
Overview
overview
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Dr. Deodutta Roy joined Florida International University (FIU) as a professor in 2004 and was the founding chairman of the Department of Environmental and Occupational Health from 2005-2011. Before joining FlU, he was a tenured professor at the University of Alabama at Birmingham from 1998-2004. Nationally and internationally recognized in the estrogen carcinogenesis field, Dr. Roy has received several awards and honors for his research work, including Junior Faculty Development Award from American Cancer Society and Scholar Awards in cancer research from the American Association for Cancer Research (AACR).
Dr. Roy is a prolific scholar and researcher, having published over one hundred peer-reviewed articles, book chapters, monographs, and two patents. He has trained 15 doctoral students and numerous postdoctoral fellows. For the last 24 years, his research program has been continuously funded through grants from the American Cancer Society, U.S. National Institutes of Health, the Department of Defense, and Veteran Affairs. Dr. Roy has served on a variety of research-related advisory boards and review panels, including National Institutes of Health, the Susan Komen Foundation, Miami VA, and the Massachusetts Public Health Breast Cancer review panels. Dr. Roy is also on the editorial boards of nine scientific journals. He has collaborated with scientists at Miami Children’s Hospital, University of Miami, and Miami Veterans Affairs Healthcare System to investigate human DNA variants, epigenetic, stochastic and environmental factors that modify responses to exposure to endocrine disrupting
Environmental Functional Genomics (Application of Human Genomics/Epigenomics to Population Sciences: Molecular Prevention): The Environmental Functional Genomics Group has been engaged in characterizing underlying genetic, epigenetic and environmental factors that contribute to variability in human responses to endocrine disrupting stressors. We especially focus on discovery of epigenetic, stochastic and environmental factors that modify responses to exposure to endocrine disrupting stressors and how these factors affect the susceptibility to complex chronic diseases, such as cancer, neurodegenerative lesions in exposed people. This information may prove useful in developing therapeutic targets for the molecular prevention and treatment of complex chronic diseases and discovery of valuable novel biomarkers for identifying at-risk individuals and devising chronic human disease-molecular prevention strategies.
research interests
- Stem Cell Aging and Cancer, Mitochondrial Dysfunction and Neurological Diseases
Scholarly & Creative Works
selected publications
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Article
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2021Is Mycobacterium tuberculosis carcinogenic to humans?Full Text via DOI: 10.1096/fj.202001581RR Web of Science: 000691122900023
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2021Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosisFull Text via DOI: 10.1016/j.csbj.2021.04.034 Web of Science: 000692620700012
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2020Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancerFull Text via DOI: 10.1007/s10585-020-10060-0 Web of Science: 000580404900001
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2020Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparitiesFull Text via DOI: 10.1007/s00432-020-03320-9 Web of Science: 000551783900003
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2018Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast CarcinogenesisFull Text via DOI: 10.3390/cells7120234 Web of Science: 000455320700012
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2018NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2+ve breast cancer signaling pathwaysFull Text via DOI: 10.1007/s10549-018-4905-9 Web of Science: 000447497300021
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2017Environmental estrogen-like endocrine disrupting chemicals and breast cancerFull Text via DOI: 10.1016/j.mce.2016.10.003 Web of Science: 000413128000011
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2015Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain TumorsFull Text via DOI: 10.1007/s12035-014-8930-3 Web of Science: 000361903400023
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2013Discovering gene-environment interactions in Glioblastoma through a comprehensive data integration bioinformatics methodFull Text via DOI: 10.1016/j.neuro.2012.11.001 Web of Science: 000316777200001
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2006SKCG-1: a new candidate growth regulatory gene at chromosome 11q23.2 in human sporadic Wilms tumoursFull Text via DOI: 10.1038/sj.bjc.6603090 Web of Science: 000237648200026
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2006Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cellsFull Text via DOI: 10.2741/1845 Web of Science: 000232528000071
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2005Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengersFull Text via DOI: 10.1021/bi047629p Web of Science: 000228962500019
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2005Mitochondrial signals to nucleus regulate estrogen-induced cell growthFull Text via DOI: 10.1016/j.mehy.2003.12.056 Web of Science: 000225481400031
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2001The biphasic stimulation of proliferation of Leydig cells by estrogen exposure.Full Text via DOI: 10.3892/ijo.18.3.623
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1991Cytochrome b
5 -mediated redox cycling of estrogenFull Text via DOI: 10.1016/0003-9861(91)90368-S -
1990Cytochrome b5 mediated redox cycling of estrogensFull Text via DOI: 10.1016/0891-5849(90)90286-r
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Book
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2010Environmental factors, genes, and the development of human cancersFull Text via DOI: 10.1007/978-1-4419-6752-7
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2010Environmental Factors, Genes, and the Development of Human Cancers IntroductionFull Text via DOI: 10.1007/978-1-4419-6752-7_1 Web of Science: 000282535900001
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Book Chapter
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2022Chapter 19 Epigenome's environmental sensitivity and its impact on health. 451-478.Full Text via DOI: 10.1016/b978-0-12-823500-3.00009-1
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2019Malformations of cortical development and epilepsy in children. 211-218.Full Text via DOI: 10.1016/B978-0-12-409548-9.11744-0
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2011Environment, Genetic and Epigenetic Alterations and Pediatric Central Nervous System Tumors. 559-568.Full Text via DOI: 10.1016/B978-0-444-52272-6.00071-4
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2011Malformations of Cortical Development and Epilepsy in Children. 595-602.Full Text via DOI: 10.1016/B978-0-444-52272-6.00073-8
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2010Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility. 197-219.Full Text via DOI: 10.1007/978-1-4419-6752-7_8 Web of Science: 000282535900008
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2010Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors. 223-252.Full Text via DOI: 10.1007/978-1-4419-6752-7_9 Web of Science: 000282535900009
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2005Estrogen-Induced Mutations and Its Role in the Development of Tumorigenesis. 475-479.Full Text via DOI: 10.1007/0-387-23761-5_51
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1998Pro-Oxidant and Antioxidant Effects of Estrogens. 425-435.Full Text via DOI: 10.1385/0-89603-472-0:425
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Conference
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2020Aberrant transcription factor activity of NRF1, NFE2L2, E2F1, RFX1, and MEF2 associated with severity of astrocytomaFull Text via DOI: 10.1158/1538-7445.AM2020-4391 Web of Science: 000590059301273
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2019Abstract 2441: Association between NRF1 regulatory gene networks and cancer and aging. 2441-2441.Full Text via DOI: 10.1158/1538-7445.sabcs18-2441
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2019Association between NRF1 regulatory gene networks and cancer and agingFull Text via DOI: 10.1158/1538-7445.AM2019-2441 Web of Science: 000488279400400
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2018Exosomal ID3 is pro-metastatic through guiding NRF1-induced breast cancer stem cells across the blood-brain-barrierFull Text via DOI: 10.1158/1538-7445.AM2018-1128 Web of Science: 000468818903101
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2018Role of NRF1 regulatory gene-networks in glioblastomaFull Text via DOI: 10.1158/1538-7445.AM2018-1127 Web of Science: 000468818903100
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2012Novel 4-N-modified gemcitabine analogsWeb of Science: 000324503201668
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2011Identifying gene alterations required for the development of astrocytoma. 1037-1041.Web of Science: 000314989301008
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2011Estrogen-induced redox signaling via NRF-1 is involved in the development of breast cancerFull Text via DOI: 10.1158/1538-7445.AM2011-LB-12 Web of Science: 000209701305418
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2010Abstract 5050: Functional characterization of a newly identified growth regulatory gene SKCG-1 in human kidney cancer. 5050-5050.Full Text via DOI: 10.1158/1538-7445.am10-5050
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2009Redox Status Contributes to Tamoxifen-Resistant Growth of Breast Cancer.. 810S-810S.Web of Science: 000272920702093
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2007
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2007
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2007General remarks. 33-35.
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2007Is in utero imprinting of the brain by pesticides involved in childhood brain cancer development?. S169-S170.Web of Science: 000249018300556
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2007
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2006
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Note
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2005Carcinogenicity of combined oestrogen-progestagen contraceptives and menopausal treatment. 552-553.Full Text via DOI: 10.1016/S1470-2045(05)70273-4
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Other Scholarly Work
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2016Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). 741-745.Full Text via DOI: 10.1136/jech-2015-207005 Web of Science: 000380152600002
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2010Differential role of estrogen receptor positive NRF1(High) and NRF1(Low) cells in breast cancer development and progression. S25-S25.Full Text via DOI: 10.1016/j.nbt.2010.01.021 Web of Science: 000209825000061
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Preprint
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Review
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2018Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression. 465-484.Full Text via DOI: 10.1007/s13402-018-0395-3 Web of Science: 000444812800001
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2016Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain DiseasesFull Text via DOI: 10.3390/ijms17122086 Web of Science: 000392280500130
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2013Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer. 60-79.Full Text via DOI: 10.1016/j.bbcan.2013.02.005 Web of Science: 000320475800006
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2011Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. 115-133.Full Text via DOI: 10.1016/j.bbcan.2010.10.005 Web of Science: 000287124400009
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2007Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. 235-257.Full Text via DOI: 10.1080/15287390600974924 Web of Science: 000247875600001
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2007Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: Potential molecular targets for cancer therapy. 154-173.Full Text via DOI: 10.2741/2056 Web of Science: 000243745000013
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2005Estrogen, mitochondria, and growth of cancer and non-cancer cellsFull Text via DOI: 10.1186/1477-3163-4-1
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2004Genetics and bioenergetics of mitochondria influencing the etiology and pharmacology of steroidal hormones. 379-390.Full Text via DOI: 10.2174/1570160043377295
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2004Estrogen-induced genetic alterations and their role in carcinogenicity. 245-257.Full Text via DOI: 10.2174/1389202043349471
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2000Estrogens as endogenous genotoxic agents--DNA adducts and mutations.. 75-93.Full Text via DOI: 10.1093/oxfordjournals.jncimonographs.a024247
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1990Free radical generation by redox cycling of estrogens. 415-423.Full Text via DOI: 10.1016/0891-5849(90)90108-U
Works By Students
chaired theses and dissertations
- Doke, Mayur Arvind, The Role of ID3 and PCB153 in the Hyperproliferation and Dysregulation of Lung Endothelial Cells 2018
- Preciados, Mark, Exposure to Estrogenic Endocrine Disrupting Chemicals and Brain Health 2018
- Morgan, Marisa L, Exposure to Endocrine Disrupting Compounds and Reproductive Toxicity in Women 2014
- Garba, Nana Aisha, The Role of Redox Signaling in the Molecular Mechanism of Tamoxifen Resistance in Breast Cancer 2012
- Kunkle, Brian W, The Potential Role of Environmental Exposures and Genomic Signaling in Development of Central Nervous System Tumors 2011
- Luna, Brenda, Prenatal Environmental Exposure and Neurodevelopmentally Important Gene Expression in Malformed Brain Tissue from Pediatric Intractable Epilepsy Patients 2011
- Penney, Rosalind B, Thioredoxin and Jab1 Control Estrogen- and Antiestrogen-Mediated Progression of the Cell Cycle Through p27 Interactions 2011
- Okoh, Victor, 4-Hydroxy Estradiol-Induced Oxidant-Mediated Signaling Is Involved In The Development Of Breast Cancer 2010
Research
principal investigator on
- Estrogen-Induced Breast Cancer Pathogenesis awarded by U.S. Department of Veterans Affairs 2014 - 2018
- Role of Estrogen-Induced Breast Cancer Pathogenesis awarded by U.S. Department of Veterans Affairs 2013 - 2015
- Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU - UM Braman Family Breast Cancer Institute. awarded by U.S. Department of Defense 2007 - 2012
- Inhibition of Estrogen-Induced Growth of Breast Cancer by Targeting Mitochondria. awarded by Army Research Office 2007 - 2010
co-principal investigator on
investigator on
Contact
full name
- Deodutta Roy
Identifiers
ORCID iD
- https://orcid.org/0000-0001-6409-1341 (confirmed)
visualizations
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Environmental Sciences & Ecology
- Genetics & Heredity
- Neurosciences & Neurology
- Oncology
- Pathology
- Pharmacology & Pharmacy
- Public, Environmental & Occupational Health
- Science & Technology - Other Topics
- Toxicology