Overview
overview
- Dr. Jun Li is an Associate Professor in the Department of Biological Sciences. He studies vector biology and host-pathogen interaction. His group has successfully identified one novel pathway mediating Plasmodium parasite invasion in mosquitoes, a candidate protein as a malaria vaccine antigen, and a compound to block malaria transmission. As a PI, he has led several research projects supported by NSF CAREER award and NIH Research grants.
research interests
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Mosquito-malaria interaction.
Mosquitoes transmit many diseases including malaria and the recent Zika virus. Li's research focuses on pathogen infection pathways using combinational approaches of genomics, chemistry and biochemistry. His group has successfully identified one novel pathway mediating Plasmodium parasite invasion in mosquitoes, a candidate protein as a malaria vaccine antigen, and a compound to block malaria transmission. As a PI, he has led several research projects supported by NSF CAREER award and NIH Research grants.
Using bioinformatics approaches to analyze the genome sequences and to visualize data
Genome-wide association approach to find mosquito genes of interest
Biochemical and molecular biology approaches to investigate the function of the candidate trait-related gene
Develop vaccines and small molecule drugs targeting the pathways
Scholarly & Creative Works
selected publications
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Article
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2022Crystal Structure Determination and Hirshfeld Analysis of a New Alternariol Packing PolymorphFull Text via DOI: 10.3390/cryst12050579 Web of Science: 000801550900001
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2022Constraints on dark photon dark matter using data from LIGO's and Virgo's third observing runFull Text via DOI: 10.1103/PhysRevD.105.063030 Web of Science: 000785798100009
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2022Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at root s(NN)=5.02 TeVFull Text via DOI: 10.1103/PhysRevLett.128.032001 Web of Science: 000748799800002
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2021Discovery of mosquitocides from fungal extracts through a high-throughput cytotoxicity-screening approachFull Text via DOI: 10.1186/s13071-021-05089-3 Web of Science: 000726281100002
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2021Sterigmatocystin Limits Plasmodium falciparum Proliferation and TransmissionFull Text via DOI: 10.3390/ph14121238 Web of Science: 000736901600001
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2021Energy efficiency assessment of China wastewater treatment plants by unit energy consumption per kg COD removedFull Text via DOI: 10.1080/09593330.2021.1969596 Web of Science: 000694756300001
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2021Studies of the Parasite-Midgut Interaction Reveal Plasmodium Proteins Important for Malaria Transmission to MosquitoesFull Text via DOI: 10.3389/fcimb.2021.654216 Web of Science: 000671942600001
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2021Extensive Variation in Drought-Induced Gene Expression Changes Between Loblolly Pine GenotypesFull Text via DOI: 10.3389/fgene.2021.661440 Web of Science: 000661188900001
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2021Racial and ethnic disparities in coronary, vascular, structural, and congenital heart diseaseFull Text via DOI: 10.1002/ccd.29745 Web of Science: 000651895400001
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2021Demand-Aware Erasure Coding for Distributed Storage SystemsFull Text via DOI: 10.1109/TCC.2018.2885306 Web of Science: 000658339200010
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2021A novel fungal metabolite inhibits Plasmodium falciparum transmission and infectionFull Text via DOI: 10.1186/s13071-021-04677-7 Web of Science: 000632382300001
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2021Do Stay at Home Orders and Cloth Face Coverings Control COVID-19 in New York City? Results From a SIER Model Based on Real-world DataFull Text via DOI: 10.1093/ofid/ofaa442 Web of Science: 000637323400001
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2020A diverse global fungal library for drug discoveryFull Text via DOI: 10.7717/peerj.10392 Web of Science: 000593689800003
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2020Evidence for Top Quark Production in Nucleus-Nucleus CollisionsFull Text via DOI: 10.1103/PhysRevLett.125.222001 Web of Science: 000591812900005
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2020Observation of the B-s(0) -> X(3872)phi DecayFull Text via DOI: 10.1103/PhysRevLett.125.152001 Web of Science: 000575690400002
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2020Observation of the Production of Three Massive Gauge Bosons at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.125.151802 Web of Science: 000575040400001
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2020Practices following the death of a loved one reported by adults from 14 countries or cultural/ethnic groupFull Text via DOI: 10.1002/nop2.646 Web of Science: 000574219500001
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2020Studies of Charm Quark Diffusion inside Jets Using Pb-Pb and pp Collisions at root s(NN)=5.02 TeVFull Text via DOI: 10.1103/PhysRevLett.125.102001 Web of Science: 000565459600006
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2020Study of central exclusive pi(+)pi(-) production in proton-proton collisions at root s=5.02 and 13 TeVFull Text via DOI: 10.1140/epjc/s10052-020-8166-5 Web of Science: 000561401400001
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2020Fungal Metabolite Asperaculane B Inhibits Malaria Infection and TransmissionFull Text via DOI: 10.3390/molecules25133018 Web of Science: 000550294000001
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2020Measurement of differential cross sections and charge ratios for t-channel single top quark production in proton-proton collisions at mml:msqrts mml:msqrt=13 mml:mspace width="0.166667em"mml:mspaceTe mml:mspace width="0.333333em"mml:mspaceFull Text via DOI: 10.1140/epjc/s10052-020-7858-1 Web of Science: 000534232700010
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2020Constraints on the chi(c1 )versus chi(c2) Polarizations in Proton-Proton Collisions at root s=8 TeVFull Text via DOI: 10.1103/PhysRevLett.124.162002 Web of Science: 000528518000007
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2020Search for a Narrow Resonance Lighter than 200 GeV Decaying to a Pair of Muons in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.124.131802 Web of Science: 000523412800003
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2020Workplace spirituality as a mediator between ethical climate and workplace deviant behaviorFull Text via DOI: 10.1016/j.ijhm.2019.102372 Web of Science: 000528564300006
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2020The association between the socioeconomic status and body pain A nationwide surveyFull Text via DOI: 10.1097/MD.0000000000019454 Web of Science: 000525472300019
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2019Search for Physics beyond the Standard Model in Events with Overlapping Photons and JetsFull Text via DOI: 10.1103/PhysRevLett.123.241801 Web of Science: 000502130400002
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2019Search for Low-Mass Quark-Antiquark Resonances Produced in Association with a Photon at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.123.231803 Web of Science: 000500732100009
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2019Studies of Beauty Suppression via Nonprompt D-0 Mesons in Pb-Pb Collisions at root s(NN)=5.02 TeVFull Text via DOI: 10.1103/PhysRevLett.123.022001 Web of Science: 000474894200007
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2019Search for W Boson Decays to Three Charged PionsFull Text via DOI: 10.1103/PhysRevLett.122.151802 Web of Science: 000465182200002
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2019Jet Shapes of Isolated Photon-Tagged Jets in Pb-Pb and pp Collisions at root S-NN=5.02 TeVFull Text via DOI: 10.1103/PhysRevLett.122.152001 Web of Science: 000465181700001
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2019Observation of Single Top Quark Production in Association with a Z Boson in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.122.132003 Web of Science: 000463901800006
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2019Observation of Two Excited B-c(+) States and Measurement of the B-c(+) (2S) Mass in pp Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.122.132001 Web of Science: 000463900300005
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2019Combination of Searches for Higgs Boson Pair Production in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.122.121803 Web of Science: 000462936700008
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2019Search for Narrow H gamma Resonances in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.122.081804 Web of Science: 000460667600005
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2019A Low Frequency Mechanical Transmitter Based on Magnetoelectric Heterostructures Operated at Their Resonance FrequencyFull Text via DOI: 10.3390/s19040853 Web of Science: 000460829200104
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2019Search for the Higgs Boson Decaying to Two Muons in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.122.021801 Web of Science: 000455687700001
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2019Search for Dark Matter Particles Produced in Association with a Top Quark Pair at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.122.011803 Web of Science: 000455687000009
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2019Smartphone-Based Health Technologies for Dementia Care: Opportunities, Challenges, and Current PracticesFull Text via DOI: 10.1177/0733464817723088 Web of Science: 000453101100004
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2018Search for Leptoquarks Coupled to Third-Generation Quarks in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.121.241802 Web of Science: 000452960100003
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2018Evidence for the Associated Production of a Single Top Quark and a Photon in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.121.221802 Web of Science: 000451582500004
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2018Search for Pair-Produced Resonances Each Decaying into at Least Four Quarks in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.121.141802 Web of Science: 000446561300002
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2018Observation of the Z -> psi l(+)l(-) Decay in pp Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.121.141801 Web of Science: 000446406900001
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2018Observation of Higgs Boson Decay to Bottom QuarksFull Text via DOI: 10.1103/PhysRevLett.121.121801 Web of Science: 000444780900004
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2018Observation of the chi(b1)(3P) and chi(b2)(3P) and Measurement of their MassesFull Text via DOI: 10.1103/PhysRevLett.121.092002 Web of Science: 000443098800003
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2018Elliptic Flow of Charm and Strange Hadrons in High-Multiplicity p plus Pb Collisions at root(NN)-N-s=8.16 TeVFull Text via DOI: 10.1103/PhysRevLett.121.082301 Web of Science: 000442348000004
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2018Constraining Gluon Distributions in Nuclei Using Dijets in Proton-Proton and Proton-Lead Collisions at root s(NN)=5.02 TeVFull Text via DOI: 10.1103/PhysRevLett.121.062002 Web of Science: 000441021400008
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2018Observation of (tt)over-barH ProductionFull Text via DOI: 10.1103/PhysRevLett.120.231801 Web of Science: 000434020400003
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2018Search for Heavy Neutral Leptons in Events with Three Charged Leptons in Proton-Proton Collisions at root s=13 TeVFull Text via DOI: 10.1103/PhysRevLett.120.221801 Web of Science: 000433292700003
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2018Search for the X(5568) State Decaying into B-s(0)pi(+/-) in Proton-Proton Collisions at root s=8 TeVFull Text via DOI: 10.1103/PhysRevLett.120.202005 Web of Science: 000433032500006
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2018Search for Narrow Resonances in the b-Tagged Dijet Mass Spectrum in Proton-Proton Collisions at root s=8 TeVFull Text via DOI: 10.1103/PhysRevLett.120.201801 Web of Science: 000432992600002
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2018ELMOD3, a novel causative gene, associated with human autosomal dominant nonsyndromic and progressive hearing lossFull Text via DOI: 10.1007/s00439-018-1885-0 Web of Science: 000431534200005
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2018Quantification of Nucleic Acid Concentration in the Nanoparticle or Polymer Conjugates Using Circular Dichroism SpectroscopyFull Text via DOI: 10.1021/acs.analchem.7b04621 Web of Science: 000424730600107
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2018Training set extension for SVM ensemble in P300-speller with familiar face paradigmFull Text via DOI: 10.3233/THC-171074 Web of Science: 000437254300009
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2017Observation of Top Quark Production in Proton-Nucleus CollisionsFull Text via DOI: 10.1103/PhysRevLett.119.242001 Web of Science: 000417934800002
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2017The fibrinogen-like domain of FREP1 protein is a broad-spectrum malaria transmission-blocking vaccine antigenFull Text via DOI: 10.1074/jbc.M116.773564 Web of Science: 000405485600031
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2017Nonsynonymous Polymorphisms in the Human AS3MT Arsenic Methylation Gene: Implications for Arsenic ToxicityFull Text via DOI: 10.1021/acs.chemrestox.7b00113 Web of Science: 000405972100011
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2017Modulation-Doped In
2 O3 /ZnO Heterojunction Transistors Processed from SolutionFull Text via DOI: 10.1002/adma.201605837 -
2017Construction of an efficient multivariate dynamic screening systemFull Text via DOI: 10.1002/qre.2160
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2016Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activationFull Text via DOI: 10.1016/j.jsb.2016.09.009 Web of Science: 000389295000015
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2016Persistent sulfate formation from London Fog to Chinese hazeFull Text via DOI: 10.1073/pnas.1616540113 Web of Science: 000388835700047
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2016Expression of arsenic resistance genes in the obligate anaerobe Bacteroides vulgatus ATCC 8482, a gut microbiome bacteriumFull Text via DOI: 10.1016/j.anaerobe.2016.03.012 Web of Science: 000377313200020
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2016A cold-adapted and glucose-stimulated type II alpha-glucosidase from a deep-sea bacterium Pseudoalteromonas sp K8Full Text via DOI: 10.1007/s10529-015-1987-x Web of Science: 000370374300019
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2015Targeting mosquito FREP1 with a fungal metabolite blocks malaria transmissionFull Text via DOI: 10.1038/srep14694
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2015Transcription factor SOHLH1 potentially associated with primary ovarian insufficiencyFull Text via DOI: 10.1016/j.fertnstert.2014.11.011 Web of Science: 000348966700040
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2014Novel variants in the SOHLH2 gene are implicated in human premature ovarian failureFull Text via DOI: 10.1016/j.fertnstert.2014.01.001 Web of Science: 000333805000045
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2013Genomic law guided gene prediction in fungi and metazoansFull Text via DOI: 10.1504/IJCBDD.2013.052197
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2010Allelic Gene Structure Variations in Anopheles gambiae MosquitoesFull Text via DOI: 10.1371/journal.pone.0010699 Web of Science: 000277845400009
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2006Natural malaria infection in Anopheles gambiae is regulated by a single genomic control regionFull Text via DOI: 10.1126/science.1124153 Web of Science: 000237296700045
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2006A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glandsFull Text via DOI: 10.1111/j.1462-5822.2005.00611.x Web of Science: 000233817900015
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2006Anopheles gambiae genome reannotation through synthesis of ab initio and comparative gene prediction algorithmsFull Text via DOI: 10.1186/gb-2006-7-3-r24 Web of Science: 000237298700014
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Book Chapter
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2005Molecular genetics of mosquito resistance to malaria parasites. 383-415.Web of Science: 000233456400015
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Conference
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2021A DIVERSE GLOBAL FUNGAL LIBRARY FOR DRUG DISCOVERY. 204-204.Web of Science: 000778105602327
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2021FUNGAL METABOLITE ASPERACULANE B INHIBITS MALARIA INFECTION AND TRANSMISSION. 67-67.Web of Science: 000778105601211
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2021
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2020Local Re-encoding for Coded Matrix Multiplication. 221-226.Web of Science: 000714963400038
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2020Straggler-free Coding for Concurrent Matrix Multiplications. 233-238.Web of Science: 000714963400040
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2020
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2019EXPLORING FUNGAL METABOLITES FOR MALARIA TRANSMISSION BLOCKING AGENTS. 285-285.Web of Science: 000507364503286
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2019INTERACTION BETWEEN PLASMODIUMAL PHATUBULIN AND ANOPHELES FREP1 ASSISTS MALARIA TRANSMISSION. 220-220.Web of Science: 000507364503068
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2019SMALL MOLECULE ASPERACULANE B INHIBITS MALARIA INFECTION AND TRANSMISSION. 92-92.Web of Science: 000507364502303
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2006Quantitative analysis of the Anopheles gambiae hemolymph immune proteome. 6-6.Web of Science: 000242343900022
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Other Scholarly Work
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Preprint
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Review
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2021Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmissionFull Text via DOI: 10.1038/s41541-021-00401-9 Web of Science: 000723649900003
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2021Insights into S-adenosyl-L-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphismsFull Text via DOI: 10.1016/j.mrrev.2021.108396 Web of Science: 000712897700001
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2021Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). 1-382.Full Text via DOI: 10.1080/15548627.2020.1797280 Web of Science: 000636121800001
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2019Clinical Use of Toxic Proteins and Peptides from Tian Hua Fen and Scorpion Venom.. 285-295.Full Text via DOI: 10.2174/1389203719666180622100641
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2017The State of the Absorb Bioresorbable Scaffold: Consensus From an Expert Panel.. 2349-2359.Full Text via DOI: 10.1016/j.jcin.2017.09.041
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2017Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research. 371-388.Full Text via DOI: 10.1007/s11481-017-9743-8 Web of Science: 000406359000001
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2016The organoarsenical biocycle and the primordial antibiotic methylarsenite. 1047-1055.Full Text via DOI: 10.1039/c6mt00168h Web of Science: 000385594000002
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2016Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 1-222.Full Text via DOI: 10.1080/15548627.2015.1100356 Web of Science: 000373595400001
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Research
principal investigator on
- Fungal metabolites block malaria transmission awarded by Allergy and Infectious Diseases 2017 - 2022
- CAREER: Genetic and Molecular Mechanisms of Parasite Infection in Insects awarded by National Science Foundation 2017 - 2021
- Targeting mosquito FREP1 protein for malaria control awarded by Allergy and Infectious Diseases 2017 - 2018
Contact
full name
- Jun Li
Identifiers
ORCID iD
- https://orcid.org/0000-0002-2121-3393 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in