- Dr. Jessica Siltberg Liberles is an Assistant Professor of Biological Sciences, specializing in Bioinformatics.
Evolutionary dynamics of protein structure and function,
Using computational biology to perform a combination of large scale and applied studies aimed at elucidating how conformational flexibility, post-translational regulation, protein-protein interactions, and signal transduction evolve and its implications in for e.g. virulence and neurodegenerative disease,
Using structural and evolutionary bioinformatics, we study essential mechanisms of biological divergence; how genomes and proteomes adapt to slow or immediate environmental changes. On time-scales ranging from nanoseconds to millions of years back in time, we elucidate structural and functional protein operations to further understand Metazoan evolution in a pathway context. We apply our knowledge in forward-looking models, to improve our tactics in the impending battles against cancer, neurodegenerative disease, and emerging viruses.
Scholarly & Creative Works
Works By Students
advised honors theses
- Suarez, Richard I., Identification of Fitness-Critical Regions in the HIV Proteome Based on Evolutionary and Structural Analysis as Targets for Broadly Neutralizing HIV Therapies 2019
- Montesino, Brittany, Structural and Evolutionary Analysis of the Activation Mechanism in the SK Channel-Calmodulin Complex 2019
co-principal investigator on
- Jessica Liberles