Xiao, Yi
Scholarly & Creative Works
selected publications
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Article
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2022DNA Aptamer-Cyanine Complexes as Generic Colorimetric Small-Molecule SensorsFull Text via DOI: 10.1002/anie.202112305 Web of Science: 000773454800016
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2021Platinum-Nanoparticle-Modified Single-Walled Carbon Nanotube-Laden Paper Electrodes for Electrocatalytic Oxidation of MethanolFull Text via DOI: 10.1021/acsanm.1c03186 Web of Science: 000733815700001
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2021DNA Aptamer–Cyanine Complexes as Generic Colorimetric Small‐Molecule SensorsFull Text via DOI: 10.1002/ange.202112305
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2021Aptamer-Integrated Multianalyte-Detecting Paper Electrochemical DeviceFull Text via DOI: 10.1021/acsami.1c01822 Web of Science: 000643578300016
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2021Immobilization Strategies for Enhancing Sensitivity of Electrochemical Aptamer-Based Sensors. ACS APPLIED MATERIALS & INTERFACES. 13:9491-9499.Full Text via DOI: 10.1021/acsami.0c20707 Web of Science: 000626502700018
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2021Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids. ANALYTICAL CHEMISTRY. 93:3172-3180.Full Text via DOI: 10.1021/acs.analchem.0c04592 Web of Science: 000620922300014
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2021Accelerating Post-SELEX Aptamer Engineering Using Exonuclease Digestion. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 143:805-816.Full Text via DOI: 10.1021/jacs.0c09559 Web of Science: 000612557200034
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2020Fabrication of Aptamer-Modified Paper Electrochemical Devices for On-Site Biosensing. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.Full Text via DOI: 10.1002/anie.202008231 Web of Science: 000597239400001
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2020Label-free profiling of DNA aptamer-small molecule binding using T5 exonuclease. NUCLEIC ACIDS RESEARCH. 48.Full Text via DOI: 10.1093/narlgkaa849 Web of Science: 000606018600006
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2020Tuning Biosensor Cross-Reactivity Using Aptamer Mixtures. ANALYTICAL CHEMISTRY. 92:5041-5047.Full Text via DOI: 10.1021/acs.analchem.9b05339 Web of Science: 000526569200047
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2019Perspective on the Future Role of Aptamers in Analytical Chemistry. ANALYTICAL CHEMISTRY. 91:15335-15344.Full Text via DOI: 10.1021/acs.analchem.9b03853 Web of Science: 000503910600002
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2019Universal Design of Structure-Switching Aptamers with Signal Reporting Functionality. ANALYTICAL CHEMISTRY. 91:14514-14521.Full Text via DOI: 10.1021/acs.analchem.9b03368 Web of Science: 000498280100048
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2019In vitro isolation of class-specific oligonucleotide-based small-molecule receptors. NUCLEIC ACIDS RESEARCH. 47.Full Text via DOI: 10.1093/nar/gkz224 Web of Science: 000475891900005
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2019Label-Free, Visual Detection of Small Molecules Using Highly Target-Responsive Multimodule Split Aptamer Constructs. ANALYTICAL CHEMISTRY. 91:7199-7207.Full Text via DOI: 10.1021/acs.analchem.9b00507 Web of Science: 000470793800036
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2018Enhancement of PCR Sensitivity and Yield Using Thiol-modified Primers. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-33223-2 Web of Science: 000446501400008
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2018No Structure-Switching Required: A Generalizable Exonuclease-Mediated Aptamer-Based Assay for Small-Molecule Detection. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 140.Full Text via DOI: 10.1021/jacs.8b04975 Web of Science: 000441475800024
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2018Introducing structure-switching functionality into small-molecule-binding aptamers via nuclease-directed truncation. NUCLEIC ACIDS RESEARCH. 46.Full Text via DOI: 10.1093/nar/gky305 Web of Science: 000444130700006
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2018In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality. NUCLEIC ACIDS RESEARCH. 46.Full Text via DOI: 10.1093/nar/gky026 Web of Science: 000431895800001
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2018Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance. ACS APPLIED MATERIALS & INTERFACES. 10:4233-4242.
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2018Sensitive Detection of Small-Molecule Targets Using Cooperative Binding Split Aptamers and Enzyme-Assisted Target Recycling. ANALYTICAL CHEMISTRY. 90:1748-1758.
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2017A Broadly Applicable Assay for Rapidly and Accurately Quantifying DNA Surface Coverage on Diverse Particles. BIOCONJUGATE CHEMISTRY. 28:933-943.
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2017A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. CHEMICAL SCIENCE. 8:131-141.
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2015Ambient Filtration Method To Rapidly Prepare Highly Conductive, Paper-Based Porous Gold Films for Electrochemical Biosensing. ACS APPLIED MATERIALS & INTERFACES. 7:27049-27058.
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2015Nanoprobe-Enhanced, Split Aptamer-Based Electrochemical Sandwich Assay for Ultrasensitive Detection of Small Molecules. ANALYTICAL CHEMISTRY. 87:7712-7719.
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2015Paper-Based Device for Rapid Visualization of NADH Based on Dissolution of Gold Nanoparticles. ACS APPLIED MATERIALS & INTERFACES. 7:15023-15030.
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2014A Label-Free Aptamer-Fluorophore Assembly for Rapid and Specific Detection of Cocaine in Biofluids. ANALYTICAL CHEMISTRY. 86:11100-11106.
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2014Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles. ANALYTICAL CHEMISTRY. 86:3461-3467.
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2013In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo ReleaseFull Text via DOI: 10.1021/nn404079v Web of Science: 000327752200016
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2013Controlling the function of DNA nanostructures with specific trigger sequencesFull Text via DOI: 10.1039/c2cc36878a Web of Science: 000311941100019
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2013Self-Assembled DNA Monolayer Buffered Dynamic Ranges of Mercuric Electrochemical Sensor. ANALYTICAL CHEMISTRY. 85:7574-7580.
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2012Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolutionFull Text via DOI: 10.1093/nar/gks899 Web of Science: 000313414800059
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2012Electrochemical DNA three-way junction based sensor for distinguishing chiral metallo-supramolecular complexes. CHEMICAL COMMUNICATIONS. 48:6900-6902.
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2011Two-Step, PCR-Free Telomerase Detection by Using Exonuclease III-Aided Target RecyclingFull Text via DOI: 10.1002/cbic.201100592 Web of Science: 000297951300007
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2011Measurement of Aptamer-Protein Interactions with Back-Scattering InterferometryFull Text via DOI: 10.1021/ac202823m Web of Science: 000297481700008
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2011Probing the Limits of Aptamer Affinity with a Microfluidic SELEX PlatformFull Text via DOI: 10.1371/journal.pone.0027051 Web of Science: 000297554300011
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2011Improving Aptamer Selection Efficiency through Volume Dilution, Magnetic Concentration, and Continuous Washing in Microfluidic ChannelsFull Text via DOI: 10.1021/ac201269f Web of Science: 000294322100063
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2011Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care DiagnosticsFull Text via DOI: 10.1021/ja203981w Web of Science: 000291667600058
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2011Selection of phage-displayed peptides on live adherent cells in microfluidic channelsFull Text via DOI: 10.1073/pnas.1014753108 Web of Science: 000289888500046
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2011Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide MismatchesFull Text via DOI: 10.1002/anie.201103482 Web of Science: 000297467100025
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2010Detection of Telomerase Activity in High Concentration of Cell Lysates Using Primer-Modified Gold NanoparticlesFull Text via DOI: 10.1021/ja106513f Web of Science: 000283621700043
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2010An Electrochemical Supersandwich Assay for Sensitive and Selective DNA Detection in Complex MatricesFull Text via DOI: 10.1021/ja104998m Web of Science: 000283276800010
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2010Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencingFull Text via DOI: 10.1073/pnas.1009331107 Web of Science: 000281468500017
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2010In vitro selection of structure-switching, self-reporting aptamersFull Text via DOI: 10.1073/pnas.1009172107 Web of Science: 000280767700017
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2010Label-Free, Dual-Analyte Electrochemical Biosensors: A New Class of Molecular-Electronic Logic GatesFull Text via DOI: 10.1021/ja101379k Web of Science: 000279196500015
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2010Electrochemical DNA Detection via Exonuclease and Target-Catalyzed Transformation of Surface-Bound ProbesFull Text via DOI: 10.1021/la100227s Web of Science: 000278427600166
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2010Sensitive and Selective Amplified Fluorescence DNA Detection Based on Exonuclease III-Aided Target RecyclingFull Text via DOI: 10.1021/ja909551b Web of Science: 000275085000040
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2010On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic InteractionsFull Text via DOI: 10.1021/ja908890q Web of Science: 000275084800034
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2010Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) TechnologyFull Text via DOI: 10.1002/anie.200904846 Web of Science: 000273847100016
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2009An Electrochemical Sensor for Single Nucleotide Polymorphism Detection in Serum Based on a Triple-Stem DNA ProbeFull Text via DOI: 10.1021/ja905068s Web of Science: 000271272000051
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2009i-Motif Quadruplex DNA-Based Biosensor for Distinguishing Single- and Multiwalled Carbon NanotubesFull Text via DOI: 10.1021/ja9051763 Web of Science: 000270186600052
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2009Label-Free Colorimetric Screening of Nuclease Activity and Substrates by Using Unmodified Gold NanoparticlesFull Text via DOI: 10.1002/cbic.200900355 Web of Science: 000269279700009
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2009Generation of Highly Specific Aptamers via Micromagnetic SelectionFull Text via DOI: 10.1021/ac900759k Web of Science: 000267609500052
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2009On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based MechanismsFull Text via DOI: 10.1002/elan.200804564 Web of Science: 000267235900006
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2009Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic, Electrochemical Aptamer-Based SensorFull Text via DOI: 10.1021/ja806531z Web of Science: 000264792900035
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2009Micromagnetic selection of aptamers in microfluidic channelsFull Text via DOI: 10.1073/pnas.0813135106 Web of Science: 000263844100006
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2009Optimization of a Reusable, DNA Pseudoknot-Based Electrochemical Sensor for Sequence-Specific DNA Detection in Blood SerumFull Text via DOI: 10.1021/ac802011d Web of Science: 000262482700019
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2009Fluorescence Detection of Single-Nucleotide Polymorphisms with a Single, Self-Complementary, Triple-Stem DNA ProbeFull Text via DOI: 10.1002/anie.200900369 Web of Science: 000267040000017
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2008Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistryFull Text via DOI: 10.1021/la800801v Web of Science: 000259120500088
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2007Label-free electrochemical detection of DNA in blood serum via target-induced resolution of an electrode-bound DNA pseudoknotFull Text via DOI: 10.1021/ja074218y Web of Science: 000249887700011
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2007Stable highly hydrophobic and oleophilic meshes for oil-water separationFull Text via DOI: 10.1016/j.apsusc.2007.05.030
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2007Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assemblyFull Text via DOI: 10.1021/ja067278x Web of Science: 000243381200010
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2007Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensingFull Text via DOI: 10.1038/nprot.2007.413 Web of Science: 000253140000024
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2006Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplexFull Text via DOI: 10.1073/pnas.0607693103 Web of Science: 000241969500012
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2005A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacementFull Text via DOI: 10.1021/ja056555h Web of Science: 000234258700013
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2005Shape and color of Au nanoparticles follow biocatalytic processesFull Text via DOI: 10.1021/la050308+ Web of Science: 000229886300004
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2005Inhibition of the acetycholine esterase-stimulated growth of Au nanoparticles: Nanotechnology-based sensing of nerve gasesFull Text via DOI: 10.1021/nl050054c Web of Science: 000228468800017
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2005Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensorFull Text via DOI: 10.1002/anie.200500989 Web of Science: 000231639400010
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2004Electrical contacting of glucose oxidase by DNA-templated polyaniline wires on surfacesFull Text via DOI: 10.1016/j.elecom.2004.08.004 Web of Science: 000224231800019
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2004Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombinFull Text via DOI: 10.1021/ja046970u Web of Science: 000224103900009
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2004DNAzyme-functionalized Au nanoparticles for the amplified detection of DNA or telomerase activityFull Text via DOI: 10.1021/nl0491428 Web of Science: 000223837200021
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2004Catalytic beacons for the detection of DNA and telomerase activityFull Text via DOI: 10.1021/ja031875r Web of Science: 000222120900009
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2004Lighting up biochemiluminescence by the surface self-assembly of DNA-hemin complexesFull Text via DOI: 10.1002/cbic.200300794 Web of Science: 000220196800019
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2004Catalytic growth of Au nanoparticles by NAD(P)H cofactors: Optical sensors for NAD(P)(+)-dependent biocatalyzed transformationsFull Text via DOI: 10.1002/anie.200460608 Web of Science: 000223755100028
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2003"Plugging into enzymes": Nanowiring of redox enzymes by a gold nanoparticleFull Text via DOI: 10.1126/science.1080664 Web of Science: 000181669700041
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2003Electrocatalytic intercalator-induced winding of double-stranded DNA with polyanilineFull Text via DOI: 10.1039/b301749d Web of Science: 000183482500034
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2000Direct electrochemistry of horseradish peroxidase immobilized on a colloid/cysteamine-modified gold electrodeFull Text via DOI: 10.1006/abio.1999.4360 Web of Science: 000084999800003
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1999Adsorption characteristics of Fe(CN)(3)(-/4)(6) on Au colloids as monolayer films on cysteamine-modified gold electrodeFull Text via DOI: 10.1016/S0022-0728(99)00113-8 Web of Science: 000080818100005
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Conference
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2005Catalytic beacons for the detection of DNA and telomerase activity. 199-205.Full Text via DOI: 10.1007/1-4020-3384-2_15 Web of Science: 000236493200015
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Early Access
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2021Advances and Challenges in Small-Molecule DNA Aptamer Isolation, Characterization, and Sensor Development. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.Full Text via DOI: 10.1002/anie.202008663 Web of Science: 000616171800001
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Letter
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2004Amplified chemiluminescence surface detection of DNA and telomerase activity using catalytic nucleic acid labels. 2152-2156.Full Text via DOI: 10.1021/ac035219l Web of Science: 000220618400057
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Other Scholarly Work
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2011Erratum: Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing (Proceedings of the National Academy of Sciences of the United States of America (2010) 107:35 (15373-15378) DOI: 10.1073/pnas.1009331107). 5472.Full Text via DOI: 10.1073/pnas.1103208108
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Review
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2019Innovative engineering and sensing strategies for aptamer-based small-molecule detection. TRAC-TRENDS IN ANALYTICAL CHEMISTRY.Full Text via DOI: 10.1016/j.trac.2019.115699 Web of Science: 000501785000018
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Research
principal investigator on
- Rapid isolation of high-affinity DNA aptamers for small-molecule targets via nuclease-assisted SELEX awarded by National Science Foundation 2019 - 2022
- Homogeneous Nuclease-Assisted SELEX for Rapid Isolation of Cross-Reactive Aptamers for Synthetic Cannabinoid detection awarded by National Institute on Drug Abuse 2019 - 2022
- Electrochemical Aptamer-Based Sensor for Rapid Identification of Marijuana from Hemp awarded by National Institute of Justice 2020 - 2021
- Optimization of Complementary DNA-Aptamer Complex for Detection of Fentanyl awarded by National Institutes of Health 2020 - 2021
- Aptamer-Based, Exonuclease-Amplified, Colorimetric, Onsite Screening of Methylenedioxypyrovalerone (MDPV) and Mephedrone in Oral Fluid awarded by National Institute on Drug Abuse 2015 - 2019
- Electrochemical and Colorimetric Aptamer-Based Sensors for Rapid On-site Screening of Synthetic Cannabinoids in Seized Substances and Biological samples. awarded by National Institute of Justice 2015 - 2019
- Rapid and Accurate On-Site Screening for a Board Range of Synthetic Cathinones by Electronic Drug Analyzer Based on A Cross-Reactive Aptamer awarded by National Institute of Justice 2017 - 2018
- Aptamer-Based, Exonuclease-Amplified, Paper Device for Point of Collection Screening of Cocaine and Methamphetamine in Oral Fluid awarded by National Institute of Justice 2014 - 2016
co-principal investigator on
- Center for Advanced Research in Forensic Science (CARFS), Phase I IUCRC Site at FIU awarded by National Science Foundation 2017 - 2023
- Aptamer-Based, Exonuclease-Amplified, Paper Device for Point of Collection Screening of Cocaine and Methamphetamine in Oral Fluid awarded by National Institute of Justice 2014 - 2016
subproject principal investigator on
- Rapid, in-plant veterinary drug screening in animal carcasses using electrochemical aptamer-based sensors awarded by National Institute of Food & Agriculture 2020 - 2024
- Center for Advanced Research in Forensic Science (CARFS), Phase I IUCRC Site at FIU awarded by National Science Foundation 2017 - 2023
- Electrochemical Aptamer-Based Sensor for Rapid Opioid Detection in Seized Substances awarded by National Institute of Justice 2020 - 2022
Identifiers
ORCID iD
- https://orcid.org/0000-0001-7278-9811 (confirmed)
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
Citation index-derived subject areas the researcher has published in