The enzymatic synthesis of 1,5-dideoxy-1,5-diimino-d-talitol and 1-deoxygalactostatin using fuculose-1-phosphate aldolase Article

Lees, WJ, Whitesides, GM. (1992). The enzymatic synthesis of 1,5-dideoxy-1,5-diimino-d-talitol and 1-deoxygalactostatin using fuculose-1-phosphate aldolase . 20(2), 173-179. 10.1016/0045-2068(92)90037-4



cited authors

  • Lees, WJ; Whitesides, GM

fiu authors

abstract

  • A new polyhydroxylated piperidine derivative of d-talo configuration, 1,5-dideoxy-1,5-imino-d-talitol (2), and 1-deoxygalactostatin 1 have been prepared using fuculose-1-phosphate aldolase (EC 4.1.2.17). The 6-azido-1,3,4,5-tetrahydroxyhexan-2-one, formed by the enzyme-catalyzed condensation of 3-azido-2-hydroxypropanal and dihydroxyacetonephosphate, is reduced stereospecifically to the corresponding polyhydroxylated piperidine derivative with hydrogen. © 1992.

publication date

  • January 1, 1992

Digital Object Identifier (DOI)

start page

  • 173

end page

  • 179

volume

  • 20

issue

  • 2