Antinuclear antibodies in sera of patients with recurrent pregnancy wastage Article

cited authors

  • Xu, L; Chang, V; Murphy, A; Rock, JA; Damewood, M; Schlaff, W; Zacur, HA

fiu authors

abstract

  • Four groups of women were studied to determine whether low-level antinuclear antibody titers are associated with a higher risk for pregnancy loss. Group A consisted of 30 patients with a history of unexplained fetal losses. Group B consisted of 30 women with "explained" fetal losses (e.g., uterine septum or luteal phase defect). Ages and number of losses were comparable between the women in groups A and B. Group C consisted of 61 healthy pregnant women. Group D involved 61 healthy nonpregnant women of reproductive age. In groups A and B, 40% and 53.3% of the respective patients had antinuclear antibody titers ≥1 : 40. In groups C and D the frequencies of positive antinuclear antibody titers were 8.2% and 5.6%, respectively. This study demonstrates a high prevalence of low-titer antinuclear antibody-positive serum in patients with explained and unexplained pregnancy losses. © 1990.

publication date

  • January 1, 1990

Digital Object Identifier (DOI)

start page

  • 1493

end page

  • 1497

volume

  • 163

issue

  • 5 PART 1