In vitro selection of self-reporting aptamers via microfluidic seperation Conference

cited authors

  • Oh, SS; Plakos, K; Xiao, Y; Soh, HT

fiu authors

abstract

  • We describe a novel method to generate smart aptamer-based biosensors capable of fluorescently reporting the presence of their molecular target via binding induced conformation change of the probes. These self-reporting aptamers (SRA) were selected in a microfluidic device, and they show high specificity and low nanomolar affinity towards the intended target (human α-thrombin). © 2009 CBMS.

publication date

  • January 1, 2009

start page

  • 1755

end page

  • 1757