Tsoukias, Nikolaos
- Associate Professor, Biomedical Engineering , College of Engineering and Computing
Overview
overview
- Dr. Nikolaos Tsoukias received his B.S. in Chemical Engineering from the National Technical University of Athens, Greece in 1994. He received a doctorate in Engineering from the University of California, Irvine in 1999. Upon completion of a three-year research fellowship at the Johns Hopkins University School of Medicine, he joined Florida International University as an Assistant Professor in 2003. His research interests are in the areas of mathematical modeling, systems physiology and biotransport. Dr. Tsoukias is a regular member of the Biomedical Engineering Society, the Microcirculatory Society and the American Physiological Society. Dr. Tsoukias established the laboratory of Vascular Physiology and Biotransport at FIU in 2003. He was the 2006 recipient of the Arthur C. Gyuton award for excellence in integrative physiology. His research has been supported by the American Heart Association and the National Institutes of Health. He has authored more than 50 peer reviewed publications in archived journals, contributed more than 75 abstracts in conference proceedings and received 2 patents.
Scholarly & Creative Works
selected publications
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Article
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2020Contractile pericytes determine the direction of blood flow at capillary junctions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117:27022-27033.Full Text via DOI: 10.1073/pnas.1922755117 Web of Science: 000582743300061
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2020The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K plus -mediated neurovascular communication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117:16626-16637.Full Text via DOI: 10.1073/pnas.2000151117 Web of Science: 000553287100001
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2019Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-53440-7 Web of Science: 000497701800029
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2018Biophysical properties of microvascular endothelium: Requirements for initiating and conducting electrical signals. MICROCIRCULATION. 25.Full Text via DOI: 10.1111/micc.12429 Web of Science: 000424813900005
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2017A "sweet-spot" for fluid-induced oscillations in the conditioning of stem cell-based engineered heart valve tissues. JOURNAL OF BIOMECHANICS. 65:40-48.
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2017Can endothelial hemoglobin-alpha regulate nitric oxide vasodilatory signaling?. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 312:H854-H866.
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2016Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stress. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 310:C479-C490.
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2016Inherent rhythm of smooth muscle cells in rat mesenteric arterioles: An eigensystem formulation. PHYSICAL REVIEW E. 93.
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2015Stochastic Model of Endothelial TRPV4 Calcium Sparklets: Effect of Bursting and Cooperativity on EDH. BIOPHYSICAL JOURNAL. 108:1566-1576.
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2013Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertension. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 35:65-71.
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2013Kinetic analysis of DAF-FM activation by NO: Toward calibration of a NO-sensitive fluorescent dye. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 28:39-46.
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2013Role of microprojections in myoendothelial feedback - a theoretical study. JOURNAL OF PHYSIOLOGY-LONDON. 591:2795-2812.
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2012Bone marrow transplantation improves endothelial function in hypertensive Dahl salt-sensitive rats. JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION. 6:331-337.
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2012Endothelial Ca2+ wavelets and the induction of myoendothelial feedback. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 302:C1226-C1242.
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2012Glutathiyl radical as an intermediate in glutathione nitrosation. FREE RADICAL BIOLOGY AND MEDICINE. 53:1968-1976.Full Text via DOI: 10.1016/j.freeradbiomed.2012.08.013 PMID: 22951977 Web of Science: 000311328300016
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2012Inhibition of Nitric Oxide Synthesis in Mouse Macrophage Cells by Feverfew Supercritical Extract. PHYTOTHERAPY RESEARCH. 26:541-545.
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2012Multiple Factors Influence Calcium Synchronization in Arterial Vasomotion. BIOPHYSICAL JOURNAL. 102:211-220.
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2011Calcium dynamics and signaling in vascular regulation: computational models. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE. 3:93-106.
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2011Multiscale FEM Modeling of Vascular Tone: From Membrane Currents to Vessel Mechanics. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 58:3456-3459.
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2010A mathematical model of vasoreactivity in rat mesenteric arterioles. II. Conducted vasoreactivity. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 298:H52-H65.
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2009A mathematical model of vasoreactivity in rat mesenteric arterioles: I. Myoendothelial communication. MICROCIRCULATION. 16:694-U69.
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2009Carbon Nanotube Reinforced Polylactide-Caprolactone Copolymer: Mechanical Strengthening and Interaction with Human Osteoblasts in Vitro. ACS APPLIED MATERIALS & INTERFACES. 1:2470-2476.
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2009Effect of carbon nanotube and aluminum oxide addition on plasma-sprayed hydroxyapatite coating's mechanical properties and biocompatibility. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 29:2195-2202.Full Text via DOI: 10.1016/j.msec.2009.05.001 Web of Science: 000270159200017
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2007A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks. JOURNAL OF THEORETICAL BIOLOGY. 248:657-674.
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2007A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 293:C277-C293.
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2006A computational model of oxygen transport in skeletal muscle for sprouting and splitting modes of angiogenesis. JOURNAL OF THEORETICAL BIOLOGY. 241:94-108.
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2005New aspects of vulnerability in heterogeneous models of ventricular wall and its modulation by loss of cardiac sodium channel function. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. 43.Full Text via DOI: 10.1007/BF02345817 Web of Science: 000230674600012
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Conference
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Editorial Material
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Meeting Abstract
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2020Modeling cerebral network hemodynamics: Effect of conducted vasodilation on brain perfusion. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.08757 Web of Science: 000546107904383
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2019Integrative: Modeling of Functional Hyperemia: From Ion Channel Activity to Functional Imaging. FASEB JOURNAL.Web of Science: 000496555201052
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2017A Mathematical Model of Cerebral Blood Flow Control: Role of Kir Channels. FASEB JOURNAL.Web of Science: 000405986504256
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2016Multi-scale Modeling of Collecting Lymphatic Vessels: From Ion Channel Activity to Lymph Transport. FASEB JOURNAL.Web of Science: 000406444707228
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2014Endothelial hemoglobin-alpha modulating NO mediated feedback response during smooth muscle stimulation.. JOURNAL OF VASCULAR RESEARCH. 50-50.Web of Science: 000346236200042
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2014Localized calcium events and endothelium derived signals in the modulation of vessel tone. JOURNAL OF VASCULAR RESEARCH. 49-49.Web of Science: 000346236200041
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2014Ratiometric detection of nitric oxide by fluorescent organometallic Re-phenanthroline complexes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348457602043
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2013Computational model of NO and NO oxidative species transport in the microcirculation. FASEB JOURNAL.Web of Science: 000319860503089
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2013Multiscale computational models of microvascular reactivity from ion channels to intercellular signaling. FASEB JOURNAL.Web of Science: 000319860505101
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2013Re-phenanthroline complexes as ratiometric fluorescent dyes for NO sensing. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324303601309
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2013Role of localized calcium events in regulation of vascular tone: A theoretical investigation. FASEB JOURNAL.Web of Science: 000319860500196
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2012Agmatine-mediated Arterial Relaxation is impaired in Salt-Sensitive Hypertension. FASEB JOURNAL.Web of Science: 000310711306436
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2012Metal complexes of phenanthroline and analogs as versatile frameworks for Nitric Oxide sensing and imaging. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000324503201124
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2012sGC in SMC acts as Nitrite Reductase leading to NO formation. FASEB JOURNAL.Web of Science: 000310711305931
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2011Agmatine Produced by Arginine Decarboxylase Activity Causes NO Dependent Rat Mesenteric Artery Relaxation. FASEB JOURNAL.Web of Science: 000310708403809
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2011Gene Expression of Calcium Channel Components in Dahl Salt-Resistant Rat Mesenteric Arteries by RT-PCR. FASEB JOURNAL.Web of Science: 000310708404112
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2011Nitrite reduction to NO in rat aortic smooth muscle cells by soluble guanylate cyclase. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. S40-S40.Full Text via DOI: 10.1016/j.niox.2011.03.298 Web of Science: 000290465600068
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2011Role of EC Projection in Myoendothelial Communication: A Theoretical Study. FASEB JOURNAL.Web of Science: 000310708405588
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2011Soluble Guanylate Cyclase Catalyzes Nitrite reduction to Nitric Oxide in Rat Aortic Smooth Muscle Cells. FASEB JOURNAL.Web of Science: 000310708403808
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2011Solving the Enigma of Myoendothelial Feedback. FASEB JOURNAL.Web of Science: 000310708405567
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2011The role of myoendothelial communication in regulating vascular contractility. JOURNAL OF VASCULAR RESEARCH. 45-45.Web of Science: 000294760800042
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2010Agmatine-mediated rat mesenteric artery relaxation via NO synthesis. FASEB JOURNAL.Web of Science: 000208675505622
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2010Bone Marrow Transplantation Improves Endothelial Function in Hypertensive Dahl Salt-Sensitive Rats. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. E262-E262.Web of Science: 000283234800361
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2010Kinetics of nitrosation of GSH using NO donors. FASEB JOURNAL.Web of Science: 000208675505462
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2010Microprojections amplify EC response to SMC stimulation: A theoretical study. FASEB JOURNAL.Web of Science: 000208675505568
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2009
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2009
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2009
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2009Inhibition of nitric oxide production by feverfew supercritical extract as part of a migraine model in vitro. FASEB JOURNAL.Web of Science: 000208621504278
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2008Experimental and theoretical studies to determine smooth muscle nitric oxide availability. FASEB JOURNAL.Web of Science: 000208467809217
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2006A mathematical model of endothelium-smooth muscle interaction in regulating microcirculatory tone. FASEB JOURNAL. A283-A283.Web of Science: 000236206502254
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2006A mathematical model of plasma membrane electrophysiology and calcium dynamics in rat mesenteric endothelial cells. FASEB JOURNAL. A410-A410.Web of Science: 000236206503279
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2004Is there frequency encoded information in EDRF?. FASEB JOURNAL.Web of Science: 000220470702676
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Proceedings Paper
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2014Multi-scale modeling of microvascular reactivity. 2014 IEEE 4TH INTERNATIONAL CONFERENCE ON COMPUTATIONAL ADVANCES IN BIO AND MEDICAL SCIENCES (ICCABS).Web of Science: 000361057400020
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2006Integrative mathematical modeling for analysis of microcirculatory function. BIOLOGICAL AND MEDICAL DATA ANALYSIS, PROCEEDINGS. 161-+.Web of Science: 000244560100015
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Review
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2018The yin and yang of K-V channels in cerebral small vessel pathologies. MICROCIRCULATION.Full Text via DOI: 10.1111/micc.12436 Web of Science: 000419666300011
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2012Intercellular Communication in the Vascular Wall: A Modeling Perspective. MICROCIRCULATION. 391-402.
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2011Modeling Ca2+ Signaling in the Microcirculation: Intercellular Communication and Vasoreactivity. 435-460.Full Text via DOI: 10.1615/CritRevBiomedEng.v39.i5.50
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2008A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: Agonist and NO stimulation. JOURNAL OF THEORETICAL BIOLOGY. 238-260.
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2008Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models. MICROCIRCULATION. 813-834.
chaired theses and dissertations
- Parikh, Jaimit B, Theoretical Investigation of Intra- and Inter-cellular Spatiotemporal Calcium Patterns in Microcirculation 2015
- Gadkari, Tushar V, Effect of Arginine and Oscillatory Ca2+ on Vascular Response Mediated Via Nitric Oxide Signaling in Normal and Salt Sensitive Hypertensive Rat Mesenteric Arterioles 2013
- Madrasi, Kumpal J, Preservation of Nitric Oxide Availability as Nitrite and Nitrosothiols 2012
- Namin, Shabnam M, An Experimental and Theoretical Analysis of Nitric Oxide in the Microcirculation 2012
- Nagaraja, Sridevi, Theoretical Investigations of Communication in the Microcirculation: Conducted Responses, Myoendothelial Projections and Endothelium Derived Hyperpolarizing Factor 2011
- Chawla, Rohit, Vascular reactivity of isolated rat mesenteric arterioles in the presence and absence of ouabain 2006
Research
research interests
- Computational and mathematical modeling, biotransport, signal transduction, cardiovascular and respiratory systems physiology
principal investigator on
- K+ sensing & electrical signaling by Kir channels in brain vasculature awarded by National Institutes of Health 2016 - 2021
- Capillary control of cerebral blood flow, and its disruption in small vessel disease awarded by National Institutes of Health 2017 - 2019
- Integrative modeling to link vascular phenotype to gene expression awarded by National Institutes of Health 2014 - 2018
- Theoretical and Experimental Investigations of Microcirculatory Signaling (SCI) awarded by National Heart, Lung and Blood Institute 2008 - 2014
- Gyuton Award. awarded by American Physiological Society 2006 - 2010
- Signal transduction in the regulation of microcirculatory vascular tone involving Nitric Oxide. awarded by American Heart Association 2007 - 2009
Teaching
teaching activities
- BME2740-U01: Biomedical Engineering Modeling and Simulation Spring Term 2019
- BME2740-U02: Biomedical Engineering Modeling and Simulation Spring Term 2019
Contact
full name
- Nikolaos Tsoukias
Identifiers
ORCID iD
- https://orcid.org/0000-0002-5164-9577 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Cardiovascular System & Cardiology
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Engineering
- Hematology
- Life Sciences & Biomedicine - Other Topics
- Mathematical & Computational Biology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Physics
- Physiology
- Research & Experimental Medicine