Jason Richardson
Overview
overview
- Dr. Jason Richardson is Professor and Associate Dean for Research in the Robert Stempel College of Public Health and Social Work at Florida International University. He is a Diplomate of the American Board of Toxicology (DABT) and a Fellow of the Academy of Toxicological Sciences (ATS). Dr. Richardson received his M.S. and Ph.D. degrees from Mississippi State University and completed postdoctoral training in at Emory University. He spent 10 years at Rutgers Robert Wood Johnson Medical School and the Environmental and Occupational Health Sciences Institute, where he served as Deputy Director and Director of the Joint Graduate Program in Toxicology. He then moved to Northeast Ohio Medical University, where he founded the Center for Neurodegenerative Disease and Aging. Dr. Richardson has served as a reviewer and Chair for several NIH grant review panels and has authored or co-authored over 90 peer-reviewed publications. He received the Outstanding New Environmental Scientist Award from NIEHS and was the inaugural recipient of the Young Investigator Award from the Toxicology Division of ASPET. He received the SOT Achievement Award in 2017. Dr. Richardson’s research focuses on the role of environmental exposures and their interactions with genetic susceptibility as contributors to neurological disease using translational approaches.
Publications
selected publications
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Article
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2021Microglia in Aging and Alzheimer's Disease: A Comparative Species ReviewFull Text via DOI: 10.3390/cells10051138 Web of Science: 000654732600001
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2020Age, sex, and regional differences in scavenger receptor CD36 in the mouse brain: Potential relevance to cerebral amyloid angiopathy and Alzheimer's disease. JOURNAL OF COMPARATIVE NEUROLOGY.Full Text via DOI: 10.1002/cne.25089 Web of Science: 000600676200001
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2020Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice. TOXICOLOGICAL SCIENCES. 178:347-357.Full Text via DOI: 10.1093/toxsci/kfaa144 Web of Science: 000608394200011
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2020Microglial depletion aggravates the severity of acute and chronic seizures in mice. BRAIN BEHAVIOR AND IMMUNITY. 89:245-255.Full Text via DOI: 10.1016/j.bbi.2020.06.028 Web of Science: 000582897600025
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2020Call for Papers for the Special Issue on NeurotoxicologyFull Text via DOI: 10.1021/acs.chemrestox.0c00295 Web of Science: 000620022600001
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2020Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration. MOLECULAR NEUROBIOLOGY. 57:2920-2933.Full Text via DOI: 10.1007/s12035-020-01921-6 Web of Science: 000534452200001
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2020Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal Neurons. TOXICOLOGICAL SCIENCES. 174:147-158.Full Text via DOI: 10.1093/toxsci/kfz239 Web of Science: 000535691100014
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2020Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration. FASEB JOURNAL. 34:1679-1694.Full Text via DOI: 10.1096/fj.201900567RR Web of Science: 000507308900111
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2019Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter. FRONTIERS IN GENETICS. 10.Full Text via DOI: 10.3389/fgene.2019.01099 Web of Science: 000497725800001
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2019Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling. MOLECULAR NEUROBIOLOGY. 56:6986-7002.Full Text via DOI: 10.1007/s12035-019-1565-7 Web of Science: 000486010800023
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2019Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice. MOLECULAR BRAIN. 12.Full Text via DOI: 10.1186/s13041-019-0492-x Web of Science: 000482907800001
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2019Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus. GLIA. 67:1434-1448.Full Text via DOI: 10.1002/glia.23616 Web of Science: 000470958100002
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2019Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. CELL REPORTS. 27:3844-+.Full Text via DOI: 10.1016/j.celrep.2019.05.087 Web of Science: 000472715000013
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2019Brain region-specific regulation of histone acetylation and efflux transporters in mice. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 33.Full Text via DOI: 10.1002/jbt.22318 Web of Science: 000487281700016
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2019Hepatic carboxylesterases are differentially regulated in PPAR alpha-null mice treated with perfluorooctanoic acid. TOXICOLOGY. 416:15-22.Full Text via DOI: 10.1016/j.tox.2019.01.014 Web of Science: 000461262900002
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2019Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin. TOXICOLOGICAL SCIENCES. 167:249-257.Full Text via DOI: 10.1093/toxsci/kfy238 Web of Science: 000462862400022
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2018Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductaseFull Text via DOI: 10.1016/j.taap.2018.09.011 Web of Science: 000448633000011
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2018The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Na-v 1.6. EXPERIMENTAL NEUROLOGY. 308.Full Text via DOI: 10.1016/j.expneurol.2018.07.005 Web of Science: 000442714900011
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2018RNAseq analysis of hippocampal microglia after kainic acid-induced seizuresFull Text via DOI: 10.1186/s13041-018-0376-5 Web of Science: 000435906000001
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2018Glycoprotein NMB: an Emerging Role in Neurodegenerative DiseaseFull Text via DOI: 10.1007/s12035-017-0707-z Web of Science: 000431991500050
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2018The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptorFull Text via DOI: 10.1186/s12974-018-1100-1 Web of Science: 000427173900001
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2018Epigenetic regulation of astrocyte function in neuroinflammation and neurodegenerationFull Text via DOI: 10.1016/j.bbadis.2017.11.004 Web of Science: 000424074300010
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2018Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's DiseaseFull Text via DOI: 10.1155/2018/6537072 Web of Science: 000428344200001
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2017MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease PhenotypeFull Text via DOI: 10.1021/acschemneuro.7b00287 Web of Science: 000418786100023
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2017Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1Full Text via DOI: 10.1016/j.neuropharm.2017.07.020 Web of Science: 000411775700016
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2017"Ephrin-A5 regulates inter-male aggression in mice (vol 286, pg 300, 2015)Full Text via DOI: 10.1016/j.bbr.2017.08.019 Web of Science: 000412034100028
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2017The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitisFull Text via DOI: 10.1016/j.taap.2017.06.023 Web of Science: 000407662600001
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2017Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expressionFull Text via DOI: 10.1016/j.neuro.2016.04.002 Web of Science: 000403133600033
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2017Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron lossFull Text via DOI: 10.1016/j.neuro.2017.03.008 Web of Science: 000403133600011
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2017Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium ChannelsFull Text via DOI: 10.1093/toxsci/kfw187 Web of Science: 000397041300010
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2016Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by DiphenyleneiodoniumFull Text via DOI: 10.1093/toxsci/kfw031 Web of Science: 000376662800013
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2016Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampusFull Text via DOI: 10.1016/j.neuro.2016.03.023 Web of Science: 000377054100008
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2016Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadioneFull Text via DOI: 10.1111/nyas.13156 Web of Science: 000394087800009
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2015Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional ActivatorsFull Text via DOI: 10.1002/jbt.21725 Web of Science: 000367688500001
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2015Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDDFull Text via DOI: 10.1016/j.ntt.2015.06.003 Web of Science: 000367108400007
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2015Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxicationFull Text via DOI: 10.1016/j.taap.2015.07.023 Web of Science: 000362145600013
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2015Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma CellsFull Text via DOI: 10.1007/s11064-015-1601-6 Web of Science: 000357509700006
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2015Ephrin-A5 regulates inter-male aggression in miceFull Text via DOI: 10.1016/j.bbr.2015.03.001 Web of Science: 000353599600040
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2015Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorderFull Text via DOI: 10.1096/fj.14-260901 Web of Science: 000354114600030
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2015Role of Calcium and Calpain in the Downregulation of Voltage-Gated Sodium Channel Expression by the Pyrethroid Pesticide DeltamethrinFull Text via DOI: 10.1002/jbt.21676 Web of Science: 000350662600005
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2015Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin ReductaseFull Text via DOI: 10.1124/jpet.114.221572 Web of Science: 000351036400012
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2015Modulation of Microglial Process Convergence Toward Neuronal Dendrites by Extracellular CalciumFull Text via DOI: 10.1523/JNEUROSCI.3279-14.2015 Web of Science: 000349686500010
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2015Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated MiceFull Text via DOI: 10.1155/2015/812532 Web of Science: 000360146800001
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2015Hippocampal ER Stress and Learning Deficits Following Repeated Pyrethroid ExposureFull Text via DOI: 10.1093/toxsci/kfu226 Web of Science: 000350101700023
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2014MDR1 Transporter Protects Against Paraquat-Induced Toxicity in Human and Mouse Proximal Tubule CellsFull Text via DOI: 10.1093/toxsci/kfu141 Web of Science: 000343045100017
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2014Testosterone as the Missing Link Between Pesticides, Alzheimer Disease, and Parkinson Disease ReplyFull Text via DOI: 10.1001/jamaneurol.2014.1814 Web of Science: 000341977300020
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2014Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and ratsFull Text via DOI: 10.1016/j.taap.2014.04.026 Web of Science: 000338756700005
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2014Alzheimer Disease Risk FactorsFull Text via DOI: 10.1001/jamaneurol.2014.1525 Web of Science: 000340481800019
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2014Elevated Serum DDE and Risk for Alzheimer Disease ReplyFull Text via DOI: 10.1001/jamaneurol.2014.1548 Web of Science: 000340481800026
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2014Fibroblast growth factor 15 deficiency impairs liver regeneration in miceFull Text via DOI: 10.1152/ajpgi.00337.2013 Web of Science: 000336844200009
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2014Repeated deltamethrin exposure causes cognitive deficits in mice: Role of ER stress and Impaired NeurogenesisFull Text via DOI: 10.1016/j.ntt.2014.04.044 Web of Science: 000338621800051
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2014Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: Role of altered catecholamines and BDNFFull Text via DOI: 10.1016/j.expneurol.2014.01.016 Web of Science: 000333321300015
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2014Elevated Serum Pesticide Levels and Risk for Alzheimer DiseaseFull Text via DOI: 10.1001/jamaneurol.2013.6030 Web of Science: 000332831600005
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2013Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegenerationFull Text via DOI: 10.1073/pnas.1318830110 Web of Science: 000327390400093
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2013Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression (vol 27, pg 165, 2013)Full Text via DOI: 10.1002/jbt.21480 Web of Science: 000317134500004
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2013Acute Effects of Pyrethroids on Serotonin Release in the Striatum of Awake Rats: An In Vivo Microdialysis StudyFull Text via DOI: 10.1002/jbt.21450 Web of Science: 000315188700006
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2013Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene ExpressionFull Text via DOI: 10.1002/jbt.21477 Web of Science: 000315188700008
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2013Inhibition of Human MDR1 and BCRP Transporter ATPase Activity by Organochlorine and Pyrethroid InsecticidesFull Text via DOI: 10.1002/jbt.21458 Web of Science: 000315188700007
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2013Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liverFull Text via DOI: 10.1016/j.taap.2012.11.012 Web of Science: 000313758200010
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2013Ephrin-A5 deficiency alters sensorimotor and monoaminergic developmentFull Text via DOI: 10.1016/j.bbr.2012.08.032 Web of Science: 000310929400018
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2013Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson's DiseaseFull Text via DOI: 10.1155/2013/587418 Web of Science: 000326757300001
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2012Inflammatory Regulation of ATP Binding Cassette Efflux Transporter Expression and Function in MicrogliaFull Text via DOI: 10.1124/jpet.112.196543 Web of Science: 000311099300012
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2012Polybrominated diphenyl ethers enhance the production of proinflammatory cytokines by the placentaFull Text via DOI: 10.1016/j.placenta.2012.06.005 Web of Science: 000308896300013
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2012A DDT metabolite is elevated in the serum of Alzheimer's disease patientsFull Text via DOI: 10.1016/j.jalz.2012.05.1348
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2012Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's diseaseFull Text via DOI: 10.1016/j.expneurol.2012.01.022 Web of Science: 000301994900025
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2011beta-Hexachlorocyclohexane levels in serum and risk of Parkinson's diseaseFull Text via DOI: 10.1016/j.neuro.2011.04.002 Web of Science: 000296671800017
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2011Mechanism of Pyrethroid Pesticide-Induced Apoptosis: Role of Calpain and the ER Stress PathwayFull Text via DOI: 10.1093/toxsci/kfr111 Web of Science: 000293914500026
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2010Developmental Neurotoxicity of Pyrethroid Insecticides in Zebrafish EmbryosFull Text via DOI: 10.1093/toxsci/kfp258 Web of Science: 000272935700017
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2009Elevated Serum Pesticide Levels and Risk of Parkinson DiseaseFull Text via DOI: 10.1001/archneurol.2009.89 Web of Science: 000268189200009
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2009Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brainFull Text via DOI: 10.1016/j.neuro.2008.12.015 Web of Science: 000264912700014
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2009Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brainFull Text via DOI: 10.1016/j.expneurol.2008.11.003 Web of Science: 000262890900019
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2008Treadmill Gait Analysis Does Not Detect Motor Deficits in Animal Models of Parkinson's Disease or Amyotrophic Lateral SclerosisFull Text via DOI: 10.3200/JMBR.40.6.568-577 Web of Science: 000260724000010
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2008Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosisFull Text via DOI: 10.1111/j.1471-4159.2008.05568.x Web of Science: 000258360000019
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2008PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicityFull Text via DOI: 10.1016/j.npep.2008.04.003 Web of Science: 000259470200005
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2008Disruption of dopamine transport by DDT and its metabolitesFull Text via DOI: 10.1016/j.neuro.2008.04.010 Web of Science: 000257819500016
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2008Na+/H+ exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditionsFull Text via DOI: 10.1111/j.1471-4159.2008.05355.x Web of Science: 000256718600020
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2007Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegenerationFull Text via DOI: 10.1523/JNEUROSCI.0319-07.2007 Web of Science: 000248484800026
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2007Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine systemFull Text via DOI: 10.1016/j.expneurol.2006.12.020 Web of Science: 000245682900013
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2007Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's diseaseFull Text via DOI: 10.1111/j.1471-4159.2006.04333.x Web of Science: 000244720700004
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2007Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: Oxidation of thioredoxin and caspase-3 activationFull Text via DOI: 10.1093/toxsci/kfl125 Web of Science: 000243072300016
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2007Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)Full Text via DOI: 10.1093/toxsci/kfl133 Web of Science: 000243072300020
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2006Pyrethroid pesticide-induced alterations in dopamine transporter functionFull Text via DOI: 10.1016/j.taap.2005.06.003 Web of Science: 000236532900002
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2005Paraquat neurotoxicity is distinct from that of MPTP and rotenoneFull Text via DOI: 10.1093/toxsci/kfi304 Web of Science: 000232428300022
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2005Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatumFull Text via DOI: 10.1016/j.neuro.2004.09.003 Web of Science: 000231689400022
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2005Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing ratsFull Text via DOI: 10.1093/toxsci/kfi081 Web of Science: 000227973900018
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2004Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing ratsFull Text via DOI: 10.1093/toxsci/kfh014 Web of Science: 000187988800011
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2003Mechanism of toxicity in rotenone models of Parkinson's diseaseFull Text via DOI: 10.1523/jneurosci.23-34-10756.2003 Web of Science: 000186902500002
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2003Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistryFull Text via DOI: 10.1080/15287390306369 Web of Science: 000180896800005
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2002Effects of PCB exposure on the toxic impact of organophosphorus insecticidesFull Text via DOI: 10.1093/toxsci/67.2.311 Web of Science: 000175852800019
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2001Analysis of the additivity of in vitro inhibition of cholinesterase by mixtures of chlorpyrifos-oxon and azinphos-methyl-oxonFull Text via DOI: 10.1006/taap.2001.9140 Web of Science: 000168452500006
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2001Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile ratsFull Text via DOI: 10.1093/toxsci/59.2.260 Web of Science: 000166638300010
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Book Chapter
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20186.04 Selective Vulnerability in the Nervous System☆Full Text via DOI: 10.1016/b978-0-08-100601-6.02188-8
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2018Selective Vulnerability in the Nervous SystemFull Text via DOI: 10.1016/B978-0-08-100601-6.02188-8
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2017Neuroprotective Properties of Dietary Polyphenols in Parkinson's DiseaseFull Text via DOI: 10.1002/9781119155195.ch11
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2017Selective Vulnerability in the Nervous SystemFull Text via DOI: 10.1016/b978-0-12-801238-3.02188-7
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2015Parkinson's Disease: Mechanisms, Models, and Biological PlausibilityFull Text via DOI: 10.1016/B978-0-12-800228-5.00013-3 Web of Science: 000416954000015
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201013.03 Selective Vulnerability in the Nervous System*Full Text via DOI: 10.1016/b978-0-08-046884-6.01303-8
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2010Selective Vulnerability in the Nervous SystemWeb of Science: 000333465100003
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Conference
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2018Retinal amyloid pathology requires CD36 receptors.Web of Science: 000442932801246
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2017
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2009Exposure to pyrethroid insecticides alters expression of genes important for dopaminergic neuronal developmentFull Text via DOI: 10.1016/j.ntt.2009.04.022 Web of Science: 000267253900025
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2008Developmental pesticide exposure: A new risk factor for ADHD?Full Text via DOI: 10.1016/j.ntt.2008.03.030 Web of Science: 000257303100038
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2006
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Meeting Abstract
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2020L-Plastin, a Novel Regulator of Microglial Activation in Parkinsons disease. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.09750 Web of Science: 000546107900342
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Review
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2020Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. DRUG METABOLISM AND DISPOSITION. 459-480.Full Text via DOI: 10.1124/dmd.119.089953 Web of Science: 000551340100006
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2019Neurotoxicity of pesticides. ACTA NEUROPATHOLOGICA. 343-362.Full Text via DOI: 10.1007/s00401-019-02033-9 Web of Science: 000480599000002
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2019Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine. PHARMACOLOGY & THERAPEUTICS. 173-187.Full Text via DOI: 10.1016/j.pharmthera.2019.03.005 Web of Science: 000474321600012
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Research
research interests
- Environmental Health Sciences; Neurodegeneration; Neuroprotection; Molecular Neuroscience; Neurodegenerative Diseases; Cellular Neuroscience; Enzyme Activity; Behavioral Analysis; Western Blot; Western Blot; Alzheimer's Disease
Contact
full name
- Jason Richardson
Identifiers
ORCID iD
- https://orcid.org/0000-0001-6521-610X (confirmed)
visualizations
publication subject areas
- Biochemistry & Molecular Biology
- Cell Biology
- Genetics & Heredity
- Life Sciences & Biomedicine - Other Topics
- Neurosciences & Neurology
- Pathology
- Pharmacology & Pharmacy
- Toxicology