Ramaswamy, Sharan
- Associate Professor, Biomedical Engineering , College of Engineering and Computing
Overview
overview
- Dr. Sharan Ramaswamy earned a PhD in Biomedical Engineering (BME) from the University of Iowa in 2003. Following a post-doctoral fellowship at the NIH and a research faculty position at the University of Pittsburgh, Dr. Ramaswamy joined the BME department at Florida International University (FIU) in December 2009 as an Assistant Professor. He is currently a tenured Associate Professor at FIU. His research expertise is in the areas of Cardiovascular Mechanobiology, Regenerative Medicine and Mechanics. He directs the Cardiovascular Therapeutics Laboratory’s (CV-PEUTICS Lab), (formerly known as the Tissue Engineered Mechanics, Imaging and Materials Laboratory (TEMIM Lab)) at FIU. He has numerous scientific articles published in his discipline in leading journals, proceedings and book chapters. His work has been funded by the American Heart Association (AHA), the Miami Heart Research Institute, the National Science Foundation, private industry and academia. He is a Fellow of the AHA and the American Society of Mechanical Engineers (ASME). Dr. Ramaswamy holds a patent in the area of bioreactors for cardiovascular regenerative medicine, a provisional patent in enhanced, stem cell-derived exosome production for the purposes of cardiac regeneration and is co-founder of a start-up company (DeNovo Biodevices LLC, Miami, FL). He is an advisor to several graduate and undergraduate students and participates in significant outreach mentorship efforts to schools in the Miami-Dade County Public School System.
Scholarly & Creative Works
selected publications
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Article
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2020Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype. FRONTIERS IN CARDIOVASCULAR MEDICINE. 7.Full Text via DOI: 10.3389/fcvm.2020.00069 Web of Science: 000538876300001
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2020Uncovering the Mechanical, Thermal, and Chemical Characteristics of Biodegradable Mushroom Leather with Intrinsic Antifungal and Antibacterial Properties. ACS APPLIED BIO MATERIALS. 3:3145-3156.Full Text via DOI: 10.1021/acsabm.0c00164 Web of Science: 000604588000061
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2020Porcine Small Intestinal Submucosa Mitral Valve Material Responses Support Acute Somatic Growth. TISSUE ENGINEERING PART A. 26:475-489.Full Text via DOI: 10.1089/ten.tea.2019.0220 Web of Science: 000507618900001
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2020Communication-Detection of Salivary Cortisol Using Zinc Oxide and Copper Porphyrin Composite Using Electrodeposition and Plasma-Assisted Deposition. ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY. 9.Full Text via DOI: 10.1149/2162-8777/aba856 Web of Science: 000557407700001
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2018Stem Cell Cytoskeletal Responses to Pulsatile Flow in Heart Valve Tissue Engineering Studies. FRONTIERS IN CARDIOVASCULAR MEDICINE. 5.Full Text via DOI: 10.3389/fcvm.2018.00058 Web of Science: 000440689200001
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2017A "sweet-spot" for fluid-induced oscillations in the conditioning of stem cell-based engineered heart valve tissues. JOURNAL OF BIOMECHANICS. 65:40-48.
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2017Hydrodynamic Assessment of Aortic Valves Prepared from Porcine Small Intestinal Submucosa. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY. 8:30-40.
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2016Relative Effects of Fluid Oscillations and Nutrient Transport in the In Vitro Growth of Valvular Tissues. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY. 7:170-181.
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2015Three Dimensional Graphene Foam/Polymer Hybrid as a High Strength Biocompatible Scaffold. ADVANCED FUNCTIONAL MATERIALS. 25:3916-3924.Full Text via DOI: 10.1002/adfm.201500876 Web of Science: 000357268900014
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2015Utility of magneto-electropolished ternary nitinol alloys for blood contacting applications. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 103:1366-1374.
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2014A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME. 136.
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2014Augmentation of engineered cartilage to bone integration using hydroxyapatite. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 102:922-932.
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2014Computational simulations predict a key role for oscillatory fluid shear stress in de novo valvular tissue formation. JOURNAL OF BIOMECHANICS. 47:3517-3523.
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2014Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING. 17:728-739.
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2013Glycosaminoglycan entrapment by fibrin in engineered heart valve tissues. ACTA BIOMATERIALIA. 9:8149-8157.
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2013Monitoring Steady Flow Effects on Cell Distribution in Engineered Valve Tissues by Magnetic Resonance Imaging. MOLECULAR IMAGING. 12.Full Text via DOI: 10.2310/7290.2013.00063 Web of Science: 000336725500004
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2013Periodontal Ligament Cells Cultured Under Steady-Flow Environments Demonstrate Potential for Use in Heart Valve Tissue Engineering. TISSUE ENGINEERING PART A. 19:458-466.
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2013Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.
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2012Graphene Nanoplatelet-Induced Strengthening of UltraHigh Molecular Weight Polyethylene and Biocompatibility In vitro. ACS APPLIED MATERIALS & INTERFACES. 4:2234-2241.
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Book Chapter
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2012Biomechanics of heart valves. 175-194.
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Conference
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2011Novel design to integrate tissue engineered cartilage to native bone using hydroxyapatite nanoparticles. 418-420.Full Text via DOI: 10.1109/ICONSET.2011.6167992
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2011Specimen dynamics and subsequent implications in heart valve tissue engineering studies. 1055-1056.Full Text via DOI: 10.1115/SBC2011-53346
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2009Flow patterns in a flow-stretch-flexure bioreactor system: Implications for the conditioning of engineered heart valve tissue. 1283-1284.Full Text via DOI: 10.1115/SBC2009-206585
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Correction
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2017Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue (vol 21, 071109, 2016). JOURNAL OF BIOMEDICAL OPTICS.Full Text via DOI: 10.1117/1.JBO.22.10.109801 Web of Science: 000414251000034
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2016Surface modification of Ni-Ti alloys for stent application after magnetoelectropolishing (vol 50, pg 37, 2015). MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 454-454.Full Text via DOI: 10.1016/j.msec.2016.02.030 Web of Science: 000376547700055
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2014Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING. 932-932.Full Text via DOI: 10.1080/10255842.2012.741806 Web of Science: 000334075400011
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Editorial Material
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Meeting Abstract
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2017EARLY HYDRODYNAMIC ASSESSMENT OF INTESTINAL SUB-MUCOSA BIOSCAFFOLD FOR MITRAL VALVE REPLACEMENT. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 590-590.Web of Science: 000397342301112
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Proceedings Paper
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2018Multiphoton microscopy of ECM proteins in baboon aortic leafletFull Text via DOI: 10.1117/12.2291024 Web of Science: 000435025800005
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2012COMPUTATIONAL PREDICTION OF FLUID INDUCED STRESS STATES IN DYNAMICALLY CONDITIONED ENGINEERED HEART VALVE TISSUES. PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B. 1047-1048.Web of Science: 000325036600523
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Review
chaired theses and dissertations
- Williams, Alex, The Oscillatory Shear Index: Quantifications for Valve Tissue Engineering and a Novel Interpretation for Calcification 2018
- Mankame, Omkar V, Hydrodynamic Assessment of a Porcine Small Intestinal Sub-Mucosa Bioscaffold Valve for Pediatric Mitral Valve Replacement 2017
- Lordeus, Makensley, Enhanced Flexible Materials for Valve Prosthesis Applications 2015
- Castellanos, Glenda L, Cellular Events Under Flow States Pertinent to Heart Valve Function 2015
- Rath, Sasmita, Regulation of Bone Marrow Stem Cells through Oscillatory Shear Stresses - A Heart Valve Tissue Engineering Perspective 2015
- Salinas, Manuel, Movement Effects on the Flow Physics and Nutrient Delivery in Engineered Valvular Tissues 2014
- Dua, Rupak, Enhanced Anchorage of Tissue-Engineered Cartilage Using an Osteoinductive Approach 2014
- Salinas, Manuel, Heart Valve Tissue Engineering: A Study of Time Varying Effects and Sample Geometry 2011
- Martinez, Catalina, The Effects of Dynamic Culturing Environments on Cell Populations Relevant to Heart Valve Tissue Engineering 2011
Research
research interests
- Cell and tissue mechanics with application in cardiovascular regenerative medicine
principal investigator on
- Terminal Sterilization awarded by Vivex Biomedical Inc 2018 - 2019
- Bioscaffold mitral valve replacement permitting somatic growth and remodeling awarded by American Heart Association 2016 - 2019
- Mechanically Conditioned 3-Dimensional Cell Culture System awarded by National Science Foundation 2016 - 2018
- Fatigue and constitutive properties of novel stent-grafts awarded by Saint George Medical Inc 2012 - 2014
- Hydrodynamic testing of a novel tri-leaflet silicone valve at four anatomically-relevant locations awarded by FIU Foundation 2012 - 2013
- Noninvasive Detection and Tracking of Cell Populations in the Development and Remodeling of Engineered Heart Valves awarded by American Heart Association 2010 - 2012
co-principal investigator on
- FIU I-Corps Teams Funding awarded by National Science Foundation 2016
Teaching
teaching activities
- BME3632-U02: Biomedical Engineering Transport Spring Term 2019
- BME4912-U11: Undergraduate Research in Biomedical Engineering Spring Term 2019
- IDH2003-U02: Honors Seminar III: Inhabiting Other Lives Fall Term 2019
- IDH2004-U02: Honors Seminar IV Spring Term 2019
- SLS1501-U07D: First Year Experience Fall Term 2019
- SLS1501-U07D: First Year Experience Fall Term 2019
Contact
full name
- Sharan Ramaswamy
Identifiers
ORCID iD
- https://orcid.org/0000-0003-4108-7141 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Biotechnology & Applied Microbiology
- Cardiovascular System & Cardiology
- Cell Biology
- Chemistry
- Computer Science
- Engineering
- Materials Science
- Optics
- Physics
- Radiology, Nuclear Medicine & Medical Imaging
- Science & Technology - Other Topics
- Spectroscopy