Cytochrome P-450 catalyzed redox cycling of orthophenylphenol Article

Roy, D. (1990). Cytochrome P-450 catalyzed redox cycling of orthophenylphenol . 22(5), 849-857.



cited authors

  • Roy, D

fiu authors

abstract

  • 0-Phenylphenol was converted to 2,5-dihydroxy biphenyl (phenylhydroquinone) by microsomal P-450. Depending on the cofactor used, microsomal enzymes catalyzed oxidation and/or reduction of phenylhydroquinone. Phenylhydroquinone was oxidized to phenyl 2,5'-p-quinone by cumene hydroperoxide-supported microsomal P-450. Phenyl 2,5'-p-quinone was reduced to phenylhydroquinone by cytochrome P-450 reductase. This study provides direct evidence of cytochrome P-450 catalyzed redox cycling of 0-phenylphenol. It is postulated that redox cycling of 0-phenylphenol may play a role in 0-phenylphenol-caused bladder cancer.

publication date

  • December 1, 1990

start page

  • 849

end page

  • 857

volume

  • 22

issue

  • 5