Yoo, Changwon
- Associate Professor, Biostatistics , Robert Stempel College of Public Health and Social Work
Overview
overview
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Dr. Changwon Yoo’s research, teaching, and service activities are shaped by three common aims: examining and developing novel computational and statistical methods, providing useful insights in improving health outcomes of the public in general, and involving a collaborative partnership of university, community agencies and organizations, and residents to achieve the first two aims. The incorporation of these aims into all levels of his scholarship (research, teaching, service) provides cohesiveness to his work, which enables him to be more efficient, effective, and productive.
Dr. Yoo’s research focuses on developing and disseminating innovative statistical methods for Big Data Analytics (BDA). His research draws from statistical machine learning, genomics, and neuroscience and seeks to identify and build statistical methods in big data such as genomics, proteomics, neuroimaging and clinical data. It is highly collaborative because understanding disease mechanisms and coming up with better treatments and prevention in medicine and public health inevitably involve analyzing complex and big data. He is currently a principal investigator in a National Institutes of Health (NIH) grant to build a novel computational causal model of key genes interactions in brain cancer development.
Scholarly & Creative Works
selected publications
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Article
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2020Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer. CLINICAL & EXPERIMENTAL METASTASIS. 37:657-674.Full Text via DOI: 10.1007/s10585-020-10060-0 Web of Science: 000580404900001
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2020Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 146:2777-2815.Full Text via DOI: 10.1007/s00432-020-03320-9 Web of Science: 000551783900003
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2020Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma. MOLECULAR NEUROBIOLOGY.Full Text via DOI: 10.1007/s12035-020-01979-2 Web of Science: 000544199400001
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2019Black, White, and Hispanic Children's Health and Function 2-13 Months After Sibling Intensive Care Unit Death. JOURNAL OF PEDIATRICS. 210:184-193.Full Text via DOI: 10.1016/j.jpeds.2019.03.017 Web of Science: 000472497600035
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2018NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2+ve breast cancer signaling pathways. BREAST CANCER RESEARCH AND TREATMENT. 172.Full Text via DOI: 10.1007/s10549-018-4905-9 Web of Science: 000447497300021
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2018Effect of zinc intake on hepatic autophagy during acute alcohol intoxication. BIOMETALS. 31:217-232.
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2017Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290Full Text via DOI: 10.1210/js.2017-00112 Web of Science: 000425346100016
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2017Development of Decision Support Formulas for the Prediction of Bladder Outlet Obstruction and Prostatic Surgery in Patients With Lower Urinary Tract Symptom/Benign Prostatic Hyperplasia: Part I, Development of the Formula and its Internal Validation. INTERNATIONAL NEUROUROLOGY JOURNAL. 21:S55-S65.
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2017Development of Decision Support Formulas for the Prediction of Bladder Outlet Obstruction and Prostatic Surgery in Patients With Lower Urinary Tract Symptom/Benign Prostatic Hyperplasia: Part II, External Validation and Usability Testing of a Smartphone App. INTERNATIONAL NEUROUROLOGY JOURNAL. 21:S66-S75.
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2017Parent Grief 1-13 Months After Death in Neonatal and Pediatric Intensive Care Units. JOURNAL OF LOSS & TRAUMA. 22:77-96.
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2015Health and Functioning in Grandparents After a Young Grandchild's Death. JOURNAL OF COMMUNITY HEALTH. 40:956-966.
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2015Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 16:25285-25322.
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2015Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. MOLECULAR NEUROBIOLOGY. 52:1341-1363.
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2015Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells. BRITISH JOURNAL OF CANCER. 112:1687-1702.
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2015The Analgesic Effect of Rolipram, a Phosphodiesterase 4 Inhibitor, on Chemotherapy-Induced Neuropathic Pain in Rats. ANESTHESIA AND ANALGESIA. 121:822-828.
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2014Bayesian Network and Mechanistic Hierarchical Structure Modeling of Increased likelihood of Developing Intractable Childhood Epilepsy from the Combined Effect of mtDNA Variants, Oxidative Damage, and Copy Number. JOURNAL OF MOLECULAR NEUROSCIENCE. 54:752-766.
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2014Establishment of the Novel Cystoscopic Classification for Bladder Trabeculation of Neurogenic Bladder. UROLOGY. 84:515-519.
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2014Factors Affecting De Novo Urinary Retention after Holmium Laser Enucleation of the Prostate. PLOS ONE. 9.Full Text via DOI: 10.1371/journal.pone.0084938 Web of Science: 000330244500023
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2014Factors Influencing Nonabsolute Indications for Surgery in Patients With Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: Analysis Using Causal Bayesian Networks. INTERNATIONAL NEUROUROLOGY JOURNAL. 18:198-205.
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2013Discovering gene-environment interactions in Glioblastoma through a comprehensive data integration bioinformatics method. NEUROTOXICOLOGY. 35:1-14.
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2013HIV infection and drugs of abuse: role of acute phase proteins. JOURNAL OF NEUROINFLAMMATION. 10.
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2013Role of Zinc in the Regulation of Autophagy During Ethanol Exposure in Human Hepatoma Cells. BIOLOGICAL TRACE ELEMENT RESEARCH. 156:350-356.
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2012Alcohol-induced serotonergic modulation: The role of histone deacetylases. ALCOHOL. 46:635-642.
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2012Gene Pathways Discovery in Asbestos-Related Diseases using Local Causal Discovery Algorithm. COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION. 41:1840-1859.Full Text via DOI: 10.1080/03610918.2011.621573 Web of Science: 000315225700007
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2012The Bayesian method for causal discovery of latent-variable models from a mixture of experimental and observational data. COMPUTATIONAL STATISTICS & DATA ANALYSIS. 56:2183-2205.Full Text via DOI: 10.1016/j.csda.2012.01.010 Web of Science: 000302106700001
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2010Discovering Gene-Gene and Gene-Environment Causal Interactions Using Bioinformatics Approaches. ENVIRONMENTAL FACTORS, GENES, AND THE DEVELOPMENT OF HUMAN CANCERS. 115-138.Full Text via DOI: 10.1007/978-1-4419-6752-7_5 Web of Science: 000282535900005
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Book Chapter
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Conference
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Meeting Abstract
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2018Identifying the regulatory network structure of the genes involved in signaling pathways underlying ER-PR-HER2+breast cancer using Bayesian modeling of genome-wide NRF1 DNA motif sequence-enriched genes. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-4274 Web of Science: 000468819502469
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2018Role of NRF1 regulatory gene-networks in glioblastoma. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-1127 Web of Science: 000468818903100
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2016DEVELOPMENT OF ANDROID PLATFORM BPH PROBABILITY CALCULATOR (R) USING BIG DATA FOR PREDICTION OF SURGERY NECESSITY IN PATIENTS WITH LUTS/BPH AND ITS VALIDATION. NEUROUROLOGY AND URODYNAMICS. S29-S30.Web of Science: 000379907200006
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2014FACTORS THAT INFLUENCE THE DECISION FOR SURGERY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: ARTIFICIAL NEURAL NETWORK ANALYSIS. NEUROUROLOGY AND URODYNAMICS. 215-215.Web of Science: 000331012800120
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2014Induction of autophagy by zinc during acute ethanol exposure. FASEB JOURNAL.Web of Science: 000346646700044
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2014NON-INVASIVE PARAMETERS FOR THE PREDICTION OF URODYNAMIC BLADDER OUTLET OBSTRUCTION: ANALYSIS USING CAUSAL BAYESIAN NETWORKS. NEUROUROLOGY AND URODYNAMICS. 658-660.Web of Science: 000339424000009
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2013HIGH BLADDER NECK ELEVATION, NOT 'KISSING SIGN', IS HIGHLY SIGNIFICANT FOR URODYNAMIC BLADDER OUTLET OBSTRUCTION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA. NEUROUROLOGY AND URODYNAMICS. 143-144.Web of Science: 000315223200084
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Proceedings Paper
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2013Combining Structure Equation Model with Bayesian Networks for predicting with high accuracy of recommending surgery for better survival in Benign prostatic hyperplasia patients. 20TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2013). 2029-2033.Web of Science: 000357105902010
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2013Integrative biostatistical approach shows better performance in missing data analysis using longitudinal study of pediatric head trauma. 20TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2013). 2018-2022.Web of Science: 000357105902008
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2013Logistic Regression and Bayesian Approaches in Modeling Acceptance of Male Circumcision in Pune, India. 20TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2013). 2023-2028.Web of Science: 000357105902009
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2011Evaluation of causal Bayesian network search algorithms using simulated mesotheliomas gene expression data. 19TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2011). 1042-1048.Web of Science: 000314989301009
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2011Identifying gene alterations required for the development of astrocytoma. 19TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2011). 1037-1041.Web of Science: 000314989301008
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2011Identifying gene-protein interactions in response to environmental estrogenic chemicals using Bayesian networks: its implication in the etiology of pulmonary vascular lesions. 19TH INTERNATIONAL CONGRESS ON MODELLING AND SIMULATION (MODSIM2011). 1056-1062.Web of Science: 000314989301011
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Review
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2016Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms17122086 Web of Science: 000392280500130
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2014Big Data Analysis Using Modern Statistical and Machine Learning Methods in Medicine. INTERNATIONAL NEUROUROLOGY JOURNAL. 50-57.
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chaired theses and dissertations
- Preciados, Mark, Exposure to Estrogenic Endocrine Disrupting Chemicals and Brain Health 2018
- Assaggaf, Hamza M, Molecular Risk Factors of Pulmonary Arterial Hypertension 2017
Research
research interests
- Statistical Methods for Big Data Analytics
principal investigator on
- Identifying Key Genes that cause Aggressive Brain Cancer awarded by National Institute of General Medical Sciences 2012 - 2018
- Developing a computer diagnosis system for Benign Prostatic Hyperplasia awarded by Seoul National University Hospital 2014 - 2016
- Analysis of Clinical Parameters of Benign Prostatic Hyperplasia using Causal Bayesian Network awarded by Seoul National University Hospital 2011 - 2012
co-principal investigator on
investigator on
- FIU Center for Reducing Health Disparities in Substance Abuse & HIV in South Florida awarded by National Institute on Minority Health and Health Disparities 2018 - 2022
- FIU Center for Reducing Health Disparities in Substance Abuse & HIV in South Florida awarded by National Institute on Minority Health and Health Disparities 2017 - 2022
Teaching
teaching activities
- PHC6052-RVC: Biostatistics I Fall Term 2019
- PHC6052-RVC: Biostatistics I Spring Term 2019
- PHC6065-RVC: Public Health Statistics Spring Term 2019
- PHC6065-RXD: Public Health Statistics Spring Term 2019
- PHC6067-U01: Probabilistic Graphical Models Fall Term 2019
- PHC6907-U01: Independent Study: Public Health Fall Term 2019
- PHC6907-U01: Independent Study: Public Health Fall Term 2019
- PHC6907-U01: Independent Study: Public Health Fall Term 2019
- PHC6907-U01: Independent Study: Public Health Fall Term 2019
- PHC6907-U01: Independent Study: Public Health Fall Term 2019
- PHC6931-RVC: Special Topics in Biostatistics Spring Term 2019
- PHC6977-U01: Master's Research Project Fall Term 2019
Contact
full name
- Changwon Yoo
visualizations
Recent publications and grants in Scholars@FIU
publication subject areas
- Anesthesiology
- Biochemistry & Molecular Biology
- Cell Biology
- Chemistry
- Computer Science
- Endocrinology & Metabolism
- Health Care Sciences & Services
- Immunology
- Infectious Diseases
- Life Sciences & Biomedicine - Other Topics
- Mathematics
- Neurosciences & Neurology
- Oncology
- Pediatrics
- Pharmacology & Pharmacy
- Psychology
- Public, Environmental & Occupational Health
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Substance Abuse
- Toxicology
- Urology & Nephrology
- Virology