Hutcheson, Joshua
- Assistant Professor, Biomedical Engineering , College of Engineering and Computing

Overview
overview
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Dr. Joshua Hutcheson joined the Department of Biomedical Engineering at Florida International University in August 2016. He is also an active member of the Biomolecular Science Institute at FIU. Prior to joining FIU, Dr. Hutcheson worked as a research fellow at Brigham and Women’s Hospital and Harvard Medical School within the Center for Interdisciplinary Cardiovascular Sciences. Dr. Hutcheson completed his Ph.D. in Biomedical Engineering at Vanderbilt University and received his B.S. and M.S. in Chemical Engineering from the Georgia Institute of Technology.
Dr. Hutcheson is passionate about teaching and researching the mechanisms of cardiovascular tissue maintenance and remodeling. His research focuses on the mechanical and molecular contributors to vascular calcification and aortic valve disease, and he is working on developing non-invasive techniques to diagnose and treat these pathologies. Dr. Hutcheson is co-founder of Thirst for Science and the Miami Heart Month, which seek to increase science enthusiasm and literacy. He also directs the Coulter Undergraduate Research Excellence (CURE) Program, which provides research and mentorship opportunities to undergraduate students in Biomedical Engineering.
research interests
- Cardiovascular disease and mechanobiology, Cell-cell and cell-matrix interactions, Tissue engineering, Molecular imaging
Scholarly & Creative Works
selected publications
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Article
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2022The Time-Dependent Role of Bisphosphonates on Atherosclerotic Plaque CalcificationFull Text via DOI: 10.3390/jcdd9060168 Web of Science: 000816404400001
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2022S2 Heart Sound Detects Aortic Valve Calcification Independent of Hemodynamic Changes in MiceFull Text via DOI: 10.3389/fcvm.2022.809301 Web of Science: 000807820700001
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2021Pigmentation Affects Elastic Fiber Patterning and Biomechanical Behavior of the Murine Aortic ValveFull Text via DOI: 10.3389/fcvm.2021.754560 Web of Science: 000743549800001
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2021A surface-based calibration approach to enable dynamic and accurate quantification of colorimetric assay systemsFull Text via DOI: 10.1039/d1ay01130h Web of Science: 000693153100001
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2021Elastogenesis Correlates With Pigment Production in Murine Aortic Valve LeafletsFull Text via DOI: 10.3389/fcvm.2021.678401 Web of Science: 000669668000001
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2021Constitutive Properties of Mitral Valve Tissues via NanoindentationFull Text via DOI: 10.1080/24748706.2021.1901492
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2021Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretionFull Text via DOI: 10.1093/cvr/cvab034 Web of Science: 000705424900016
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2021ApoC-III is a novel inducer of calcification in human aortic valvesFull Text via DOI: 10.1074/jbc.RA120.015700 Web of Science: 000672866400171
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2020A Method to Quantify Tensile Biaxial Properties of Mouse Aortic Valve LeafletsFull Text via DOI: 10.1115/1.4046921 Web of Science: 000613295700001
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2020Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like DepositsFull Text via DOI: 10.3390/cells9102164 Web of Science: 000584223600001
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2019Toxicity assessment of wearable wound sensor constituents on keratinocytesFull Text via DOI: 10.1016/j.tiv.2019.03.034 Web of Science: 000472589900019
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2019Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic FlexureFull Text via DOI: 10.3390/bioengineering6020039 Web of Science: 000475298500012
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2018Uricase Based Enzymatic Biosensor for Non-invasive Detection of Uric Acid by Entrapment in PVA-SbQ Polymer MatrixFull Text via DOI: 10.1002/elan.201800360 Web of Science: 000446660400022
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2018P5090Sortilin is a key driver of fibrocalcific aortic valve diseaseFull Text via DOI: 10.1093/eurheartj/ehy566.p5090
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2018Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving DiseaseFull Text via DOI: 10.1161/CIRCULATIONAHA.117.032291 Web of Science: 000439571700008
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2018In Silico Investigations of Calcium Phosphate Mineralization in Extracellular VesiclesFull Text via DOI: 10.1021/acs.jpcb.8b00169 Web of Science: 000430641900011
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2017Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative StressFull Text via DOI: 10.1161/CIRCRESAHA.116.310293 Web of Science: 000405893400009
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2017Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in MenFull Text via DOI: 10.1161/ATVBAHA.116.308932 Web of Science: 000401939000037
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2016Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease DevelopmentFull Text via DOI: 10.3389/fcvm.2016.00044 Web of Science: 000407027200001
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2016Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and InflammationFull Text via DOI: 10.3791/54017 Web of Science: 000380259900071
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2016Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiationFull Text via DOI: 10.1016/j.yjmcc.2016.03.004 Web of Science: 000376839000003
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2016Sortilin mediates vascular calcification via its recruitment into extracellular vesiclesFull Text via DOI: 10.1172/JCI80851 Web of Science: 000373522300024
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2016Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaquesFull Text via DOI: 10.1038/nmat4519 Web of Science: 000370967400020
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2016Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial HypertensionFull Text via DOI: 10.1371/journal.pone.0148657 Web of Science: 000370046600092
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2015Valvular interstitial cells suppress calcification of valvular endothelial cellsFull Text via DOI: 10.1016/j.atherosclerosis.2015.07.008 Web of Science: 000360100900040
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2015Directing Valvular Interstitial Cell Myofibroblast-Like Differentiation in a Hybrid Hydrogel PlatformFull Text via DOI: 10.1002/adhm.201400029 Web of Science: 000347540100014
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2014Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocolFull Text via DOI: 10.3402/jev.v3.25129 Web of Science: 000215617200014
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2013Cadherin-11 Regulates Cell-Cell Tension Necessary for Calcific Nodule Formation by Valvular MyofibroblastsFull Text via DOI: 10.1161/ATVBAHA.112.300278 Web of Science: 000312392500018
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20125-HT2B antagonism arrests non-canonical TGF-beta 1-induced valvular myofibroblast differentiationFull Text via DOI: 10.1016/j.yjmcc.2012.08.012 Web of Science: 000310394200015
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2012Intracellular Ca2+ accumulation is strain-dependent and correlates with apoptosis in aortic valve fibroblastsFull Text via DOI: 10.1016/j.jbiomech.2011.11.031 Web of Science: 000302040800021
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2010An electrically active microneedle array for electroporationFull Text via DOI: 10.1007/s10544-009-9381-x Web of Science: 000275459800009
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2010CHANGES IN CELL MORPHOLOGY DUE TO PLASMA MEMBRANE WOUNDING BY ACOUSTIC CAVITATIONFull Text via DOI: 10.1016/j.ultrasmedbio.2010.01.010 Web of Science: 000278012500016
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Book
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Book Chapter
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2020Calcifying Extracellular Vesicles: Biology, Characterization, and Mineral Formation. 97-116.Full Text via DOI: 10.1007/978-3-030-46725-8_5
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2020The History of Cardiovascular Calcification. 3-11.Full Text via DOI: 10.1007/978-3-030-46725-8_1
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2019Calcific aortic valve disease: Pathobiology, basic mechanisms, and clinical strategies. 153-179.Full Text via DOI: 10.1007/978-3-030-01993-8_7
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2017Comprehensive Biomaterials: Immunohistochemistry. 387-405.Full Text via DOI: 10.1016/b978-0-12-803581-8.09828-3
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2015Optical molecular imaging of inflammation and calcification in atherosclerosis. 107-120.Full Text via DOI: 10.1007/978-3-319-09268-3_5
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2015Pathobiology and optical molecular imaging of calcific aortic valve disease. 185-200.Full Text via DOI: 10.1007/978-3-319-09268-3_9
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2014Pathobiology and Optical Molecular Imaging of Calcific Aortic Valve Disease. 187-199.Full Text via DOI: 10.1007/978-3-319-09268-3_9
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2011Mechanobiology of heart valves. 107-126.
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Conference
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2021Synthetic photoplethysmographic waveform at the radial artery. 6.Full Text via DOI: 10.1117/12.2578951
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2020Flap Endonuclease 1 Cleaves RNAs to Resolve R-loops Through DNA Base Excision Repair.. 51-52.Web of Science: 000571638700086
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2020Flap Endonuclease 1 Cleaves RNAs to Resolve R-loops Through DNA Base Excision Repair.. 71-72.Web of Science: 000571638700153
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2019Computational Study of Calcium Phosphate Mineralization in Extracellular Vesicles. 572A-572A.Full Text via DOI: 10.1016/j.bpj.2018.11.3075 Web of Science: 000460779802874
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2018Sortilin is a key driver of fibrocalcific aortic valve disease. 1057-1057.Web of Science: 000459824003334
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20125-HT2B antagonism inhibits strain- and cytokine-dependent formation of calcific nodules by aortic valve interstitial cells. 1039-1040.Full Text via DOI: 10.1115/SBC2012-80496
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2011Strain and substrate stiffness affect calcium accumulation in aortic valve interstitial cells. 1209-1210.Full Text via DOI: 10.1115/SBC2011-53611
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2010Controlling the mechanical myofibroblast via SRC: A potential drug discovery platform. 345-346.Full Text via DOI: 10.1115/SBC2010-19187
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2010Serotonin antagonists prevent cytokine and mechanical activation of aortic valve interstitial cells. 279-280.Full Text via DOI: 10.1115/SBC2010-19389
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Other Scholarly Work
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2022The Developmental Origin of Calcific Aortic Stenosis. 1372-1374.Full Text via DOI: 10.1056/NEJMcibr2200439 Web of Science: 000805040200015
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2021Editorial: Extracellular Matrix for Cardiovascular ReconstructionFull Text via DOI: 10.3389/fcvm.2021.664803 Web of Science: 000641975300001
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2020Oscillatory fluid-induced mechanobiology in heart valves with parallels to the vasculature.. R59-R71.Full Text via DOI: 10.1530/vb-19-0031
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2019Exploring the Frontiers of Regenerative Cardiovascular MedicineFull Text via DOI: 10.3389/fcvm.2019.00013 Web of Science: 000467190900001
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2017Giving Calcification Its Due: Recognition of a Diverse Disease A First Attempt to Standardize the Field. 270-273.Full Text via DOI: 10.1161/CIRCRESAHA.116.310060 Web of Science: 000392226200009
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2013International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013)Full Text via DOI: 10.3402/jev.v2i0.23070 Web of Science: 000215615100017
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Preprint
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Review
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2021Dissecting Calcific Aortic Valve Disease-The Role, Etiology, and Drivers of Valvular FibrosisFull Text via DOI: 10.3389/fcvm.2021.660797 Web of Science: 000653061900001
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2018Extracellular vesicles in cardiovascular homeostasis and disease. 290-297.Full Text via DOI: 10.1097/HCO.0000000000000510 Web of Science: 000430139900005
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2017Extracellular Vesicles As Mediators of Cardiovascular CalcificationFull Text via DOI: 10.3389/fcvm.2017.00078 Web of Science: 000426128700001
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2016Extracellular vesicles in cardiovascular calcification: expanding current paradigms. 2895-2903.Full Text via DOI: 10.1113/JP271338 Web of Science: 000379188400016
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2016Zooming in on the genesis of atherosclerotic plaque microcalcifications. 2915-2927.Full Text via DOI: 10.1113/JP271339 Web of Science: 000379188400018
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2015Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach. 68-77.Full Text via DOI: 10.1016/j.semcdb.2015.09.004 Web of Science: 000366137400009
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2015Cardiovascular calcification: current controversies and novel concepts. 207-212.Full Text via DOI: 10.1016/j.carpath.2015.03.002 Web of Science: 000355449100002
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2014Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability. 327-332.Full Text via DOI: 10.1097/MOL.0000000000000105 Web of Science: 000341836600001
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2014Potential drug targets for calcific aortic valve disease. 218-231.Full Text via DOI: 10.1038/nrcardio.2014.1 Web of Science: 000333335600005
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2013MicroRNA in Cardiovascular Calcification Focus on Targets and Extracellular Vesicle Delivery Mechanisms. 1073-1084.Full Text via DOI: 10.1161/CIRCRESAHA.113.300937 Web of Science: 000316858400012
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2011Serotonin receptors and heart valve disease-It was meant 2B. 146-157.Full Text via DOI: 10.1016/j.pharmthera.2011.03.008 Web of Science: 000295433700002
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Research
principal investigator on
- Targeting the Caveolae-Dependent Mechanism of Calcifying Extracellular Vesicle Formation awarded by National Heart, Lung, & Blood Institute 2021 - 2026
- Correlating Aortic Valve Structure to Heart Sound Characteristic awarded by National Heart, Lung, & Blood Institute 2020 - 2023
- Aortic Valve Leaflet Innervation in Tissue Mechanics and Disease Progression awarded by Florida Heart Research Foundation Inc 2021 - 2022
- Aortic Valve Leaflet Innervation in Tissue Mechanics and Disease Progression awarded by Florida Heart Research Foundation Inc 2020 - 2022
- Development of a Biosensing Platform for Vascular Calcification awarded by National Science Foundation 2017 - 2022
- I-Corps: Cardiacoustics: AI-based Heart Sound Screening for Early-Stage Heart Disease awarded by National Science Foundation 2020 - 2022
- A Novel Small Molecule Therapy for Late-Stage Atherosclerosis awarded by Florida Heart Research Foundation Inc 2021 - 2022
- Tracing the Therapeutic Efficacy of Bisphosphonates in Bone and Vascular Mineralization awarded by American Heart Association 2017 - 2020
co-principal investigator on
Contact
full name
- Joshua Hutcheson
Identifiers
ORCID iD
- https://orcid.org/0000-0002-8383-4435 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in