Time-related effects of RU486 treatment in experimentally induced endometriosis in the rat Article

cited authors

  • Tjaden, B; Galetto, D; Woodruff, JD; Rock, JA

fiu authors

abstract

  • Objective: To evaluate the time-dependent effect of the progesterone antagonist RU486 on experimentally induced endometriosis in the rat. Design: Endometriosis was induced by implanting endometrium onto the peritoneal side wall. Size of the implants was measured before and after treatment. Participants: Fifty-two adult female Sprague-Dawley female rats weighing 200 to 225 g. Setting: Departmental research laboratory of university hospital. Intervention: Animals treated with RU486 or vehicle only for 2, 4, 6, or 8 weeks. Main Outcome Measures: Size of the implant was measured before and after treatment; relative change in size of the implants was calculated. Results: There was not a statistically significant difference between the treatment groups and the control groups. There was no regression of endometriosis in any of the treatment groups. Conclusions: RU486 administered for 8 weeks in the rat model was not effective therapy for endometriosis.

publication date

  • January 1, 1993

Digital Object Identifier (DOI)

start page

  • 437

end page

  • 440

volume

  • 59

issue

  • 2