Suspect Screening of Pharmaceuticals and Related Bioactive Compounds, Their Metabolites and Their Transformation Products in the Aquatic Environment, Biota and Humans Using LC-HR-MS Techniques Article

Aceña, J, Heuett, N, Gardinali, P et al. (2016). Suspect Screening of Pharmaceuticals and Related Bioactive Compounds, Their Metabolites and Their Transformation Products in the Aquatic Environment, Biota and Humans Using LC-HR-MS Techniques . 71 357-378. 10.1016/bs.coac.2016.02.011

cited authors

  • Aceña, J; Heuett, N; Gardinali, P; Pérez, S

fiu authors

abstract

  • The interdisciplinary nature of the field of high-resolution mass spectrometry (HRMS) has substantially broadened the possibilities in the environmental, forensic and clinical fields with numerous advances in each of the areas or a combination of them. Through a multitude of studies reported to date, presence of several hundreds of microconstituents, ranging from pesticides, drugs of abuse, pharmaceuticals and personal care products, in water and soil matrices originating from anthropogenic activities has been confirmed. This chapter presents a general overview regarding the capabilities of HRMS coupled to liquid chromatography (LC) and its applications in monitoring human pollution using a qualitative approach called suspect screening. This is the simplest form of qualitative analysis in HRMS in which some information of the suspected analytes is collected a priori. Three main areas are discussed in this chapter: the review focuses on many studies carried out with LC-HRMS in the field of suspect screening in wastewaters, in surface waters and biota. In particular the book chapter describes different workflows for the detection and identification of transformation products and metabolites applying suspect screening approaches. © 2016 Elsevier B.V.

publication date

  • January 1, 2016

Digital Object Identifier (DOI)

start page

  • 357

end page

  • 378

volume

  • 71