- Schmidt, S; Horch, K; Normann, R
- The passive biocompatibility of silicon‐based electrode arrays was studied in feline cortical tissue. Three types of arrays were used: uncoated, coated with polyimide, and coated with polyimide over an adhesion promoter. Fifteen arrays were implanted for 24 h to determine early tissue reaction to the implantation procedure, and twelve arraays were implanted for 6 months to determine structural and material biocompatibility. Edema and hemorrhage were present around the short‐term implants, but involved less than 6% of the total area of the tissue covered by the array. With chronic implants, leukocytes were rarely present and macrophages were found around roughly one‐third of the tracks. Remnants of foreign material from the electrodes could be identified in less than 10% of the tracks. Gliosis was found around all tracks, forming an annulus between 20 and 40 μm thick. A capsule was not always present, and never exceeded a thickness of 9 μm. These results suggest that the implantation procedure produces limited amounts of tissue damage, and that the arrays are biocompatible. However, the arrays insulated with polyimide over a primer had significantly greater involvement of macrophages, gliosis, and capsule formation than uncoated arrays and arrays insulated with polyimide without printer, perhaps indicating a reaction to aluminum oxide in the primer. © 1993 John Wiley & Sons, Inc. Copyright © 1993 John Wiley & Sons, Inc.
- January 1, 1993
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