Overview
overview
- My research group is interested in identifying genes involved in neural crest development expression and functional analysis of transcription factors and signaling pathways that play a role in melanocyte and Schwann cell development. We are interested to determine intrinsic and extrinsic factors that control melanocyte development, melanoma generation and metastasis.
research interests
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Identifying genes involved in neural crest development expression and functional analysis of transcription factors and signaling pathways that play a role in melanocyte and Schwann cell development
Determining the intrinsic and extrinsic factors that control melanocyte development, melanoma generation and metastasis.
Neural Crest Development: Genes mutated in neurocristopathies such as Hirschprung's Disease and Waardenburg syndrome
My research group is interested in identifying genes involved in neural crest development expression and functional analysis of transcription factors and signaling pathways that play a role in melanocyte and Schwann cell development. We are interested to determine intrinsic and extrinsic factors that control melanocyte development, melanoma generation and metastasis.
Scholarly & Creative Works
selected publications
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Article
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2021Pigmentation Affects Elastic Fiber Patterning and Biomechanical Behavior of the Murine Aortic ValveFull Text via DOI: 10.3389/fcvm.2021.754560 Web of Science: 000743549800001
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2021The immunosuppressive role of Edn3 overexpression in the melanoma microenvironmentFull Text via DOI: 10.1111/pcmr.13002 Web of Science: 000679122600001
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2021Elastogenesis Correlates With Pigment Production in Murine Aortic Valve LeafletsFull Text via DOI: 10.3389/fcvm.2021.678401 Web of Science: 000669668000001
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2020Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assaysFull Text via DOI: 10.1038/s41598-020-75890-0 Web of Science: 000589618700022
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2020Simultaneous mapping of nanoscale topography and surface potential of charged surfaces by scanning ion conductance microscopyFull Text via DOI: 10.1039/d0nr04555a Web of Science: 000581650100016
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2020Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic SitesFull Text via DOI: 10.1016/j.celrep.2020.107765 Web of Science: 000541973800008
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2015The transcription factors Ets1 and Sox10 interact during murine melanocyte developmentFull Text via DOI: 10.1016/j.ydbio.2015.04.012 Web of Science: 000366068100011
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2012Specifying and Sustaining Pigmentation Patterns in Domestic and Wild CatsFull Text via DOI: 10.1126/science.1220893 Web of Science: 000308912900051
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2011Quantification of carbon nanotube induced adhesion of osteoblast on hydroxyapatite using nano-scratch techniqueFull Text via DOI: 10.1088/0957-4484/22/35/355703 Web of Science: 000294716900011
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2011Wear behavior and in vitro cytotoxicity of wear debris generated from hydroxyapatite-carbon nanotube composite coatingFull Text via DOI: 10.1002/jbm.a.32952 Web of Science: 000285041400001
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2010Structural and functional characterization of the mouse tescalcin promoterFull Text via DOI: 10.1016/j.gene.2010.06.002 Web of Science: 000281096300006
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2009Melanocyte pigmentation stiffens murine cardiac tricuspid valve leafletFull Text via DOI: 10.1098/rsif.2009.0174 Web of Science: 000270143300012
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2009Carbon Nanotube Reinforced Polylactide-Caprolactone Copolymer: Mechanical Strengthening and Interaction with Human Osteoblasts in VitroFull Text via DOI: 10.1021/am900423q Web of Science: 000272039700009
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2008Timeline and distribution of melanocyte precursors in the mouse heartFull Text via DOI: 10.1111/j.1755-148X.2008.00459.x Web of Science: 000257571300009
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2008Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse modelFull Text via DOI: 10.1038/sj.jid.5700948 Web of Science: 000251613600018
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2005Endothelin-1 and neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouseFull Text via DOI: 10.1002/dvdy.20284 Web of Science: 000228473800002
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2003Role of Pax genes in eye evolution: A cnidarian PaxB gene uniting Pax2 and Pax6 functionsFull Text via DOI: 10.1016/S1534-5807(03)00325-3 Web of Science: 000186544400014
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2001J3-crystallin of the jellyfish lens: Similarity to saposinsFull Text via DOI: 10.1073/pnas.231310698 Web of Science: 000171806100016
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1998Sox10 mutation disrupts neural crest development in Dom hirschsprung mouse modelFull Text via DOI: 10.1038/ng0198-60
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1998Endothelin signalling in the development of neural crest-derived melanocytesFull Text via DOI: 10.1139/o99-006
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1997Eyes absent: A gene family found in several metazoan phylaFull Text via DOI: 10.1007/s003359900480
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1993
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Book Chapter
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2003Molecular biology techniques and applications. 13-1-13-22.Full Text via DOI: 10.1201/9780203491492-21
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Conference
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2021
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2017Abstract 848: Netropsin blocks EMT of murine BRAF mutated melanoma cells. 848-848.Full Text via DOI: 10.1158/1538-7445.am2017-848
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2014Ultraviolet radiation induces carcinogenesis in a novel transgenic mouse model of melanomaFull Text via DOI: 10.1158/1538-7445.AM2014-5352 Web of Science: 000349910204271
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2013UV radiation interacts with Endothelin 3 and loss of nucleotide excision repair pathway to promote melanomagenesis.Full Text via DOI: 10.1158/1538-7445.AM2013-1276 Web of Science: 000331212902260
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2011Edn3 promotes metastasis and alters tumor heterogeneity in a mouse model of melanoma. 803-804.Web of Science: 000294019200171
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2011Ets1 interacts with Sox10 during murine melanocyte development. 778-778.Web of Science: 000294019200087
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2011
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2011The other ones: non-cutaneous melanocytes. 766-766.Web of Science: 000294019200050
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2008Neuregulin/ErbB3 signaling affects early melanocyte development. 310-310.Web of Science: 000255061700247
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Editorial Material
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2015Let's make it happen: For gender equality in science!. 641-642.Full Text via DOI: 10.1111/pcmr.12421
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Letter
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2014Novel UV-induced melanoma mouse model dependent on Endothelin3 signaling. 839-842.Full Text via DOI: 10.1111/pcmr.12281 Web of Science: 000341778700024
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Other Scholarly Work
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2013Role of endothelin 3 in melanoma progression and metastasisFull Text via DOI: 10.1158/1538-7445.AM2013-2819 Web of Science: 000331212905273
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Preprint
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Review
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2010The Untranslated Side of Hair and Skin Mammalian Pigmentation: Beyond Coding Sequences. 340-346.Full Text via DOI: 10.1002/iub.318 Web of Science: 000277602000003
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2010Roles of endothelin signaling in melanocyte development and melanoma. 160-170.Full Text via DOI: 10.1111/j.1755-148X.2010.00678.x Web of Science: 000275466400006
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Works By Students
chaired theses and dissertations
- Pino, Javier, Transgneic Endothelin 3 Regulates Murine Pigment Production and Coat Color 2017
- Li, Xiaoshuang, Identification and Phenotypic Plasticity of Metastatic Cells in a Mouse Model of Melanoma 2017
- Chin, Nikeisha L, The Role of Endothelin 3 in Melanoma Progression and Metastasis 2015
- Afjei, Feng, A Content Analysis of Sustainability Dimensions in Annual Reports 2015
- Benaduce, Ana Paula, UV-Induced Melanoma Mouse Model Dependent on Endothelin 3 Over-Expression 2014
- Tavares, Amy Saldana, The Role of the Transcription Factor Ets1 in Melanocyte Development 2014
- Lowenstein, Marcia, Interactions between Endothelin Receptor B and Transcription Factors Sox10 and Pax3 in the Melanocyte Lineage 2009
- Brito, Flavia Carneiro, Melanocytes in the developing and adult atrioventricular valves of the murine heart 2008
- Fernandez, Irina, The role of ErbB3 in melanocyte development 2006
- Ayala, Aniveny, Identification of genes downstream of endothelin-3 signaling: characterization of WSB1 and SPC12 2001
advised honors theses
- Abujamra, Beatriz Abdo, Elastogenesis in developing murine aortic valve 2019
- Lopez, Jesus R., Over-expression of endothelin-3 increases tumor volume in a transgenic murine melanoma model 2019
- Durango, Alexander, Mechanism of Endothelin3 Regulation on Murine Coat Color 2018
- Torres, Raúl, Timing the Establishment of Metastatic Cell Intravasation in a Mouse Model of Melanoma 2018
- Garcia, Ruslan, Effects of Endothelin 3 on the Tumor-Angiogenic Response in a Novel Melanoma Mouse Model 2013
- Batista, Deannys, Over-Expression of Endothelin 3 Sensitizes Mice to Uv-Induced Melanoma Metastasis 2012
- Diaz, Denisse, Transgenic Expression of Endothelin Receptor-B Rescues the Aganglionosis Phenotype of Piebald Lethal Mice 2008
- won, Chulhan K, Cardiac Neural Crest Cells and Their Role in Murine Purkinje Fiber Development 2006
- Figueroa, Jessica, Inducible Overexpression of Endothelin-3 in a Transgenic Mouse Leads to Hyperpigmentation That Decreases Over Time 2006
- Prado, Jose R. Morillo, Expression of the Myod and T-Box Families of Transcription Factors in the Developing Purkinje Fiber 2005
- Piloto, Sarah, Analysis of the Expression Pattern of Wnt Receptor Frizzled 3 2004
- Salazar, Armando, Mus Musculus Neural Crest Development: Is Pax3 Regulating the Expression of Endothelin Receptor B? 2002
Research
principal investigator on
- The AGEP Florida Alliance Model: Improving Pathways in the Professoriate for Academic Minority Women in STEM awarded by National Science Foundation 2019 - 2023
- Phenotypic and functional characterization of neural crest derived aortic valve interstitial cells awarded by Florida Heart Research Foundation Inc 2018 - 2021
- The role of metabotropic glutamate receptor 1 signaling in leptomeningeal melanoma awarded by National Cancer Institute 2016 - 2018
- The Role of Ets1 in Melanocyte Development awarded by Arthritis & Musculoskeletal & Skin Disea 2012 - 2016
- Bridge Funding for Dr. Lidia Kos awarded by FIU Office of Research and Economic Deve 2011 - 2012
- Generation of a UV-Dependent Mouse Model of Melanoma. awarded by General Medical Sciences 2008 - 2012
co-principal investigator on
- Transdisciplinary Training in Biomolecular and Biomedical Sciences awarded by General Medical Sciences 2019 - 2024
- LSAMP BD: Florida International University FGLSAMP awarded by National Science Foundation 2018 - 2021
investigator on
- Florida International University MARC U*STAR Program awarded by General Medical Sciences 2019 - 2024
Contact
full name
- Lidia Kos
Identifiers
ORCID iD
- https://orcid.org/0000-0002-4106-695X (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in