Overview
overview
- Sarkarai Nadar joined HWCOM in 2012. His research aims to understand the mechanism of arsenic resistance and detoxification using biophysical methods and X-ray crystallography. He crystallized and solved the three-dimensional structure of ArsI, C-As lyase, a carbon arsenic bond cleaving enzyme from the thermophilic bacterium Thermomonospora curvata and Ars, Arsinothricin N-acetyltransferase from Pseudomonas putida KT2440. The focus of Nadar’s Ph.D. research was to design the DNA oligonucleotide sequences that form a four-way junction, characterize them using various biophysical methods, and find three-dimensional structures using X-ray crystallography.
research interests
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Protein structures and the structure-function relationship of enzymes involved in arsenic biotransformation
Anti-cancer drugs for Trible Negative Breast Cancer (TNBC) using computational methods and consecutive biophysical and biochemical assays
Scholarly & Creative Works
selected publications
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Article
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2022An ArsRC fusion protein enhances arsenate sensing and detoxificationFull Text via DOI: 10.1111/1462-2920.15957 Web of Science: 000763772300001
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2022Functional characterization of the methylarsenite-inducible arsRM operon from Noviherbaspirillum denitrificans HC18Full Text via DOI: 10.1111/1462-2920.15909 Web of Science: 000749656000001
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2021Chemical synthesis of the organoarsenical antibiotic arsinothricinFull Text via DOI: 10.1039/d1ra06770b Web of Science: 000714163200001
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2021Aquaglyceroporin AqpS from Sinorhizobium meliloti conducts both trivalent and pentavalent methylarsenicalsFull Text via DOI: 10.1016/j.chemosphere.2020.129379 Web of Science: 000631734500070
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2019Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibioticFull Text via DOI: 10.1038/s42003-019-0365-y Web of Science: 000465423400001
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2017A novel MAs(III)-selective ArsR transcriptional repressorFull Text via DOI: 10.1111/mmi.13826 Web of Science: 000413542800010
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2017Biochemical Characterization of Arsl: A Novel C-As Lyase for Degradation of Environmental OrganoarsenicalsFull Text via DOI: 10.1021/acs.est.7b03180 Web of Science: 000412716500023
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2016Structure of the Arsl C-As Lyase: Insights into the Mechanism of Degradation of Organoarsenical Herbicides and Growth PromotersFull Text via DOI: 10.1016/j.jmb.2016.04.022 Web of Science: 000377733200016
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2014Mutations in the ArsA ATPase that restore interaction with the ArsD metallochaperoneFull Text via DOI: 10.1007/s10534-014-9788-6 Web of Science: 000344736200013
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2014Crystallization and preliminary X-ray crystallographic studies of the ArsI C-As lyase from Thermomonospora curvataFull Text via DOI: 10.1107/S2053230X14008814 Web of Science: 000337062500015
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2012Interactions of Mn2+ with a non-self-complementary Z-type DNA duplexFull Text via DOI: 10.1107/S1744309112041759 Web of Science: 000311693300001
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2012Ring crystals of oligonucleotides: Growth stages and X-ray diffraction studiesFull Text via DOI: 10.1016/j.jcrysgro.2012.05.029 Web of Science: 000306605400004
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2012Structure of the tetradecanucleotide d(CCCCGGTACCGGGG)(2) as an A-DNA duplexFull Text via DOI: 10.1107/S174430911200869X Web of Science: 000302457900007
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2012CRYSTALLOGRAPHIC AND SPECTROSCOPIC STUDIES OF d(CCGGTACCGG)Full Text via DOI: 10.1080/15257770.2011.648363 Web of Science: 000302276700016
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2011Structure of d(CGGGTACCCG)4 as a four-way Holliday junctionFull Text via DOI: 10.1107/S1744309111046616 Web of Science: 000297741100008
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2011The sequence d(CGGCGGCCGC) self-assembles into a two dimensional rhombic DNA latticeFull Text via DOI: 10.1016/j.bbrc.2011.03.056 Web of Science: 000289958500019
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2011The structure of a full turn of an A-DNA duplex d(CGCGGGTACCCGCG)(2)Full Text via DOI: 10.1016/j.bbrc.2011.03.007 Web of Science: 000289746700007
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2009The structure of d(CACACG)center dot d(CGTGTG)Full Text via DOI: 10.1107/S1744309108037706 Web of Science: 000262175400003
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Conference
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2018A novel MAs(III)-selective ArsR transcriptional repressor. 178-179.Web of Science: 000507999600071
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2018Arsinothricin: a novel arsenic-containing antibiotic. 319-321.Web of Science: 000507999600126
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Research
subproject principal investigator on
Contact
full name
- Venkadesh Sarkarai Nadar
Identifiers
ORCID iD
- https://orcid.org/0000-0002-9500-6397 (confirmed)
