Sex hormone-induced nuclear DNA damage and lipid peroxidation in the dorsolaterel prostates of Noble rats Article

Ho, SM, Roy, D. (1994). Sex hormone-induced nuclear DNA damage and lipid peroxidation in the dorsolaterel prostates of Noble rats . 84(2), 155-162. 10.1016/0304-3835(94)90370-0



cited authors

  • Ho, SM; Roy, D

fiu authors

abstract

  • To date, few studies have been reported on any aspect of DNA damage in organs of intact animals. We and others demonstrated induction of high incidences of dysplasia, a precancerous proliferative lesion, and adenocarcinoma selectively in the dorsolateral prostates (DLPs) of Noble rats exposed to a long-term combined testosterone and estradiol-17β treatment (T + E2-treatment). We here report induction of a significant increase in DNA strand breakage and accumulation of lipid peroxidation fluorescent products in the DLPs, but not in the ventral prostates (VPs), of rats treated with T + E2 for 16 weeks. These results indicate that this dual hormone treatment has free radical-based DNA damaging effect on rat DLP and therefore may have tumor-initiating action. Since a similar effect was not observed in regenerating DLPs of castrated rats following testosterone replacement, we conclude that the genotoxic effect of the dual hormone treatment is a direct result of hormone action and not secondarily due to enhancement of cell proliferation. © 1994.

publication date

  • September 15, 1994

Digital Object Identifier (DOI)

start page

  • 155

end page

  • 162

volume

  • 84

issue

  • 2