Hossain, Muhammad
- Assistant Professor, Environmental Health Sciences , Robert Stempel College of Public Health and Social Work

Overview
overview
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Dr. Muhammad Hossain is a Veterinarian and Neurotoxicologist with advanced training in pharmacology and molecular neuroscience. Before joining Florida International University, he was an Assistant Professor in the Department of Pharmaceutical Sciences at Northeast Ohio Medical University. After completion of Doctor of Veterinary Medicine (DVM), Dr. Hossain pursued MS in pharmacology and PhD in neurotoxicology and received postdoctoral training in molecular neuroscience and neurotoxicology at Mississippi State University and Rutgers-Robert Wood Johnson Medical School. Dr. Hossain has been working in the field of environmental neurotoxicology and molecular neuroscience for over 14 years and has extensive experience in pesticide neurotoxicity. Dr. Hossain received several awards and honors, including the Japanese Government Scholarship (MONBUSHO), the Faculty Fund Fellowship, and the Society of Toxicology (SOT) Mechanisms Specialty Section Travel Award. He is an active member of SOT and a regular reviewer for several scientific journals. Dr. Hossain served on the US Environmental Protection Agency FIFRA Scientific Advisory Panel in 2015 and Chemical Safety Advisory Sub-committee in 2016. His current research investigates the molecular and cellular mechanisms of neurotoxicity underlying the disruption of adult neurogenesis and cognitive dysfunction and targeting new therapeutic approaches to improve hippocampal neurogenesis and ameliorate cognitive deficits in humans. Dr. Hossain recently awarded R01 grant (5R01ES027481) from NIH/NIEHS.
LAB
The goals of Hossain Lab are to (a) determine the role of environmental toxicants and genetic susceptibility in the etiology and pathogenesis of neurodegenerative diseases (b) investigate the potential for environmental exposures, adult neurogenesis, and learning and memory, (c) determine the mechanistic links between ER-stress, neuroinflammation, disruption of hippocampal neurogenesis, and cognitive dysfunction, and (d) develop animal and cell-based models to study neurological disease and dysfunction caused by environmental exposures and test therapeutic agents in these models.
His Lab uses in vitro cell culture models to in vivo animal models with a combination of cutting-edge techniques including morphological, behavioral, genetic, and pharmacological approaches. His research program is funded by the grants from National Institutes of Health (NIH).
research interests
- ER-stress and Neuroinflammation, Adult Neurogenesis, and Learning and Memory
Scholarly & Creative Works
selected publications
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Article
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2020Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in MiceFull Text via DOI: 10.1093/toxsci/kfaa144 Web of Science: 000608394200011
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2020Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal NeuronsFull Text via DOI: 10.1093/toxsci/kfz239 Web of Science: 000535691100014
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2019Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to DeltamethrinFull Text via DOI: 10.1093/toxsci/kfy238 Web of Science: 000462862400022
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2018The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Na-v 1.6Full Text via DOI: 10.1016/j.expneurol.2018.07.005 Web of Science: 000442714900011
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2017Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium ChannelsFull Text via DOI: 10.1093/toxsci/kfw187 Web of Science: 000397041300010
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2015Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDDFull Text via DOI: 10.1016/j.ntt.2015.06.003 Web of Science: 000367108400007
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2015Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma CellsFull Text via DOI: 10.1007/s11064-015-1601-6 Web of Science: 000357509700006
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2015Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorderFull Text via DOI: 10.1096/fj.14-260901 Web of Science: 000354114600030
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2015Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin ReductaseFull Text via DOI: 10.1124/jpet.114.221572 Web of Science: 000351036400012
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2015Hippocampal ER Stress and Learning Deficits Following Repeated Pyrethroid ExposureFull Text via DOI: 10.1093/toxsci/kfu226 Web of Science: 000350101700023
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2014Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: Role of altered catecholamines and BDNFFull Text via DOI: 10.1016/j.expneurol.2014.01.016 Web of Science: 000333321300015
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2014Elevated Serum Pesticide Levels and Risk for Alzheimer DiseaseFull Text via DOI: 10.1001/jamaneurol.2013.6030 Web of Science: 000332831600005
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2013Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegenerationFull Text via DOI: 10.1073/pnas.1318830110 Web of Science: 000327390400093
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2013Acute Effects of Pyrethroids on Serotonin Release in the Striatum of Awake Rats: An In Vivo Microdialysis StudyFull Text via DOI: 10.1002/jbt.21450 Web of Science: 000315188700006
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2012Inflammatory Regulation of ATP Binding Cassette Efflux Transporter Expression and Function in MicrogliaFull Text via DOI: 10.1124/jpet.112.196543 Web of Science: 000311099300012
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2011Mechanism of Pyrethroid Pesticide-Induced Apoptosis: Role of Calpain and the ER Stress PathwayFull Text via DOI: 10.1093/toxsci/kfr111 Web of Science: 000293914500026
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Conference
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2003Neurotoxicity and Brain Regional Distribution of Manganese in Mice. 679-689.Full Text via DOI: 10.1081/TXR-120026921
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Other Scholarly Work
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2019"Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin" (vol 167, pg 249, 2019). 281-281.Full Text via DOI: 10.1093/toxsci/kfy305 Web of Science: 000462865100026
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2014Repeated deltamethrin exposure causes cognitive deficits in mice: Role of ER stress and Impaired Neurogenesis. 89-89.Full Text via DOI: 10.1016/j.ntt.2014.04.044 Web of Science: 000338621800051
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2005Erratum: Neurotoxicity and brain regional distribution of manganese in mice (Toxin Reviews (2003) 22:4 (679-689)). 556-557.Full Text via DOI: 10.1081/TXR-200038428
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Preprint
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Review
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2013Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson's DiseaseFull Text via DOI: 10.1155/2013/587418 Web of Science: 000326757300001
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Research
principal investigator on
- Pesticide Exposure and Adult Neurogenesis: Role of ER Stress awarded by Environmental Health Sciences 2018 - 2022
investigator on
- Advanced Development of Drugs to Mitigate Parathion Intoxication awarded by Neurological Disorders and Stroke 2021 - 2022
- Advanced Development of Drugs to Mitigate Parathion Intoxication awarded by Neurological Disorders and Stroke 2018 - 2021
Contact
full name
- Muhammad Hossain
Identifiers
ORCID iD
- https://orcid.org/0000-0003-1210-7350 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in