Rodriguez Martinez, Myosotys

Rodriguez Martinez, Myosotys
Close

Positions

Assistant Professor, Immunology and Nano-Medicine , Herbert Wertheim College of Medicine

Contact Info

myrodrig@fiu.edu

overview

Myosotys Rodriguez is an Assistant Professor in the Department of Immunology and Nano-Medicine at Herbert Wertheim College of Medicine, Florida International University. She received her Ph.D. in Cellular and Molecular Biology from the Department of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, Puerto Rico in 2014. Her doctoral research involved examining the effects of opioid dependence treatment in HIV immunopathology in the peripheral immune system and the central nervous system (CNS).

Dr. Rodriguez joined FIU in 2015 to pursue postdoctoral training under the mentorship of Dr. Nazira El-Hage. As a postdoctoral fellow her training was focused in demonstrating that autophagy is an essential mechanism through which HIV replication is mediated in the CNS. Specifically, how imbalances in autophagy alter HIV and opiates-induced astroglia metabolic dysfunctions.

research interests

Investigating whether targeting autophagy lessen the metabolic dysfunctions induced by HIV within the brain in the presence of antiretroviral therapy
The use of nanotherapy to attenuate HIV and neuroinflammation

selected publications

Article
- 2021
  
  Different Roles of Beclin 1 in the Interaction Between Glia and Neurons after Exposure to Morphine and the HIV- Trans-Activator of Transcription (Tat) Protein
  Full Text via DOI: 10.1007/s11481-021-10017-4 Web of Science: 000714824900001
- 2021
  
  Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles. PHARMACEUTICS. 13.
  Full Text via DOI: 10.3390/pharmaceutics13020223 Web of Science: 000623002300001
- 2020
  
  Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy. VIRUSES-BASEL. 12.
  Full Text via DOI: 10.3390/v12060608 Web of Science: 000551247500001
- 2020
  
  Comparative Cytotoxicity of Inorganic Arsenite and Methylarsenite in Human Brain Cells. ACS CHEMICAL NEUROSCIENCE. 11:743-751.
  Full Text via DOI: 10.1021/acschemneuro.9b00653 Web of Science: 000518702400007
- 2019
  
  GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice. JOURNAL OF CONTROLLED RELEASE. 315:139-149.
  Full Text via DOI: 10.1016/j.jconrel.2019.10.027 Web of Science: 000500710700012
- 2019
  
  Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes. JOURNAL OF NEUROVIROLOGY. 25:263-274.
  Full Text via DOI: 10.1007/s13365-018-0715-4 Web of Science: 000467445200013
- 2019
  
  Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLOS ONE. 14.
  Full Text via DOI: 10.1371/journal.pone.0208543 Web of Science: 000458181200007
- 2018
  
  Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13.
  Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
- 2017
  
  Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 12:120-132.
  Full Text via DOI: 10.1007/s11481-016-9688-3 PMID: 27287620 Web of Science: 000394969800009
- 2017
  
  Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes. VIRUSES-BASEL. 9.
  Full Text via DOI: 10.3390/v9080201 PMID: 28788100 Web of Science: 000408742900006
- 2017
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. SCIENTIFIC REPORTS. 7.
  Full Text via DOI: 10.1038/s41598-017-01819-9 PMID: 28500326 Web of Science: 000401262400055
- 2016
  
  beta-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. JOURNAL OF NEUROVIROLOGY. 22:866-870.
  Full Text via DOI: 10.1007/s13365-016-0464-1 PMID: 27400929 Web of Science: 000389342900016
- 2015
  
  Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. FRONTIERS IN MICROBIOLOGY. 6.
  Full Text via DOI: 10.3389/fmicb.2015.00653 PMID: 26217309 Web of Science: 000358382000001
- 2015
  
  HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse
  Full Text via DOI: 10.1128/JVI.02022-14
- 2014
  
  Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine
  Full Text via DOI: 10.1097/QAD.0000000000000291
- 2014
  
  Opiate addiction therapies and HIV-1 tat: Interactive effects on glial [Ca²⁺]i, oxyradical and neuroinflammatory chemokine production and correlative neurotoxicity
  Full Text via DOI: 10.2174/1570162x1206150311161147
Correction
- 2018
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation (vol 7, year 2017). SCIENTIFIC REPORTS.
  Full Text via DOI: 10.1038/s41598-018-23078-y PMID: 29540788 Web of Science: 000427370700001
Meeting Abstract
- 2018
  
  Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S60-S60.
  Web of Science: 000429149100207
- 2017
  
  Drug-drug interaction of cART and Morphine mediated by autophagy exacerbates the overall effect of cART in brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S38-S38.
  Web of Science: 000414227700084
- 2017
  
  Intranasal administration of small interfering (si) RNA Beclin1 encapsulated with linear polyethylenimine (PEI) nano-plexes to attenuate HIV-1 infection in the brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S70.
  Web of Science: 000414227700167
- 2016
  
  ROLE OFAUTOPHAGYON HIV-INFECTED HUMAN ASTROCYTES FUNCTIONALITY.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S41-S41.
  Web of Science: 000377566000105
- 2015
  
  Differing roles of autophagy in HIV-associated Neurocognitive Impairment and Encephalitis with Implications for Morphine Co-exposure. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S96-S97.
  Web of Science: 000367554100105
- 2015
  
  Methanandamide bound to Magnetic Electric Nanoparticle did not compromise resistance and permeability of the Blood Brain Barrier. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S111-S111.
  Web of Science: 000367554100144
- 2009
  
  Comparative Immunovirological Study between Buprenorphine and Methadone Using Human Lymphocytes and Glial Cells. JOURNAL OF NEUROVIROLOGY. 80-81.
  Web of Science: 000270278700166
Other Scholarly Work
- 2022
  
  Corrigendum to “GDNF-expressing macrophages restore motor functions at a severe late-stage and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice”, [J Control Release, 315 (2019) 139–149] (Journal of Controlled Release (2019) 315 (139–149), (S0168365919305905), (10.1016/j.jconrel.2019.10.027)). 813-814.
  Full Text via DOI: 10.1016/j.jconrel.2022.01.007
Review
- 2020
  
  Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration. FRONTIERS IN NEUROLOGY.
  Full Text via DOI: 10.3389/fneur.2020.583459 Web of Science: 000593917400001
- 2018
  
  Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.
  Full Text via DOI: 10.3389/fcimb.2018.00362 Web of Science: 000447588800001
- 2018
  
  Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus. FRONTIERS IN IMMUNOLOGY.
  Full Text via DOI: 10.3389/fimmu.2018.02340 Web of Science: 000447256100001
- 2017
  
  HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency. CURRENT PHARMACEUTICAL DESIGN. 4133-4144.
  Full Text via DOI: 10.2174/1381612823666170622101319 PMID: 28641535 Web of Science: 000414366900008
- 2017
  
  Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications. VIRUSES-BASEL.
  Full Text via DOI: 10.3390/v9070176 PMID: 28684681 Web of Science: 000406684400018
- 2016
  
  Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections. JOURNAL OF BIOMEDICAL SCIENCE.
  Full Text via DOI: 10.1186/s12929-016-0292-x PMID: 27784307 Web of Science: 000386719500001

full name

Myosotys Rodriguez Martinez

visualizations

Recent publications and grants in Scholars@FIU

Co-author Network

publication subject areas

Citation index-derived subject areas the researcher has published in