Xiaotang Wang
- Associate Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education
Publications
selected publications
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Article
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2020DNA and RNA editing without sequence limitation using the flap endonuclease 1 guided by hairpin DNA probes. NUCLEIC ACIDS RESEARCH. 48.Full Text via DOI: 10.1093/nar/gkaa843 Web of Science: 000606018600003
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2020Improving the thermostability of a GH97 dextran glucosidase by rational design. BIOTECHNOLOGY LETTERS.Full Text via DOI: 10.1007/s10529-020-02928-8 Web of Science: 000537407400004
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2020An unusual GH1 beta-glucosidase from marine sediment with beta-galactosidase and transglycosidation activities for superior galacto-oligosaccharide synthesis. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 104:4927-4943.Full Text via DOI: 10.1007/s00253-020-10578-z Web of Science: 000525476800001
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2020An oroxylin A-loaded aggregation-induced emission active polymeric system greatly increased the antitumor efficacy against squamous cell carcinoma. JOURNAL OF MATERIALS CHEMISTRY B. 8:2040-2047.Full Text via DOI: 10.1039/c9tb01818b Web of Science: 000520502600018
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2020Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3 beta-modulated mitochondrial binding of HKII. FREE RADICAL BIOLOGY AND MEDICINE. 146:119-129.Full Text via DOI: 10.1016/j.freeradbiomed.2019.10.413 Web of Science: 000504866900010
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2019LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells. CELL DEATH & DISEASE. 10.Full Text via DOI: 10.1038/s41419-019-1714-y Web of Science: 000472439500001
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2019AmyZ1: a novel alpha-amylase from marine bacterium Pontibacillus sp. ZY with high activity toward raw starches. BIOTECHNOLOGY FOR BIOFUELS. 12.Full Text via DOI: 10.1186/s13068-019-1432-9 Web of Science: 000465384500002
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2019Enhancing the catalytic performance of chloroperoxidase by co-immobilization with glucose oxidase on magnetic graphene oxide. BIOCHEMICAL ENGINEERING JOURNAL. 143:101-109.Full Text via DOI: 10.1016/j.bej.2018.12.013 Web of Science: 000460809900012
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2017Bioconversion of non-steroidal anti-inflammatory drugs diclofenac and naproxen by chloroperoxidase. BIOCHEMICAL ENGINEERING JOURNAL. 120:7-16.Full Text via DOI: 10.1016/j.bej.2016.12.018 Web of Science: 000395603900002
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2017PLSCR1/IP3R1/Ca2+ axis contributes to differentiation of primary AML cells induced by wogonoside. CELL DEATH & DISEASE. 8.
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2017Pseudoruegeria marinistellae sp nov., isolated from an unidentified starfish in Sanya, China. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY. 110:187-194.
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2016A cold-adapted and glucose-stimulated type II alpha-glucosidase from a deep-sea bacterium Pseudoalteromonas sp K8. BIOTECHNOLOGY LETTERS. 38:345-349.
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2016A novel ethanol-tolerant laccase, Tvlac, from Trametes versicolor. BIOTECHNOLOGY LETTERS. 38:471-476.
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2016Improve ethanol tolerance of beta-glucosidase Bgl1A by semi-rational engineering for the hydrolysis of soybean isoflavone glycosides. JOURNAL OF BIOTECHNOLOGY. 227:64-71.
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2016Lutimaribacter marinistellae sp nov., isolated from a starfish. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY. 66:3675-3680.
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2016Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. MOLECULAR CARCINOGENESIS. 55:1275-1289.
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2016PspAG97A: A Halophilic alpha-Glucoside Hydrolase with Wide Substrate Specificity from Glycoside Hydrolase Family 97. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY. 26:1933-1942.
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2016Spectroscopic and QM/MM investigations of Chloroperoxidase catalyzed degradation of orange G. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 596:1-9.
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2016Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. JOURNAL OF STRUCTURAL BIOLOGY. 196:426-436.
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2015A mechanism of glucose tolerance and stimulation of GH1 beta-glucosidases. SCIENTIFIC REPORTS. 5.
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2015Genome sequence of a laccase producing fungus Trametes sp AH28-2. JOURNAL OF BIOTECHNOLOGY. 216:167-168.
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2015Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol production. BIOTECHNOLOGY FOR BIOFUELS. 8.
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2015Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. JOURNAL OF HEMATOLOGY & ONCOLOGY. 8.
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2014Characterization of a Novel beta-Glucosidase from Gongronella sp W5 and Its Application in the Hydrolysis of Soybean Isoflavone Glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 62:11688-11695.
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2014Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPAR gamma and RXR alpha. INTERNATIONAL JOURNAL OF CANCER. 134:1195-1206.
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2014Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells. ONCOTARGET. 5:8188-8201.
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2012A 3D localized surface plasmon resonance biosensor for the study of trivalent arsenic binding to the ArsA ATPase. BIOSENSORS & BIOELECTRONICS. 38:19-26.
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2012Beclin 1-mediated autophagy in hepatocellular carcinoma cells: Implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. CELLULAR SIGNALLING. 24:1722-1732.
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2012Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells. BIOCHEMISTRY AND CELL BIOLOGY. 90:718-730.
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2012HIF-1 alpha is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. CELL DEATH AND DIFFERENTIATION. 19:284-294.
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2012The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450. BIOORGANIC & MEDICINAL CHEMISTRY. 20:3742-3745.
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2009Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. CANCER LETTERS. 279:13-21.
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2009MAC related mitochondrial pathway in oroxylin A induces apoptosis in human hepatocellular carcinoma HepG2 cells. CANCER LETTERS. 284:198-207.
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2009Speciation, formation, stability and analytical challenges of human arsenic metabolites. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 24:1397-1405.
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2008Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells. BIOCHEMISTRY AND CELL BIOLOGY. 86:386-395.
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2008Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H-22 transplanted mice. INTERNATIONAL IMMUNOPHARMACOLOGY. 8:1493-1502.
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2008Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. MOLECULAR CANCER THERAPEUTICS. 7:3298-3305.
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2008Inhibition of glioblastoma growth and angiogenesis by garnbogic acid: An in vitro and in vivo study. BIOCHEMICAL PHARMACOLOGY. 75:1083-1092.
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2008Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. JOURNAL OF MOLECULAR MEDICINE-JMM. 86:1367-1377.
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2008Oroxylin A induces G(2)/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. JOURNAL OF PHARMACY AND PHARMACOLOGY. 60:1459-1463.
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2008Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells. CANCER LETTERS. 262:223-231.
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2008Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKC delta phosphorylation. EUROPEAN JOURNAL OF PHARMACOLOGY. 591:7-12.
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2008Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. LIFE SCIENCES. 82:956-963.
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2007Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. CANCER LETTERS. 256:259-266.
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2007Large scale preparation of the mammalian high mobility group protein A2 for biophysical studies. PROTEIN AND PEPTIDE LETTERS. 14:87-91.
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2006Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. LIFE SCIENCES. 78:1238-1245.
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2006Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. ANTI-CANCER DRUGS. 17:797-805.Full Text via DOI: 10.1097/01.cad.0000217431.64118.3f PMID: 16926629 Web of Science: 000240257100007
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2006Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 351:521-527.
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2006Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. CANCER CHEMOTHERAPY AND PHARMACOLOGY. 58:434-443.
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2006The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 29:1132-1137.
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2005Potential energy surface and product branching ratios for the reaction of F(P-2) with the methyl radical: An ab initio/RRKM study. CHEMICAL PHYSICS LETTERS. 406:60-74.Full Text via DOI: 10.1016/j.cplett.2005.02.081 Web of Science: 000228612200011
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2004Crystallographic and NMR investigation of cobalt-substituted amicyaninFull Text via DOI: 10.1021/bi049635r
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2004Proton NMR study of the heme environment in bacterial quinol oxidasesFull Text via DOI: 10.1016/j.abb.2003.11.016
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2002Redox properties of an engineered purple Cu
A azurinFull Text via DOI: 10.1016/S0003-9861(02)00282-5 -
2001Coupled oxidation of heme by myoglobin is mediated by exogenous peroxideFull Text via DOI: 10.1021/ja015776u
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2000Ligand replacement study at the His120 site of purple Cu(A) azurinFull Text via DOI: 10.1016/S0162-0134(99)00214-7
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1999The role of histidine ligands in the structure of purple Cu(A) azurin [23]Full Text via DOI: 10.1021/ja991304s
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1999Kinetics of copper incorporation into an engineered purple azurinFull Text via DOI: 10.1021/ja982636k
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1998Spectroscopic Characterization of an Engineered Purple Cu
A Center in AzurinFull Text via DOI: 10.1021/ic971232a
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Conference
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2004Photochemical reaction of chrysene in acetonitrile/waterFull Text via DOI: 10.1080/10406630490468243
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Correction
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2019Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells (vol 8, 41, 2015). JOURNAL OF HEMATOLOGY & ONCOLOGY.Full Text via DOI: 10.1186/s13045-019-0792-8 Web of Science: 000510918500001
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Meeting Abstract
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2018Effects of the pro-cys-pro tripeptide stretch on the structural and biochemical properties of chloroperoxidase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000435537701001
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2017Chloroperoxidase oxidative transformation of roxarsone. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000430569101264
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2017Elucidating the role of the proximal ligand loop in chloroperoxidase catalysis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000429525601346
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2015Role of proximal thiolate ligand in chloroperoxidase catalysis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000411183300569
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2014Reactivity of chloroperoxidase, a promising bioengineering target, revealed through simulation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000348455204612
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2010Structural Dynamics in Chloroperoxidase: A Photoacoustic Study. BIOPHYSICAL JOURNAL. 643A-643A.Full Text via DOI: 10.1016/j.bpj.2009.12.3523 Web of Science: 000208762006221
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2009Dynamics And Energetics Associated With Ligand Photodissociation From Co Bound Chloroperoxidase. BIOPHYSICAL JOURNAL. 437A-437A.Web of Science: 000426354000332
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2009Relative stability of iron-sulfur bond vs. iron-nitrogen bond in heme thiolate protein: Evidence from an engineered cytochrome P450cam with a novel heme iron ligand set. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207862000778
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2009Single amino acid switch turns P450cam from a monooxygenase to an efficient peroxidase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207857805748
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2008INOR 523-Engineering P450 into P420 with catalytic activities. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000271775106503
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2007Catalytic roles of Phe103 at the substrate-binding pocket of chloroperoxidase: Remote control of heme chemistry in heme-thiolate proteins. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207593909599
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2006INOR 1013-Structure of the green prosthetic group in chloroperoxidase following mechanism-based modification with terminal alkenes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Web of Science: 000207781606676
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Proceedings Paper
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2010Analytical challenges of human arsenic metabolites. ARSENIC IN GEOSPHERE AND HUMAN DISEASES. 498-499.Web of Science: 000392030500196
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Review
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2012Engineered Proteins: Redox Properties and Their Applications. ANTIOXIDANTS & REDOX SIGNALING. 1796-1822.
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chaired theses and dissertations
- tan, yi, Enzyme Catalyzed and Ultrasound Assisted Transformation of Selected Pollutants 2017
- He, Qinghao, The Degradation of Pharmaceutical Pollutants in Wastewater Catalyzed by Chloroperoxidase and the Construction of Chloroperoxidase H105R Mutant 2016
- Shersher, Elena, The Influence of the Proximal Thiolate Ligand and Hydrogen Bond Network of the Proximal Helix on the Structural and Biochemical Properties of Chloroperoxidase 2016
- Zhang, Rui, Nuclear Magnetic Resonance Spectroscopic and Computational Investigations of Chloroperoxidase Catalyzed Regio- and Enantio-Selective Transformations 2013
- Jiang, Lin, Mechanisms of Chloroperoxidase-catalyzed Enantioselective Reactions as Probed by Site-directed Mutagenesis and Isotopic Labeling 2012
- Chen, Taiyi, Chloroperoxidase Catalyzed Enantioselective Epoxidation of Selected Olefins and Regiospecific Degradation of Dimethylsulfoniopropionate 2011
- Wang, Zhonghua, Proton Nuclear Magnetic Resonance Investigation of the Native and Modified Active Site Structure of Heme Proteins 2011
- Wang, Zheng, Characterization of Recombinant Chloroperoxidase, and F103A and C29H/C79H/C87H Mutants 2011
- Tian, Hui, Tailoring Heme-Thiolate Proteins into Efficient Biocatalysts with High Specificity and Selectivity 2010
Research
principal investigator on
- Consortium Agreement on the Metabolism and Mechanism of the Anticancer Effects of Wogonin, Baicalein and their Derivatives awarded by China Pharmaceutical University 2016 - 2021
- Structural Basis for the Chloroperoxidase-Catalyzed Enantioselective Transformations. awarded by National Science Foundation 2005 - 2010
co-principal investigator on
Teaching
teaching activities
- BCH6831-U01: Introduction to Biochemical Research Spring Term 2019
- BCH7930-U01: Biochemistry Graduate Seminar Fall Term 2019
- CHM4304-U01: Biological Chemistry I Fall Term 2019
- CHM4930-U02: Senior Seminar Fall Term 2019
- CHM5305-U01: Graduate Biological Chemistry Fall Term 2019
- CHM7910-U24: Dissertation Research Spring Term 2019
- CHM7910-U27: Dissertation Research Fall Term 2019
- CHM7980-U24: PH.D. Dissertation Spring Term 2019
- CHM7980-U27: PH.D. Dissertation Fall Term 2019
Contact
full name
- Xiaotang Wang
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Agriculture
- Biochemistry & Molecular Biology
- Biophysics
- Biotechnology & Applied Microbiology
- Cell Biology
- Chemistry
- Electrochemistry
- Endocrinology & Metabolism
- Energy & Fuels
- Engineering
- Food Science & Technology
- Genetics & Heredity
- Hematology
- Immunology
- Instruments & Instrumentation
- Microbiology
- Oncology
- Pharmacology & Pharmacy
- Physics
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Spectroscopy