Xiao, Yi
- Associate Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education
Overview
overview
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Dr. Xiao's research will pave the way to bring highly sensitive sensors with great specificity into portable micro/nano-sized devices, which will impact the most pressing problems associated with analytical life sciences, including clinical diagnosis, drug abuse test, food safety and environmental pollution monitoring.
Nanomaterial-Based Biosensors
DNA-Based Biosensors
In vitro Directed Evolution
Scholarly & Creative Works
selected publications
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Article
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2021Immobilization Strategies for Enhancing Sensitivity of Electrochemical Aptamer-Based Sensors. ACS APPLIED MATERIALS & INTERFACES. 13:9491-9499.Full Text via DOI: 10.1021/acsami.0c20707 Web of Science: 000626502700018
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2021Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids. ANALYTICAL CHEMISTRY. 93:3172-3180.Full Text via DOI: 10.1021/acs.analchem.0c04592 Web of Science: 000620922300014
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2021Accelerating Post-SELEX Aptamer Engineering Using Exonuclease Digestion. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 143:805-816.Full Text via DOI: 10.1021/jacs.0c09559 Web of Science: 000612557200034
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2020Fabrication of Aptamer-Modified Paper Electrochemical Devices for On-Site Biosensing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.Full Text via DOI: 10.1002/anie.202008231 Web of Science: 000597239400001
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2020Label-free profiling of DNA aptamer-small molecule binding using T5 exonuclease. NUCLEIC ACIDS RESEARCH. 48.Full Text via DOI: 10.1093/narlgkaa849 Web of Science: 000606018600006
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2020Tuning Biosensor Cross-Reactivity Using Aptamer Mixtures. ANALYTICAL CHEMISTRY. 92:5041-5047.Full Text via DOI: 10.1021/acs.analchem.9b05339 Web of Science: 000526569200047
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2019Perspective on the Future Role of Aptamers in Analytical Chemistry. ANALYTICAL CHEMISTRY. 91:15335-15344.Full Text via DOI: 10.1021/acs.analchem.9b03853 Web of Science: 000503910600002
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2019Universal Design of Structure-Switching Aptamers with Signal Reporting Functionality. ANALYTICAL CHEMISTRY. 91:14514-14521.Full Text via DOI: 10.1021/acs.analchem.9b03368 Web of Science: 000498280100048
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2019In vitro isolation of class-specific oligonucleotide-based small-molecule receptors. NUCLEIC ACIDS RESEARCH. 47.Full Text via DOI: 10.1093/nar/gkz224 Web of Science: 000475891900005
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2019Label-Free, Visual Detection of Small Molecules Using Highly Target-Responsive Multimodule Split Aptamer Constructs. ANALYTICAL CHEMISTRY. 91:7199-7207.Full Text via DOI: 10.1021/acs.analchem.9b00507 Web of Science: 000470793800036
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2018Enhancement of PCR Sensitivity and Yield Using Thiol-modified Primers. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-33223-2 Web of Science: 000446501400008
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2018No Structure-Switching Required: A Generalizable Exonuclease-Mediated Aptamer-Based Assay for Small-Molecule Detection. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 140.Full Text via DOI: 10.1021/jacs.8b04975 Web of Science: 000441475800024
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2018Introducing structure-switching functionality into small-molecule-binding aptamers via nuclease-directed truncation. NUCLEIC ACIDS RESEARCH. 46.Full Text via DOI: 10.1093/nar/gky305 Web of Science: 000444130700006
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2018In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality. NUCLEIC ACIDS RESEARCH. 46.Full Text via DOI: 10.1093/nar/gky026 Web of Science: 000431895800001
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2018Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance. ACS APPLIED MATERIALS & INTERFACES. 10:4233-4242.
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2018Sensitive Detection of Small-Molecule Targets Using Cooperative Binding Split Aptamers and Enzyme-Assisted Target Recycling. ANALYTICAL CHEMISTRY. 90:1748-1758.
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2017A Broadly Applicable Assay for Rapidly and Accurately Quantifying DNA Surface Coverage on Diverse Particles. BIOCONJUGATE CHEMISTRY. 28:933-943.
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2017A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. CHEMICAL SCIENCE. 8:131-141.
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2015Ambient Filtration Method To Rapidly Prepare Highly Conductive, Paper-Based Porous Gold Films for Electrochemical Biosensing. ACS APPLIED MATERIALS & INTERFACES. 7:27049-27058.
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2015Nanoprobe-Enhanced, Split Aptamer-Based Electrochemical Sandwich Assay for Ultrasensitive Detection of Small Molecules. ANALYTICAL CHEMISTRY. 87:7712-7719.
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2015Paper-Based Device for Rapid Visualization of NADH Based on Dissolution of Gold Nanoparticles. ACS APPLIED MATERIALS & INTERFACES. 7:15023-15030.
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2014A Label-Free Aptamer-Fluorophore Assembly for Rapid and Specific Detection of Cocaine in Biofluids. ANALYTICAL CHEMISTRY. 86:11100-11106.
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2014Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles. ANALYTICAL CHEMISTRY. 86:3461-3467.
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2013Self-Assembled DNA Monolayer Buffered Dynamic Ranges of Mercuric Electrochemical Sensor. ANALYTICAL CHEMISTRY. 85:7574-7580.
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2012Electrochemical DNA three-way junction based sensor for distinguishing chiral metallo-supramolecular complexes. CHEMICAL COMMUNICATIONS. 48:6900-6902.
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Conference
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Review
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2019Innovative engineering and sensing strategies for aptamer-based small-molecule detection. TRAC-TRENDS IN ANALYTICAL CHEMISTRY.Full Text via DOI: 10.1016/j.trac.2019.115699 Web of Science: 000501785000018
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Research
research interests
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Biosensors and biomaterials and their applications in solving a broad range of problems in vitro and in vivo
Employing new biomaterials, nanomaterials and new platforms to design ultra-sensitive sensors for specific in vitro or in vivo sensing in complex sample at the point-of-care
High specificity is achieved via biotechnology platforms - innovative selection technology (SELEX) are used to generate bio-functionalized elements capable of performing specific target recognition, and high sensitivity is obtained with subsequent biomolecular cascading, self-assembled amplifications
principal investigator on
- Aptamer-Based, Exonuclease-Amplified, Colorimetric, Onsite Screening of Methylenedioxypyrovalerone (MDPV) and Mephedrone in Oral Fluid awarded by National Institutes of Health 2015 - 2019
- Rapid and Accurate On-Site Screening for a Board Range of Synthetic Cathinones by Electronic Drug Analyzer Based on A Cross-Reactive Aptamer awarded by National Institute of Justice 2017 - 2018
- Electrochemical and Colorimetric Aptamer-Based Sensors for Rapid On-site Screening of Synthetic Cannabinoids in Seized Substances and Biological samples. awarded by National Institute of Justice 2015 - 2018
- Aptamer-Based, Exonuclease-Amplified, Paper Device for Point of Collection Screening of Cocaine and Methamphetamine in Oral Fluid awarded by National Institute of Justice 2014 - 2016
investigator on
Teaching
teaching activities
- CHM4130-U01: Instrumental Analysis Fall Term 2019
- CHM4910-U30: Undergraduate Research in Chemistry Fall Term 2019
- CHM4930-U03: Senior Seminar Spring Term 2019
- CHM5150-U01: Graduate Analytical Methods Fall Term 2019
- CHM7910-U27: Dissertation Research Spring Term 2019
- CHM7910-U29: Dissertation Research Fall Term 2019
- CHM7980-U27: PH.D. Dissertation Spring Term 2019
- CHM7980-U29: PH.D. Dissertation Fall Term 2019
Contact
full name
- Yi Xiao
Identifiers
ORCID iD
- https://orcid.org/0000-0001-7278-9811 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Biochemistry & Molecular Biology
- Chemistry
- Materials Science
- Science & Technology - Other Topics