Raymond, Andrea
- Associate Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine

Overview
overview
- Andrea Raymond, PhD, joined Herbert Wertheim College of Medicine in 2012. Her research has focused on understanding the impact and role of extracellular vesicles (EVs) in the pathogenesis of neurotropic viruses specifically, Human Immunodeficiency Virus (HIV) and Zika Virus(ZIKV). EVs include microvesicles and exosomes both of which have been shown to modulate immune responses, to disrupt cellular functions, and to contain several oncological biomarkers critical for some cancer diagnostics. Raymond’s lab is among the first to demonstrate a potential role for exosomal EVs in HIV-associated neuropathogenesis. Her research group has shown in vitro that HIV-infected cells release EVs containing the HIV Nef protein and has demonstrated ex vivo the presence Nef-containing EVs in the serum of aviremic HIV-infected subjects. However, the functional role of these Nef-containing EVs in HIV neuropathogenesis is still unknown. Raymond seeks to understand how the content (and function) of brain cell-derived EVs vary upon HIV infection and/or opiate exposure. Ultimately, the Raymond lab research focuses on the identification of EV-based associated with biomarkers HIV neuropathogenesis and opiate addiction.
research interests
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Studying the initiation and regulation of anti-viral immunity
Understanding molecular mechanism HIV/AIDS and substance abuse, specifically opiates and cocaine
Investigating the role of HIV Negative factor(Nef) and Exosomal Extracellular Vesicles(xEVs) in HIV-associated neuropathology/neurocognitive impairment(NCI)
Identfying xEV-based biosignatures/biomarkers of NCI HIV-associated NCI and cancers.
Develop a personalized Nanomedicine approach to treat HIV neuropathology/AIDS associated cancers using an xEV-based nanotherapeutic.
Scholarly & Creative Works
selected publications
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Article
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2020Development of Multifunctional Biopolymeric Auto-Fluorescent Micro- and Nanogels as a Platform for Biomedical ApplicationsFull Text via DOI: 10.3389/fbioe.2020.00315 Web of Science: 000535564500001
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2018Hybrid magneto-plasmonic liposomes for multimodal image-guided and brain-targeted HIV treatmentFull Text via DOI: 10.1039/c7nr07255d Web of Science: 000418621000018
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2017Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brainFull Text via DOI: 10.1039/C6NR07520G Web of Science: 000394780200035
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2015Investigation of Neuropathogenesis in HIV-1 Clade B and C Infection Associated with IL-33 and ST2 RegulationFull Text via DOI: 10.1021/acschemneuro.5b00156 Web of Science: 000361505100011
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2015HIV Subtypes B and C gp120 and Methamphetamine Interaction: Dopaminergic System Implicates Differential Neuronal ToxicityFull Text via DOI: 10.1038/srep11130 Web of Science: 000356087900001
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2015Preparation and characterization of anti-HIV nanodrug targeted to microfold cell of gut-associated lymphoid tissueFull Text via DOI: 10.2147/IJN.S68348 Web of Science: 000361620300001
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2014Immunopathogenesis of HIV Infection in Cocaine Users: Role of Arachidonic AcidFull Text via DOI: 10.1371/journal.pone.0106348 Web of Science: 000341127500154
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2014Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulationFull Text via DOI: 10.1088/0957-4484/25/5/055101 Web of Science: 000330191400001
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2013Cocaine Enhances HIV-1 Infectivity in Monocyte Derived Dendritic Cells by Suppressing microRNA-155Full Text via DOI: 10.1371/journal.pone.0083682 Web of Science: 000329325200106
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2011HIV Type 1 Nef Is Released from Infected Cells in CD45(+) Microvesicles and Is Present in the Plasma of HIV-Infected IndividualsFull Text via DOI: 10.1089/aid.2009.0170 Web of Science: 000287006200010
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Conference
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2017
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2015MicroRNA regulation of SAMHD1 mediated HIV restriction. S56-S57.Web of Science: 000367826400122
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2015
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2015
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2015MicroRNA-155 regulates SAMHD1 facilitated HIV restriction in astrocytes. S93-S93.Web of Science: 000367554100096
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2015
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2014
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2014Bath salts alter synaptic plasticity gene expression in neurons. 62-62.Web of Science: 000333121600158
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2014Immunopathogenesis of HIV-1 Infection in Cocaine users: Role of Arachidonic Acid. 55-55.Web of Science: 000333121600139
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2014MAGNETIC NANOPARTICLE FOR TARGETTED ANTI-HIV DRUG DELIVERY IN IN VIVO MODEL. 48-49.Web of Science: 000333121600121
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2014SAMHD1 facilitates HIV-1 persistence: Role of miR-155. 44-45.Web of Science: 000333121600111
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2013Cocaine mediated downregulation of SAMHD1 facilitates HIV-1 infection in CNS cells. S65-S66.Web of Science: 000325777200139
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2013CLINICAL CORRELATION WITH CD4 COUNT AND MENTAL DIAGNOSIS AMONG HIV INFECTED DRUG USERS. 426-426.Web of Science: 000320312000131
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2013DYSREGULATION OF IL-33 AND ST2 IN HIV1 B AND C CLADES.. 435-436.Web of Science: 000320312000159
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2013
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2013HIV NEUROPATHOGENESIS: ROLE OF NEF plus EXOSOMES (EXNEF), METHAMPHETAMINE AND OPIATES. 430-431.Web of Science: 000320312000144
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2013IMMUNOPATHOGENIC MECHANISMS OF HIV-1 CLADE B AND C: ROLE OF DOPAMINERGIC SYSTEM.. 434-434.Web of Science: 000320312000154
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Other Scholarly Work
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Preprint
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Review
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2020Extracellular Vesicles in the Pathogenesis of Viral Infections in HumansFull Text via DOI: 10.3390/v12101200 Web of Science: 000585314900001
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2017Current application of CRISPR/Cas9 gene-editing technique to eradication of HIV/AIDS. 377-384.Full Text via DOI: 10.1038/gt.2017.35 Web of Science: 000405300900001
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Research
principal investigator on
- Role of exosome extracellular vesicles in opiate abuse and HIV neuropathogenesis awarded by National Institute on Drug Abuse 2017 - 2020
- NanoString Technology to identify biomarkers of Zika Virus infection and pathology in Extracellular Vesicles(EVs) awarded by FIU Foundation 2018 - 2019
- Development of circulating exosomes as a theranostic of neurodisease progression in aviremic HIV+ participants and virological failure awarded by Allergy and Infectious Diseases 2016 - 2018
- Nef+ Exosomes: Neurotoxin, biomarker, and theragnostic of neurocognitive status in HIV disease awarded by Allergy and Infectious Diseases 2015 - 2017
- Exosome incorporation of HIV-1 Nef antigen and drug metabolizing enzymes as biomarkers of disease progression in aviremic cocaine-abusers awarded by College of Medicine Foundation 2015 - 2017
- Identification by targeted exome capture of immunogenetic variations in anti-viral pattern recognition receptors that predispose African-Americans to HIV infection and neuroAIDS awarded by National Institute of Mental Health 2014 - 2016
investigator on
Contact
full name
- Andrea Raymond
Identifiers
ORCID iD
- https://orcid.org/0000-0003-4249-2296 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in