Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution Article

Hillier, LW, Miller, W, Birney, E et al. (2004). Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution . 432(7018), 695-716. 10.1038/nature03154

cited authors

  • Hillier, LW; Miller, W; Birney, E; Warren, W; Hardison, RC; Ponting, CP; Bork, P; Burt, DW; Groenen, MAM; Delany, ME; Dodgson, JB; Chinwalla, AT; Cliften, PF; Clifton, SW; Delehaunty, KD; Fronick, C; Fulton, RS; Graves, TA; Kremitzki, C; Layman, D; Magrini, V; McPherson, JD; Miner, TL; Minx, P; Nash, WE; Nhan, MN; Nelson, JO; Oddy, LG; Pohl, CS; Randall-Maher, J; Smith, SM; Wallis, JW; Yang, SP; Romanov, MN; Rondelli, CM; Paton, B; Smith, J; Morrice, D; Daniels, L; Tempest, HG; Robertson, L; Masabanda, JS; Griffin, DK; Vignal, A; Fillon, V; Jacobbson, L; Kerje, S; Andersson, L; Crooijmans, RPM; Aerts, J; van der Poel, JJ; Ellegren, H; Caldwell, RB; Hubbard, SJ; Grafham, DV; Kierzek, AM; McLaren, SR; Overton, IM; Arakawa, H; Beattie, KJ; Bezzubov, Y; Boardman, PE; Bonfield, JK; Croning, MDR; Davies, RM; Francis, MD; Humphray, SJ; Scott, CE; Taylor, RG; Tickle, C; Brown, WRA; Rogers, J; Buerstedde, JM; Wilson, SA; Stubbs, L; Ovcharenko, I; Gordon, L; Lucas, S; Miller, MM; Inoko, H; Shiina, T; Kaufman, J; Salomonsen, J; Skjoedt, K; Wong, GKS; Wang, J; Liu, B; Wang, J; Yu, J; Yang, H; Nefedov, M; Koriabine, M; Dejong, PJ; Goodstadt, L; Webber, C; Dickens, NJ; Letunic, I; Suyama, M; Torrents, D; von Mering, C

fiu authors

abstract

  • We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome-composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes-provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.

publication date

  • December 9, 2004

Digital Object Identifier (DOI)

start page

  • 695

end page

  • 716

volume

  • 432

issue

  • 7018