Overview
overview
-
After receiving his bachelor’s degree in pharmacy from the University of Saskatchewan, Dr. Kim Tieu practiced as a pharmacist for several years. During this time, he also secured a scholarship to join a doctoral program at the University of Saskatchewan to investigate a series of newly developed compounds, known as propargylamines, for the treatment of Parkinson’s disease (PD) and other neurological disorders. He subsequently left Canada to accept a postdoctoral position at Columbia University to further develop his expertise in PD research. In 2004 Dr. Tieu was recruited by the Department of Environmental Medicine at the University of Rochester Medical Center to establish his independent research laboratory. In Rochester, his laboratory received funding supports from the National Institute of Environmental Health Sciences (NIEHS) to investigate the novel pathogenic mechanisms mediated by glia-neuron interactions, gene-environment interactions and imbalanced mitochondrial fission/fusion in PD. In 2012 Dr. Tieu was recruited by Plymouth University in England to establish a research program in PD. Recognizing his significant and translational research, both the NIH and the UK Medical Research Council funded his laboratory to investigate the role of mitochondrial dynamics in PD.
Dr. Tieu was recruited back to the U.S. to join the Department of Environmental Health Sciences at the Florida International University in 2016. His lab has been awarded the NIEHS Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) grant after discovering a new function of a protein that could be targeted as potential therapeutics for neurological disorders such as Parkinson’s disease.
research interests
- Pathogenic mechanisms and therapeutic strategies for Parkinson’s disease
Scholarly & Creative Works
selected publications
-
Article
-
2020Microglial exosomes facilitate alpha-synuclein transmission in Parkinson's diseaseFull Text via DOI: 10.1093/brain/awaa090 Web of Science: 000541777000028
-
2019Exosome release and neuropathology induced by alpha-synuclein: new insights into protective mechanisms of Drp1 inhibitionFull Text via DOI: 10.1186/s40478-019-0821-4 Web of Science: 000509586300001
-
2017PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's diseaseFull Text via DOI: 10.1093/brain/awx258 Web of Science: 000417337600024
-
2017Mitochondrial division inhibitor-1 is neuroprotective in the A53T-alpha-synuclein rat model of Parkinson's diseaseFull Text via DOI: 10.1038/s41598-017-07181-0 Web of Science: 000407179800013
-
2015Local anesthetics induce autophagy in young permanent tooth pulp cellsFull Text via DOI: 10.1038/cddiscovery.2015.24 Web of Science: 000463069500017
-
2014Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivoFull Text via DOI: 10.1038/ncomms6244 Web of Science: 000345653100001
-
2012Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activityFull Text via DOI: 10.1073/pnas.1120997109 Web of Science: 000303246100072
-
2011Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3Full Text via DOI: 10.1073/pnas.1115141108 Web of Science: 000298289400098
-
2011D-beta-Hydroxybutyrate Is Protective in Mouse Models of Huntington's DiseaseFull Text via DOI: 10.1371/journal.pone.0024620 Web of Science: 000294803200032
-
2011A Guide to Neurotoxic Animal Models of Parkinson's DiseaseFull Text via DOI: 10.1101/cshperspect.a009316 Web of Science: 000208623800010
-
2010Neurosteroid transport by the organic solute transporter OST alpha-OST betaFull Text via DOI: 10.1111/j.1471-4159.2010.06920.x Web of Science: 000281828200021
-
2010Adenosine A1 receptors mediate local anti-nociceptive effects of acupunctureFull Text via DOI: 10.1038/nn.2562 Web of Science: 000279173900022
-
2010PINK1-dependent recruitment of Parkin to mitochondria in mitophagyFull Text via DOI: 10.1073/pnas.0911187107 Web of Science: 000273559200066
-
2009The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathwayFull Text via DOI: 10.1073/pnas.0900358106 Web of Science: 000266208900066
-
2005Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damageFull Text via DOI: 10.1073/pnas.0508215102 Web of Science: 000234350000062
-
2005Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in miceFull Text via DOI: 10.1523/JNEUROSCI.0970-05.2005 Web of Science: 000230478100012
-
2004MPTP as a mitochondrial neurotoxic model of Parkinson's diseaseFull Text via DOI: 10.1023/B:JOBB.0000041771.66775.d5 Web of Science: 000223916300020
-
2004L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's diseaseFull Text via DOI: 10.1002/ana.20133 Web of Science: 000222425600008
-
2003D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson diseaseFull Text via DOI: 10.1172/JCI200318797 Web of Science: 000185376400013
-
2003NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's diseaseFull Text via DOI: 10.1073/pnas.0937239100 Web of Science: 000182939400103
-
2003Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegenerationFull Text via DOI: 10.1073/pnas.0837397100 Web of Science: 000182612600091
-
2003
-
2002Glial cell response: A pathogenic factor in Parkinson's diseaseFull Text via DOI: 10.1080/13550280290100905 Web of Science: 000180306600009
-
2002Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTPFull Text via DOI: 10.1073/pnas.172514599 Web of Science: 000178967400099
-
2001The role of glial cells in Parkinson's diseaseFull Text via DOI: 10.1097/00019052-200108000-00009 Web of Science: 000170327900009
-
1998
-
Book Chapter
-
2017Chapter Eight Mitochondrial Dynamics in Neurodegenerative Diseases. 211-246.Full Text via DOI: 10.1016/bs.ant.2017.07.006
-
2017Mitochondrial Dynamics in Neurodegenerative Diseases. 211-246.Full Text via DOI: 10.1016/bs.ant.2017.07.006 Web of Science: 000424949900009
-
2015Organic cation transporters as modulators of neurodegeneration and neuroprotection in the brain. 205-216.Full Text via DOI: 10.1007/978-3-319-23793-0_8
-
2014Chapter 3 - Principles of Mitophagy and Beyond. 65-83.Full Text via DOI: 10.1016/B978-0-12-405528-5.00003-1
-
-
Conference
-
2020Oxidative DNA Damage in Parkinson's Disease-Associated Genes.. 75-75.Web of Science: 000571638700166
-
2003COX-2 and neurodegeneration in Parkinson's disease. 272-277.Web of Science: 000184302100025
-
-
Note
-
2010Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. 38-39.Full Text via DOI: 10.1016/j.dza.2010.08.002
-
-
Other Scholarly Work
-
2014Cytosolic PINK1 escapes form mitochondria to promote dendritic outgrowth. 787-789.Full Text via DOI: 10.1111/jnc.12529 Web of Science: 000332347300001
-
2012Cultured astrocytes do not release adenosine during hypoxic conditions. E1-E7.Full Text via DOI: 10.1038/jcbfm.2011.142 Web of Science: 000299010000001
-
2004Pathogenic role of glial cells Parkinson's disease (vol 18, pg 121, 2003). 118-118.Full Text via DOI: 10.1002/mds.10701 Web of Science: 000188210900027
-
-
Preprint
-
Review
-
2021Exosomes in Parkinson disease. 413-428.Full Text via DOI: 10.1111/jnc.15288 Web of Science: 000609916700001
-
2017Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's DiseaseFull Text via DOI: 10.3389/fgene.2017.00177 Web of Science: 000415602000001
-
2017Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP. 541-555.Full Text via DOI: 10.1016/j.tips.2017.03.010 Web of Science: 000401516500006
-
2010Astrocytes and Therapeutics for Parkinson's Disease. 413-423.Full Text via DOI: 10.1016/j.nurt.2010.07.001 Web of Science: 000282198500008
-
2009Glutathione dysregulation and the etiology and progression of human diseases. 191-214.Full Text via DOI: 10.1515/BC.2009.033 Web of Science: 000264921500001
-
2003Nitric oxide and reactive oxygen species in Parkinson's disease. 329-335.Full Text via DOI: 10.1080/1521654032000114320 Web of Science: 000184460000007
-
2003Pathogenic role of glial cells in Parkinson's disease. 121-129.Full Text via DOI: 10.1002/mds.10332 Web of Science: 000181007900001
-
Research
principal investigator on
Contact
full name
- Kim Tieu
Identifiers
ORCID iD
- https://orcid.org/0000-0001-6606-4371 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in