This study examined the relationship between delay of gratification and substance use in middle adolescence using a modified version of the stress-coping model of addiction. Predictor variables included impulsivity, delay of gratification, stress, and perceived peer substance use. Multiple regression path analysis supported the hypotheses that impulsivity, emotion-focused relief-oriented coping, stress, and peer substance use are each related to adolescent substance use. Delay of gratification and problem-focused coping were unrelated to substance use, and stress did not moderate the relationship between coping and substance use. Exploratory structural equation modeling procedures suggested an even more parsimonious model. Neither coping nor impulsivity was significantly related to substance use, and peer substance use proved to be the most powerful predictor of adolescent substance use followed by perceived stress.