Nefzi, Adel
Contact Info
Overview
overview
- Dr. Nefzi obtained a PhD in organic chemistry in 1995 from the University of Lausanne, Switzerland. His lab research interests are in the broadly defined fields of organic synthesis and medicinal chemistry. His group efforts over the past twenty-five years have been focused on the design and the diversity-oriented synthesis of low molecular weight acyclic and heterocyclic natural product-like and existing drug-like combinatorial libraries from modified peptides for the use in therapeutic applications. The large numbers of chemical libraries of linear and cyclic peptides, non-peptide oligomers, peptidomimetics, small-molecules, and natural product-like organic molecules provide for an exponential increase in screening efficiencies, rich initial SAR, and a unique chemical space while maintaining critical drug like chemical properties. As evidenced by his group publication’s record, the synthetic libraries developed have impacted numerous fields of human health, including cancer, inflammation, pain, diabetes, CNS disorders, antimalarial, and bacterial resistance. Dr. Nefzi research has been supported by the National Institute of Health (NIH), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute on Drug Abuse (NIDA), the National Cancer Institute (NCI), the National Institute of Aging (NIA) and the National Science Foundation (NSF).
Scholarly & Creative Works
selected publications
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Article
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2021Discovery of a Lead Compound for Specific Inhibition of Type I Collagen Production in Fibrosis. ACS MEDICINAL CHEMISTRY LETTERS. 12:477-484.Full Text via DOI: 10.1021/acsmedchemlett.1c00006 Web of Science: 000629174700018
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2020Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 30.Full Text via DOI: 10.1016/j.bmcl.2020.127108 Web of Science: 000522861200012
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2015Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT). CHEMICAL RESEARCH IN TOXICOLOGY. 28:2419-2425.
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2009Synthetic small-molecule prohormone convertase 2 inhibitorsFull Text via DOI: 10.1124/mol.108.051334
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2006Synthesis of platimim(II) chiral tetraamine coordination complexesFull Text via DOI: 10.1021/cc060045h
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2002Parallel Solid-Phase Synthesis of Disubstituted 1,6-Piperazine-2-onesFull Text via DOI: 10.1021/cc0200235
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2002Solid-phase synthesis of 1,2,5-trisubstituted 4-imidazolidinonesFull Text via DOI: 10.1021/cc0100565
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2002Solid-phase synthesis of linear ureas tethered to hydantoins and thiohydantoinsFull Text via DOI: 10.1021/cc010064l
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2001Solid-phase synthesis of α,α-difluoro-β-amino acids via the Reformatsky reactionFull Text via DOI: 10.1021/jo010872z
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2001Parallel synthesis of 4,5-dihydro-1H-1,4-benzodiazepine-2,3-dionesFull Text via DOI: 10.1016/S0040-4039(01)00939-X
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2000Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptidesFull Text via DOI: 10.1021/ol000225e
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2000Solid phase synthesis of 1-substituted pyroglutamatesFull Text via DOI: 10.1016/S0040-4039(99)02208-X
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2000Solid phase synthesis of 1,3-disubstituted succinimidesFull Text via DOI: 10.1016/S0040-4039(99)02166-8
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1999Solid phase synthesis of 1,4-benzothiazepin-5-one derivativesFull Text via DOI: 10.1016/S0040-4039(99)00964-8
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1999Solid-phase synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethionesFull Text via DOI: 10.1021/cc980019m
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1998Efficient solid phase synthesis of 3,5-disubstituted hydantoinsFull Text via DOI: 10.1016/S0040-4039(98)01874-7
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1998Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-onesFull Text via DOI: 10.1016/S0040-4039(98)00645-5
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1997The current status of heterocyclic combinatorial librariesFull Text via DOI: 10.1021/cr960010b
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Other Scholarly Work
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Review
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1999Mixture-based synthetic combinatorial libraries. 3743-3778.Full Text via DOI: 10.1021/jm990174v
Contact
full name
- Adel Nefzi
