An earlier empirical investigation found the interaction of negative-feedback seeking and roommate rejection to be predictive of increases in depressive symptoms. This study replicated and elaborated this finding. Participants who sought negative feedback and performed below their personal standard of success were more likely to experience a subsequent increase in depressive symptoms compared with all other students. Furthermore, the interaction of negative-feedback seeking and midterm failure was specific to predicting increases in depressive symptoms, and did not predict anxious symptoms, thus supporting the specificity of the model to depression. These findings suggest that negative-feedback seeking, combined with a negative life event, may place an individual at increased risk for depressive symptoms. Potential methods and consequences of disrupting the pattern of negative-feedback seeking are discussed.