With the onset of global migration, nurses are faced with dealing with cultures from around the world. Having an understanding of transcultural nursing concepts and translating them to practice will be key to nurses meeting the needs of an ever changing patient population. Acculturation is one example of how transcultural nursing concepts need to be better understood. The purpose of this paper is to describe the state of the science of acculturation in terms of the nursing discipline. It offers a historical review and evolution of acculturation, uses in nursing theory, and clinical implications.