Nikolaos Tsoukias
- Associate Professor, Biomedical Engineering , College of Engineering and Computing
Publications
selected publications
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Article
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2020Contractile pericytes determine the direction of blood flow at capillary junctions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117:27022-27033.Full Text via DOI: 10.1073/pnas.1922755117 Web of Science: 000582743300061
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2020The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K plus -mediated neurovascular communication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117:16626-16637.Full Text via DOI: 10.1073/pnas.2000151117 Web of Science: 000553287100001
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2019Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-53440-7 Web of Science: 000497701800029
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2018Biophysical properties of microvascular endothelium: Requirements for initiating and conducting electrical signals. MICROCIRCULATION. 25.Full Text via DOI: 10.1111/micc.12429 Web of Science: 000424813900005
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2017A "sweet-spot" for fluid-induced oscillations in the conditioning of stem cell-based engineered heart valve tissues. JOURNAL OF BIOMECHANICS. 65:40-48.
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2017Can endothelial hemoglobin-alpha regulate nitric oxide vasodilatory signaling?. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 312:H854-H866.
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2016Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stress. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 310:C479-C490.
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2016Inherent rhythm of smooth muscle cells in rat mesenteric arterioles: An eigensystem formulation. PHYSICAL REVIEW E. 93.
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2015Stochastic Model of Endothelial TRPV4 Calcium Sparklets: Effect of Bursting and Cooperativity on EDH. BIOPHYSICAL JOURNAL. 108:1566-1576.
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2013Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertension. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 35:65-71.
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2013Kinetic analysis of DAF-FM activation by NO: Toward calibration of a NO-sensitive fluorescent dye. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 28:39-46.
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2013Role of microprojections in myoendothelial feedback - a theoretical study. JOURNAL OF PHYSIOLOGY-LONDON. 591:2795-2812.
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2012Bone marrow transplantation improves endothelial function in hypertensive Dahl salt-sensitive rats. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION. 6:331-337.
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2012Endothelial Ca2+ wavelets and the induction of myoendothelial feedback. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 302:C1226-C1242.
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2012Glutathiyl radical as an intermediate in glutathione nitrosation. FREE RADICAL BIOLOGY AND MEDICINE. 53:1968-1976.Full Text via DOI: 10.1016/j.freeradbiomed.2012.08.013 PMID: 22951977 Web of Science: 000311328300016
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2012Inhibition of Nitric Oxide Synthesis in Mouse Macrophage Cells by Feverfew Supercritical Extract. PHYTOTHERAPY RESEARCH. 26:541-545.
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2012Multiple Factors Influence Calcium Synchronization in Arterial Vasomotion. BIOPHYSICAL JOURNAL. 102:211-220.
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2011Calcium dynamics and signaling in vascular regulation: computational models. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE. 3:93-106.
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2011Multiscale FEM Modeling of Vascular Tone: From Membrane Currents to Vessel Mechanics. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 58:3456-3459.
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2010A mathematical model of vasoreactivity in rat mesenteric arterioles. II. Conducted vasoreactivity. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 298:H52-H65.
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2009A mathematical model of vasoreactivity in rat mesenteric arterioles: I. Myoendothelial communication. MICROCIRCULATION. 16:694-U69.
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2009Carbon Nanotube Reinforced Polylactide-Caprolactone Copolymer: Mechanical Strengthening and Interaction with Human Osteoblasts in Vitro. ACS APPLIED MATERIALS & INTERFACES. 1:2470-2476.
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2009Effect of carbon nanotube and aluminum oxide addition on plasma-sprayed hydroxyapatite coating's mechanical properties and biocompatibility. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 29:2195-2202.Full Text via DOI: 10.1016/j.msec.2009.05.001 Web of Science: 000270159200017
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2007A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks. JOURNAL OF THEORETICAL BIOLOGY. 248:657-674.
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2007A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 293:C277-C293.
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2006A computational model of oxygen transport in skeletal muscle for sprouting and splitting modes of angiogenesis. JOURNAL OF THEORETICAL BIOLOGY. 241:94-108.
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2005New aspects of vulnerability in heterogeneous models of ventricular wall and its modulation by loss of cardiac sodium channel function. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. 43.Full Text via DOI: 10.1007/BF02345817 Web of Science: 000230674600012
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2004A theoretical model of nitric oxide transport in arterioles: frequency- vs. amplitude-dependent control of cGMP formationFull Text via DOI: 10.1152/ajpheart.00525.2003 Web of Science: 000188783200031
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2003A model of nitric oxide capillary exchangeFull Text via DOI: 10.1038/sj.mn.7800210 Web of Science: 000187216000006
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2002Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobinFull Text via DOI: 10.1152/ajpheart.01080.2001 Web of Science: 000175531800041
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2002Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutesFull Text via DOI: 10.1152/ajpheart.00972.2001 Web of Science: 000175531800038
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2001Impact of volume-dependent alveolar diffusing capacity on exhaled nitric oxide concentrationFull Text via DOI: 10.1114/1.1397786 Web of Science: 000171358400001
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2000Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: I. TheoryFull Text via DOI: 10.1016/S0034-5687(00)00103-1 Web of Science: 000087359700004
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2000Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: II. ExperimentFull Text via DOI: 10.1016/S0034-5687(00)00104-3 Web of Science: 000087359700005
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1998
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Conference
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2009Multiscale mathematical modeling of microvascular tone regulationFull Text via DOI: 10.1007/978-3-642-01697-4_104
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2000
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Meeting Abstract
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2020Modeling cerebral network hemodynamics: Effect of conducted vasodilation on brain perfusion. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.08757 Web of Science: 000546107904383
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2019Integrative: Modeling of Functional Hyperemia: From Ion Channel Activity to Functional Imaging. FASEB JOURNAL.Web of Science: 000496555201052
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2017A Mathematical Model of Cerebral Blood Flow Control: Role of Kir Channels. FASEB JOURNAL.Web of Science: 000405986504256
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2016Multi-scale Modeling of Collecting Lymphatic Vessels: From Ion Channel Activity to Lymph Transport. FASEB JOURNAL.Web of Science: 000406444707228
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2014Endothelial hemoglobin-alpha modulating NO mediated feedback response during smooth muscle stimulation.. JOURNAL OF VASCULAR RESEARCH. 50-50.Web of Science: 000346236200042
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2014Localized calcium events and endothelium derived signals in the modulation of vessel tone. JOURNAL OF VASCULAR RESEARCH. 49-49.Web of Science: 000346236200041
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2014Ratiometric detection of nitric oxide by fluorescent organometallic Re-phenanthroline complexes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348457602043
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2013Computational model of NO and NO oxidative species transport in the microcirculation. FASEB JOURNAL.Web of Science: 000319860503089
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2013Multiscale computational models of microvascular reactivity from ion channels to intercellular signaling. FASEB JOURNAL.Web of Science: 000319860505101
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2013Re-phenanthroline complexes as ratiometric fluorescent dyes for NO sensing. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324303601309
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2013Role of localized calcium events in regulation of vascular tone: A theoretical investigation. FASEB JOURNAL.Web of Science: 000319860500196
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2012Agmatine-mediated Arterial Relaxation is impaired in Salt-Sensitive Hypertension. FASEB JOURNAL.Web of Science: 000310711306436
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2012Metal complexes of phenanthroline and analogs as versatile frameworks for Nitric Oxide sensing and imaging. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503201124
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2012sGC in SMC acts as Nitrite Reductase leading to NO formation. FASEB JOURNAL.Web of Science: 000310711305931
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2011Agmatine Produced by Arginine Decarboxylase Activity Causes NO Dependent Rat Mesenteric Artery Relaxation. FASEB JOURNAL.Web of Science: 000310708403809
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2011Gene Expression of Calcium Channel Components in Dahl Salt-Resistant Rat Mesenteric Arteries by RT-PCR. FASEB JOURNAL.Web of Science: 000310708404112
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2011Nitrite reduction to NO in rat aortic smooth muscle cells by soluble guanylate cyclase. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. S40-S40.Full Text via DOI: 10.1016/j.niox.2011.03.298 Web of Science: 000290465600068
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2011Role of EC Projection in Myoendothelial Communication: A Theoretical Study. FASEB JOURNAL.Web of Science: 000310708405588
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2011Soluble Guanylate Cyclase Catalyzes Nitrite reduction to Nitric Oxide in Rat Aortic Smooth Muscle Cells. FASEB JOURNAL.Web of Science: 000310708403808
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2011Solving the Enigma of Myoendothelial Feedback. FASEB JOURNAL.Web of Science: 000310708405567
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2011The role of myoendothelial communication in regulating vascular contractility. JOURNAL OF VASCULAR RESEARCH. 45-45.Web of Science: 000294760800042
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2010Agmatine-mediated rat mesenteric artery relaxation via NO synthesis. FASEB JOURNAL.Web of Science: 000208675505622
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2010Bone Marrow Transplantation Improves Endothelial Function in Hypertensive Dahl Salt-Sensitive Rats. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. E262-E262.Web of Science: 000283234800361
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2010Kinetics of nitrosation of GSH using NO donors. FASEB JOURNAL.Web of Science: 000208675505462
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2010Microprojections amplify EC response to SMC stimulation: A theoretical study. FASEB JOURNAL.Web of Science: 000208675505568
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2009
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2009
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2009
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2009Inhibition of nitric oxide production by feverfew supercritical extract as part of a migraine model in vitro. FASEB JOURNAL.Web of Science: 000208621504278
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2008Experimental and theoretical studies to determine smooth muscle nitric oxide availability. FASEB JOURNAL.Web of Science: 000208467809217
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2006A mathematical model of endothelium-smooth muscle interaction in regulating microcirculatory tone. FASEB JOURNAL. A283-A283.Web of Science: 000236206502254
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2006A mathematical model of plasma membrane electrophysiology and calcium dynamics in rat mesenteric endothelial cells. FASEB JOURNAL. A410-A410.Web of Science: 000236206503279
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2004Is there frequency encoded information in EDRF?. FASEB JOURNAL.Web of Science: 000220470702676
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Proceedings Paper
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2014Multi-scale modeling of microvascular reactivity. 2014 IEEE 4TH INTERNATIONAL CONFERENCE ON COMPUTATIONAL ADVANCES IN BIO AND MEDICAL SCIENCES (ICCABS).Web of Science: 000361057400020
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2006Integrative mathematical modeling for analysis of microcirculatory function. BIOLOGICAL AND MEDICAL DATA ANALYSIS, PROCEEDINGS. 161-+.Web of Science: 000244560100015
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Review
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2018The yin and yang of K-V channels in cerebral small vessel pathologies. MICROCIRCULATION.Full Text via DOI: 10.1111/micc.12436 Web of Science: 000419666300011
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2012Intercellular Communication in the Vascular Wall: A Modeling Perspective. MICROCIRCULATION. 391-402.
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2008A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: Agonist and NO stimulation. JOURNAL OF THEORETICAL BIOLOGY. 238-260.
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2008Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models. MICROCIRCULATION. 813-834.
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chaired theses and dissertations
- Parikh, Jaimit B, Theoretical Investigation of Intra- and Inter-cellular Spatiotemporal Calcium Patterns in Microcirculation 2015
- Gadkari, Tushar V, Effect of Arginine and Oscillatory Ca2+ on Vascular Response Mediated Via Nitric Oxide Signaling in Normal and Salt Sensitive Hypertensive Rat Mesenteric Arterioles 2013
- Madrasi, Kumpal J, Preservation of Nitric Oxide Availability as Nitrite and Nitrosothiols 2012
- Namin, Shabnam M, An Experimental and Theoretical Analysis of Nitric Oxide in the Microcirculation 2012
- Nagaraja, Sridevi, Theoretical Investigations of Communication in the Microcirculation: Conducted Responses, Myoendothelial Projections and Endothelium Derived Hyperpolarizing Factor 2011
- Chawla, Rohit, Vascular reactivity of isolated rat mesenteric arterioles in the presence and absence of ouabain 2006
Research
principal investigator on
- K+ sensing & electrical signaling by Kir channels in brain vasculature awarded by National Institutes of Health 2016 - 2021
- Capillary control of cerebral blood flow, and its disruption in small vessel disease awarded by National Institutes of Health 2017 - 2019
- Integrative modeling to link vascular phenotype to gene expression awarded by National Institutes of Health 2014 - 2018
- Theoretical and Experimental Investigations of Microcirculatory Signaling (SCI) awarded by National Heart, Lung and Blood Institute 2008 - 2014
- Gyuton Award. awarded by American Physiological Society 2006 - 2010
- Signal transduction in the regulation of microcirculatory vascular tone involving Nitric Oxide. awarded by American Heart Association 2007 - 2009
Teaching
teaching activities
- BME2740-U01: Biomedical Engineering Modeling and Simulation Spring Term 2019
- BME2740-U02: Biomedical Engineering Modeling and Simulation Spring Term 2019
Contact
full name
- Nikolaos Tsoukias
Identifiers
ORCID iD
- https://orcid.org/0000-0002-5164-9577 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Cardiovascular System & Cardiology
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Engineering
- Hematology
- Life Sciences & Biomedicine - Other Topics
- Mathematical & Computational Biology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Physics
- Physiology
- Research & Experimental Medicine