Overview
overview
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Dr. Clemencia Pinilla is recognized as a pioneer in the field of combinatorial chemistry and the inventor of positional scanning libraries. She has over 30 years of research experience in the identification of ligands using mixture-based libraries, supported by more than 145 peer-review publications. She joined Florida International University (FIU) in March 2020 as part of the group of investigators from Torrey Pines Institute for Molecular Studies. Dr. Pinilla has work closely with other investigators now at the Center of Translational Sciences at FIU on all the aspects of ligand identification for basic research and drug-lead discovery.
Most of Dr. Pinilla’s current work focuses on T-cell specificity, identification of melanocortin receptor ligands and identification of compounds that inhibit antimicrobial resistance.
research interests
- Ligand identification using combinatorial libraries, T cell specificity, G-coupled protein receptors, Infectious diseases
Scholarly & Creative Works
selected publications
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Article
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2021CD4(+) T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitopeFull Text via DOI: 10.1084/jem.20210785 Web of Science: 000702150000004
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2021Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) AntagonistFull Text via DOI: 10.1021/acs.jmedchem.1c01417 Web of Science: 000709633100049
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2021Beryllium-specific CD4(+)T cells induced by chemokine neoantigens perpetuate inflammationFull Text via DOI: 10.1172/JCI144864 Web of Science: 000647672600001
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2016ATIM-19. CATEGORIZING IMMUNE RESPONDERS WITH FUSION METRICS AND SIMULATION FOR ASSOCIATION TO SURVIVAL AND PROGRESSION FREE SURVIVAL WITH IMMUNE RESPONSE IN HLA-A2+ PATIENTS WITH GBM FROM A PHASE 2 TRIAL OF DENDRITIC CELL (DC) IMMUNOTHERAPY (ICT-107)Full Text via DOI: 10.1093/neuonc/now212.084
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2011Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymesFull Text via DOI: 10.1007/s11030-011-9333-2 Web of Science: 000300364700017
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2011Integrating computational and mixture-based screening of combinatorial librariesFull Text via DOI: 10.1007/s00894-010-0850-1 Web of Science: 000291041800025
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2010ChemInform Abstract: Utility of Soluble Peptide Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199543292
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2010Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctionsFull Text via DOI: 10.1016/j.bmcl.2010.06.029 Web of Science: 000279866300053
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2010ChemInform Abstract: Mixture‐Based Synthetic Combinatorial LibrariesFull Text via DOI: 10.1002/chin.199949239
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2008Characterization of Melan-A reactive memory CD8+ T cells in a healthy donorFull Text via DOI: 10.1093/intimm/dxn066
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2006491 POSTER Trageting XIAP in paediatric cancersFull Text via DOI: 10.1016/s1359-6349(06)70496-7
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2006Synthesis of platinum(II) chiral tetraamine coordination complexesFull Text via DOI: 10.1021/cc060045h Web of Science: 000240403200020
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2005Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosisFull Text via DOI: 10.1182/blood-2005-02-0695 Web of Science: 000231495000040
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2005How the T cell repertoire becomes peptide and MHC specificFull Text via DOI: 10.1016/j.cell.2005.05.013
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2005Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cellsFull Text via DOI: 10.1182/blood-2004-08-3168 Web of Science: 000229009000050
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2004Peptidic complex mixtures as therapeutic agents in CNS autoimmunityFull Text via DOI: 10.1016/j.molimm.2003.11.006
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2004Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activityFull Text via DOI: 10.1016/S1535-6108(03)00332-5 Web of Science: 000188400300007
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2004The initiation of the autoimmune response in multiple sclerosisFull Text via DOI: 10.1016/j.clineuro.2004.02.018
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2003Application of support vector machines for T-cell epitopes predictionFull Text via DOI: 10.1093/bioinformatics/btg255
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2003Use of combinatorial peptide libraries for T-cell epitope mappingFull Text via DOI: 10.1016/S1046-2023(02)00346-8
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1998Mapping the prion protein using recombinant antibodiesFull Text via DOI: 10.1128/jvi.72.11.9413-9418.1998
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1996Exploring antibody polyspecificity using synthetic combinatorial librariesFull Text via DOI: 10.1007/BF01718697
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1995A review of the utility of soluble peptide combinatorial librariesFull Text via DOI: 10.1002/bip.360370306
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Book Chapter
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2018High-throughput flow cytometry screening of multidrug efflux systems. 293-318.Full Text via DOI: 10.1007/978-1-4939-7454-2_16
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2013Use of Positional Scanning Libraries to Identify Immunologically Relevant Peptides. 617-624.Full Text via DOI: 10.1016/B978-0-12-385095-9.00084-1
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2013Chapter 84 Use of Positional Scanning Libraries to Identify Immunologically Relevant Peptides. 617-624.Full Text via DOI: 10.1016/b978-0-12-385095-9.00084-1
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2013Soluble synthetic combinatorial libraries: The use of molecular diversities for drug discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
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2007The versatility of nonsupport-bound combinatorial libraries. 139-171.Full Text via DOI: 10.1002/9783527614912.ch05
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2001Characterization of Highly Stimulatory T Cell Ligands Identified Using Positional Scanning Libraries. 1051-1052.Full Text via DOI: 10.1007/978-94-010-0464-0_492
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2001Identification and Optimization of HIV-Specific CTL Antigens for Vaccine Design. 1023-1024.Full Text via DOI: 10.1007/978-94-010-0464-0_478
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2001The Integration of Positional Scanning Libraries with Bioinformatics and Proteomics. 194-195.Full Text via DOI: 10.1007/978-94-010-0464-0_86
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2000Peptide Mimicry of Streptococcal Group A Carbohydrate. 83-94.Full Text via DOI: 10.1128/9781555818074.ch7
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19961 Soluble Synthetic Combinatorial Libraries: The Use of Molecular Diversities for Drug Discovery. 1-26.Full Text via DOI: 10.1515/9783110808902.1
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1996The generation of peptide combinatorial libraries using tea-bag synthesis. 835-845.Full Text via DOI: 10.1016/b978-012442710-5.50085-x
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1995Detailed studies of antibody specificity using synthetic peptide combinatorial libraries. 113-114.Full Text via DOI: 10.1007/978-94-011-1468-4_42
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1995Study of peptide-antibody interactions using a decapeptide positional scanning library. 815-816.Full Text via DOI: 10.1007/978-94-011-1468-4_374
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1994Identification of an antigenic determinant for the surface antigen of hepatitis B virus using peptide libraries. 1016-1017.Full Text via DOI: 10.1007/978-94-011-0683-2_343
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1994Optimal peptide length determination using synthetic peptide combinatorial libraries. 971-974.Full Text via DOI: 10.1007/978-94-011-0683-2_327
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1993Positional scanning synthetic peptide combinatorial libraries. 65-66.Full Text via DOI: 10.1007/978-94-011-1470-7_19
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1992Comparison of structural and functional approaches for the study of peptide-mAb interactions. 867-868.Full Text via DOI: 10.1007/978-94-011-2264-1_351
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1992The use of a peptide library composed of 34 012 224 hexamers for basic research and drug discovery. 560-561.Full Text via DOI: 10.1007/978-94-011-2264-1_218
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Conference
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2001Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS lyme disease. 187-192.Full Text via DOI: 10.1006/jaut.2000.0501
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Other Scholarly Work
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1999Mixture-based synthetic combinatorial libraries. 3743-3778.Full Text via DOI: 10.1021/jm990174v Web of Science: 000082783200001
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Preprint
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Review
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2020The value of antimicrobial peptides in the age of resistance. e216-e230.Full Text via DOI: 10.1016/S1473-3099(20)30327-3
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2008Visualization of the chemical space in drug discovery. 322-333.Full Text via DOI: 10.2174/157340908786786010
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2007Polyspecificity of T cell and B cell receptor recognition. 216-224.Full Text via DOI: 10.1016/j.smim.2007.02.012
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2007Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools. 75-82.Full Text via DOI: 10.1002/jmr.815
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2003Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries. 118-122.Full Text via DOI: 10.1038/nm0103-118
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2000Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. 276-285.Full Text via DOI: 10.1016/S1359-6446(00)01513-0
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1995Peptide, peptidomimetic, and organic synthetic combinatorial libraries. 481-496.Full Text via DOI: 10.1002/med.2610150603
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Research
principal investigator on
- T cell in sarcodiosis awarded by National Heart, Lung, & Blood Institute 2020 - 2022
- Discovery of small molecule glucagon receptor agonists and ketogenic compounds awarded by Aarhus University 2021 - 2022
- Immunoregulatory effect of microparticle delivered STING agonist in the control of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) awarded by Allergy and Infectious Diseases 2021 - 2022
Contact
full name
- Clemencia Pinilla
