Yuan Liu
- Associate Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education
Publications
selected publications
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Article
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2021Scanning Ion Conductance Microscopy Study Reveals the Disruption of the Integrity of the Human Cell Membrane Structure by Oxidative DNA Damage. ACS APPLIED BIO MATERIALS. 4:1632-1639.Full Text via DOI: 10.1021/acsabm.0c01461 Web of Science: 000620346200049
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2020R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities. JOURNAL OF BIOLOGICAL CHEMISTRY. 295:13902-13913.Full Text via DOI: 10.1074/jbc.RA120.014161 Web of Science: 000578444100016
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2020N-6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation. ENVIRONMENTAL POLLUTION. 259.Full Text via DOI: 10.1016/j.envpol.2019.113908 Web of Science: 000528534600030
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2020Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells. SCIENTIFIC REPORTS. 10.Full Text via DOI: 10.1038/s41598-020-60849-y Web of Science: 000562886900005
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2020Inhibition of base excision repair by natamycin suppresses prostate cancer cell proliferation. BIOCHIMIE. 168:241-250.Full Text via DOI: 10.1016/j.biochi.2019.11.008 Web of Science: 000503444300022
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2020Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase beta and a de novo DNA Methyltransferase. CELLS. 9.Full Text via DOI: 10.3390/cells9010225 Web of Science: 000515398200225
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2019Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents. CANCERS. 11.Full Text via DOI: 10.3390/cancers11101416 Web of Science: 000498826000013
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2019Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an N-Unsubstituted 1,2,3-Triazol-4-yl Moiety. JOURNAL OF ORGANIC CHEMISTRY. 84:3624-3631.Full Text via DOI: 10.1021/acs.joc.8b03135 Web of Science: 000461844000051
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2019Diastereomeric Recognition of 5 ',8-cyclo-2 '-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model. CELLS. 8.Full Text via DOI: 10.3390/cells8020116 Web of Science: 000460896000038
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2019Methods to Study Trinucleotide Repeat Instability Induced by DNA Damage and Repair. DNA REPAIR: METHODS AND PROTOCOLS. 1999:87-101.Full Text via DOI: 10.1007/978-1-4939-9500-4_5 Web of Science: 000486994800006
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2018Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. ORGANIC LETTERS. 20.Full Text via DOI: 10.1021/acs.orglett.8b03035 Web of Science: 000452930100012
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2018The deoxyribose phosphate lyase of DNA polymerase beta suppresses a processive DNA synthesis to prevent trinucleotide repeat instability. NUCLEIC ACIDS RESEARCH. 46.Full Text via DOI: 10.1093/nar/gky700 Web of Science: 000450952000029
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2018Pyrimidine Nucleosides with a Reactive (ss-Chlorovinyl)sulfone or (ss-Keto)sulfone Group at the C5 Position, Their Reactions with Nucleophiles and Electrophiles, and Their Polymerase-Catalyzed Incorporation into DNA. ACS OMEGA. 3.Full Text via DOI: 10.1021/acsomega.8b00584 Web of Science: 000430200300070
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2017Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1. TOXICOLOGY AND APPLIED PHARMACOLOGY. 329:58-66.
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2017Precision Sports Medicine: The Future of Advancing Health and Performance in Youth and Beyond. STRENGTH AND CONDITIONING JOURNAL. 39:48-58.Web of Science: 000400010400007
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2017Protection of Nrf2 Against Arsenite-induced Oxidative Damage is Regulated by the Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Pathway. ENVIRONMENTAL TOXICOLOGY. 32:2004-2020.
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2017miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells. SCIENTIFIC REPORTS. 7.
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2016Crosstalk between MSH2-MSH3 and pol beta promotes trinucleotide repeat expansion during base excision repair. NATURE COMMUNICATIONS. 7.
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2015AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair. NUCLEIC ACIDS RESEARCH. 43:5948-5960.
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2015Resveratrol Protects Against Arsenic Trioxide-Induced Oxidative Damage Through Maintenance of Glutathione Homeostasis and Inhibition of Apoptotic Progression. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 56:333-346.
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2014A 5 ', 8-cyclo-2 '-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase beta. NUCLEIC ACIDS RESEARCH. 42:13749-13763.
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2014Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles. ANALYTICAL CHEMISTRY. 86:3461-3467.
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2014Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion. NUCLEIC ACIDS RESEARCH. 42:3675-3691.
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2014Critical role of cellular glutathione homeostasis for trivalent inorganic arsenite-induced oxidative damage in human bronchial epithelial cells. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS. 770:35-45.
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2013Involvement of DNA polymerase beta overexpression in the malignant transformation induced by benzo[a]pyrene. TOXICOLOGY. 309:73-80.
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2012Deregulated expression of DNA polymerase beta is involved in the progression of genomic instability. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 53:325-333.
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Meeting Abstract
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2018DNA damage landscape and trinucleotide repeat instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800129
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2018Long intergenic non-coding RNA ROR is involved in arsenite-induced oxidative stress in HBE cells.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800146
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2018Oxidative DNA damage alters miRNA expression.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800077
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2018The deoxyribose phosphate lyase of DNA polymerase beta suppresses a processive DNA synthesis to prevent trinucleotide repeat instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.Web of Science: 000442847800133
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20175-Azido-modified pyrimidine nucleosides: Chemistry and biology. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430569105432
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20175-azidomethyl-2'-deoxyuridine triphosphate can be efficiently incorporated by a repair DNA polymerase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430568500835
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2017Base Excision Repair in a GAA Repeat R-loop Leads to GAA Repeats Instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S57-S57.Web of Science: 000408314700115
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2017Identification of miRNAs and Its Target Gene Network in Mediating Arsenite-induced Malignant Transformation in Human Bronchial Epithelial Cells by miRNA Microarray Analysis. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S71.Web of Science: 000408314700154
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2016Environmentally-Induced Oxidative DNA Damage Disrupts DNA Methylation Pattern in Human Breast Cancer Type 1 (BRCA1) Gene via Base Excision Repair.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000383587400092
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2016Functional Coordination of Dual Enzymatic Activities of DNA Polymerase beta Prevents Trinucleotide Repeat Instability.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S70.Web of Science: 000383587400116
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2016Oxidized DNA Base Lesions Promote Trinucleotide Repeat Expansion.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S69-S69.Web of Science: 000383587400113
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2016The Deoxyribose Phosphate Lyase Activity of DNA Polymerase beta Suppresses Trinucleotide Repeat Deletions During Base Excision Repair.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S70.Web of Science: 000383587400115
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2016miRNA-155 Mediates Cellular Resistance to Arsenic Trioxide by Modulating Nrf2 Signaling Pathway.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S72-S72.Web of Science: 000383587400125
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2015A Protective Role of Nrf2 in Arsenite-Induced Oxidative Damage is Regulated by cGMP-PKG Pathway. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S75-S75.Web of Science: 000360226400179
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2015AP Endonuclease 1 Combats the Extension of a T/G Mismatch by DNA Polymerase b in CpG Dinucleotides during Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000360226400128
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2015DNA Polymerase beta R137Q Polymorphism Does Not Significantly Alter Trinucleotide Repeat Instability. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S63-S63.Web of Science: 000360226400130
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2015Environmentally-Induced Oxidative DNA Damage Disrupts DNA Methylation Pattern in Human Breast Cancer Type 1 (BRCA1) Gene Promoter Region. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S63-S63.Web of Science: 000360226400131
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2015Proliferating Cell Nuclear Antigen Stimulates Flap Endonuclease 1 to Modulate GAA Repeat Stability via Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000360226400129
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2015Temozolomide Upregulates Frataxin in Friedreich's Ataxia Patient Cells via Contractions of Expanded GAA Repeats. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.Web of Science: 000360226400127
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2015The Interaction between PCNA and FEN1 Modulates TNR Instability. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S64-S64.Web of Science: 000360226400135
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2014A 5 ', 8-deoxypurine Lesion Induces Genome Instability via DNA Polymerase beta during DNA Replication and Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S55-S55.Web of Science: 000341176900158
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2014A 5 ', 8-deoxypurine Lesion Induces Trinucleotide Repeat Deletion via DNA Polymerase beta. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S54-S54.Web of Science: 000341176900153
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2014AP Endonuclease 1 Cooperates with Flap Endonuclease 1 to Remove a Trinucleotide Repeat Hairpin.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S54-S54.Web of Science: 000341176900152
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2014DNA Polymerase (beta) Plays a Predominant Role in Bypassing a 5 ', 8-deoxypurine Lesion during DNA Replication and Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S54-S54.Web of Science: 000341176900154
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2014MSH2-MSH3 Promotes GAA Repeat Expansion by Stimulating DNA Polymerase beta Activity during Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S55-S55.Web of Science: 000341176900155
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2014Resveratrol Inhibits Oxidative Damage Induced by Arsenic Trioxide. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S61-S61.Web of Science: 000341176900180
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2013Base Excision Repair of Oxidative DNA Damage is Coupled with Removal of a CAG Repeat Hairpin to Attenuate Trinucleotide Repeat Expansion. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S30-S30.Web of Science: 000323429400072
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2013MSH2-MSH3 Promotes GAA Repeat Expansion by Stimulating DNA Polymerase beta Activity during Base Excision Repair. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S30-S30.Web of Science: 000323429400071
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2013Trinucleotide Repeat Expansion via DNA Base Lesion Repair.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S32-S32.Web of Science: 000323429400079
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Review
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2020Trinucleotide repeat instability via DNA base excision repair. DNA REPAIR.Full Text via DOI: 10.1016/j.dnarep.2020.102912 Web of Science: 000579361800007
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20195 ',8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance. CELLS.Full Text via DOI: 10.3390/cells8060513 Web of Science: 000475309200001
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2017Dynamics of p53: A Master Decider of Cell Fate. GENES.Full Text via DOI: 10.3390/genes8020066 Web of Science: 000399058000021
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2012DNA base excision repair: a mechanism of trinucleotide repeat expansion. TRENDS IN BIOCHEMICAL SCIENCES. 162-172.
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2011A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. MOLECULAR BIOLOGY. 536-550.
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chaired theses and dissertations
- Ren, Yaou, Trinucleotide Repeat Instability Modulated by DNA Repair Enzymes and Cofactors 2018
- Jiang, Zhongliang, Epigenetic Instability Induced by DNA Base Lesion via DNA Base Excision Repair 2017
- Beaver, Jill M, Trinucleotide Repeat Instability is Modulated by DNA Base Lesions and DNA Base Excision Repair 2016
- Xu, Meng, Oxidative DNA Damage Modulates Trinucleotide Repeat Instability Via DNA Base Excision Repair 2014
- Zhou, Jing, Roles of DNA Base Excision Repair in Maintaining the Integrity of DNA Methylation 2013
Research
principal investigator on
- Trinucleotide Repeat Instability via DNA Damage and Repair awarded by National Institutes of Health 2013 - 2019
- Mechanisms of Trinucleotide Repeat Expansion via Oxidative DNA Damage and Repair awarded by National Institute of Environmental Health Sciences 2010 - 2014
- Mechanisms of Trinucleotide Repeat Expansion via Oxidative DNA Damage and Repair awarded by National Institutes of Health 2010 - 2013
co-principal investigator on
investigator on
Teaching
teaching activities
- BCH7930-U01: Biochemistry Graduate Seminar Fall Term 2019
- CHM4910-U02: Undergraduate Research in Chemistry Fall Term 2019
- CHM4910-U16: Undergraduate Research in Chemistry Spring Term 2019
- CHM6910-U02: Graduate Research in Chemistry Fall Term 2019
- CHM6910-U02: Graduate Research in Chemistry Spring Term 2019
- CHM6936-U01: Chemistry Colloquium Fall Term 2019
- CHM7910-U15: Dissertation Research Spring Term 2019
- CHM7910-U16: Dissertation Research Fall Term 2019
- CHM7980-U15: PH.D. Dissertation Spring Term 2019
- CHM7980-U16: PH.D. Dissertation Fall Term 2019
Contact
full name
- Yuan Liu
Identifiers
ORCID iD
- https://orcid.org/0000-0003-4797-6396 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cell Biology
- Chemistry
- Environmental Sciences & Ecology
- Genetics & Heredity
- Pharmacology & Pharmacy
- Science & Technology - Other Topics
- Sport Sciences
- Toxicology
- Water Resources