Wang, Xiaotang
- Associate Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education
Overview
research interests
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Structural and functional characterization of heme proteins containing thiolate axial ligand
Design and engineering of metalloproteins for asymmetric catalysis
Enzymatic synthesis of chiral synthons
NMR spectroscopic study of the active site structure of paramagnetic metalloproteins
The role of metal ions in cancer and neurodegenerative diseases
Scholarly & Creative Works
selected publications
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Article
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2022ThhspA1 is involved in lacA transcriptional regulation of Trametes hirsuta AH28-2 exposed to o-toluidineFull Text via DOI: 10.1016/j.fgb.2022.103716 Web of Science: 000821771000002
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2020DNA and RNA editing without sequence limitation using the flap endonuclease 1 guided by hairpin DNA probesFull Text via DOI: 10.1093/nar/gkaa843 Web of Science: 000606018600003
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2020Improving the thermostability of a GH97 dextran glucosidase by rational designFull Text via DOI: 10.1007/s10529-020-02928-8 Web of Science: 000537407400004
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2019AmyZ1: a novel alpha-amylase from marine bacterium Pontibacillus sp. ZY with high activity toward raw starchesFull Text via DOI: 10.1186/s13068-019-1432-9 Web of Science: 000465384500002
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2019Enhancing the catalytic performance of chloroperoxidase by co-immobilization with glucose oxidase on magnetic graphene oxideFull Text via DOI: 10.1016/j.bej.2018.12.013 Web of Science: 000460809900012
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2017PLSCR1/IP3R1/Ca2+ axis contributes to differentiation of primary AML cells induced by wogonosideFull Text via DOI: 10.1038/cddis.2017.175 Web of Science: 000402195700031
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2017Bioconversion of non-steroidal anti-inflammatory drugs diclofenac and naproxen by chloroperoxidaseFull Text via DOI: 10.1016/j.bej.2016.12.018 Web of Science: 000395603900002
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2017Pseudoruegeria marinistellae sp nov., isolated from an unidentified starfish in Sanya, ChinaFull Text via DOI: 10.1007/s10482-016-0789-z Web of Science: 000393743900002
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2016Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activationFull Text via DOI: 10.1016/j.jsb.2016.09.009 Web of Science: 000389295000015
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2016PspAG97A: A Halophilic alpha-Glucoside Hydrolase with Wide Substrate Specificity from Glycoside Hydrolase Family 97Full Text via DOI: 10.4014/jmb.1606.06047 Web of Science: 000388666200012
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2016Lutimaribacter marinistellae sp nov., isolated from a starfishFull Text via DOI: 10.1099/ijsem.0.001251 Web of Science: 000386871200068
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2016Spectroscopic and QM/MM investigations of Chloroperoxidase catalyzed degradation of orange GFull Text via DOI: 10.1016/j.abb.2016.02.026 Web of Science: 000374626900001
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2016A novel ethanol-tolerant laccase, Tvlac, from Trametes versicolorFull Text via DOI: 10.1007/s10529-015-1994-y Web of Science: 000371242700014
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2016A cold-adapted and glucose-stimulated type II alpha-glucosidase from a deep-sea bacterium Pseudoalteromonas sp K8Full Text via DOI: 10.1007/s10529-015-1987-x Web of Science: 000370374300019
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2015Genome sequence of a laccase producing fungus Trametes sp AH28-2Full Text via DOI: 10.1016/j.jbiotec.2015.11.001 Web of Science: 000365769000026
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2015A mechanism of glucose tolerance and stimulation of GH1 beta-glucosidasesFull Text via DOI: 10.1038/srep17296 Web of Science: 000365387500001
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2015Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol productionFull Text via DOI: 10.1186/s13068-015-0235-x Web of Science: 000352940200001
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2014Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cellsFull Text via DOI: 10.18632/oncotarget.2340 Web of Science: 000348030900018
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2014Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPAR gamma and RXR alphaFull Text via DOI: 10.1002/ijc.28435 Web of Science: 000328246700019
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2012Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cellsFull Text via DOI: 10.1139/O2012-030 Web of Science: 000311893500006
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2012A 3D localized surface plasmon resonance biosensor for the study of trivalent arsenic binding to the ArsA ATPaseFull Text via DOI: 10.1016/j.bios.2012.04.026 Web of Science: 000308455700003
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2012The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450Full Text via DOI: 10.1016/j.bmc.2012.04.046 Web of Science: 000304486500007
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2012HIF-1 alpha is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathwayFull Text via DOI: 10.1038/cdd.2011.95 Web of Science: 000299160600011
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2009MAC related mitochondrial pathway in oroxylin A induces apoptosis in human hepatocellular carcinoma HepG2 cellsFull Text via DOI: 10.1016/j.canlet.2009.04.021 Web of Science: 000270530700011
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2009Isolation and characterization of cancer stem like cells in human glioblastoma cell linesFull Text via DOI: 10.1016/j.canlet.2009.01.016 Web of Science: 000266418100003
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2009Speciation, formation, stability and analytical challenges of human arsenic metabolitesFull Text via DOI: 10.1039/b910943a Web of Science: 000270138800010
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2008Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H-22 transplanted miceFull Text via DOI: 10.1016/j.intimp.2008.05.013 Web of Science: 000260125800002
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2008Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cellsFull Text via DOI: 10.1139/O08-104 Web of Science: 000262711600004
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2008Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cellsFull Text via DOI: 10.1158/1535-7163.MCT-08-0212 Web of Science: 000260202000019
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2008Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKC delta phosphorylationFull Text via DOI: 10.1016/j.ejphar.2008.06.024 Web of Science: 000259162300002
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2008Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2Full Text via DOI: 10.1016/j.lfs.2008.02.013 Web of Science: 000255607600008
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2008Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cellsFull Text via DOI: 10.1016/j.canlet.2007.12.002 Web of Science: 000254684200009
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2008Inhibition of glioblastoma growth and angiogenesis by garnbogic acid: An in vitro and in vivo studyFull Text via DOI: 10.1016/j.bcp.2007.10.033 Web of Science: 000253614200010
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2007Wetland restoration response analysis using MODIS and groundwater dataFull Text via DOI: 10.3390/s7091916 Web of Science: 000249723500017
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2007Large scale preparation of the mammalian high mobility group protein A2 for biophysical studiesFull Text via DOI: 10.2174/092986607779117281 Web of Science: 000245376700014
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2006Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activityFull Text via DOI: 10.1016/j.bbrc.2006.10.064 Web of Science: 000242119200033
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2006Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cellsFull Text via DOI: 10.1007/s00280-005-0177-2 Web of Science: 000238740200003
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2006Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721Full Text via DOI: 10.1097/01.cad.0000217431.64118.3f Web of Science: 000240257100007
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2006The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivoFull Text via DOI: 10.1248/bpb.29.1132 Web of Science: 000238470500010
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2006Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cellsFull Text via DOI: 10.1016/j.lfs.2005.06.046 Web of Science: 000235402000014
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2004Crystallographic and NMR investigation of cobalt-substituted amicyaninFull Text via DOI: 10.1021/bi049635r
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2004Proton NMR study of the heme environment in bacterial quinol oxidasesFull Text via DOI: 10.1016/j.abb.2003.11.016
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2002Redox properties of an engineered purple Cu
A azurinFull Text via DOI: 10.1016/S0003-9861(02)00282-5 -
2000Ligand replacement study at the His120 site of purple Cu(A) azurinFull Text via DOI: 10.1016/S0162-0134(99)00214-7
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1999Kinetics of copper incorporation into an engineered purple azurinFull Text via DOI: 10.1021/ja982636k
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1998Spectroscopic Characterization of an Engineered Purple Cu
A Center in AzurinFull Text via DOI: 10.1021/ic971232a
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Conference
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2017
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2015
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2010Analytical challenges of human arsenic metabolites. 498-499.Web of Science: 000392030500196
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2008
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2004Photochemical reaction of chrysene in acetonitrile/water. 249-256.Full Text via DOI: 10.1080/10406630490468243
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Letter
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2001Coupled oxidation of heme by myoglobin is mediated by exogenous peroxide. 6945-6946.Full Text via DOI: 10.1021/ja015776u
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1999The role of histidine ligands in the structure of purple Cu(A) azurin [23]. 7449-7450.Full Text via DOI: 10.1021/ja991304s
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Other Scholarly Work
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2010Structural Dynamics in Chloroperoxidase: A Photoacoustic Study. 643A-643A.Full Text via DOI: 10.1016/j.bpj.2009.12.3523 Web of Science: 000208762006221
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2009Dynamics And Energetics Associated With Ligand Photodissociation From Co Bound Chloroperoxidase. 437A-437A.Full Text via DOI: 10.1016/j.bpj.2008.12.2242 Web of Science: 000426354000332
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Review
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2012Engineered Proteins: Redox Properties and Their Applications. 1796-1822.Full Text via DOI: 10.1089/ars.2011.4001 Web of Science: 000310061100011
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Works By Students
chaired theses and dissertations
- tan, yi, Enzyme Catalyzed and Ultrasound Assisted Transformation of Selected Pollutants 2017
- He, Qinghao, The Degradation of Pharmaceutical Pollutants in Wastewater Catalyzed by Chloroperoxidase and the Construction of Chloroperoxidase H105R Mutant 2016
- Shersher, Elena, The Influence of the Proximal Thiolate Ligand and Hydrogen Bond Network of the Proximal Helix on the Structural and Biochemical Properties of Chloroperoxidase 2016
- Zhang, Rui, Nuclear Magnetic Resonance Spectroscopic and Computational Investigations of Chloroperoxidase Catalyzed Regio- and Enantio-Selective Transformations 2013
- Jiang, Lin, Mechanisms of Chloroperoxidase-catalyzed Enantioselective Reactions as Probed by Site-directed Mutagenesis and Isotopic Labeling 2012
- Chen, Taiyi, Chloroperoxidase Catalyzed Enantioselective Epoxidation of Selected Olefins and Regiospecific Degradation of Dimethylsulfoniopropionate 2011
- Wang, Zhonghua, Proton Nuclear Magnetic Resonance Investigation of the Native and Modified Active Site Structure of Heme Proteins 2011
- Wang, Zheng, Characterization of Recombinant Chloroperoxidase, and F103A and C29H/C79H/C87H Mutants 2011
- Tian, Hui, Tailoring Heme-Thiolate Proteins into Efficient Biocatalysts with High Specificity and Selectivity 2010
Research
principal investigator on
- Acquisition of an X-Ray/UV photoelectron spectroscopy setup for materials research and education. awarded by U.S. Army 2007 - 2009
- Consortium Agreement on the Metabolism and Mechanism of the Anticancer Effects of Wogonin, Baicalein and their Derivatives awarded by China Pharmaceutical University 2016 - 2022
- Structural Basis for the Chloroperoxidase-Catalyzed Enantioselective Transformations. awarded by National Science Foundation 2005 - 2010
co-principal investigator on
Contact
full name
- Xiaotang Wang
visualizations
publication subject areas
- Agriculture
- Biochemistry & Molecular Biology
- Biophysics
- Biotechnology & Applied Microbiology
- Cell Biology
- Chemistry
- Electrochemistry
- Endocrinology & Metabolism
- Energy & Fuels
- Engineering
- Food Science & Technology
- Genetics & Heredity
- Hematology
- Immunology
- Instruments & Instrumentation
- Microbiology
- Oncology
- Pharmacology & Pharmacy
- Physics
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Spectroscopy