Rodriguez Martinez, Myosotys
- Assistant Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine
Contact Info

Overview
overview
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Myosotys Rodriguez is an Assistant Professor in the Department of Immunology and Nano-Medicine at Herbert Wertheim College of Medicine, Florida International University. She received her Ph.D. in Cellular and Molecular Biology from the Department of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, Puerto Rico in 2014. Her doctoral research involved examining the effects of opioid dependence treatment in HIV immunopathology in the peripheral immune system and the central nervous system (CNS).
Dr. Rodriguez joined FIU in 2015 to pursue postdoctoral training under the mentorship of Dr. Nazira El-Hage. As a postdoctoral fellow her training was focused in demonstrating that autophagy is an essential mechanism through which HIV replication is mediated in the CNS. Specifically, how imbalances in autophagy alter HIV and opiates-induced astroglia metabolic dysfunctions.
research interests
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Investigating whether targeting autophagy lessen the metabolic dysfunctions induced by HIV within the brain in the presence of antiretroviral therapy
The use of nanotherapy to attenuate HIV and neuroinflammation
Scholarly & Creative Works
selected publications
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Article
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2021Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles. PHARMACEUTICS. 13.Full Text via DOI: 10.3390/pharmaceutics13020223 Web of Science: 000623002300001
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2020Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy. VIRUSES-BASEL. 12.Full Text via DOI: 10.3390/v12060608 Web of Science: 000551247500001
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2020Comparative Cytotoxicity of Inorganic Arsenite and Methylarsenite in Human Brain Cells. ACS CHEMICAL NEUROSCIENCE. 11:743-751.Full Text via DOI: 10.1021/acschemneuro.9b00653 Web of Science: 000518702400007
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2019GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice. JOURNAL OF CONTROLLED RELEASE. 315:139-149.Full Text via DOI: 10.1016/j.jconrel.2019.10.027 Web of Science: 000500710700012
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2019Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes. JOURNAL OF NEUROVIROLOGY. 25:263-274.Full Text via DOI: 10.1007/s13365-018-0715-4 Web of Science: 000467445200013
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2019Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLOS ONE. 14.Full Text via DOI: 10.1371/journal.pone.0208543 Web of Science: 000458181200007
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2018Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13.Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
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2017Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 12:120-132.
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2016beta-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. JOURNAL OF NEUROVIROLOGY. 22:866-870.
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2015Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. FRONTIERS IN MICROBIOLOGY. 6.
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Correction
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Meeting Abstract
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2018Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S60-S60.Web of Science: 000429149100207
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2017Drug-drug interaction of cART and Morphine mediated by autophagy exacerbates the overall effect of cART in brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S38-S38.Web of Science: 000414227700084
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2017Intranasal administration of small interfering (si) RNA Beclin1 encapsulated with linear polyethylenimine (PEI) nano-plexes to attenuate HIV-1 infection in the brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S70.Web of Science: 000414227700167
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2016ROLE OFAUTOPHAGYON HIV-INFECTED HUMAN ASTROCYTES FUNCTIONALITY.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S41-S41.Web of Science: 000377566000105
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2015Differing roles of autophagy in HIV-associated Neurocognitive Impairment and Encephalitis with Implications for Morphine Co-exposure. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S96-S97.Web of Science: 000367554100105
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2015Methanandamide bound to Magnetic Electric Nanoparticle did not compromise resistance and permeability of the Blood Brain Barrier. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S111-S111.Web of Science: 000367554100144
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2009Comparative Immunovirological Study between Buprenorphine and Methadone Using Human Lymphocytes and Glial Cells. JOURNAL OF NEUROVIROLOGY. 80-81.Web of Science: 000270278700166
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Other Scholarly Work
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2022Corrigendum to “GDNF-expressing macrophages restore motor functions at a severe late-stage and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice”, [J Control Release, 315 (2019) 139–149] (Journal of Controlled Release (2019) 315 (139–149), (S0168365919305905), (10.1016/j.jconrel.2019.10.027)). 813-814.Full Text via DOI: 10.1016/j.jconrel.2022.01.007
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Review
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2020Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration. FRONTIERS IN NEUROLOGY.Full Text via DOI: 10.3389/fneur.2020.583459 Web of Science: 000593917400001
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2018Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.Full Text via DOI: 10.3389/fcimb.2018.00362 Web of Science: 000447588800001
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2018Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus. FRONTIERS IN IMMUNOLOGY.Full Text via DOI: 10.3389/fimmu.2018.02340 Web of Science: 000447256100001
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2017HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency. CURRENT PHARMACEUTICAL DESIGN. 4133-4144.
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2016Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections. JOURNAL OF BIOMEDICAL SCIENCE.
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Contact
full name
- Myosotys Rodriguez Martinez
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publication subject areas
Citation index-derived subject areas the researcher has published in