Deodutta Roy
Overview
overview
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Dr. Deodutta Roy joined Florida International University (FIU) as a professor in 2004 and was the founding chairman of the Department of Environmental and Occupational Health from 2005-2011. Before joining FlU, he was a tenured professor at the University of Alabama at Birmingham from 1998-2004. Nationally and internationally recognized in the estrogen carcinogenesis field, Dr. Roy has received several awards and honors for his research work, including Junior Faculty Development Award from American Cancer Society and Scholar Awards in cancer research from the American Association for Cancer Research (AACR).
Dr. Roy is a prolific scholar and researcher, having published over one hundred peer-reviewed articles, book chapters, monographs, and two patents. He has trained 15 doctoral students and numerous postdoctoral fellows. For the last 24 years, his research program has been continuously funded through grants from the American Cancer Society, U.S. National Institutes of Health, the Department of Defense, and Veteran Affairs. Dr. Roy has served on a variety of research-related advisory boards and review panels, including National Institutes of Health, the Susan Komen Foundation, Miami VA, and the Massachusetts Public Health Breast Cancer review panels. Dr. Roy is also on the editorial boards of nine scientific journals. He has collaborated with scientists at Miami Children’s Hospital, University of Miami, and Miami Veterans Affairs Healthcare System to investigate human DNA variants, epigenetic, stochastic and environmental factors that modify responses to exposure to endocrine disrupting
Environmental Functional Genomics (Application of Human Genomics/Epigenomics to Population Sciences: Molecular Prevention): The Environmental Functional Genomics Group has been engaged in characterizing underlying genetic, epigenetic and environmental factors that contribute to variability in human responses to endocrine disrupting stressors. We especially focus on discovery of epigenetic, stochastic and environmental factors that modify responses to exposure to endocrine disrupting stressors and how these factors affect the susceptibility to complex chronic diseases, such as cancer, neurodegenerative lesions in exposed people. This information may prove useful in developing therapeutic targets for the molecular prevention and treatment of complex chronic diseases and discovery of valuable novel biomarkers for identifying at-risk individuals and devising chronic human disease-molecular prevention strategies.
Publications
selected publications
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Article
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2020Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer. CLINICAL & EXPERIMENTAL METASTASIS. 37:657-674.Full Text via DOI: 10.1007/s10585-020-10060-0 Web of Science: 000580404900001
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2020Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 146:2777-2815.Full Text via DOI: 10.1007/s00432-020-03320-9 Web of Science: 000551783900003
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2020Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma. MOLECULAR NEUROBIOLOGY.Full Text via DOI: 10.1007/s12035-020-01979-2 Web of Science: 000544199400001
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2018Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast Carcinogenesis. CELLS. 7.Full Text via DOI: 10.3390/cells7120234 Web of Science: 000455320700012
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2018NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2+ve breast cancer signaling pathways. BREAST CANCER RESEARCH AND TREATMENT. 172.Full Text via DOI: 10.1007/s10549-018-4905-9 Web of Science: 000447497300021
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2017Environmental estrogen-like endocrine disrupting chemicals and breast cancer. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 457:89-102.
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2015Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 16:25285-25322.
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2015Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. MOLECULAR NEUROBIOLOGY. 52:1341-1363.
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2015Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells. BRITISH JOURNAL OF CANCER. 112:1687-1702.
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2014Bayesian Network and Mechanistic Hierarchical Structure Modeling of Increased likelihood of Developing Intractable Childhood Epilepsy from the Combined Effect of mtDNA Variants, Oxidative Damage, and Copy Number. JOURNAL OF MOLECULAR NEUROSCIENCE. 54:752-766.
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2013Discovering gene-environment interactions in Glioblastoma through a comprehensive data integration bioinformatics method. NEUROTOXICOLOGY. 35:1-14.
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2010Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 197-219.Full Text via DOI: 10.1007/978-1-4419-6752-7_8 Web of Science: 000282535900008
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2010Environmental Factors, Genes, and the Development of Human Cancers Introduction. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 3-9.Full Text via DOI: 10.1007/978-1-4419-6752-7_1 Web of Science: 000282535900001
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2010Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 223-252.Full Text via DOI: 10.1007/978-1-4419-6752-7_9 Web of Science: 000282535900009
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2006Development of a self-proliferating Leydig cell line: A hyper-sensitive E-screening model. ONCOLOGY REPORTS. 16:73-77.PMID: 16786125 Web of Science: 000238520400010
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2006Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. FRONTIERS IN BIOSCIENCE. 11:889-898.
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2006SKCG-1: a new candidate growth regulatory gene at chromosome 11q23.2 in human sporadic Wilms tumours. BRITISH JOURNAL OF CANCER. 94:1524-1532.
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2005Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengersFull Text via DOI: 10.1021/bi047629p Web of Science: 000228962500019
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2005Estrogen, mitochondria, and growth of cancer and non-cancer cellsFull Text via DOI: 10.1186/1477-3163-4-1
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2005Mitochondrial signals to nucleus regulate estrogen-induced cell growthFull Text via DOI: 10.1016/j.mehy.2003.12.056 Web of Science: 000225481400031
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2004Estrogen-induced genetic alterations and their role in carcinogenicityFull Text via DOI: 10.2174/1389202043349471
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2001The biphasic stimulation of proliferation of Leydig cells by estrogen exposure.Full Text via DOI: 10.3892/ijo.18.3.623
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1991Cytochrome b
5 -mediated redox cycling of estrogenFull Text via DOI: 10.1016/0003-9861(91)90368-S -
1990Free radical generation by redox cycling of estrogensFull Text via DOI: 10.1016/0891-5849(90)90108-U
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Book
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2010Environmental factors, genes, and the development of human cancersFull Text via DOI: 10.1007/978-1-4419-6752-7
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Book Chapter
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2019Malformations of cortical development and epilepsy in childrenFull Text via DOI: 10.1016/B978-0-12-409548-9.11744-0
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2011Malformations of Cortical Development and Epilepsy in ChildrenFull Text via DOI: 10.1016/B978-0-444-52272-6.00073-8
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Conference
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2007
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Editorial Material
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2016Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 741-745.
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Meeting Abstract
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2018Exosomal ID3 is pro-metastatic through guiding NRF1-induced breast cancer stem cells across the blood-brain-barrier. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-1128 Web of Science: 000468818903101
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2018Role of NRF1 regulatory gene-networks in glioblastoma. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-1127 Web of Science: 000468818903100
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2015Overexpression of NRF1 leads to the generation of cancer stem-like cells and resistance to anoikis _ pathways to anchorage-independent growth during estrogen-induced malignant transformation. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-803 Web of Science: 000371578501256
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2015Phosphodeficient NRF1 mutant suppresses the susceptibility of the breast epithelial cells to develop tumors when exposed to estrogen - a major breast cancer risk factor. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2015-4559 Web of Science: 000371597104187
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2014Redox signaling to nuclear respiratory factor-1 proteins by reactive oxygen species contributes to the estrogen-induced breast tumor development. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-3179 Web of Science: 000349910200183
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2012Novel 4-N-modified gemcitabine analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503201668
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2011Estrogen-induced redox signaling via NRF-1 is involved in the development of breast cancer. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2011-LB-12 Web of Science: 000209701305418
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2009NRF-1 signaling participates in the estrogen-mediated growth of breast cancer cells.. CANCER RESEARCH.Web of Science: 000209701803459
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2009Redox Status Contributes to Tamoxifen-Resistant Growth of Breast Cancer.. CANCER RESEARCH. 810S-810S.Web of Science: 000272920702093
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20074-OH-E2-induced oxidants through NRF-1 controls transcription of G1-S and G2-M phase cell cycle genes. FEBS JOURNAL. 179-179.Web of Science: 000253283800541
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2007Is in utero imprinting of the brain by pesticides involved in childhood brain cancer development?. EPIDEMIOLOGY. S169-S170.Web of Science: 000249018300556
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Proceedings Paper
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2013Increased Risk of Childhood Brain Tumors among Children Whose Parents had Farm-Related Pesticide Exposures during Pregnancy. 20TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2013). 2012-2017.Web of Science: 000357105902007
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2011Identifying gene alterations required for the development of astrocytoma. 19TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2011). 1037-1041.Web of Science: 000314989301008
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2009Hierarchical clustering method identifies adaptation of mitochondrial signaling to the treatment of mitochondrial blockers that regulates the expression of cell cycle genes.. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 708-714.Web of Science: 000290045000109
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2009Meta-analysis of brain tumor microarray data using Oncomine identifies NRF1, Tfam and Myc co-expressed genes: its implications in the development of childhood brain tumors. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 720-726.Web of Science: 000290045000111
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2009Oncomine meta-analysis of breast cancer microarray data identifies upregulation of NRF-1 expression in human breast carcinoma. 18TH WORLD IMACS CONGRESS AND MODSIM09 INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION. 715-719.Web of Science: 000290045000110
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Review
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2020Environmental DNA and RNA as Records of Human Exposome, Including Biotic/Abiotic Exposures and Its Implications in the Assessment of the Role of Environment in Chronic Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms21144879 Web of Science: 000557165000001
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2018Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression. CELLULAR ONCOLOGY.Full Text via DOI: 10.1007/s13402-018-0395-3 Web of Science: 000444812800001
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2016Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms17122086 Web of Science: 000392280500130
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2013Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 60-79.
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2011Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 115-133.
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2007Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. 235-257.
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2007Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: Potential molecular targets for cancer therapy. FRONTIERS IN BIOSCIENCE. 154-173.
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chaired theses and dissertations
- Doke, Mayur Arvind, The Role of ID3 and PCB153 in the Hyperproliferation and Dysregulation of Lung Endothelial Cells 2018
- Preciados, Mark, Exposure to Estrogenic Endocrine Disrupting Chemicals and Brain Health 2018
- Morgan, Marisa L, Exposure to Endocrine Disrupting Compounds and Reproductive Toxicity in Women 2014
- Garba, Nana Aisha, The Role of Redox Signaling in the Molecular Mechanism of Tamoxifen Resistance in Breast Cancer 2012
- Kunkle, Brian W, The Potential Role of Environmental Exposures and Genomic Signaling in Development of Central Nervous System Tumors 2011
- Luna, Brenda, Prenatal Environmental Exposure and Neurodevelopmentally Important Gene Expression in Malformed Brain Tissue from Pediatric Intractable Epilepsy Patients 2011
- Penney, Rosalind B, Thioredoxin and Jab1 Control Estrogen- and Antiestrogen-Mediated Progression of the Cell Cycle Through p27 Interactions 2011
- Okoh, Victor, 4-Hydroxy Estradiol-Induced Oxidant-Mediated Signaling Is Involved In The Development Of Breast Cancer 2010
Research
research interests
- Stem Cell Aging and Cancer, Mitochondrial Dysfunction and Neurological Diseases
principal investigator on
- Estrogen-Induced Breast Cancer Pathogenesis awarded by U.S. Department of Veterans Affairs 2014 - 2018
- Role of Estrogen-Induced Breast Cancer Pathogenesis awarded by U.S. Department of Veterans Affairs 2013 - 2015
- Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU - UM Braman Family Breast Cancer Institute. awarded by U.S. Department of Defense 2007 - 2012
- Inhibition of Estrogen-Induced Growth of Breast Cancer by Targeting Mitochondria. awarded by Army Research Office 2007 - 2010
co-principal investigator on
Teaching
teaching activities
- PHC6914-U02: Current Topics in Environmental Health Sciences Research Lab Fall Term 2019
- PHC6914-U02: Current Topics in Environmental Health Sciences Research Lab Spring Term 2019
- PHC6917-U03: Environmental and Occupational Health Sciences Pre Doctoral Research Fall Term 2019
- PHC6917-U03: Environmental and Occupational Health Sciences Pre Doctoral Research Spring Term 2019
- PHC7327-RVC: Emerging Issues in Environmental Health Sciences Spring Term 2019
- PHC7980-U01: Dissertation Fall Term 2019
- PHC7980-U01: Dissertation Fall Term 2019
- PHC7980-U01: Dissertation Fall Term 2019
- PHC7980-U14: Dissertation Spring Term 2019
- PHC7980-U14: Dissertation Spring Term 2019
- PHC7980-U14: Dissertation Spring Term 2019
Contact
full name
- Deodutta Roy
Identifiers
ORCID iD
- https://orcid.org/0000-0001-6409-1341 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Environmental Sciences & Ecology
- Genetics & Heredity
- Neurosciences & Neurology
- Oncology
- Pathology
- Pharmacology & Pharmacy
- Public, Environmental & Occupational Health
- Science & Technology - Other Topics
- Toxicology