Rodriguez Martinez, Myosotys

Rodriguez Martinez, Myosotys

Positions

Assistant Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine

myrodrig@fiu.edu

overview

Myosotys Rodriguez is an Assistant Professor in the Department of Immunology and Nano-Medicine at Herbert Wertheim College of Medicine, Florida International University. She received her Ph.D. in Cellular and Molecular Biology from the Department of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, Puerto Rico in 2014. Her doctoral research involved examining the effects of opioid dependence treatment in HIV immunopathology in the peripheral immune system and the central nervous system (CNS).

Dr. Rodriguez joined FIU in 2015 to pursue postdoctoral training under the mentorship of Dr. Nazira El-Hage. As a postdoctoral fellow her training was focused in demonstrating that autophagy is an essential mechanism through which HIV replication is mediated in the CNS. Specifically, how imbalances in autophagy alter HIV and opiates-induced astroglia metabolic dysfunctions.

research interests

Investigating whether targeting autophagy lessen the metabolic dysfunctions induced by HIV within the brain in the presence of antiretroviral therapy
The use of nanotherapy to attenuate HIV and neuroinflammation

selected publications

Article
- 2021
  
  Different Roles of Beclin 1 in the Interaction Between Glia and Neurons after Exposure to Morphine and the HIV- Trans-Activator of Transcription (Tat) Protein
  Full Text via DOI: 10.1007/s11481-021-10017-4 Web of Science: 000714824900001
- 2021
  
  Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles
  Full Text via DOI: 10.3390/pharmaceutics13020223 Web of Science: 000623002300001
- 2020
  
  Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy
  Full Text via DOI: 10.3390/v12060608 Web of Science: 000551247500001
- 2020
  
  Comparative Cytotoxicity of Inorganic Arsenite and Methylarsenite in Human Brain Cells
  Full Text via DOI: 10.1021/acschemneuro.9b00653 Web of Science: 000518702400007
- 2019
  
  GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice
  Full Text via DOI: 10.1016/j.jconrel.2019.10.027 Web of Science: 000500710700012
- 2019
  
  Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes
  Full Text via DOI: 10.1007/s13365-018-0715-4 Web of Science: 000467445200013
- 2019
  
  Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes
  Full Text via DOI: 10.1371/journal.pone.0208543 Web of Science: 000458181200007
- 2018
  
  Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse
  Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
- 2017
  
  Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes
  Full Text via DOI: 10.3390/v9080201 Web of Science: 000408742900006
- 2017
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
  Full Text via DOI: 10.1038/s41598-017-01819-9 Web of Science: 000401262400055
- 2017
  
  Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro
  Full Text via DOI: 10.1007/s11481-016-9688-3 Web of Science: 000394969800009
- 2016
  
  beta-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization
  Full Text via DOI: 10.1007/s13365-016-0464-1 Web of Science: 000389342900016
- 2015
  
  Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure
  Full Text via DOI: 10.3389/fmicb.2015.00653 Web of Science: 000358382000001
- 2015
  
  HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse
  Full Text via DOI: 10.1128/JVI.02022-14
- 2014
  
  Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine
  Full Text via DOI: 10.1097/QAD.0000000000000291
- 2014
  
  Opiate addiction therapies and HIV-1 tat: Interactive effects on glial [Ca²⁺]i, oxyradical and neuroinflammatory chemokine production and correlative neurotoxicity
  Full Text via DOI: 10.2174/1570162x1206150311161147
Conference
- 2018
  
  Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. S60-S60.
  Web of Science: 000429149100207
- 2017
  
  Drug-drug interaction of cART and Morphine mediated by autophagy exacerbates the overall effect of cART in brain. S38-S38.
  Web of Science: 000414227700084
- 2017
  
  Intranasal administration of small interfering (si) RNA Beclin1 encapsulated with linear polyethylenimine (PEI) nano-plexes to attenuate HIV-1 infection in the brain. S69-S70.
  Web of Science: 000414227700167
- 2016
  
  ROLE OFAUTOPHAGYON HIV-INFECTED HUMAN ASTROCYTES FUNCTIONALITY.. S41-S41.
  Web of Science: 000377566000105
- 2015
  
  Differing roles of autophagy in HIV-associated Neurocognitive Impairment and Encephalitis with Implications for Morphine Co-exposure. S96-S97.
  Web of Science: 000367554100105
- 2015
  
  Methanandamide bound to Magnetic Electric Nanoparticle did not compromise resistance and permeability of the Blood Brain Barrier. S111-S111.
  Web of Science: 000367554100144
- 2009
  
  Comparative Immunovirological Study between Buprenorphine and Methadone Using Human Lymphocytes and Glial Cells. 80-81.
  Web of Science: 000270278700166
Other Scholarly Work
- 2022
  
  GDNF-expressing macrophages restore motor functions at a severe late-stage and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice (vol 315, pg 139, 2019). 813-814.
  Full Text via DOI: 10.1016/j.jconrel.2022.01.007 Web of Science: 000802746900001
- 2018
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation (vol 7, year 2017)
  Full Text via DOI: 10.1038/s41598-018-23078-y Web of Science: 000427370700001
Review
- 2020
  
  Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration
  Full Text via DOI: 10.3389/fneur.2020.583459 Web of Science: 000593917400001
- 2018
  
  Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time
  Full Text via DOI: 10.3389/fcimb.2018.00362 Web of Science: 000447588800001
- 2018
  
  Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus
  Full Text via DOI: 10.3389/fimmu.2018.02340 Web of Science: 000447256100001
- 2017
  
  Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications
  Full Text via DOI: 10.3390/v9070176 Web of Science: 000406684400018
- 2017
  
  HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency. 4133-4144.
  Full Text via DOI: 10.2174/1381612823666170622101319 Web of Science: 000414366900008
- 2016
  
  Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections
  Full Text via DOI: 10.1186/s12929-016-0292-x Web of Science: 000386719500001

full name

Myosotys Rodriguez Martinez

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publication subject areas

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