Thangavel, Samikkannu
Publications
selected publications
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Article
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2018Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters. ANTIOXIDANTS & REDOX SIGNALING. 28:324-337.
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2016Development of TIMP1 magnetic nanoformulation for regulation of synaptic plasticity in HIV-1 infection. INTERNATIONAL JOURNAL OF NANOMEDICINE. 11:4287-4298.
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2016Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages. SCIENTIFIC REPORTS. 6.
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2015Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). FRONTIERS IN MICROBIOLOGY. 6.
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2015HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. FRONTIERS IN MICROBIOLOGY. 6.
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2014HIV-1 Subtypes B and C Tat Differentially Impact Synaptic Plasticity Expression and Implicates HIV-Associated Neurocognitive Disorders. CURRENT HIV RESEARCH. 12:397-405.PMID: 25613138 Web of Science: 000351001100004
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2014Immunoneuropathogenesis of HIV-1 clades B and C: Role of redox expression and thiol modification. FREE RADICAL BIOLOGY AND MEDICINE. 69:136-144.Full Text via DOI: 10.1016/j.freeradbiomed.2013.12.025 PMID: 24480751 Web of Science: 000333490500014
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2013Differential expression and functional role of cannabinoid genes in alcohol users. DRUG AND ALCOHOL DEPENDENCE. 133:789-793.
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2013HIV infection and drugs of abuse: role of acute phase proteins. JOURNAL OF NEUROINFLAMMATION. 10.
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2012Differential Regulation of Neurotoxin in HIV Clades: Role of Cocaine and Methamphetamine. CURRENT HIV RESEARCH. 10:429-434.PMID: 22591367 Web of Science: 000308004200009
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2012HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: Role in HIV associated neurocognitive disorder. NEUROCHEMISTRY INTERNATIONAL. 61:807-814.
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2011Effects of Alcohol on Histone Deacetylase 2 (HDAC2) and the Neuroprotective Role of Trichostatin A (TSA). ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 35:1550-1556.
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2011HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND). NEUROCHEMISTRY INTERNATIONAL. 58:656-664.
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2011Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS. JOURNAL OF NEUROVIROLOGY. 17:230-238.
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2010Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS. JOURNAL OF NEUROVIROLOGY. 16:255-263.
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2010Role of Dendritic Cells in HIV Infection: DC-SIGN and Novel Therapeutic Approaches. DENDRITIC CELLS: TYPES, LIFE CYCLES AND BIOLOGICAL FUNCTIONS. 167-177.Web of Science: 000284081600010
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2009Differential Effects of HIV Type 1 Clade B and Clade C Tat Protein on Expression of Proinflammatory and Antiinflammatory Cytokines by Primary Monocytes. AIDS RESEARCH AND HUMAN RETROVIRUSES. 25:691-699.
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2009Differential Regulation of Indoleamine-2,3-Dioxygenase (IDO) by HIV Type 1 Clade B and C Tat Protein. AIDS RESEARCH AND HUMAN RETROVIRUSES. 25:329-335.
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2009Upregulation of Serotonin Transporter by Alcohol in Human Dendritic Cells: Possible Implication in Neuroimmune Deregulation. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 33:1731-1738.
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Meeting Abstract
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2017Cocaine and HIV Upregulate Glycolytic Enzymes and Mitochondrial Biogenesis in Astrocytes. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S73-S74.Web of Science: 000414227700178
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2017Inflammasome Gene Expression and their role in HIV and Cocaine Induced Apoptosis. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S49-S50.Web of Science: 000414227700114
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2015HIV and Morphine: Oxidative Stress Impact Cell Cycle Regulation and Neurodegeneration. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S104-S104.Web of Science: 000367554100125
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2015Methamphetamine treatment and HIV-1 infection dysregulate Synaptic plasticity in SKNMC neuronal cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S59-S60.Web of Science: 000367554100009
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2015beta-Amyloid, HIV-1 Infection and Drugs of Abuse Induced Neurodegeneration and Protective Effects of Ashwagandha. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S82-S82.Web of Science: 000367554100067
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2014Ashwagandha (Withania somnifera) reverses HIV-1 induced neurodegeneration via attenuation of beta-Amyloid plaques: Implications in HIV-Associated Neurocognitive Disorders (HAND). JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 29-30.Web of Science: 000333121600071
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2014Cannabinoid Agonists Regulate Alcohol-induced Inflammation in Human Dendritic Cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 3-4.Web of Science: 000333121600004
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2014Development of hybrid nanocarrier (Au/Fe3O4) for active drug delivery to brain to eliminate HIV-1 persistence. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 14-14.Web of Science: 000333121600030
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2014Immunopathogenesis of HIV-1 Infection in Cocaine users: Role of Arachidonic Acid. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 55-55.Web of Science: 000333121600139
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2014MAGNETIC NANOPARTICLE FOR TARGETTED ANTI-HIV DRUG DELIVERY IN IN VIVO MODEL. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 48-49.Web of Science: 000333121600121
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2014Polydrug mediated effects on HIV Nef plus exosome release and neuropathogenesis is modulated by Nef peptide magnetic nanocarriers. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 46-47.Web of Science: 000333121600116
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2014Role of HDAC2 and miR-485 in regulation of synaptic plasticity genes in HIV infection: Implication in HAND. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 6-6.Web of Science: 000333121600011
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2013ASHWAGANDHA (WITHANIA SOMNIFERA) REVERSES B-AMYLOID INDUCED NEURONAL TOXICITY: IMPLICATIONS IN HAND. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 422-422.Web of Science: 000320312000121
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2013DUAL MECHANISM ENHANCED BBB CROSSING BY TRANSFERRIN CONJUGATED FLUORESCENT MAGNETIC LIPOSOME.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 414-414.Web of Science: 000320312000098
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2013EFFECT OF NICOTINE ON SYNAPTIC PLASTICITY GENE EXPRESSION IN HIV-1 INFECTION: IMPLICATION IN HAND.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 438-438.Web of Science: 000320312000164
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2013HIV NEUROPATHOGENESIS: ROLE OF NEF plus EXOSOMES (EXNEF), METHAMPHETAMINE AND OPIATES. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 430-431.Web of Science: 000320312000144
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2013IMMUNOPATHOGENIC MECHANISMS OF HIV-1 CLADE B AND C: ROLE OF DOPAMINERGIC SYSTEM.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 434-434.Web of Science: 000320312000154
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2012Neuropathogenic Mechanisms by HIV-1 Clade B And C: Role of Lipid Rafts.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S78-S79.Web of Science: 000302288800193
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2011Activation of the Antioxidant Defensive Enzymes Against HIV-1 gp120 are Mediated by Oxidative Stress and Elevated Intracellular Calcium Levels. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S55-S56.Web of Science: 000302402500134
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2011Association of Dopamine Receptor D2 C957T Gene SNP in Learning and Memory Among HIV-Positive Alcohol Abusers. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S51-S51.Web of Science: 000302402500122
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2011Differential Expression of Cannabinoid Genes in Alcoholics. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S23-S23.Web of Science: 000302402500039
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2011Differential Regulation of Neuroplasticity Associated Genes by HIV-1B and C Clades. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S57-S57.Web of Science: 000302402500139
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2011Differential Regulation of Thiol Modification by HIV-1 Clade B and C Protein. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S57-S58.Web of Science: 000302402500140
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2011Molecular Mechanism of Immunosuppression by Cocaine in HIV-1 Infected Subjects: Role of TLR3. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S31-S31.Web of Science: 000302402500062
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2010Effects of Alcohol on Cannabinoid (CB2) and Serotonin (5-HT3) Receptors in the Human Neuroblastoma Cell Line, SK-N-MC, and the Role of Histone Deacetylase 2 (HDAC2).. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S39-S39.Web of Science: 000276567600089
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2010HIV-1 Tat upregulates expression of histone deacetylase-2 in human neurons: Implication for HAND. JOURNAL OF NEUROVIROLOGY. 75-76.Web of Science: 000283409800163
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2010Histone Deacetylase Activity in Development of HIV-Associated Neurocognitive Disorder.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S46-S46.Web of Science: 000276567600109
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2010Human Immunodeficiency Virus type-1 Glade B and C gp120 Inhibit NMDA-receptor mediated induction of Arachidonic Acid: Implications on Neuro-AIDS. JOURNAL OF NEUROVIROLOGY. 76-76.Web of Science: 000283409800164
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2010Neuropathogenic Mechanisms of HIV-1 Clade B and C: Role of Methamphetamine (METH).. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S53-S53.Web of Science: 000276567600130
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2009Alcohol Upregulates Serotonin transporter and Monoamine oxidase in Human Dendritic Cells: Possible Implication in Neuroimmune Deregulation. JOURNAL OF NEUROVIROLOGY. 40-40.Web of Science: 000270278700088
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2009Comparative Immunovirological Study between Buprenorphine and Methadone Using Human Lymphocytes and Glial Cells. JOURNAL OF NEUROVIROLOGY. 80-81.Web of Science: 000270278700166
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2009Differential Effects of HIV-1 Clade B and Clade C Tat Protein on Expression of Pro- and Anti-inflammatory Cytokines by Primary Monocytes. JOURNAL OF NEUROVIROLOGY. 30-30.Web of Science: 000270278700065
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2009HIV-1 Clade B and C Tat differentially Induces Indoleamine-2, 3-Dioxygenase (IDO) and Serotonin in Immature Dendritic Cells (IDC): Implications for Neuro-AIDS. JOURNAL OF NEUROVIROLOGY. 98-98.Web of Science: 000270278700204
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2009Proteomic Fingerprints of Primary Human Neurons treated with HIV-1 Clade B and C Proteins: Implications for Neuro-AIDS. JOURNAL OF NEUROVIROLOGY. 11-11.Web of Science: 000270278700024
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Review
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2015Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update. FRONTIERS IN CELLULAR NEUROSCIENCE.
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2015Synaptic Plasticity and Neurological Disorders in Neurotropic Viral Infections. NEURAL PLASTICITY.Full Text via DOI: 10.1155/2015/138979 Web of Science: 000365577100001
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Research
principal investigator on
- Immuno-Neuropathogenic Mechanisms of HIV-1 clade B and C awarded by National Institutes of Health 2012 - 2014
investigator on
- Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC-2 awarded by National Institutes of Health 2013 - 2017
Contact
full name
- Samikkannu Thangavel
visualizations
Recent publications and grants in Scholars@FIU
research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Immunology
- Infectious Diseases
- Materials Science
- Microbiology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Physics
- Psychiatry
- Science & Technology - Other Topics
- Substance Abuse
- Virology