Yanhao Lai
- Postdoctoral Associate, Chemistry and Biochemistry , College of Arts, Sciences & Education
Overview
overview
- Yanhao obtained her BS and PhD degrees in Biomedical Sciences from West China School of Public Health, Sichuan University, China. Yanhao joined Dr. Liu's research group in 2014 as a postdoctoral fellow. Her research focuses on understanding the molecular mechanisms underlying trinucleotide repeat (TNR) instability associated with human neurodegeneration. Specifically, she has been studying TNR instability via base lesions and base excision repair (BER) and their interplay with chromatin structures. For the first time, she demonstrated that BER of a DNA base lesion located in different positions of a CTG repeat tract determines if the repeats are expanded or deleted. Furthermore, she has discovered that the crosstalk between BER and chromatin structures can predominantly shorten expanded GAA repeats that cause Friedreich’s ataxia (FA), suggesting that the coordination between BER and chromatin structures can be developed as a treatment for TNR expansion-related neurodegenerative diseases. Yanhao has published more than 20 research articles in peer-reviewed journals from her research in Dr. Liu’s group, including Nature Communication, Nucleic Acids Research, PLoS One, Cells, and DNA Repair. She received the 2015 Environmental Mutagenesis and Genomics Society Student and New Investigator Travel Award and 2018 FASEB Research Conference Travel Award.
Publications
selected publications
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Article
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2021Scanning Ion Conductance Microscopy Study Reveals the Disruption of the Integrity of the Human Cell Membrane Structure by Oxidative DNA Damage. ACS APPLIED BIO MATERIALS. 4:1632-1639.Full Text via DOI: 10.1021/acsabm.0c01461 Web of Science: 000620346200049
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2020R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities. JOURNAL OF BIOLOGICAL CHEMISTRY. 295:13902-13913.Full Text via DOI: 10.1074/jbc.RA120.014161 Web of Science: 000578444100016
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2020Dynamic single-cell intracellular pH sensing using a SERS-active nanopipette. ANALYST. 145:4852-4859.Full Text via DOI: 10.1039/d0an00838a Web of Science: 000548664800012
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2020N-6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation. ENVIRONMENTAL POLLUTION. 259.Full Text via DOI: 10.1016/j.envpol.2019.113908 Web of Science: 000528534600030
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2020Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. SCIENTIFIC REPORTS. 10.Full Text via DOI: 10.1038/s41598-020-60849-y Web of Science: 000562886900005
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2020Inhibition of base excision repair by natamycin suppresses prostate cancer cell proliferation. BIOCHIMIE. 168:241-250.Full Text via DOI: 10.1016/j.biochi.2019.11.008 Web of Science: 000503444300022
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2020Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase beta and a de novo DNA Methyltransferase. CELLS. 9.Full Text via DOI: 10.3390/cells9010225 Web of Science: 000515398200225
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2019Replication Stress and Consequential Instability of the Genome and EpigenomeFull Text via DOI: 10.3390/molecules24213870 Web of Science: 000498055500059
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2019Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents. CANCERS. 11.Full Text via DOI: 10.3390/cancers11101416 Web of Science: 000498826000013
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2019Diastereomeric Recognition of 5 ',8-cyclo-2 '-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model. CELLS. 8.Full Text via DOI: 10.3390/cells8020116 Web of Science: 000460896000038
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2019Methods to Study Trinucleotide Repeat Instability Induced by DNA Damage and Repair. DNA REPAIR: METHODS AND PROTOCOLS. 1999:87-101.Full Text via DOI: 10.1007/978-1-4939-9500-4_5 Web of Science: 000486994800006
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2018The deoxyribose phosphate lyase of DNA polymerase beta suppresses a processive DNA synthesis to prevent trinucleotide repeat instability. NUCLEIC ACIDS RESEARCH. 46.Full Text via DOI: 10.1093/nar/gky700 Web of Science: 000450952000029
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2017Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1. TOXICOLOGY AND APPLIED PHARMACOLOGY. 329:58-66.
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2017Protection of Nrf2 Against Arsenite-induced Oxidative Damage is Regulated by the Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Pathway. ENVIRONMENTAL TOXICOLOGY. 32:2004-2020.
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2017miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells. SCIENTIFIC REPORTS. 7.
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2016Crosstalk between MSH2-MSH3 and pol beta promotes trinucleotide repeat expansion during base excision repair. NATURE COMMUNICATIONS. 7.
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2015AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair. NUCLEIC ACIDS RESEARCH. 43:5948-5960.
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2015Resveratrol Protects Against Arsenic Trioxide-Induced Oxidative Damage Through Maintenance of Glutathione Homeostasis and Inhibition of Apoptotic Progression. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 56:333-346.
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2014A 5 ', 8-cyclo-2 '-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase beta. NUCLEIC ACIDS RESEARCH. 42:13749-13763.
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2014Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion. NUCLEIC ACIDS RESEARCH. 42:3675-3691.
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2013Involvement of DNA polymerase beta overexpression in the malignant transformation induced by benzo[a]pyrene. TOXICOLOGY. 309:73-80.
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2012Deregulated expression of DNA polymerase beta is involved in the progression of genomic instability. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 53:325-333.
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2011Role of DNA Polymerase Beta in the Genotoxicity of ArsenicFull Text via DOI: 10.1002/em.20643 Web of Science: 000293250700004
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2011Links between DNA polymerase beta expression and sensitivity to bleomycinFull Text via DOI: 10.1016/j.tox.2011.01.008 Web of Science: 000288341900008
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Meeting Abstract
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2018DNA damage landscape and trinucleotide repeat instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800129
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2018Long intergenic non-coding RNA ROR is involved in arsenite-induced oxidative stress in HBE cells.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800146
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2018Oxidative DNA damage alters miRNA expression.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800077
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2018The deoxyribose phosphate lyase of DNA polymerase beta suppresses a processive DNA synthesis to prevent trinucleotide repeat instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800133
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2017Base Excision Repair in a GAA Repeat R-loop Leads to GAA Repeats Instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S57-S57.Web of Science: 000408314700115
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2017Identification of miRNAs and Its Target Gene Network in Mediating Arsenite-induced Malignant Transformation in Human Bronchial Epithelial Cells by miRNA Microarray Analysis. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S71.Web of Science: 000408314700154
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2017The Deoxyribose Phosphate Lyase Activity Of DNA Polymerase beta Prevents Trinucleotide Repeat Instability By Suppressing DNA Slippage. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S86-S87.Web of Science: 000408314700200
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2016Environmentally-Induced Oxidative DNA Damage Disrupts DNA Methylation Pattern in Human Breast Cancer Type 1 (BRCA1) Gene via Base Excision Repair.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000383587400092
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2016Functional Coordination of Dual Enzymatic Activities of DNA Polymerase beta Prevents Trinucleotide Repeat Instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S70.Web of Science: 000383587400116
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2016The Deoxyribose Phosphate Lyase Activity of DNA Polymerase beta Suppresses Trinucleotide Repeat Deletions During Base Excision Repair.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S70.Web of Science: 000383587400115
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2016miRNA-155 Mediates Cellular Resistance to Arsenic Trioxide by Modulating Nrf2 Signaling Pathway.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S72-S72.Web of Science: 000383587400125
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2015A Protective Role of Nrf2 in Arsenite-Induced Oxidative Damage is Regulated by cGMP-PKG Pathway. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S75-S75.Web of Science: 000360226400179
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2015AP Endonuclease 1 Combats the Extension of a T/G Mismatch by DNA Polymerase b in CpG Dinucleotides during Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000360226400128
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2015DNA Polymerase beta R137Q Polymorphism Does Not Significantly Alter Trinucleotide Repeat Instability. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S63-S63.Web of Science: 000360226400130
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2015Environmentally-Induced Oxidative DNA Damage Disrupts DNA Methylation Pattern in Human Breast Cancer Type 1 (BRCA1) Gene Promoter Region. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S63-S63.Web of Science: 000360226400131
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2015Proliferating Cell Nuclear Antigen Stimulates Flap Endonuclease 1 to Modulate GAA Repeat Stability via Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000360226400129
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2015Temozolomide Upregulates Frataxin in Friedreich's Ataxia Patient Cells via Contractions of Expanded GAA Repeats. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000360226400127
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2014MSH2-MSH3 Promotes GAA Repeat Expansion by Stimulating DNA Polymerase beta Activity during Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S55-S55.Web of Science: 000341176900155
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2014Resveratrol Inhibits Oxidative Damage Induced by Arsenic Trioxide. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S61-S61.Web of Science: 000341176900180
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2013Base Excision Repair of Oxidative DNA Damage is Coupled with Removal of a CAG Repeat Hairpin to Attenuate Trinucleotide Repeat Expansion. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S30-S30.Web of Science: 000323429400072
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2013MSH2-MSH3 Promotes GAA Repeat Expansion by Stimulating DNA Polymerase beta Activity during Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S30-S30.Web of Science: 000323429400071
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2013Trinucleotide Repeat Expansion via DNA Base Lesion Repair.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S32-S32.Web of Science: 000323429400079
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Review
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2020Trinucleotide repeat instability via DNA base excision repair. DNA REPAIR.Full Text via DOI: 10.1016/j.dnarep.2020.102912 Web of Science: 000579361800007
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Research
research interests
- Trinucleotide repeat (TNR) instability associated with human neurodegeneration; TNR
Contact
full name
- Yanhao Lai
visualizations
publication subject areas
- Biochemistry & Molecular Biology
- Cell Biology
- Environmental Sciences & Ecology
- Genetics & Heredity
- Pharmacology & Pharmacy
- Science & Technology - Other Topics
- Toxicology
- Water Resources