Lin, Wei-Chiang
- Associate Professor, Biomedical Engineering , College of Engineering and Computing

Overview
overview
- Dr. Wei-Chiang Lin is an Associate Professor of the Department of Biomedical Engineering at Florida International University, where he has been since 2004. He served as the interim chair of the Department from 2015 to 2017. Also, he is the co-director of the Orthotics and Prosthetics track, a self-supporting program within the Master’s Program in Biomedical Engineering. Dr. Lin obtained his B.S. degree in Biomedical Engineering from the Chung-Yuan Christian University in Taiwan, ROC in 1987. He received his M.S. and Ph.D. degrees in Biomedical Engineering from the University of Texas at Austin under the supervision of Dr. Ashley J. Welch and Dr. Massoud Motamedi. When he completed his Ph.D. degree in 1997, he received a postdoctoral fellowship from the W. M. Keck Foundation Free Electron Laser Center and joined the Department of Biomedical Engineering at Vanderbilt University in Nashville, TN, and he became a Research Assistant Professor in the Department in 2000. Dr. Lin’s research is focused on developing engineering solutions for diagnosing and treating tissue disorders and injuries, with a strong emphasis on pediatric brain disorders. To date, his research projects have been funded by the National Institute of Health, Department of Defense, Thrasher Research Fund, and American Heart Association.
research interests
- Biophotonics, Ultrasound, and Medical Instrumentation
Scholarly & Creative Works
selected publications
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Article
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2022Embedded-Component Planar Fan-Out Packaging for Biophotonic ApplicationsFull Text via DOI: 10.1109/OJNANO.2022.3163386 Web of Science: 000790810300002
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2020Advances in imaging and analysis of 4 fluorescent components through the rat cortical columnFull Text via DOI: 10.1016/j.jneumeth.2020.108792 Web of Science: 000546302200001
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2018Histological Characterization of the Irritative Zones in Focal Cortical Dysplasia Using a Preclinical Rat ModelFull Text via DOI: 10.3389/fncel.2018.00052 Web of Science: 000432606600001
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2018Effects of Closed Endotracheal Suctioning on Systemic and Cerebral Oxygenation and Hemodynamics in ChildrenFull Text via DOI: 10.1097/PCC.0000000000001377 Web of Science: 000419769000004
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2018Heart Rate Variability in Children Following Drowning InjuryFull Text via DOI: 10.4103/ijccm.IJCCM_120_16 Web of Science: 000423340500014
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2017Polyaniline/multi-walled carbon nanotube composites for structural vibration damping and strain sensingFull Text via DOI: 10.1557/jmr.2016.361 Web of Science: 000393878300008
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2016Dysfunction of Neurovascular/Metabolic Coupling in Chronic Focal EpilepsyFull Text via DOI: 10.1109/TBME.2015.2461496 Web of Science: 000369311700010
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2016Intraoperative optical mapping of epileptogenic cortices during non-ictal periods in pediatric patientsFull Text via DOI: 10.1016/j.nicl.2016.02.015 Web of Science: 000379504500048
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2015Peptide modified polymer poly (glycerol- dodecanedioate co-fumarate) for efficient control of motor neuron differentiationFull Text via DOI: 10.1088/1748-6041/10/6/065013 Web of Science: 000367801000013
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2015Distributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal EpilepsyFull Text via DOI: 10.1371/journal.pone.0134352 Web of Science: 000358837700077
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2013Molecular aspects of Dravet syndrome patients in TaiwanFull Text via DOI: 10.1016/j.cca.2013.02.015 Web of Science: 000320220900006
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2013Optical ATP biosensor for extracellular ATP measurementFull Text via DOI: 10.1016/j.bios.2012.12.027 Web of Science: 000316525300058
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2013In vivo detection of epileptic brain tissue using static fluorescence and diffuse reflectance spectroscopyFull Text via DOI: 10.1117/1.JBO.18.2.027006 Web of Science: 000315159900044
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2011Spectral-profile-based algorithm for hemoglobin oxygen saturation determination from diffuse reflectance spectraFull Text via DOI: 10.1364/BOE.2.001082 Web of Science: 000299878000005
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2010Diffuse reflectance spectroscopy for in vivo pediatric brain tumor detectionFull Text via DOI: 10.1117/1.3505012 Web of Science: 000287171100016
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2010In vivo characterization of myocardial infarction using fluorescence and diffuse reflectance spectroscopyFull Text via DOI: 10.1117/1.3442505 Web of Science: 000280642900051
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2009Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesionsFull Text via DOI: 10.1117/1.3080144 Web of Science: 000264551900033
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2008The role of optical spectroscopy in epilepsy surgery in childrenFull Text via DOI: 10.3171/FOC/2008/25/9/E24 Web of Science: 000258823500024
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2008Effects of probe contact pressure on in vivo optical spectroscopyFull Text via DOI: 10.1364/OE.16.004250 Web of Science: 000254121400080
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2005INTRAOPERATIVE OPTICAL SPECTROSCOPY IDENTIFIES INFILTRATING GLIOMA MARGINS WITH HIGH SENSITIVITYFull Text via DOI: 10.1227/01.NEU.000176855.39826.2D Web of Science: 000208209000045
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2004In vivoassessment of thermal damage in the liver using optical spectroscopyFull Text via DOI: 10.1117/1.1779627
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2001Intraoperative application of optical spectroscopy in the presence of bloodFull Text via DOI: 10.1109/2944.983305
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2001Brain tissue characterization using Spectral Imaging: A potential clinical toolFull Text via DOI: 10.1117/12.432484
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2000Brain tumor demarcation using optical spectroscopy; An in vitro studyFull Text via DOI: 10.1117/1.429989
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1996Dynamics of tissue optics during laser heating of turbid mediaFull Text via DOI: 10.1364/AO.35.003413
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1995Nonlinear optical behavior of ocular tissue during laser irradiationFull Text via DOI: 10.1364/AO.34.007979
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Book
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Book Chapter
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2006Prediction of Thermal Tissue Damage Using Fluorescence Spectroscopy. 125-138.Full Text via DOI: 10.1007/0-387-33016-x_5
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Conference
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2021Chipscale Piezo-Magnetostrictive Interfaces - A new simplified and microminiaturized telemetry paradigm for Medical Device Packages. 1219-1225.Full Text via DOI: 10.1109/ECTC32696.2021.00199 Web of Science: 000702282700187
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2021Wireless Photonic Sensors with Flex Fan-Out Packaged Devices and Enhanced Power Telemetry. 1550-1556.Full Text via DOI: 10.1109/ECTC32696.2021.00246 Web of Science: 000702282700234
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2018Cerebral Oximetry Index in Critically Ill ChildrenFull Text via DOI: 10.1542/peds.142.1_MeetingAbstract.23 Web of Science: 000540807300026
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2013Optical Spectroscopy for In Vivo Estimation of Hemodynamics and Structural Properties of the Brain. 107-108.Full Text via DOI: 10.1109/SBEC.2013.62 Web of Science: 000324751700054
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2010
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2010
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2010In Vivo Characterization of Myocardial Infarct using Optical Spectroscopy. bsud66.Full Text via DOI: 10.1364/biomed.2010.bsud66
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2008Optical characterization of myocardial infarction: An in vivo studyFull Text via DOI: 10.1364/biomed.2008.btuf41
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2007In-vivo optical detection of brain tumor and tumor margin: a combined autofluoreseence and diffuse reflectance spectroscopic studyFull Text via DOI: 10.1117/12.724875 Web of Science: 000245947500007
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2007In vivo optical characterization of pediatric epileptogenic lesionsFull Text via DOI: 10.1117/12.700717 Web of Science: 000246515600044
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2005Decline in NAD(P)H autofluorescence precedes apoptotic cell death from chemotherapyFull Text via DOI: 10.1117/12.630711
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2003Feedback control of liver thermotherapy using optical spectroscopy. 201-212.Full Text via DOI: 10.1117/12.479803
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2002Detection of radiation injured brain tissue using optical spectroscopy. tuc5.Full Text via DOI: 10.1364/bio.2002.tuc5
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2001Development And Implementation Of An Interactive Instructional Module For Light Distribution In Tissue. 6.363.1-6.363.13.Full Text via DOI: 10.18260/1-2--9113
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2001Accelerated stressing and degradation mechanisms for Si-based photo-emitters. 200-205.Full Text via DOI: 10.1109/RELPHY.2001.922902
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2000Optical spectroscopy for intra-operative guidance of brain tumor resection. sud2.Full Text via DOI: 10.1364/bosd.2000.sud2
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1994Dynamics of tissue reflectance and transmittance during laser irradiation. 296-303.Full Text via DOI: 10.1117/12.182947
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Other Scholarly Work
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2020Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.. 745-759.Full Text via DOI: 10.1016/j.annonc.2020.02.011
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2013The Role of Complementary and Alternative Medicine in Regenerative MedicineFull Text via DOI: 10.1155/2013/420458 Web of Science: 000325022700001
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2010
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2008Time-dependent diffuse reflectance spectroscopy for in vivo characterization of pediatric epileptogenic brain lesionsFull Text via DOI: 10.1117/12.763407 Web of Science: 000255314100045
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Review
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2006Neuro-oncological applications of optical spectroscopy. 231-238.Full Text via DOI: 10.1177/153303460600500306
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Works By Students
chaired theses and dissertations
- Le, Anh Van, The Development of a Novel Polymer Based System for Gene Delivery 2015
- Song, Yinchen, Intraoperative Guidance for Pediatric Brain Surgery based on Optical Techniques 2015
- Dai, Xizi, Fiber Scaffolds of Poly (glycerol-dodecanedioate) and its Derivative via Electrospinning for Neural Tissue Engineering 2015
- Yadav, Nitin, In Vivo characterization of Epileptic Tissue with Optical Spectroscopy 2012
- Chen, Po-Ching, In Vivo Tissue Diagnosis for Myocardial Infarction Using Optical Spectroscopy with Novel Spectral Interpretation Algorithms 2011
- Fernald, Bradley A., Mathematical method for physiological interpretation of diffuse reflectance spectroscopic signals 2008
Research
principal investigator on
- Paper based Disposable Biosensors for Trace Analysis of Organophosphate awarded by Everglades Foundation 2015 - 2021
- The Biomedical Engineering Lecture Series Endowment. awarded by Wallace H. Coulter Foundation 2005 - 2018
- Biomedical Engineering Distinguished Professorship in Bioinstrumentation and Biomeasurement awarded by Wallace H. Coulter Foundation 2004 - 2018
- Biomedical Engineering Excellence Scholarship Fund awarded by Wallace H. Coulter Foundation 2001 - 2018
- Biomedical Engineering Research Initiation Program. awarded by Wallace H. Coulter Foundation 2001 - 2018
- Graduate Fellowship in Biomedical Engineering Fund awarded by Wallace H. Coulter Foundation 2001 - 2018
- Multimodal Neuromonitoring and Neuroprotection in Critically Ill Children awarded by U.S. Army 2013 - 2018
- The Young Inventor Program Endowment awarded by Wallace H. Coulter Foundation 2004 - 2017
- Biomedical Engineering Excellence Fund. awarded by Wallace H. Coulter Foundation 2001 - 2017
- Cardiovascular Engineering Center Fund awarded by Wallace H. Coulter Foundation 2001 - 2017
- The Norman R. Weldon Biomedical Engineering Fellowship(s) Endowment awarded by Norman R. Weldon 2001 - 2017
- Smart Intraoperative Guidance for Pediatric Brain Tumor Surgery awarded by National Cancer Institute 2013 - 2017
- Hand-held Optical Imager for Breast Cancer Imaging awarded by National Cancer Institute 2011 - 2014
- Novel Optical Guidance for Surgical Resection of Pediatric Neoplastic and Epileptogenic Brain Lesions awarded by Nicklaus Children's Hospital 2010 - 2013
- DOD II: Multimodal Neuromonitoring and Neuroprotection in Critically Ill Children awarded by Nicklaus Children's Hospital 2010 - 2012
- Optimizing Pediatric Brain Tumor Surgery through Optical Spectoscopy to Enhance Survival and Quality of Life. awarded by Nicklaus Children's Hospital 2007 - 2011
- In Vivo Differentiation of Normal, Stunned, Hibernating, and Scarred Myocardium Using Optical Spectroscopy. awarded by American Heart Association 2006 - 2010
co-principal investigator on
- Additive Manufacturing of Heterogeneous-Integrated Systems With Chiplet-First Embedding for Wireless Sensors awarded by Nano Dimensions 2021 - 2023
- Cancer Research in Memory of Barbara and Jerome Block. awarded by FIU Foundation 2008 - 2013
- 25th Southern Biomedical Engineering Conference. awarded by National Science Foundation 2009 - 2010
- Image Guided Intervention for Breast Cancer: Combined Hyperthermia and Chemotherapy with Reduced Cardiotoxicity. awarded by Florida Department of Health 2008 - 2009
Contact
full name
- Wei-Chiang Lin
Identifiers
ORCID iD
- https://orcid.org/0000-0003-2706-1017 (confirmed)
visualizations
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Biotechnology & Applied Microbiology
- Cell Biology
- Chemistry
- Electrochemistry
- Engineering
- General & Internal Medicine
- Instruments & Instrumentation
- Integrative & Complementary Medicine
- Life Sciences & Biomedicine - Other Topics
- Materials Science
- Medical Laboratory Technology
- Neurosciences & Neurology
- Optics
- Pediatrics
- Radiology, Nuclear Medicine & Medical Imaging
- Science & Technology - Other Topics
- Spectroscopy
- Surgery