Kos, Lidia
Contact Info
Overview
overview
- My research group is interested in identifying genes involved in neural crest development expression and functional analysis of transcription factors and signaling pathways that play a role in melanocyte and Schwann cell development. We are interested to determine intrinsic and extrinsic factors that control melanocyte development, melanoma generation and metastasis.
Scholarly & Creative Works
selected publications
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Article
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2020Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. SCIENTIFIC REPORTS. 10.Full Text via DOI: 10.1038/s41598-020-75890-0 Web of Science: 000589618700022
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2020Simultaneous mapping of nanoscale topography and surface potential of charged surfaces by scanning ion conductance microscopy. NANOSCALE. 12:20737-20748.Full Text via DOI: 10.1039/d0nr04555a Web of Science: 000581650100016
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2020Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites. CELL REPORTS. 31.Full Text via DOI: 10.1016/j.celrep.2020.107765 Web of Science: 000541973800008
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2015The transcription factors Ets1 and Sox10 interact during murine melanocyte development. DEVELOPMENTAL BIOLOGY. 407:300-312.
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2013Periodontal Ligament Cells Cultured Under Steady-Flow Environments Demonstrate Potential for Use in Heart Valve Tissue Engineering. TISSUE ENGINEERING PART A. 19:458-466.
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2012Specifying and Sustaining Pigmentation Patterns in Domestic and Wild Cats. SCIENCE. 337:1536-1541.
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2011Boron nitride nanotube reinforced hydroxyapatite composite: Mechanical and tribological performance and in-vitro biocompatibility to osteoblasts. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. 4:44-56.
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2011Wear behavior and in vitro cytotoxicity of wear debris generated from hydroxyapatite-carbon nanotube composite coating. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 96A:1-12.
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2009Carbon Nanotube Reinforced Polylactide-Caprolactone Copolymer: Mechanical Strengthening and Interaction with Human Osteoblasts in Vitro. ACS APPLIED MATERIALS & INTERFACES. 1:2470-2476.
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2009Melanocyte pigmentation stiffens murine cardiac tricuspid valve leaflet. JOURNAL OF THE ROYAL SOCIETY INTERFACE. 6:1097-1102.
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2008Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 128:131-142.
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2008Timeline and distribution of melanocyte precursors in the mouse heart. PIGMENT CELL & MELANOMA RESEARCH. 21:464-470.
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2005Endothelin-1 and neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouse. DEVELOPMENTAL DYNAMICS. 233.Full Text via DOI: 10.1002/dvdy.20284 Web of Science: 000228473800002
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2003Role of Pax genes in eye evolution: A cnidarian PaxB gene uniting Pax2 and Pax6 functions. DEVELOPMENTAL CELL. 5.Full Text via DOI: 10.1016/S1534-5807(03)00325-3 Web of Science: 000186544400014
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2001J3-crystallin of the jellyfish lens: Similarity to saposins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 98.Full Text via DOI: 10.1073/pnas.231310698 Web of Science: 000171806100016
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2001Tescalcin, a novel gene encoding a putative EF-hand Ca2+-binding protein, Col9a3, and renin are expressed in the mouse testis during the early stages of gonadal differentiation. ENDOCRINOLOGY. 142.Full Text via DOI: 10.1210/en.142.1.455 Web of Science: 000166308700052
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Book Chapter
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Letter
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2014Novel UV-induced melanoma mouse model dependent on Endothelin3 signaling. PIGMENT CELL & MELANOMA RESEARCH. 839-842.
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Meeting Abstract
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2014Ultraviolet radiation induces carcinogenesis in a novel transgenic mouse model of melanoma. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-5352 Web of Science: 000349910204271
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2011Edn3 promotes metastasis and alters tumor heterogeneity in a mouse model of melanoma. PIGMENT CELL & MELANOMA RESEARCH. 803-804.Web of Science: 000294019200171
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2011Ets1 interacts with Sox10 during murine melanocyte development. PIGMENT CELL & MELANOMA RESEARCH. 778-778.Web of Science: 000294019200087
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2011Melanocytes and melanoma cells present different mechanical properties that can be modulated by Endothelin 3. PIGMENT CELL & MELANOMA RESEARCH. 805-805.Web of Science: 000294019200175
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2011The other ones: non-cutaneous melanocytes. PIGMENT CELL & MELANOMA RESEARCH. 766-766.Web of Science: 000294019200050
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2008Committed melanocyte precursors reach the heart and persist in the atrioventricular valves in areas of Versican B and elastin expression. PIGMENT CELL & MELANOMA RESEARCH. 309-310.Web of Science: 000255061700246
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2008Neuregulin/ErbB3 signaling affects early melanocyte development. PIGMENT CELL & MELANOMA RESEARCH. 310-310.Web of Science: 000255061700247
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Publication
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Review
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2010Roles of endothelin signaling in melanocyte development and melanoma. PIGMENT CELL & MELANOMA RESEARCH. 160-170.
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2010The Untranslated Side of Hair and Skin Mammalian Pigmentation: Beyond Coding Sequences. IUBMB LIFE. 340-346.
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Works By Students
chaired theses and dissertations
- Pino, Javier, Transgneic Endothelin 3 Regulates Murine Pigment Production and Coat Color 2017
- Li, Xiaoshuang, Identification and Phenotypic Plasticity of Metastatic Cells in a Mouse Model of Melanoma 2017
- Chin, Nikeisha L, The Role of Endothelin 3 in Melanoma Progression and Metastasis 2015
- Afjei, Feng, A Content Analysis of Sustainability Dimensions in Annual Reports 2015
- Benaduce, Ana Paula, UV-Induced Melanoma Mouse Model Dependent on Endothelin 3 Over-Expression 2014
- Tavares, Amy Saldana, The Role of the Transcription Factor Ets1 in Melanocyte Development 2014
- Lowenstein, Marcia, Interactions between Endothelin Receptor B and Transcription Factors Sox10 and Pax3 in the Melanocyte Lineage 2009
- Brito, Flavia Carneiro, Melanocytes in the developing and adult atrioventricular valves of the murine heart 2008
- Fernandez, Irina, The role of ErbB3 in melanocyte development 2006
- Ayala, Aniveny, Identification of genes downstream of endothelin-3 signaling: characterization of WSB1 and SPC12 2001
advised honors theses
- Abujamra, Beatriz Abdo, Elastogenesis in developing murine aortic valve 2019
- Lopez, Jesus R., Over-expression of endothelin-3 increases tumor volume in a transgenic murine melanoma model 2019
- Durango, Alexander, Mechanism of Endothelin3 Regulation on Murine Coat Color 2018
- Torres, Raúl, Timing the Establishment of Metastatic Cell Intravasation in a Mouse Model of Melanoma 2018
- Garcia, Ruslan, Effects of Endothelin 3 on the Tumor-Angiogenic Response in a Novel Melanoma Mouse Model 2013
- Batista, Deannys, Over-Expression of Endothelin 3 Sensitizes Mice to Uv-Induced Melanoma Metastasis 2012
- Diaz, Denisse, Transgenic Expression of Endothelin Receptor-B Rescues the Aganglionosis Phenotype of Piebald Lethal Mice 2008
- won, Chulhan K, Cardiac Neural Crest Cells and Their Role in Murine Purkinje Fiber Development 2006
- Figueroa, Jessica, Inducible Overexpression of Endothelin-3 in a Transgenic Mouse Leads to Hyperpigmentation That Decreases Over Time 2006
- Prado, Jose R. Morillo, Expression of the Myod and T-Box Families of Transcription Factors in the Developing Purkinje Fiber 2005
- Piloto, Sarah, Analysis of the Expression Pattern of Wnt Receptor Frizzled 3 2004
- Salazar, Armando, Mus Musculus Neural Crest Development: Is Pax3 Regulating the Expression of Endothelin Receptor B? 2002
Research
research interests
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Identifying genes involved in neural crest development expression and functional analysis of transcription factors and signaling pathways that play a role in melanocyte and Schwann cell development
Determining the intrinsic and extrinsic factors that control melanocyte development, melanoma generation and metastasis.
Neural Crest Development: Genes mutated in neurocristopathies such as Hirschprung's Disease and Waardenburg syndrome
My research group is interested in identifying genes involved in neural crest development expression and functional analysis of transcription factors and signaling pathways that play a role in melanocyte and Schwann cell development. We are interested to determine intrinsic and extrinsic factors that control melanocyte development, melanoma generation and metastasis.
principal investigator on
- The role of metabotropic glutamate receptor 1 signaling in leptomeningeal melanoma awarded by National Institutes of Health 2016 - 2018
- The Role of Ets1 in Melanocyte Development awarded by National Institutes of Health 2012 - 2016
- Bridge Funding for Dr. Lidia Kos awarded by FIU Division of Research 2011 - 2012
- Generation of a UV-Dependent Mouse Model of Melanoma. awarded by National Institute of General Medical Sciences 2008 - 2012
co-principal investigator on
- LSAMP BD: Florida International University FGLSAMP awarded by National Science Foundation 2018 - 2020
Teaching
teaching activities
- BSC3941-U30: Biological Sciences Research Internship Fall Term 2019
- BSC4915-U20: Honors Research Fall Term 2019
- BSC6913-U22: Student Research Lab Fall Term 2019
- BSC6913-U22: Student Research Lab Spring Term 2019
Contact
full name
- Lidia Kos
Identifiers
ORCID iD
- https://orcid.org/0000-0002-4106-695X (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
Citation index-derived subject areas the researcher has published in