Tsoukias, Nikolaos
- Associate Professor, Biomedical Engineering , College of Engineering and Computing

Overview
overview
- Dr. Nikolaos Tsoukias received his B.S. in Chemical Engineering from the National Technical University of Athens, Greece in 1994. He received a doctorate in Engineering from the University of California, Irvine in 1999. Upon completion of a three-year research fellowship at the Johns Hopkins University School of Medicine, he joined Florida International University as an Assistant Professor in 2003. His research interests are in the areas of mathematical modeling, systems physiology and biotransport. Dr. Tsoukias is a regular member of the Biomedical Engineering Society, the Microcirculatory Society and the American Physiological Society. Dr. Tsoukias established the laboratory of Vascular Physiology and Biotransport at FIU in 2003. He was the 2006 recipient of the Arthur C. Gyuton award for excellence in integrative physiology. His research has been supported by the American Heart Association and the National Institutes of Health. He has authored more than 50 peer reviewed publications in archived journals, contributed more than 75 abstracts in conference proceedings and received 2 patents.
research interests
- Computational and mathematical modeling, biotransport, signal transduction, cardiovascular and respiratory systems physiology
Scholarly & Creative Works
selected publications
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Article
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2020Contractile pericytes determine the direction of blood flow at capillary junctionsFull Text via DOI: 10.1073/pnas.1922755117 Web of Science: 000582743300061
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2019Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamicsFull Text via DOI: 10.1038/s41598-019-53440-7 Web of Science: 000497701800029
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2018Biophysical properties of microvascular endothelium: Requirements for initiating and conducting electrical signalsFull Text via DOI: 10.1111/micc.12429 Web of Science: 000424813900005
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2017A "sweet-spot" for fluid-induced oscillations in the conditioning of stem cell-based engineered heart valve tissuesFull Text via DOI: 10.1016/j.jbiomech.2017.09.035 Web of Science: 000417665400005
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2017Can endothelial hemoglobin-alpha regulate nitric oxide vasodilatory signaling?Full Text via DOI: 10.1152/ajpheart.00315.2016 Web of Science: 000400684100007
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2016Inherent rhythm of smooth muscle cells in rat mesenteric arterioles: An eigensystem formulationFull Text via DOI: 10.1103/PhysRevE.93.042415 Web of Science: 000374962600005
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2016Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stressFull Text via DOI: 10.1152/ajpcell.00171.2015 Web of Science: 000372091500011
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2015Stochastic Model of Endothelial TRPV4 Calcium Sparklets: Effect of Bursting and Cooperativity on EDHFull Text via DOI: 10.1016/j.bpj.2015.01.034 Web of Science: 000351774800029
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2013Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertensionFull Text via DOI: 10.1016/j.niox.2013.08.005 Web of Science: 000328312400009
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2013Role of microprojections in myoendothelial feedback - a theoretical studyFull Text via DOI: 10.1113/jphysiol.2012.248948 Web of Science: 000319772500009
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2013Kinetic analysis of DAF-FM activation by NO: Toward calibration of a NO-sensitive fluorescent dyeFull Text via DOI: 10.1016/j.niox.2012.10.001 Web of Science: 000315065900007
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2012Glutathiyl radical as an intermediate in glutathione nitrosationFull Text via DOI: 10.1016/j.freeradbiomed.2012.08.013 Web of Science: 000311328300016
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2012Bone marrow transplantation improves endothelial function in hypertensive Dahl salt-sensitive ratsFull Text via DOI: 10.1016/j.jash.2012.08.003 Web of Science: 000309437400006
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2012Endothelial Ca2+ wavelets and the induction of myoendothelial feedbackFull Text via DOI: 10.1152/ajpcell.00418.2011 Web of Science: 000303662600015
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2012Inhibition of Nitric Oxide Synthesis in Mouse Macrophage Cells by Feverfew Supercritical ExtractFull Text via DOI: 10.1002/ptr.3594 Web of Science: 000302620000011
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2012Multiple Factors Influence Calcium Synchronization in Arterial VasomotionFull Text via DOI: 10.1016/j.bpj.2011.12.032 Web of Science: 000299244100006
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2011Multiscale FEM Modeling of Vascular Tone: From Membrane Currents to Vessel MechanicsFull Text via DOI: 10.1109/TBME.2011.2162513 Web of Science: 000297341500007
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2011Calcium dynamics and signaling in vascular regulation: computational modelsFull Text via DOI: 10.1002/wsbm.97 Web of Science: 000286042300007
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2010A mathematical model of vasoreactivity in rat mesenteric arterioles. II. Conducted vasoreactivityFull Text via DOI: 10.1152/ajpheart.00546.2009 Web of Science: 000272831600008
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2009Carbon Nanotube Reinforced Polylactide-Caprolactone Copolymer: Mechanical Strengthening and Interaction with Human Osteoblasts in VitroFull Text via DOI: 10.1021/am900423q Web of Science: 000272039700009
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2009A mathematical model of vasoreactivity in rat mesenteric arterioles: I. Myoendothelial communicationFull Text via DOI: 10.3109/10739680903177539 Web of Science: 000271476000004
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2007A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networksFull Text via DOI: 10.1016/j.jtbi.2007.06.012 Web of Science: 000250302600007
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2007A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cellsFull Text via DOI: 10.1152/ajpcell.00542.2006 Web of Science: 000247968900030
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2006A computational model of oxygen transport in skeletal muscle for sprouting and splitting modes of angiogenesisFull Text via DOI: 10.1016/j.jtbi.2005.11.019 Web of Science: 000238714600010
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2005New aspects of vulnerability in heterogeneous models of ventricular wall and its modulation by loss of cardiac sodium channel functionFull Text via DOI: 10.1007/BF02345817 Web of Science: 000230674600012
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2004A theoretical model of nitric oxide transport in arterioles: frequency- vs. amplitude-dependent control of cGMP formationFull Text via DOI: 10.1152/ajpheart.00525.2003 Web of Science: 000188783200031
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2003A model of nitric oxide capillary exchangeFull Text via DOI: 10.1038/sj.mn.7800210 Web of Science: 000187216000006
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2002Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobinFull Text via DOI: 10.1152/ajpheart.01080.2001 Web of Science: 000175531800041
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2002Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutesFull Text via DOI: 10.1152/ajpheart.00972.2001 Web of Science: 000175531800038
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2001Impact of volume-dependent alveolar diffusing capacity on exhaled nitric oxide concentrationFull Text via DOI: 10.1114/1.1397786 Web of Science: 000171358400001
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2001A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungsFull Text via DOI: 10.1152/jappl.2001.91.1.477 Web of Science: 000169471700061
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2000Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: I. TheoryFull Text via DOI: 10.1016/S0034-5687(00)00103-1 Web of Science: 000087359700004
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2000Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: II. ExperimentFull Text via DOI: 10.1016/S0034-5687(00)00104-3 Web of Science: 000087359700005
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1998A two-compartment model of pulmonary nitric oxide exchange dynamicsFull Text via DOI: 10.1152/jappl.1998.85.2.653 Web of Science: 000075592300037
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1998Single-exhalation profiles of NO and CO2 in humans: effect of dynamically changing flow rateFull Text via DOI: 10.1152/jappl.1998.85.2.642 Web of Science: 000075592300036
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Conference
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2020Modeling cerebral network hemodynamics: Effect of conducted vasodilation on brain perfusionFull Text via DOI: 10.1096/fasebj.2020.34.s1.08757 Web of Science: 000546107904383
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2017
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2014
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2014
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2014Multi-scale modeling of microvascular reactivityWeb of Science: 000361057400020
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2012
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2011The role of myoendothelial communication in regulating vascular contractility. 45-45.Web of Science: 000294760800042
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2011Nitrite reduction to NO in rat aortic smooth muscle cells by soluble guanylate cyclase. S40-S40.Full Text via DOI: 10.1016/j.niox.2011.03.298 Web of Science: 000290465600068
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2011Solving the Enigma of Myoendothelial FeedbackWeb of Science: 000310708405567
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2010Bone Marrow Transplantation Improves Endothelial Function in Hypertensive Dahl Salt-Sensitive Rats. E262-E262.Web of Science: 000283234800361
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2010
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2010Kinetics of nitrosation of GSH using NO donorsWeb of Science: 000208675505462
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2009Multiscale mathematical modeling of microvascular tone regulation. 297-298.Full Text via DOI: 10.1007/978-3-642-01697-4_104
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2006Integrative mathematical modeling for analysis of microcirculatory function. 161-+.Web of Science: 000244560100015
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2006A mathematical model of endothelium-smooth muscle interaction in regulating microcirculatory tone. A283-A283.Web of Science: 000236206502254
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2006
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2005Effect of hemoglobin-based blood substitutes on nitric oxide transport: Mathematical models. 176-185.Web of Science: 000226550800012
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2004Is there frequency encoded information in EDRF?. A1319-A1319.Web of Science: 000220470702676
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2002A theoretical model of nitric oxide transport in arterioles: transient versus sustained NO production. A853-A853.Web of Science: 000174593900710
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2002Effect of hemoglobin-based oxygen carrier on smooth muscle nitric oxide availability. A853-A853.Web of Science: 000174593900707
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2002
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2000Local nitric oxide concentrations in co-sleeping infants. 477A-477A.Web of Science: 000086155302816
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1999A new method to measure the dependence of DLNO and DLCO on alveolar volume.. A843-A843.Web of Science: 000082237104705
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1998
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Editorial Material
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Other Scholarly Work
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Review
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2018The yin and yang of K-V channels in cerebral small vessel pathologiesFull Text via DOI: 10.1111/micc.12436 Web of Science: 000419666300011
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2012Intercellular Communication in the Vascular Wall: A Modeling Perspective. 391-402.Full Text via DOI: 10.1111/j.1549-8719.2012.00171.x Web of Science: 000306177700003
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2011Modeling Ca2+ Signaling in the Microcirculation: Intercellular Communication and Vasoreactivity. 435-460.Full Text via DOI: 10.1615/CritRevBiomedEng.v39.i5.50
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2008A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: Agonist and NO stimulation. 238-260.Full Text via DOI: 10.1016/j.jtbi.2008.03.004 Web of Science: 000257542300003
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2008Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models. 813-834.Full Text via DOI: 10.1080/10739680802010070 Web of Science: 000261339000009
Works By Students
chaired theses and dissertations
- Parikh, Jaimit B, Theoretical Investigation of Intra- and Inter-cellular Spatiotemporal Calcium Patterns in Microcirculation 2015
- Gadkari, Tushar V, Effect of Arginine and Oscillatory Ca2+ on Vascular Response Mediated Via Nitric Oxide Signaling in Normal and Salt Sensitive Hypertensive Rat Mesenteric Arterioles 2013
- Madrasi, Kumpal J, Preservation of Nitric Oxide Availability as Nitrite and Nitrosothiols 2012
- Namin, Shabnam M, An Experimental and Theoretical Analysis of Nitric Oxide in the Microcirculation 2012
- Nagaraja, Sridevi, Theoretical Investigations of Communication in the Microcirculation: Conducted Responses, Myoendothelial Projections and Endothelium Derived Hyperpolarizing Factor 2011
- Chawla, Rohit, Vascular reactivity of isolated rat mesenteric arterioles in the presence and absence of ouabain 2006
Research
principal investigator on
- Cerebral microvascular signaling and NVC: An integrated approach to investigate VCID awarded by Neurological Disorders and Stroke 2021 - 2026
- Capillaries as a sensory web that controls cerebral blood flow in health and disease awarded by National Heart, Lung, & Blood Institute 2019 - 2025
- Capillary control of cerebral blood flow, and its disruption in small vessel disease awarded by National Institutes of Health 2019 - 2022
- Ion Channel Dysfunction in small vessel disease in the brain. awarded by National Institutes of Health 2019 - 2021
- K+ sensing & electrical signaling by Kir channels in brain vasculature awarded by National Heart, Lung, & Blood Institute 2016 - 2021
- Capillary control of cerebral blood flow, and its disruption in small vessel disease awarded by National Heart, Lung, & Blood Institute 2017 - 2019
- Integrative modeling to link vascular phenotype to gene expression awarded by National Heart, Lung, & Blood Institute 2014 - 2018
- Theoretical and Experimental Investigations of Microcirculatory Signaling (SCI) awarded by National Heart, Lung, & Blood Institute 2008 - 2014
- Gyuton Award. awarded by American Physiological Society 2006 - 2010
- Signal transduction in the regulation of microcirculatory vascular tone involving Nitric Oxide. awarded by American Heart Association 2007 - 2009
Contact
full name
- Nikolaos Tsoukias
Identifiers
ORCID iD
- https://orcid.org/0000-0002-5164-9577 (confirmed)
visualizations
publication subject areas
- Biochemistry & Molecular Biology
- Biophysics
- Cardiovascular System & Cardiology
- Cell Biology
- Chemistry
- Endocrinology & Metabolism
- Engineering
- Hematology
- Life Sciences & Biomedicine - Other Topics
- Mathematical & Computational Biology
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Physics
- Physiology
- Research & Experimental Medicine