text via DOI: 10.1117/12.476531
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Letter
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2015Diabetic wound imaging using a noncontact near-infrared scanner: A pilot study. 1158-1159.Full Text via DOI: 10.1177/1932296815590828
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Meeting Abstract
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2006A novel optical imager towards breast cancer diagnosis. MEDICAL PHYSICS. 1989-1989.Full Text via DOI: 10.1118/1.2240150 Web of Science: 000238688500072
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Proceedings Paper
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2019Low-cost smartphone-based imaging device to detect subsurface tissue oxygenation of wounds. OPTICS AND BIOPHOTONICS IN LOW-RESOURCE SETTINGS V.Full Text via DOI: 10.1117/12.2510425 Web of Science: 000464093300012
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2019Oxygenation based perfusion assessment of diabetic foot ulcers using a breath-hold paradigm. OPTICAL BIOPSY XVII: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS.Full Text via DOI: 10.1117/12.2509917 Web of Science: 000492344300001
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2019Semi-automated machine learning approach to segment and register tissue oxygenation maps onto clinical images of wounds. OPTICAL BIOPSY XVII: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS.Full Text via DOI: 10.1117/12.2510065 Web of Science: 000492344300002
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2016Quantitative wound healing studies using a portable, low-cost, hand-held near-infrared optical scanner: Preliminary sensitivity and specificity analysis. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2212070 Web of Science: 000378119600022
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2016Wound size measurement of lower extremity ulcers using segmentation algorithms. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2212046 Web of Science: 000378218400039
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2015Non-contact optical imaging of healing and non-healing diabetic foot ulcers. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2080716 Web of Science: 000353479900002
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2014Anatomical Co-Registration using Spatio-Temporal Features of a Non-contact Near-Infrared Optical Scanner. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2037290 Web of Science: 000337064900005
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2013A Gen-2 Hand-Held Optical Imager: Phantom and preliminary in-vivo breast imaging studies. 2016 32ND SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE (SBEC). 103-104.Full Text via DOI: 10.1109/SBEC.2013.60 Web of Science: 000324751700052
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2013Implementation of a Novel, Integrative Approach for Optical 3D Positional Tracking towards Accurate Co-registered Imaging Using Hand-Held Optical Imagers. 2016 32ND SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE (SBEC). 81-82.Full Text via DOI: 10.1109/SBEC.2013.49 Web of Science: 000324751700041
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2013Investigation of Planning and Execution of Motor Skills in Healthy Adults using Simultaneous Near Infrared Spectroscopy and Kinematics Study. 2016 32ND SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE (SBEC). 135-136.Full Text via DOI: 10.1109/SBEC.2013.76 Web of Science: 000324751700068
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2013Phantom and in-vivo imaging using a Gen-2 hand-held optical imager: reflectance and transmission studies. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2004834 Web of Science: 000326708600012
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2013Portable Wide-Field Hand-Held NIR Scanner. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2002704 Web of Science: 000337082600007
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2013Resolution Studies of a Hand-Held Optical Imager. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2002760 Web of Science: 000326708600058
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2013Simultaneous NIRS and kinematics study of planning and execution of motor skill task: towards cerebral palsy rehabilitation. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2004746 Web of Science: 000324807200076
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2012Breast cancer imaging and tomography using a hand-held optical imager. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.908528 Web of Science: 000302567700014
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20113D tomographic breast imaging in vivo using a hand-held optical imager. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.874347 Web of Science: 000297631300051
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2011Joint attention studies in normal and autistic children using NIRS. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.874360 Web of Science: 000293947200068
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2011Temporal Mapping and Connectivity Using NIRS for Language-Related Tasks. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.875256 Web of Science: 000293947200071
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2010BRAIN CONNECTIVITY STUDY OF JOINT ATTENTION USING FREQUENCY-DOMAIN OPTICAL IMAGING TECHNIQUE. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.841504 Web of Science: 000283924300081
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2010Fast coregistered breast imaging in vivo using a hand-held optical imager. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.842328 Web of Science: 000284396000010
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2010Non-invasive Diagnostic Breast Imaging using a Hand-held Optical Imager. WMSCI 2010: 14TH WORLD MULTI-CONFERENCE ON SYSTEMICS, CYBERNETICS AND INFORMATICS, VOL II. 158-161.Web of Science: 000391419900031
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2009Brain Activation and Connectivity of Social Cognition using Diffuse Optical Imaging. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.809942 Web of Science: 000285713200063
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2009Multi-projection based fluorescence optical tomography using a hand-held probe based optical imager. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.809935 Web of Science: 000285714800032
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2009Real-Time Coregistered Imaging using a Novel Hand-held Optical Imager. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.809928 Web of Science: 000284395100024
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2008Fluorescence-enhanced imaging using a novel hand-held based optical imager: Phantom studies - art. no. 684809. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VI. 84809-84809.Full Text via DOI: 10.1117/12.764531 Web of Science: 000255549900003
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2007Hand-held probe based optical imaging system towards breast cancer diagnosis. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS V.Full Text via DOI: 10.1117/12.700637 Web of Science: 000245947500010
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Review
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2016Critical Review of Noninvasive Optical Technologies for Wound Imaging. ADVANCES IN WOUND CARE. 349-359.
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2016Near-Infrared Fluorescence-Enhanced Optical Tomography. BIOMED RESEARCH INTERNATIONAL.Full Text via DOI: 10.1155/2016/5040814 Web of Science: 000386269500001
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2015Optical imaging for breast cancer prescreening. BREAST CANCER-TARGETS AND THERAPY.Full Text via DOI: 10.2147/BCTT.S51702 Web of Science: 000366129000001
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2009Hand-held based near-infrared optical imaging devices: A review. MEDICAL ENGINEERING & PHYSICS. 495-509.
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chaired theses and dissertations
- Chaudhary, Ujwal, Funtional Near Infrared Spectroscopy Study of Language, Joint Attention and Motor Skills 2013
- Gonzalez, Jean, Development and Testing of a Second Generation Hand-held Optical Imager 2012
- Hall, Michael A, Temporal Mapping and Connectivity using NIRS for Language Related Tasks 2012
- Erickson, Sarah J., Clinical Translation of a Novel Hand-held Optical Imager for Breast Cancer Diagnosis 2011
- Martinez, Sergio L, Performance Enhancement In Accuracy and Imaging Time of a Hand-Held Probe-Based Optical Imager 2011
Research
research interests
- Near-infrared optical imaging; device development; wound imaging; smartphone imaging technologies; diabetic ulcers; radiation dermatitis; radiation mucositis
principal investigator on
- Ultraportable wide-field NIR scanner awarded by FIU Division of Research 2012 - 2014
- Coulter Translational Research Award in Biomedical Engin awarded by Wallace H. Coulter Foundation 2009 - 2012
- Function Brain Mapping of Autism Using Optical Imaging. awarded by University of Miami 2006 - 2012
- A Novel Hand-Held Based Optical Imager for Fluorescence Imaging of Breast Cancer. awarded by National Cancer Institute 2007 - 2011
- Subproject to Main Project OSRANbr 7396 (212100531): A Novel Hand-Held Based Optical Imager for Fluorescence Imaging of Breast Cancer. awarded by National Cancer Institute 2009 - 2010
- Hand Held Optical Probe for Fluorescence Imaging of Brea awarded by National Institutes of Health 2009 - 2010
- Diagnostic Mammography Using Real Time Co-Registering Novel Hand-Held Optical Imager. awarded by Florida Department of Health 2008 - 2009
- Bedside Optical Imaging of Epilepsy Patients. awarded by FIU Foundation 2006 - 2008
- Novel Breast Tissue Phantoms with Known Optical Properties. awarded by Imaging Diagnostic Systems 2006 - 2007
co-principal investigator on
- Clinical Translation of a Hand-held Optical Imager for Breast Imaging awarded by American Cancer Society 2011 - 2013
- Cancer Research in Memory of Barbara and Jerome Block. awarded by FIU Foundation 2008 - 2013
- Image Guided Intervention for Breast Cancer: Combined Hyperthermia and Chemotherapy with Reduced Cardiotoxicity. awarded by Florida Department of Health 2008 - 2009
investigator on
- Hand-held Optical Imager for Breast Cancer Imaging awarded by National Institutes of Health 2011 - 2014
- Hand-held Optical Imager for Breast Cancer Imaging awarded by National Institutes of Health 2012 - 2013
- Biomedical Engineering Research Initiation Program. awarded by Wallace H. Coulter Foundation 2001 - 2012
Teaching
teaching activities
- BME4562-UHA: Introduction to Biomedical Optics Fall Term 2019
- BME5560-UHA: Biomedical Engineering Optics Fall Term 2019
- BME6564-RXA: Optical Imaging Biomedicine Spring Term 2019
- BME6564-U01: Optical Imaging Biomedicine Spring Term 2019
Contact
full name
- Anuradha Godavarty
Identifiers
ORCID iD
- https://orcid.org/0000-0002-6094-5909 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Behavioral Sciences
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Chemistry
- Dermatology
- Electrochemistry
- Engineering
- Instruments & Instrumentation
- Linguistics
- Materials Science
- Mathematics
- Metallurgy & Metallurgical Engineering
- Neurosciences & Neurology
- Oncology
- Optics
- Physics
- Psychology
- Radiology, Nuclear Medicine & Medical Imaging
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Spectroscopy