Agricultural activities significantly impact water quality, including increases in stream sediment, nutrients, pesticides, and salt concentrations from runoff. South Florida is unique in having agricultural areas located next to areas of ecological values, which results in conflicts between agricultural practices and preservation of the environment. Improving agricultural practices to allow agricultural development in a sustainable environment is of high priority. ARC/INFO Geographic Information System (GIS) technology is used to predict, map, monitor, and manage pollutants from agricultural areas. In doing so, software is used to interface existing computer codes (HSPF) for nonpoint pollution from agricultural areas with GIS software. Initial data collection, calibration, and process application is done for a pilot site in south Florida. Transport of typically dissolved and adsorbed pollutants is simulated as a basis to develop procedures. Topographic and historical data and model results are mapped through GIS. Management practices for pesticide and fertilizer application are evaluated using the model.