
Overview
overview
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Respected scientist, educator and academic leader, Tomás R. Guilarte, Ph.D., became dean of Robert Stempel College of Public Health & Social Work at Florida International University (FIU) in January 2016. He joined FIU after serving as the inaugural Leon Hess Professor and Chairman of the Department of Environmental Health Sciences at Columbia University-Mailman School of Public Health in the City of New York.
Prior to Columbia University, Guilarte received his doctorate and spent three decades as a professor and researcher in the Department of Environmental Health Sciences at the Johns Hopkins University Bloomberg School of Public Health. As of 2018, Guilarte is a member of the Johns Hopkins Society of Scholars, which was established in 1967 on the recommendation of then president Milton S. Eisenhower and was approved by the University’s Board of Trustees.
Guilarte’s research explores the impact of environmental pollutants on neurological and mental disease. His work uses behavioral, cellular and molecular approaches, ranging from studies using primary culture of brain cells to the application of brain imaging technologies.
He is renowned for revealing the effects that low-level lead exposure has on the central nervous system during brain development, a discovery that led to strategies for mitigating learning deficits. In fact, these strategies are now translated to human populations.
Guilarte’s research team played an important role in the validation and application of a biomarker for brain injury and inflammation that is used clinically in major medical centers around the world. In 2017, Guilarte worked closely with Anna Rothschild, the host of NOVA’s Gross Science, to translate his National Institute of Environmental Health Sciences (NIEHS) research into insights for WGBH/PBS Digital Studios’ web segment “What Does Lead Poisoning do to the Brain?” and feature-length documentary on Flint’s “Poisoned Water“. Both productions take a deeper look at lead poisoning in adults and children, while illustrating how damaging this heavy metal is to the body—especially the brain—and how science may be on the right path to eventually finding a treatment.
His laboratory has also made seminal findings in the neurotoxicology of manganese and associated neurological disease.
Guilarte’s research is funded—and has been for more than 23 years—by grants from the NIEHS, for which he served as a member of the Advisory Council until 2017. Guilarte has also participated in many NIH study sections, review panels, and committees at the national and international level. In Miami, he has served as a member of the Miami-Dade County Mayor’s HIV/AIDS Getting to Zero Task Force and Opioid Addiction Task Force.
In 2018, the Hispanic Organization of Toxicologists (HOT) honored Guilarte as the recipient of the Distinguished Toxicologist Award, which celebrates a toxicologist of Hispanic origin for his or her outstanding professional achievements, excellence in research and level of service to the Society of Toxicology (SOT).
research interests
- Brain Science; Neurotoxicology
Scholarly & Creative Works
selected publications
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Article
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2021The Translocator Protein (TSPO) Genetic Polymorphism A147T Is Associated with Worse Survival in Male Glioblastoma PatientsFull Text via DOI: 10.3390/cancers13184525 Web of Science: 000700724100001
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2021Behavioral and neurochemical studies of inherited manganese-induced dystonia-parkinsonism in Slc39a14-knockout miceFull Text via DOI: 10.1016/j.nbd.2021.105467 Web of Science: 000697003600002
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2021Clinical Utility of Functional Precision Medicine in the Management of Recurrent/Relapsed Childhood RhabdomyosarcomaFull Text via DOI: 10.1200/PO.20.00438 Web of Science: 000757141900012
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2021Early-life lead exposure and neurodevelopmental disordersFull Text via DOI: 10.1016/j.cotox.2021.03.007 Web of Science: 000663270500004
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2021Chronic developmental lead exposure increases mu-opiate receptor levels in the adolescent rat brainFull Text via DOI: 10.1016/j.neuro.2020.11.008 Web of Science: 000610832500015
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2020Awake Delta and Theta-Rhythmic Hippocampal Network Modes During Intermittent Locomotor Behaviors in the RatFull Text via DOI: 10.1037/bne0000409 Web of Science: 000618966400005
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2020A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in MicrogliaFull Text via DOI: 10.1007/s12035-020-02042-w Web of Science: 000554842100002
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2019PET imaging of dopamine release in the frontal cortex of manganese-exposed non-human primatesFull Text via DOI: 10.1111/jnc.14681 Web of Science: 000475402700005
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2016Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brainFull Text via DOI: 10.1016/j.tox.2016.11.010 Web of Science: 000390743200001
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2016Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapsesFull Text via DOI: 10.1186/s40360-016-0098-1 Web of Science: 000387283600003
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2016TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiologyFull Text via DOI: 10.1016/j.nbd.2015.11.001 Web of Science: 000366955200017
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2015Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way ForwardFull Text via DOI: 10.1093/toxsci/kfv188 Web of Science: 000367195500001
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2015Presynaptic Mechanisms of Lead Neurotoxicity: Effects on Vesicular Release, Vesicle Clustering and Mitochondria NumberFull Text via DOI: 10.1371/journal.pone.0127461 Web of Science: 000355183900095
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2015Effects of chronic manganese exposure on attention and working memory in non-human primatesFull Text via DOI: 10.1016/j.neuro.2015.04.004 Web of Science: 000355641600023
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2015Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot studyFull Text via DOI: 10.1016/j.nbd.2014.10.019 Web of Science: 000349655900006
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2015Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative PhenotypeFull Text via DOI: 10.3233/JHD-140116 Web of Science: 000358511900002
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2014Regional brain distribution of translocator protein using [C-11]DPA-713 PET in individuals infected with HIVFull Text via DOI: 10.1007/s13365-014-0239-5 Web of Science: 000336804900003
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2014Sex Differences in Translocator Protein 18 kDa (TSPO) in the Heart: Implications for Imaging Myocardial InflammationFull Text via DOI: 10.1007/s12265-013-9538-0 Web of Science: 000331961700006
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2013Chronic manganese exposure impairs visuospatial associative learning in non-human primatesFull Text via DOI: 10.1016/j.toxlet.2013.06.211 Web of Science: 000323087000009
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2013The impact of environmental metals in young urbanites' brainsFull Text via DOI: 10.1016/j.etp.2012.02.006 Web of Science: 000322292700006
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2013ASTROCYTES RELEASE D-SERINE BY A LARGE VESICLEFull Text via DOI: 10.1016/j.neuroscience.2013.02.029 Web of Science: 000318825700022
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2013Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imagingFull Text via DOI: 10.1093/hmg/ddt007 Web of Science: 000316965400008
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2013Manganese exposure induces alpha-synuclein aggregation in the frontal cortex of non-human primatesFull Text via DOI: 10.1016/j.toxlet.2012.12.006 Web of Science: 000315160400001
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2012Pathophysiology of manganese-associated neurotoxicityFull Text via DOI: 10.1016/j.neuro.2011.12.010 Web of Science: 000307617200035
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2011Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibitionFull Text via DOI: 10.1016/j.neuro.2010.12.013 Web of Science: 000288310500015
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2011Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primatesFull Text via DOI: 10.1016/j.neuro.2010.11.003 Web of Science: 000288310500006
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2010Molecular Neurobiology of Lead (Pb2+): Effects on Synaptic FunctionFull Text via DOI: 10.1007/s12035-010-8146-0 Web of Science: 000284654000001
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2010APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primatesFull Text via DOI: 10.1016/j.neuro.2010.02.004 Web of Science: 000281939200021
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2010Silica-Based Nanoparticle Uptake and Cellular Response by Primary MicrogliaFull Text via DOI: 10.1289/ehp.0901534 Web of Science: 000277846800020
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2009Synthesis of [I-125]iodoDPA-713: A new probe for imaging inflammationFull Text via DOI: 10.1016/j.bbrc.2009.08.102 Web of Science: 000274534900015
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2009Effects of Chronic Manganese Exposure on Glutamatergic and GABAergic Neurotransmitter Markers in the Nonhuman Primate BrainFull Text via DOI: 10.1093/toxsci/kfp124 Web of Science: 000269002200014
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2009Effects of chronic manganese exposure on working memory in non-human primatesFull Text via DOI: 10.1016/j.brainres.2008.12.035 Web of Science: 000264536100011
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2008Developmental lead exposure impairs extinction of conditioned fear in young adult ratsFull Text via DOI: 10.1016/j.neuro.2008.06.010 Web of Science: 000261551800027
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2008Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primatesFull Text via DOI: 10.1111/j.1471-4159.2008.05295.x Web of Science: 000255835000032
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2008VMAT2 and dopamine neuron loss in a primate model of Parkinson's diseaseFull Text via DOI: 10.1111/j.1471-4159.2007.05108.x Web of Science: 000254383800007
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2008Dysregulation of glutamate carboxypeptidase II in psychiatric diseaseFull Text via DOI: 10.1016/j.schres.2007.11.013 Web of Science: 000254306600038
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2007Manganese inhibits NMDA receptor channel function: Implications to psychiatric and cognitive effectsFull Text via DOI: 10.1016/j.neuro.2007.06.005 Web of Science: 000251537700010
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2007Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genesFull Text via DOI: 10.1158/1535-7163.MCT-06-0516 Web of Science: 000243759800017
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2006In vivo modulation of the Parkinsonian phenotype by Nrf2Full Text via DOI: 10.1016/j.neuro.2006.07.019 Web of Science: 000243211300016
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2006Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primatesFull Text via DOI: 10.1016/j.expneurol.2006.06.015 Web of Science: 000242107300013
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2006Effects of chronic manganese exposure on cognitive and motor functioning in non-human primatesFull Text via DOI: 10.1016/j.brainres.2006.08.054 Web of Science: 000242147400024
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2006An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challengeFull Text via DOI: 10.1016/j.neuroimage.2006.06.038 Web of Science: 000241406800013
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2006Experience-dependent regulation of zif268 gene expression and spatial learningFull Text via DOI: 10.1016/j.expneurol.2006.02.006 Web of Science: 000239503000022
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2006Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelinationFull Text via DOI: 10.1093/toxsci/kfj172 Web of Science: 000237697300023
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2006Acute manganese administration alters dopamine transporter levels in the non-human primate striatumFull Text via DOI: 10.1016/j.neuro.2005.10.008 Web of Science: 000235756500013
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2005Glutamate carboxypeptidase II levels in rodent brain using [I-125]DCIT quantitative autoradiographyFull Text via DOI: 10.1016/j.neulet.2005.06.015 Web of Science: 000231743800005
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2005Imaging glial cell activation with [C-11]-R-PK11195 in patients with AIDSFull Text via DOI: 10.1080/13550280500187351 Web of Science: 000231877000004
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2005Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed ratsFull Text via DOI: 10.1016/j.brainres.2005.02.076 Web of Science: 000229276700007
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2004Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localizationFull Text via DOI: 10.1093/brain/awh161 Web of Science: 000221751200015
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2003Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitisFull Text via DOI: 10.1080/13550280390173283 Web of Science: 000181060100009
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2003Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposureFull Text via DOI: 10.1002/ana.10399 Web of Science: 000180186400008
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2003Methamphetamine-induced deficits of brain monoaminergic neuronal markers: Distal axotomy or neuronal plasticityFull Text via DOI: 10.1016/S0306-4522(03)00476-7 Web of Science: 000186862600019
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2002Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brainFull Text via DOI: 10.1016/S0165-3806(02)00569-2 Web of Science: 000180077200013
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2001Is methamphetamine abuse a risk factor in Parkinsonism?Full Text via DOI: 10.1016/S0161-813X(01)00046-8 Web of Science: 000173554300001
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2001Molecular changes in glutamatergic synapses induced by Pb2+: Association with deficits of LTP and spatial learningFull Text via DOI: 10.1016/S0161-813X(01)00035-3 Web of Science: 000172745000013
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2001Low level Pb2+ exposure affects hippocampal protein kinase C gamma gene and protein expression in ratsFull Text via DOI: 10.1016/S0304-3940(00)01741-9 Web of Science: 000166787700017
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2000Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicityFull Text via DOI: 10.1046/j.1471-4159.2000.0741694.x Web of Science: 000085951400041
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1999NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2+ during developmentFull Text via DOI: 10.1016/S0169-328X(99)00005-4 Web of Science: 000079389200005
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1999Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicityFull Text via DOI: 10.1093/toxsci/48.1.107 Web of Science: 000083454800014
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1998Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposureFull Text via DOI: 10.1016/S0006-8993(98)00054-7 Web of Science: 000073767700012
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1997Developmental lead exposure causes spatial learning deficits in adult ratsFull Text via DOI: 10.1016/S0304-3940(97)00633-2 Web of Science: A1997XY00400011
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1997Age-dependent effects of developmental lead exposure on performance in the Morris water mazeFull Text via DOI: 10.1016/S0091-3057(96)00350-4 Web of Science: A1997XA08800037
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1997Intrahippocampal administration of lead (Pb) impairs performance of rats in the Morris water mazeFull Text via DOI: 10.1016/S0091-3057(96)00349-8 Web of Science: A1997XA08800036
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1997The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicityFull Text via DOI: 10.1016/S0006-8993(96)01409-6 Web of Science: A1997WQ80700013
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1995MICE LACKING TISSUE NONSPECIFIC ALKALINE-PHOSPHATASE DIE FROM SEIZURES DUE TO DEFECTIVE METABOLISM OF VITAMIN-B-6Full Text via DOI: 10.1038/ng0995-45 Web of Science: A1995RR72800014
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1995INTRASTRIATAL DOPAMINE INFUSION REVERSES COMPENSATORY INCREASES IN D-2-DOPAMINE RECEPTORS IN THE 6-OHDA LESIONED RATFull Text via DOI: 10.1006/neur.1995.0020 Web of Science: A1995RG17300006
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1994CULTURE OF ARTERIAL CHEMORECEPTOR CELLS FROM ADULT CATS IN DEFINED MEDIUMFull Text via DOI: 10.1016/S0006-8993(09)90011-7 Web of Science: A1994PH00200010
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1993POSTNATAL-DEVELOPMENT AND GABA ALLOSTERIC MODULATION OF BENZODIAZEPINE RECEPTOR-BINDING IN THE VITAMIN B-6 DEFICIENT RAT-BRAINFull Text via DOI: 10.1007/BF00975043 Web of Science: A1993MD63400006
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1992AGE-DEPENDENT EFFECTS OF LEAD ON [H-3] MK-801 BINDING TO THE NMDA RECEPTOR-GATED IONOPHORE - INVITRO AND INVIVO STUDIESFull Text via DOI: 10.1016/0304-3940(92)90796-A Web of Science: A1992KF56400007
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1992UPTAKE OF 3-HYDROXYKYNURENINE MEASURED IN RAT-BRAIN SLICES AND IN A NEURONAL CELL-LINEFull Text via DOI: 10.1016/0006-8993(92)90883-B Web of Science: A1992JG68900013
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1991RADIOMETRIC MICROBIOLOGICAL ASSAY OF VITAMINS-B .2. EXTRACTION METHODSFull Text via DOI: 10.1016/0955-2863(91)90100-J Web of Science: A1991FV26300008
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1991DEVELOPMENTAL EFFECTS OF VITAMIN-B6 RESTRICTION ON THE LOCOMOTOR BEHAVIOR OF RATSFull Text via DOI: 10.1016/0361-9230(91)90249-J Web of Science: A1991FV76500004
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1991RADIOMETRIC MICROBIOLOGICAL ASSAY OF B-VITAMINS .1. ASSAY PROCEDUREFull Text via DOI: 10.1016/0955-2863(91)90079-K Web of Science: A1991FQ05700007
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1991RESPONSE OF VITAMIN-B6 CONTENT OF MUSCLE TO CHANGES IN VITAMIN-B6 INTAKE IN MENFull Text via DOI: 10.1093/ajcn/53.6.1436 Web of Science: A1991FN39900016
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1991ABNORMAL ENDOGENOUS AMINO-ACID RELEASE IN BRAIN-SLICES FROM VITAMIN-B6 RESTRICTED NEONATAL RATSFull Text via DOI: 10.1016/0304-3940(91)90685-M Web of Science: A1991ET96800052
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1991REDUCED NMDA RECEPTOR-ION CHANNEL FUNCTION IN THE VITAMIN-B6 RESTRICTED NEONATAL RAT-BRAINFull Text via DOI: 10.1016/0304-3940(91)90686-N Web of Science: A1991ET96800053
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1990SYNTHESIS AND ENANTIOMERIC RESOLUTION OF TRITIATED (D,L)-3-HYDROXYKYNURENINEFull Text via DOI: 10.1002/jlcr.2580281113 Web of Science: A1990EG49100012
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1990THE ROLE OF HYDROGEN-PEROXIDE IN THE INVITRO CYTOTOXICITY OF 3-HYDROXYKYNURENINEFull Text via DOI: 10.1007/BF01101711 Web of Science: A1990EW48500009
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1989CYTO-TOXICITY OF 3-HYDROXYKYNURENINE IN A NEURONAL HYBRID CELL-LINEFull Text via DOI: 10.1016/0006-8993(89)90216-3 Web of Science: A1989AL96900003
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1989A RADIOMETRIC MICROBIOLOGICAL ASSAY FOR PANTOTHENIC-ACID IN BIOLOGICAL-FLUIDSFull Text via DOI: 10.1016/0003-2697(89)90357-6 Web of Science: A1989T871000012
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1988ASSESSMENT OF [C-11] L-METHIONINE TRANSPORT INTO THE HUMAN-BRAINFull Text via DOI: 10.1038/jcbfm.1988.69 Web of Science: A1988N458700006
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1987INCREASED CONCENTRATIONS OF 3-HYDROXYKYNURENINE IN VITAMIN-B6 DEFICIENT NEONATAL RAT-BRAINFull Text via DOI: 10.1111/j.1471-4159.1987.tb02455.x Web of Science: A1987K813400032
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1987EFFECTS OF PERINATAL VITAMIN-B6 DEFICIENCY ON DOPAMINERGIC NEUROCHEMISTRYFull Text via DOI: 10.1111/j.1471-4159.1987.tb04111.x Web of Science: A1987F671200014
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1985RADIOMETRIC-MICROBIOLOGICAL ASSAY OF BIOTIN IN HUMAN-PLASMAFull Text via DOI: 10.1111/j.1749-6632.1985.tb18457.x Web of Science: A1985AML0600036
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1985THE EFFECTS OF TOTAL PARENTERAL-NUTRITION ON GASTROINTESTINAL GROWTH AND DEVELOPMENTFull Text via DOI: 10.1016/S0022-3468(85)80044-0 Web of Science: A1985AVV9900044
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1984VITAMIN-B-6 CONTENT OF PLASMA OF DOMESTIC-ANIMALS DETERMINED BY HPLC, ENZYMATIC AND RADIOMETRIC MICROBIOLOGICAL METHODSFull Text via DOI: 10.1093/jn/114.12.2269 Web of Science: A1984TX29700013
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1983RADIOMETRIC-MICROBIOLOGIC ASSAY OF NIACIN USING KLOECKERA-BREVIS - ANALYSIS OF HUMAN-BLOOD AND FOODFull Text via DOI: 10.1093/jn/113.12.2587 Web of Science: A1983RW24000023
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1982KINETICS AND DISTRIBUTION OF INDIUM-111-LABELED PLATELETS IN PATIENTS WITH HOMOCYSTINURIAFull Text via DOI: 10.1056/NEJM198209233071303 Web of Science: A1982PH06500003
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1982NUTRITIONAL AMBLYOPIA - FOLIC-ACID, VITAMIN-B12, AND OTHER VITAMINSFull Text via DOI: 10.1097/00006982-198202040-00014 Web of Science: A1982PX67800013
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1981RADIOMETRIC-MICROBIOLOGIC ASSAY OF VITAMIN B-6 - ANALYSIS OF PLASMA SAMPLESFull Text via DOI: 10.1093/jn/111.11.1861 Web of Science: A1981MP26700001
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1981RADIOMETRIC-MICROBIOLOGIC ASSAY OF VITAMIN B-6 - APPLICATION TO FOOD ANALYSISFull Text via DOI: 10.1093/jn/111.11.1869 Web of Science: A1981MP26700002
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1980GROWTH-RESPONSE OF THE YEASTS SACCHAROMYCES-UVARUM AND KLOECKERA-BREVIS TO THE FREE BIOLOGICALLY-ACTIVE FORMS OF VITAMIN-B-6Full Text via DOI: 10.1093/jn/110.5.954 Web of Science: A1980JT16800014
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Book
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1994CULTURING CAROTID BODY CELLS OF ADULT CATS. Ed. 360.Web of Science: A1994BB74U00018
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Book Chapter
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2021The Role of Vitamin B-6 in Central Nervous System Development: Neurochemistry and Behavior. 77-91.Full Text via DOI: 10.1201/9781003210368-5
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201013.31 Molecular Imaging: The New Frontier in Neurotoxicology. 537-551.Full Text via DOI: 10.1016/b978-0-08-046884-6.01332-4
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2010Molecular Imaging: The New Frontier in Neurotoxicology. 537-551.Web of Science: 000333465100031
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2004Peripheral Benzodiazepine Receptor (PBR) Imaging in Glial Cells. 207-219.Full Text via DOI: 10.1201/9781420039740.ch12
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2001Molecular Mechanisms of Low-Level Pb2+ Neurotoxicity. 107-133.Full Text via DOI: 10.1385/1-59259-132-9:107
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1998Chapter 15 The N-Methyl-D- Aspartate Receptor Physiology and Neurotoxicology in the Developing Brain. 285-304.Full Text via DOI: 10.1016/b978-012648860-9.50020-0
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1984Homocystinuria: Kinetics and Distribution of 111In-Labelled Platelets. 242-261.Full Text via DOI: 10.1007/978-94-009-6027-5_20
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Conference
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2017Early Life Lead Exposure and Schizophrenia: An Environmental Model of NMDA Receptor Hypofunction. S39-S40.Full Text via DOI: 10.1016/j.biopsych.2017.02.106 Web of Science: 000400348700095
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2012Mapping CB1 cannabinoid receptors with [H-3]OMAR in the Flinders rodent model of depression. S24-S25.Web of Science: 000307138000016
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2011DOPAMINE ABNORMALITIES IN DISC1 MOUSE MODELS. 107-108.Web of Science: 000287746000308
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2009Dopamine Abnormalities in Two DISC1 Transgenic Mouse Models. 167S-167S.Web of Science: 000265144200530
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2007Early upregulation of peripheral benzodiazepine receptor expression by radiation-induced damage to mouse lung in vivo. S150-S151.Full Text via DOI: 10.1016/j.ijrobp.2007.07.275 Web of Science: 000249950200269
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2006Neurochemical changes in the living nonhuman primate brain following manganese exposure.. 896-897.Web of Science: 000240408800082
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2006
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2006
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2003
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2002A multiparametric, longitudinal study of brain metabolism in SIV encephalitis.. 237P-237P.Web of Science: 000175560800875
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2002R-C-11-PK11195-PET of peripheral benzodiazepine receptors in AIDS dementia.. 65P-65P.Web of Science: 000175560800235
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1997Glutamatergic system and developmental lead neurotoxicity. 665-672.Web of Science: A1997XZ55900005
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1994NEUROCHEMICAL ASPECTS OF HIPPOCAMPAL AND CORTICAL PB2+ NEUROTOXICITY. 459-466.Web of Science: A1994PN14800005
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1993REGULATION OF INTRACELLULAR PH (PH) AND HYPOXIC CHEMOTRANSDUCTION OF CAT CAROTID-BODY (CB). A282-A282.Web of Science: A1993LB14901046
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1993IDENTIFICATION OF FUNCTIONING CULTURED CAROTID-BODY TYPE-I CELLS FROM ADULT CAT. A458-A458.Web of Science: A1993KP97402652
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1991KINETICS OF DEUTERATED VITAMIN-B6 METABOLISM IN MEN ON A MARGINAL VITAMIN-B6 INTAKE. A1660-A1660.Web of Science: A1991FE55701185
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1991EFFECT OF DIETARY VITAMIN-B6 RESTRICTION ON THE LOCOMOTOR BEHAVIOR OF THE DEVELOPING RAT. A1319-A1319.Web of Science: A1991FC55002332
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1991Cytotoxicity of 3-hydroxykynurenine: Implications for CNS damage in neonatal vitamin B-6 deficiency. 625-629.Full Text via DOI: 10.1007/978-1-4684-5952-4_81
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1988RADIOMETRIC-MICROBIOLOGICAL ASSAY OF B-VITAMINS IN HUMAN-MILK. A654-A654.Web of Science: A1988M612102074
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1986
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1986EFFECTS OF VITAMIN-B6 DEFICIENCY ON NEUROTRANSMISSION AND ITS RELATIONSHIP TO EPILEPSY. 969-969.Web of Science: A1986C469600411
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1986
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1986
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1986
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1986A SIMPLE METHOD FOR ASSESSMENT OF NEUTRAL AMINO-ACID-TRANSPORT INTO THE HUMAN-BRAIN. 189-189.Web of Science: A1986D084900040
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1985DIMINISHED CARDIAC-FUNCTION IN PYRIDOXINE-DEFICIENCY. A184-A184.Web of Science: A1985AEY9300149
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1985EFFECT OF AGE AND VITAMIN-B-6 DEFICIENCY ON DOPAMINE-RECEPTORS. A598-A598.Web of Science: A1985AEY9302619
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1985EFFECT OF MATERNAL VITAMIN-B-6 DEFICIENCY ON THE DOPAMINERGIC SYSTEM OF NEWBORN RATS. 939-939.Web of Science: A1985ACZ0200368
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1985EFFECTS OF TPN ON INTESTINAL DEVELOPMENT. A220-A220.Full Text via DOI: 10.1203/00006450-198504000-00687 Web of Science: A1985AEU1800658
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1984THE EFFECT OF NEOSTIGMINE ON RESPIRATION IN AWAKE DOGS. 530-530.Web of Science: A1984SF05201430
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1984
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1982A SIMPLE RADIOMETRIC ASSAY FOR CHOLINESTERASE ACTIVITY IN HUMAN-PLASMA. P60-P61.Web of Science: A1982NN30000276
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1982
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1982HOMOCYSTINURIA - KINETICS AND BIODISTRIBUTION OF INDIUM-111-LABELED PLATELETS. A106-A106.Web of Science: A1982PU21100239
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1982KINETICS AND BIODISTRIBUTION OF INDIUM-111-LABELED PLATELETS IN PATIENTS WITH HOMOCYSTINURIA. P58-P58.Web of Science: A1982NN30000263
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1981A SIMPLE RADIOMETRIC ASSAY FOR ACETYLCHOLINESTERASE ACTIVITY. P46-P46.Web of Science: A1981LQ26800210
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1979RADIOMETRIC ASSAY FOR ALL ACTIVE FORMS OF VITAMIN-B-6 IN BIOLOGICAL-MATERIAL. 676-676.Web of Science: A1979GX28700365
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Letter
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2022Race as a moderator of the association between ethnicity, preeclampsia and neonatal respiratory distress syndromeFull Text via DOI: 10.1007/s12519-022-00571-z Web of Science: 000804525900001
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2019Residential Lead-Hazard Interventions, Childhood Anxiety, and Cognitive Impairment. 198-199.Full Text via DOI: 10.1001/jamapediatrics.2018.4710 Web of Science: 000457570600031
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2016The US Cancer Moonshot initiative. E178-E180.Full Text via DOI: 10.1016/S1470-2045(16)30054-7 Web of Science: 000374829800009
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2009Prenatal Lead Exposure and Schizophrenia: Further Evidence and More Neurobiological Connections. A190-A191.Full Text via DOI: 10.1289/ehp.0800484 Web of Science: 000265721300005
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2004Prenatal lead exposure and schizophrenia: A plausible neurobiologic connection. A724-A724.Full Text via DOI: 10.1289/ehp.112-a724a Web of Science: 000224547000002
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1993IS 3-HYDROXYKYNURENINE AN ENDOGENOUS NEUROTOXIN IN HUNTINGTONS-DISEASE. 227-228.Full Text via DOI: 10.1016/0022-510X(93)90330-2 Web of Science: A1993LF86300016
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1983MICROBIOLOGICAL ASSAYS OF TOTAL VITAMIN-B-6 USING THE YEASTS SACCHAROMYCES-UVARUM AND KLOECKERA-BREVIS. 721-722.Full Text via DOI: 10.1093/jn/113.3.721 Web of Science: A1983QF95700030
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1980RE - A RADIOMETRIC MICROBIOLOGIC ASSAY FOR THE BIOLOGICALLY-ACTIVE FORMS OF NIACIN - REPLY. 1206-1206.Web of Science: A1980KT67900028
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Note
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1993CHRONIC PRENATAL AND POSTNATAL PB2+ EXPOSURE INCREASES [H-3] MK8O1 BINDING-SITES IN ADULT-RAT FOREBRAIN. 273-275.Full Text via DOI: 10.1016/0926-6917(93)90054-T Web of Science: A1993ME08900008
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1983A SIMPLE RADIOMETRIC INVITRO ASSAY FOR ACETYLCHOLINESTERASE INHIBITORS. 90-92.Full Text via DOI: 10.1002/jps.2600720123 Web of Science: A1983PY09600023
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Other Scholarly Work
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2016Neurochemistry of lead and manganese. 561-562.Full Text via DOI: 10.1039/c6mt90017h Web of Science: 000379593600001
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2015Early life lead exposure and schizophrenia neuropathology: Effects on parvalbumin-positive GABAergic interneurons and subcortical dopaminergic activity. 116-117.Full Text via DOI: 10.1016/j.ntt.2015.04.058 Web of Science: 000357142700062
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2014Biomarker and more: can translocator protein 18 kDa predict recovery from brain injury and myocarditis?. 605-607.Full Text via DOI: 10.2217/BMM.14.46 Web of Science: 000341015700001
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2014Erratum: Mechanisms of lead and manganese neurotoxicity (Toxicology Research (2013) 2 (99-114) DOI: 10.1039/c2tx20064c). 400-401.Full Text via DOI: 10.1039/C4TX90012J
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2007Research explains how lead exposure produces learning deficits. 58-59.Web of Science: 000250098800010
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1996Breastmilk micronutrient concentrations in HIV infection. 2883-2883.Web of Science: A1996TZ28402884
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Preprint
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Review
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2020Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. 1086-1096.Full Text via DOI: 10.1038/s41386-020-0648-5 Web of Science: 000519155800001
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2019TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward. 44-58.Full Text via DOI: 10.1016/j.pharmthera.2018.09.003 Web of Science: 000457951500003
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2016TSPO Finds NOX2 in Microglia for Redox Homeostasis. 334-343.Full Text via DOI: 10.1016/j.tips.2016.02.008 Web of Science: 000375822600002
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2015Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson's Disease: Environmental and Genetic Evidence. 204-212.Full Text via DOI: 10.1093/toxsci/kfv099 Web of Science: 000359630300001
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2013Mechanisms of lead and manganese neurotoxicity. 99-114.Full Text via DOI: 10.1039/c2tx20064c Web of Science: 000317586200002
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2012Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses. 560-574.Full Text via DOI: 10.1016/j.neuro.2011.11.008 Web of Science: 000304730100035
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2011
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2010Manganese and Parkinson's Disease: A Critical Review and New Findings. 1071-1080.Full Text via DOI: 10.1289/ehp.0901748 Web of Science: 000280583500020
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2009Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates. 325-332.Full Text via DOI: 10.1289/ehp.0800035 Web of Science: 000263933600016
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2008Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair. 1-17.Full Text via DOI: 10.1016/j.pharmthera.2007.12.004 Web of Science: 000256240900001
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2007Manganese: Recent advances in understanding its transport and neurotoxicity. 131-147.Full Text via DOI: 10.1016/j.taap.2007.03.001 Web of Science: 000246993200001
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2006Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. 402-409.Full Text via DOI: 10.1016/j.tips.2006.06.005 Web of Science: 000239886300002
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2005Lead neurotoxicity: From exposure to molecular effects. 529-554.Full Text via DOI: 10.1016/j.brainresrev.2005.02.004 Web of Science: 000233516300006
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1993VITAMIN-B6 AND COGNITIVE-DEVELOPMENT - RECENT RESEARCH FINDINGS FROM HUMAN AND ANIMAL STUDIES. 193-198.Web of Science: A1993LP90400001
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1992VITAMIN B-6, KYNURENINES, AND CENTRAL-NERVOUS-SYSTEM FUNCTION - DEVELOPMENTAL ASPECTS. 618-632.Full Text via DOI: 10.1016/0955-2863(92)90081-S Web of Science: A1992KB46800001
Research
principal investigator on
- Peripheral BDZ Receptor A Biomarker of Neurotoxicity awarded by Environmental Health Sciences 2019 - 2024
- Cholinergic Neuron Degeneration in Mn Neurotoxicity awarded by Environmental Health Sciences 2018 - 2022
- NMDA Receptor Function in Lead Neurotoxicity awarded by Environmental Health Sciences 2016 - 2021
- Development of GHRH antagonist as therapy for Alzheimer's Disease awarded by Neuroscience Centers of Florida Foundati 2017 - 2020
- TSPO Analysis of Rodents Exposed to N-Butylbenzenesulfonamide (NBBS) as a Biomarker of Neuroinflammation awarded by Environmental Health Sciences 2018 - 2020
- Peripheral BDZ Receptor Biomarker of Neurontoxicity awarded by Environmental Health Sciences 2016 - 2019
- TSPO Analysis on TPP/IPP studies awarded by Battelle Memorial Institute 2017 - 2019
- Presynaptic Mechanisms of Lead Neurotoxicity awarded by Environmental Health Sciences 2016 - 2018
- Molecular and Behavioral Effects of Low Level Manganese Exposure awarded by Environmental Health Sciences 2016
subproject principal investigator on
investigator on
Videos
videos
Contact
full name
- Tomas Guilarte
Identifiers
ORCID iD
- https://orcid.org/0000-0002-5376-6347 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in